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Light-sensing cells in retina develop before vision

Researchers discovered that light-sensing retinal ganglion cells are active and functioning at birth, surprising the developmental timeline of the mouse retina. The cells react to light in two ways, sending messages to parts of the brain controlling circadian rhythms and visual development.

SourceWashU Medicine·JournalNeuron·DateDec 21, 2005

The synapse is a shotgun

Researchers have developed a biologically accurate computer simulation of synaptic function, indicating that the synapse may behave like a shotgun firing buckshot-like bursts of neurotransmitter to reach receptors arrayed beyond known receiving sites. The new data suggest an alternative mode of neurotransmission called ectopic release.

Study suggests potential new approach to glaucoma therapy

Researchers at Washington University School of Medicine have identified a potential new approach to treating glaucoma by inhibiting an enzyme that produces excessive nitric oxide, leading to cell damage. The study found that rats with elevated eye pressure lost less than 10% of their retinal ganglion cells when treated with the inhibitor.

SourceWashU Medicine·JournalProceedings of the National Academy of Sciences·DateAug 17, 1999