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Decoding fear: KAIST identifies an affective brain circuit crucial for fear memory formation by non-nociceptive threat stimulus​

A KAIST research team has identified a key neural pathway involved in forming fear memories triggered by psychological threats. The pIC-PBN circuit processes psychological distress and drives fear memory formation, offering a significant advance in understanding how psychological distress is processed.

SourceThe Korea Advanced Institute of Science and Technology (KAIST)·JournalScience Advances·TypeMeta-analysis·DateMay 19, 2025

Mount Sinai researchers specific therapy that teaches patients to tolerate stomach and body discomfort improved functional brain deficits linked to visceral disgust that can cause of food avoidance in adolescent females with anorexia nervosa

Researchers developed a new therapy that teaches patients to tolerate stomach and body discomfort, improving functional brain deficits linked to visceral disgust. The study showed improved outcomes for adolescents with low-weight eating disorders compared to traditional family-based treatment.

SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalJournal of the American Academy of Child & Adolescent Psychiatry·TypeRandomized controlled/clinical trial·DateMar 17, 2025

AI-driven tool for distinguishing Lewy body dementia via changes in vocal emotional expression

A new AI-driven tool can accurately diagnose Lewy body dementia by analyzing changes in vocal emotional expressions. The study found that individuals with Lewy body dementia exhibited more negative and calmer emotional expressions compared to those with Alzheimer's disease and healthy controls.

SourceUniversity of Tsukuba·JournalAlzheimer s & Dementia Diagnosis Assessment & Disease Monitoring·DateJun 4, 2024

Novel optical and fMRI platform identifies brain regions that control large-scale brain network

Researchers have developed a novel experimental platform that combines optical and fMRI techniques to study large-scale brain networks. The platform identified the anterior insular cortex as a key player in controlling the Default Mode Brain Network, which is active during daydreaming, memory retrieval, and envisioning the future.

SourceUniversity of North Carolina Health Care·JournalScience Advances·TypeExperimental study·DateFeb 15, 2023

Balancing fear

The insular cortex processes both positive and negative emotions and receives information from the body, including heart rate and breathing. In mice, the brain uses bodily signals to regulate fear, keeping it within a healthy range.

SourceMax-Planck-Gesellschaft·JournalScience·TypeExperimental study·DateNov 18, 2021

An inflammation to remember

Researchers find that neurons in the insular cortex can induce inflammation in mice, suggesting a link between the brain and psychosomatic illnesses. The study suggests that 'remembering' an inflammatory response can reactivate it, opening new avenues for treating chronic inflammatory conditions.

Neuroimaging reveals how ideology affects race perception

Research using neuroimaging found that white conservatives exhibit higher sensitivity to racial ambiguity in the anterior insula, leading them to overcategorize mixed-race faces as Black. This effect is linked to an affective reaction to racial mixing rather than a sensitivity to Blackness.

SourceCornell University·JournalPhilosophical Transactions of the Royal Society of London (B )·DateMar 3, 2021

Politics and the brain: Attention perks up when politicians break with party lines

A new study by University of Nebraska-Lincoln psychologist Ingrid Haas found that humans process politically incongruent statements differently, with stronger neurological responses for inconsistent positions. Participants showed increased activity in brain regions involved in cognitive function when reading statements deviating from p...

SourceUniversity of Nebraska-Lincoln·JournalPhilosophical Transactions of the Royal Society of London (B )·DateFeb 22, 2021

How expectations influence learning

Neuroscientists at Ruhr-University Bochum have found that the thalamus plays a key role in decision-making during learning, while the insular cortex is active when participants make correct or incorrect decisions. This suggests that expectations influence brain activity and sensory perception.

SourceRuhr-University Bochum·JournalCerebral Cortex·DateApr 15, 2020

Anterior insula activation restores prosocial behavior in animal model of opioid addiction

Researchers at Arizona State University found that activating the anterior insula restored prosocial behaviors in animals with opioid addiction, a potential breakthrough in treating social behavioral deficits. The study used chemogenetic methods to selectively activate the brain region involved in both prosocial and addictive behaviors.

SourceArizona State University·JournalSocial Neuroscience·DateApr 3, 2020

The facial expressions of mice

Researchers at Max Planck Institute describe different emotional facial expressions in mice, linking them to specific brain regions and emotions. The discovery enables the investigation of emotional mechanisms and their relationship with neuronal activity.

SourceMax-Planck-Gesellschaft·JournalScience·DateApr 2, 2020

Scientists find sexual dimorphism in cannabinoid 1 receptor expression in mice

Researchers mapped CB1R mRNA expression in male and female mice, revealing distinct patterns in brain regions associated with Parkinson's disease, maternal behaviors, and the estrus cycle. The study provides a foundation for understanding sex differences in physiological and pathological brain functions related to cannabinoids.

SourceChinese Academy of Sciences Headquarters·JournalThe Journal of Comparative Neurology·DateMar 17, 2020

Making sense of the self

Researchers at Beth Israel Deaconess Medical Center discovered that the insular cortex plays a crucial role in assessing and predicting physiological states. The study's findings provide potential new avenues for addressing diseases such as eating disorders, obesity, and drug addiction by targeting the brain's reward system.

Craving junk food after a sleepless night?

A study by Northwestern University found that sleep-deprived individuals are more likely to choose high-energy dense foods due to an imbalance in brain regions receiving food signals. The researchers suggest that paying attention to our nose's influence on food choices may help alleviate unhealthy snacking habits.

Touch and neural processing

Researchers discovered significant differences in neural processing between self-touch and touch from others at the cortical and spinal cord levels. This finding has implications for understanding perception and social behavior, highlighting the brain's unique response to self-produced versus external tactile input.

SourceProceedings of the National Academy of Sciences·JournalProceedings of the National Academy of Sciences·DateJan 21, 2019

What makes rats relapse

A recent study published in JNeurosci found that activation of the anterior insular cortex is a key predictor of relapse after abstinence in male rats. This finding has implications for understanding the neurobiology of relapse and may inform preventative strategies for alcohol use disorder in humans.

Neuroscientists map brain's response to cold touch

Researchers have mapped the feeling of cool touch to the brain's insula in a mouse model, providing an experimental model for studying conditions like pain and hypersensitivity. The study found that the region was activated in mice with functional TrpM8 receptors, suggesting a highly specific response to cold exposure.

SourceCarnegie Mellon University·JournalJournal of Comparative Neurology·DateJun 18, 2018

Chatter in the deep brain spurs empathy in rats

A study by neuroscientists at Duke and Stanford University found that multiple brain regions collaborate to produce empathetic decision-making in rats. The results clarify conflicting findings on the role of specific brain regions in guiding antisocial behavior, suggesting a more complex neural context.

SourceDuke University·JournalBrain and Behavior·DateJun 23, 2017

Dynamic connections in the brain

Researchers at the University of Miami studied dynamic functional network connectivity in the insular cortex, revealing unique and overlapping profiles of its subdivisions. The findings suggest that changes in connection patterns between brain areas may contribute to the region's flexibility in multiple cognitive processes.

SourceUniversity of Miami·JournalHuman Brain Mapping·DateMar 30, 2016

Salience network is linked to brain disorders

The insula is essential for selecting salient stimuli, and dysfunction can lead to deficits in attention, social, and cognitive processes. Mapping the structure and function of the insular cortex may provide targeted treatments for developmental and degenerative disorders.

SourceUniversity of Miami·JournalNature Reviews Neuroscience·DateDec 5, 2014