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'Rewriting' the way to make natural drug compounds

By rewriting genes from a fungus to produce a specific compound of potential therapeutic importance, researchers have successfully synthesized natural drug compounds in large quantities. This innovative approach leverages the native machinery of an organism to address long-standing challenges in drug synthesis.

SourceUniversity of Utah Health·JournalACS Synthetic Biology·DateNov 6, 2014

To wilt or not to wilt

UC Riverside researchers have identified a new molecular mechanism for resistance and susceptibility to Fusarium oxysporum, a common fungus causing wilt in tomato plants. The study reveals that microRNAs play a crucial role in regulating gene expression, with specific targets contributing to resistance.

SourceUniversity of California - Riverside·JournalPLOS Pathogens·DateOct 23, 2014

Termites evolved complex bioreactors 30 million years ago

Termite fungus farmers developed a sophisticated system of cooperation between fungi and gut bacteria to break down complex plant components. The symbiotic community optimized for efficient plant decomposition involves division of labor, with fungi handling carbohydrates and gut microbes contributing enzymes for final digestion.

SourceUniversity of Copenhagen - Faculty of Science·JournalProceedings of the National Academy of Sciences·DateSep 23, 2014

An 'anchor' that keeps proteins together

Researchers at Ruhr-University Bochum have discovered a new scaffold protein called PRO40 that plays a crucial role in the production of fruiting bodies in hyphae fungi. By binding to specific kinases, PRO40 enables signal transmission and regulates MAP kinase modules.

SourceRuhr-University Bochum·JournalPLOS Genetics·DateSep 4, 2014

Zombie ant fungi 'know' brains of their hosts

A parasitic fungus controls the behavior of ants by emitting specific chemicals when encountering their brain, not when infecting other ant species. The fungus produces a mixture of known and unknown chemicals that work in synergy to manipulate the ants' behavior.

SourcePenn State·JournalBMC Evolutionary Biology·DateAug 25, 2014

Alternate mechanism of species formation picks up support, thanks to a South American ant

A newly discovered species of ant, Mycocepurus castrator, has been found to support the theory of sympatric speciation, where a new species develops within a single colony. The research team found that the parasitic ants were genetically close to their host, but no longer reproductively compatible and had stopped reproducing together 3...

SourceUniversity of Rochester·JournalCurrent Biology·DateAug 21, 2014

Choosing cheese

Researchers at Harvard University studied 137 varieties of cheese from 10 countries to identify three general types of microbial communities. These findings provide a model for studying microbial communities and their interactions, with potential applications in understanding various biological processes. The study also reveals the imp...

SourceHarvard University·JournalCell·DateJul 17, 2014

Recalled yogurt contained highly pathogenic mold

A study by Duke University scientists identified a highly virulent strain of Mucor circinelloides fungus in Chobani yogurt that caused severe symptoms in consumers. The researchers found that the fungus can survive passage through the gastrointestinal tract and produce a lethal systemic infection in diabetic mice.

SourceDuke University·JournalmBio·DateJul 8, 2014

Termites, fungi and climate change

A new study reveals that local-scale factors, such as terrain and temperature, explain most of the variation in wood decomposition, while climate plays a smaller role. The research suggests that termites and fungi have a more significant impact on decomposition than previously thought, which can improve climate change projections.

SourceUniversity of Central Florida·JournalNature Climate Change·DateJun 5, 2014

Gap closed in the genetic map of kingdom fungi

Researchers have closed the genetic map of the fungal kingdom by sequencing the genome of Pyronema confluens, a basal filamentous ascomycete. The study reveals key differences between this species and higher ascomycetes, shedding light on the evolution of mating type genes and light-activated processes.

SourceRuhr-University Bochum·JournalPLOS Genetics·DateSep 20, 2013