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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

Resting-state functional connection during low back pain

A study published in Neural Regeneration Research found that experimental low back pain altered the functional connections between the insula and default mode network, affecting regions involved in cognition and emotion. The findings suggest a crucial role of these brain regions in pain processing.

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Study uncovers why almost winning is just as good for some gamblers

A new study found that gamblers' brains exhibit similar increases in theta activity to wins and near-misses, particularly in the insula and orbitofrontal cortex. This response is associated with gambling severity and susceptibility to problem gambling. The research suggests that brain responses to near-misses resemble those to actual w...

Males and females differ in specific brain structures

A recent meta-analysis of 20 years of neuroscience research reveals significant sex differences in brain structure, with males on average having larger total brain volumes and higher tissue densities in certain regions. Females, on the other hand, have higher density in the left frontal pole and larger volumes in other areas.

Brain size may signal risk of developing an eating disorder

Research found that teens with anorexia nervosa had larger insula and orbitofrontal cortex brain areas, which may contribute to their ability to starve themselves. These brain regions process taste and body perception, potentially leading to a distorted sense of hunger and fullness.

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Schizophrenia symptoms linked to faulty 'switch' in brain

Researchers at the University of Nottingham have discovered a faulty 'switch' between brain regions that may cause psychotic symptoms in people with schizophrenia. The study suggests that detecting this disconnection could help identify patients with the condition, and potentially lead to more effective treatments.

Scan predicts whether therapy or meds will best lift depression

A new biomarker has been identified to predict which type of depression treatment is most likely to be successful, either therapy or medication. The study used pre-treatment brain scans to identify a pivotal predictor of outcomes from two standard forms of depression treatment: cognitive behavior therapy (CBT) or escitalopram.

Why older adults become fraud victims more often

A new UCLA study suggests that older adults' brains are less active in the anterior insula region, which is linked to disgust and detecting dishonest faces. This reduced activity makes it harder for older adults to recognize untrustworthy faces, leading to increased vulnerability to financial exploitation.

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Rare neurons discovered in monkey brains

Researchers at Max Planck Institute discover von Economo neurons in macaque monkeys, suggesting a primitive form of self-awareness. The finding opens new avenues for studying brain regions involved in human self-awareness and mental disorders like autism.

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Friendly to a fault, yet tense: Personality traits traced in brain

Researchers found abnormal development of the insula circuit hub is rooted in genes and causes overly friendly yet anxious behavior in individuals with Williams syndrome. The study uses neuroimaging to pinpoint the suspect brain area in people with the disorder, revealing structural and functional abnormalities.

How muscle fatigue originates in the head

Researchers discovered that nerve impulses from muscles inhibit motor areas in the brain, leading to muscle fatigue. The insular cortex plays a key role in regulating muscle performance, with increased activity preceding fatigue.

MRI study finds that depression uncouples brain's hate circuit

A recent MRI study published in Molecular Psychiatry found that depression frequently uncouples the brain's 'hate circuit', which includes regions involved in risk and action responses, reward and emotion processing. This disruption may lead to impaired ability to control social interactions and increased self-loathing.

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New research from Psychological Science

Researchers investigate how the insula integrates affective and cognitive processes, and how neural systems develop with age. They also examine the role of vision in auditory and tactile integration, and find that vision plays a crucial role in developing this integration.

Biofeedback for your brain?

Researchers found that individuals can learn to control the activity of specific brain regions when receiving fMRI feedback signals. The study, published in Biological Psychiatry, used functional magnetic resonance imaging (fMRI) to assess visual emotional stimuli and demonstrated the ability to modulate the response to aversive stimuli.

Barrow scientist leads insula research

Barrow scientist A.D. Bud Craig is leading the global conversation about the insula, a hidden lobe of the brain involved in virtually every human emotion and behavior. The latest research indicates that the insula plays a crucial role in conditions such as addiction, anxiety, depression, and schizophrenia.

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Study reveals second pathway to feeling your heartbeat

Researchers found two independent pathways contributing to feeling one's own heartbeat, contrary to prior assertions. The study used a rare neurological patient and healthy comparison participants to confirm the existence of these pathways, which could have implications for emotion and self-awareness.

Nicotine activates more than just the brain's pleasure pathways

Duke University researchers found that nicotine sends signals directly to sensory systems by several pathways, similar to how taste is perceived. They also discovered a previously unknown link between nicotinic acetylcholine receptors and activity in the insula region.

Brain's 'hate circuit' identified

Researchers at UCL found a 'hate circuit' in the brain that is distinct from those related to love, fear, and aggression. The study reveals that the 'hate circuit' involves structures in the cortex and sub-cortex that are also activated by romantic love, but with a different pattern of activity.

Why an exciting book is just as thrilling as a hair-raising movie

Researchers found that the same brain regions are activated when observing facial expressions of disgust in others and experiencing it oneself. This study suggests that reading a book can elicit emotional responses comparable to those experienced while watching a movie, thanks to the shared brain activity patterns.

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How fairness is wired in the brain

Studies revealed that people's brains respond differently to unfairness, with the orbital frontal cortex reacting to giving and the insula processing inequity. The findings suggest that a basic impulse to be fair is hardwired in humans, driven by emotional responses.

Justice in the brain: Equity and efficiency are encoded differently

A study using fMRI scans found that people prioritize equity over efficiency in allocating donations, with the brain responding differently to both. The insula region was activated by changes in equity, while the putamen responded to efficiency, with the caudate integrating both factors after a decision was made.

A little anxiety pays sometimes, study shows

Researchers found that higher levels of brain activation in the anterior insula region can help individuals learn to avoid losses and financial risks, but excessive activity may be problematic. A healthy amount of anxiety grants survival value, but too much can lead to excessive worry and clinical conditions.

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Smokers quit after damage to brain region

Researchers found that damage to the insula, a brain region linked to emotion and feelings, enables smokers to quit instantly. The discovery opens new directions for therapies targeting this specific region.

Aggression-related gene weakens brain's impulse control circuits

Research suggests that a specific gene variant linked to aggression impairs the brain's ability to regulate impulses and emotions, particularly in males. This impairment can lead to increased reactivity in the fear hub and reduced activity in higher brain areas that regulate emotional responses.

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Can heart failure impair thinking?

A new study found significant gray matter loss in the insular cortex and basal ganglia of advanced heart failure patients. The insular cortex was affected on both sides, with greater loss on the right side, while basal ganglia damage was also observed.

Researcher Discovers Key Brain Center For Speech

A UC Davis researcher has discovered that damage to the insula region is a crucial impediment to motor control necessary for words and sentences. The insula, located deep within each hemisphere, is about two inches wide and contains a small area critical for coordinating speech sounds.