Articles tagged with Fibrils
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers found that an imbalance between two peptides, AB40 and AB42, can lead to the formation of senile plaques and dementia. Introducing more AB40 may stop or slow down Alzheimer's development by balancing with AB42.
Researchers have discovered that Alzheimer's, Parkinson's, and type 2 diabetes share a common molecular mechanism, involving amyloid fibrils with a universal 'molecular zipper' structure. This finding could lead to new diagnostic tools and treatment options through 'structure-based drug design'.
Scientists have uncovered the molecular structure of cartilage's collagen fibrils, a key factor in osteoarthritis. The discovery could lead to treatments that prevent fibril deterioration and ultimately alleviate joint pain.
Researchers found that mice born to mothers with senile amyloidosis exhibited elevated levels of amyloid fibrils, accelerating disease onset. The presence of fibrils in the milk of affected mothers was confirmed, demonstrating transmission via nursing.
Researchers have discovered a potential treatment for Alzheimer's disease by combining gold nanoparticles with microwave radiation. The approach breaks up beta amyloid fibrils and reduces protein re-aggregation, offering hope for other neurodegenerative diseases like Parkinson's and Huntington's.
Researchers have determined the structure of pre-fibril assemblies, smaller assemblies that may be toxic culprits in Alzheimer's disease. The findings provide a new clue to understanding how these molecules interact and may lead to designing molecules that prevent misfolding proteins.
Scientists at UC Santa Barbara have made a groundbreaking discovery about the molecular mechanisms that hold human bone together, revealing a 'glue' that absorbs shock and helps prevent fractures. The findings may lead to new therapies for bone fracture treatment and prevention.
Researchers at UCLA have discovered a 'molecular zipper' structure in proteins linked to Alzheimer's, Parkinson's and mad cow disease. The discovery provides a potential rational basis for developing drugs to fight these diseases.
Researchers have gained a detailed understanding of the interconnected protein segments that form amyloid fibrils, a key feature in various diseases. The structure reveals a 'spine' made up of short zippers that are tightly bonded together.
Researchers found that small soluble protein clusters called oligomers cause neurotoxicity by increasing membrane permeability. This challenges the long-held idea that insoluble fibrils are responsible for disease symptoms.
Researchers find specific shapes of amyloid fibrils, not amino acid sequences, determine prion infectivity across species. This breakthrough offers insights into the mechanisms behind prion diseases and potential transmission between previously separate animals.
Researchers found that rifampicin stabilizes alpha-synuclein in a soluble form, preventing fibril formation and disaggregating existing fibrils. This finding suggests potential therapeutic benefits for Parkinson's disease when administered early in the disease process.
Researchers used computer simulations to visualize the formation of amyloid fibrils, similar to those found in Alzheimer's and Parkinson's patients. The study suggests that understanding how these fibrils form could lead to discoveries of how to slow or halt their growth.
Researchers discovered that apolipoprotein E and clusterin proteins can delay amyloid plaque formation in mice with Alzheimer's-like brain damage. The findings imply that these proteins cooperate to suppress Abeta protein levels and deposition, paving the way for future drug or gene therapy treatments.
Researchers used AFM to study the effects of two monoclonal antibodies on beta amyloid peptide aggregation. The m266.2 antibody effectively inhibited protofibril formation, suggesting a promising approach for understanding conformational diseases like Alzheimer's.
Myxococcus xanthus bacteria evolved the ability to swarm socially on soft agar without filamentous appendages (pili), relying on an enhanced adhesive matrix composed of fibrils. This cooperative behavior depends on individual cells contributing to a public commons, enabling efficient swarming and cooperation.
USC researchers have successfully used gene therapy to prompt mouse cells to produce human collagen, a crucial step towards treating patients with dystrophic epidermolysis bullosa. This breakthrough could lead to the development of new treatments for this debilitating skin condition, which causes blisters and permanent scars.
Researchers at UNC-CH discovered a pentapeptide that breaks apart collagen fibrils, allowing for improved restricted movement due to joint injuries. The discovery has the potential to lead to new treatments, including injecting peptides into patients to loosen up stiff joints.