Articles tagged with Forebrain
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A new technique using focused sound waves and microbubbles has shown great promise in treating debilitating brain lesions called cerebral cavernous malformations. The approach has halted the growth of lesions almost entirely, offering a potential paradigm shift in treatment.
Researchers have identified the medial prefrontal cortex (mPFC) as the basis of emotional inference in animals and humans. In a study published in Nature, Xiaowei Gu and Joshua Johansen found that rats can learn inferred emotions by associating a neutral stimulus with an unpleasant experience.
Research reveals that long-range projecting inhibitory neurons, particularly those expressing parvalbumin, play a key role in learning from aversive stimuli. These neurons are necessary for integrating multiple sources of aversive information and transmitting integrated data to the limbic system.
Researchers successfully regenerated mouse brain circuits in mice using rat stem cells, offering new opportunities for restoring lost brain function due to disease and aging. The studies found that blastocyst complementation can synchronize the development of stem cells from different species with the host's brain.
Researchers found that anxious individuals rely on a less efficient section of the forebrain for emotional control, making it difficult for them to choose alternative behavior. This leads to avoidance of social situations and prevents them from learning that they are not as negative as they think.
A new NIH grant will help researchers better understand brain respiratory control and develop neuromodulation strategies to prevent Sudden Unexpected Death in Epilepsy (SUDEP). The goal is to identify optimal stimulation paradigms for breathing enhancement during a critical time window after seizures.
Researchers developed a self-organizing system that models key cellular processes involved in embryogenesis, shedding light on the self-organization of ectodermal cells during neurulation. The study could inform ways to prevent or counteract central nervous system birth defects by optimizing human ectodermal development.
Researchers identified boundary vector cells in goldfish central telencephalon that encode spatial information for the first time in a vertebrate. These cells enable unique positioning and represent a significant discovery in understanding fish navigation systems.
Germ-free zebrafish larvae have altered neural connections due to reduced microglia pruning by immune cells. Reintroducing normal microbiota restores normal development and social behavior. Microorganisms stimulate microglial activity, promoting neural connection remodeling.
Neflamapimod, a p38α kinase inhibitor, demonstrates reversible neurodegeneration in animal models and improves clinical endpoints associated with cholinergic neuronal function in patients with dementia with Lewy bodies. The findings support the initiation of a confirmatory Phase 2b clinical trial for neflamapimod.
Researchers found woodpeckers have brain regions similar to those in songbirds that control vocal learning and production. The study suggests drumming is a learned behavior with complex motor movements and adaptations for territorial defense.
A study published in Journal of Psychiatric Research found a significant biological difference between psychopaths and non-psychopaths, with psychopaths having a larger striatum region in the brain. This finding is linked to increased need for stimulation, impulsive behaviors, and higher likelihood of violent behavior.
Researchers have identified a single gene, FOXG1, that can control brain cell growth in humans. The discovery provides hope for developing new treatments for neurodevelopmental disorders and stopping brain tumor cells from growing.
A new study published in Nature Communications found that amylin peptide plays a crucial role in regulating social contact-seeking behavior in female mice. The researchers discovered that isolation leads to a decrease in amylin levels, while social reunion increases them.
A recent study from the Okinawa Institute of Science and Technology Graduate University identified a crucial protein linked to increased appetite and obesity in mice. The researchers found that mice lacking this protein, XRN1, exhibited leptin resistance, leading to insatiable hunger and weight gain.
Scientists have identified two new candidate genes, ULK4 and PTTG1, that positively influence the development of an embryo by restoring a strong Sonic Hedgehog signaling pathway. This finding provides new insights into the causes of holoprosencephaly, a congenital malformation affecting around one to four in every 1,000 unborns.
Rare fossils from the Cambrian period confirm the presence of an ancestral frontal domain in arthropods, which gives rise to crucial neural centers involved in decision-making and memory. The discovery also sheds new light on the evolutionary origin of visual systems in arthropods.
Two studies found that birds' pallium exhibits a layered architecture similar to mammals', potentially enabling complex cognitive abilities like consciousness. This structure may have been present in the last common ancestor of birds and mammals 320 million years ago, or evolved independently through convergent evolution.
Brain region-specific organoids reveal transcriptional signatures of neuropsychiatric disorders and allow researchers to study chromatin accessibility and gene expression in specific cells over critical developmental stages. The development of the human forebrain is a complex process guided by epigenetic gene regulation.
A study by University of Wisconsin-Madison researchers links piperonyl butoxide, a common insecticide synergist, to stunted forebrain development and facial abnormalities in mice. The chemical's interference with the sonic hedgehog signaling pathway suggests a potential link to rare human birth defects like holoprosencephaly.
Exposure to a widely used flame retardant chemical mixture can disrupt placental function, leading to altered production of the neurotransmitter serotonin. This study found evidence of endocrine, inflammatory and neurotransmitter signaling pathway disruption in placentas.
A recent study published in PLOS Biology has made the first detailed map of the brain regions in amphioxus, a fish-like marine chordate closely related to vertebrates. The findings challenge prevailing ideas about brain formation and suggest that the vertebrate brain evolved from two initial regions rather than three.
Researchers created 3D brain organoids that replicate human forebrain circuitry, revealing the role of cell migration in autism. They successfully corrected defective neuron migration using a drug, paving the way for personalized treatments.
Researchers at the University of Freiburg discovered that dopamine release is triggered by tactile and visual stimuli in the forebrain, affecting brain function. This finding may lead to new treatments for restless leg syndrome, a condition causing unpleasant sensations during sleep.
A study by Prof. Dr. Wolfgang Driever and his team discovered that specific tactile and visual stimuli activate dopaminergic nerve cells in the forebrain, affecting brain function and basic behaviour. This finding could lead to new treatments for conditions like restless leg syndrome.
Researchers challenge the widely held belief that Alzheimer's disease originates in the temporal lobe by identifying the basal forebrain region as a critical area of degeneration. The study shows that degeneration in this region predicts subsequent spread to other brain areas, opening new avenues for detection and intervention.
A study at Mount Sinai Hospital found that brain reward circuits, specifically the basal forebrain and lateral habenula, mediate motivation to engage in or avoid bullying. The research used a mouse model to demonstrate that activating this circuit makes bullying behavior pleasurable for some individuals.
The study visualizes the human brain's neural anatomy, revealing previously unidentified connections between the brainstem and forebrain. These connections support the concept of an integrated central homeostatic network in the brain.
Researchers at the University of Missouri have found that nicotine weakens the sleep-inducing effects of alcohol by stimulating the basal forebrain. This discovery sheds light on the close link between alcohol and nicotine usage, which affects millions of people worldwide.
Scientists have discovered a new role for basal forebrain neurons in controlling action, enabling rapid stop of planned behaviors. This discovery opens the door to novel approaches for neurological and psychiatric conditions affecting cognitive functions.
Research at Harvard Medical School identifies basal forebrain GABA parvalbumin neurons as crucial for triggering synchronized brain waves associated with conscious thought and perception. These neurons use the neural inhibitor GABA to create a pulsing rhythm, fine-tuning cognition and organization of data from the world around us.
Researchers from the University of Leicester used electrophysiology to capture electrical signals from dopamine neurons in the forebrain, revealing that these cells are active when fish swim. The study suggests that dopamine plays a key role in regulating excitability of spinal networks and may contribute to motor side effects of dopam...
A study found that youths with a family history of substance use disorders have impaired forebrain function, which may contribute to their increased risk of developing substance-use disorders. Forebrain regions responsible for decision-making and impulse control showed less efficient activity in those with a family history.
Researchers at Bonn University Hospital have achieved remarkable results using deep brain stimulation to treat treatment-resistant major depression. In six out of seven patients, symptoms improved considerably and rapidly, with significant improvements observed in anxiety, despondence, listlessness, and joylessness.
Research reveals ATRX mutations cause DNA damage leading to premature aging symptoms such as shortened lifespan, cataracts and low bone density. The study found mice without the ATRX gene displayed problems in learning and memory, body growth and metabolism.
Researchers at MDC Berlin-Buch have identified a receptor for cholesterol that plays a key role in forebrain development. The study found that defective binding sites can lead to severe anomalies, highlighting the crucial importance of cholesterol metabolism in embryonic development.
A groundbreaking study by USC researchers shows the human placenta synthesizes serotonin, providing a new source of this neurotransmitter to the fetal forebrain. This discovery has implications for treating health impacts such as cardiovascular disease and mental illness.
Researchers propose a new target structure for deep brain stimulation to treat depression, with promising results. The method has already shown significant improvement in mood for half of patients with the most severe depression, and may lead to even better success rates with fewer side effects.
A recent study demonstrates that the polycomb group protein Bmi-1 plays a crucial role in maintaining forebrain neural stem cell self-renewal. The findings show that overexpression of Bmi-1 increases stem cell self-renewal both in vitro and in vivo, highlighting its potential for neural regeneration and repair.
Researchers found that bird brain structures for singing and learning are embedded in areas controlling movement, indicating a possible evolutionary link between vocal learning and motor control. This discovery may also shed light on human language origins, with spoken language possibly emerging from pre-existing motor pathways.
Neurobiologists studying finch brains found a crucial learning circuit that generates trial and error necessary for mastering sophisticated motor skills. The region, LMAN, tunes song variations by introducing different pitches and frequencies, allowing birds to improvise and learn.
Researchers recorded neuronal firing patterns in rats during normal sleep-wake cycles and found that neural activity reappeared after novel experiences for up to 48 hours. This reverberation was enhanced during slow-wave sleep and may support a mechanism for recalling and amplifying memories.
The study reveals that the SIX3 protein secures anterior neural cells by blocking out a posteriorizing signal, crucial for forebrain formation. In mouse models and zebrafish, forced expression of Six3 rescues forebrain development, demonstrating its critical role in vertebrate head development.
The Six3 gene plays a vital role in brain development by halting Wnt1 activity, preventing abnormal forebrain extension. In mutant mice and zebrafish, genetic material from the mouse Six3 gene restores normal forebrain development.
A new study suggests that galanin, previously thought to be detrimental to Alzheimer's patients, may actually enhance acetylcholine release from remaining cholinergic basal forebrain neurons. This compensatory role could delay disease progression and inform the development of galanin antagonists as a potential treatment option.
Researchers at Emory University found that growth factor BDNF stimulates the production of new neurons in several areas of the adult brain, including the striatum and hypothalamus. This discovery suggests a more profound capacity for neurogenesis in the adult forebrain than previously thought.
A protein called NR2B makes mice more aware of minor pain for longer periods of time, a phenomenon that mimics what happens in people with chronic pain. The researchers suggest that interfering with NR2B in humans might be a strategy for treating chronic pain.