Research on the liver in health and disease. Covers liver-disease subtypes, the liver's role in circadian timing, targeted therapies, and cell regulation.
The study discovered two tandem binding sites in ABCB11 that enable precise recognition and export of bile acids. The results provide structural insights into the transport mechanism, contributing to understanding of bile acid metabolism and potential therapeutic interventions.
Research by the University of Queensland found that male livers with hepatic diseases undergo a sex change as part of a self-protective mechanism. The study suggests that this transformation may be driven by the female hormone oestrogen, which helps to slow down disease progression.
A new scoring system, MIAAH, accurately identifies patients at highest risk of death and those likely to survive from alcohol-associated hepatitis. The tool incorporates laboratory variables and demographic data, offering a valuable prognostic model for clinicians.
A new pathway has been discovered to explain how excessive alcohol consumption damages the liver, specifically through mitochondrial dysfunction. By targeting an enzyme called MATα1, researchers believe they can develop a new treatment for people suffering from alcohol-associated liver disease.
A comprehensive analysis of over 2,200 patients in Europe reveals the complexity of cholangiocarcinoma, a rare cancer often diagnosed at an advanced stage. The study highlights the need for education programs to raise awareness and improve early diagnosis, survival, and quality of life.
A nationwide study in Germany found that liver cirrhosis has the highest mortality rate among chronic diseases, with 0.94% of hospital admissions affected. The study also showed a decline in mortality rates due to improvements in Hepatitis C treatment, but an increase in non-alcoholic fatty liver disease cases.
Scientists at Cold Spring Harbor Laboratory have developed a way to interfere with the energy pathway that allows liver cancer to grow and spread by targeting the pyruvate kinase protein. This approach uses antisense oligonucleotides, which reduce tumor development in mouse models, offering a potential treatment for liver cancer.
Researchers discovered that a hormone called FGF21 suppresses alcohol consumption in primates by altering neural transmission in the brain. This finding provides a mechanism for a liver-to-brain endocrine feedback loop to protect the liver from damage and may lead to potential treatment options for alcohol use disorder.
A new study aims to improve antibody responses in kidney and liver transplant recipients to COVID-19 mRNA vaccine doses, exploring the impact of reduced immunosuppressive medication. The CPAT-ISR trial will enroll up to 400 adults with a history of organ transplants and evaluate the effectiveness of this strategy.
Researchers at MUSC found that fungal infections are common in cirrhosis patients, often resistant to antibiotics. Patients with cirrhosis are immunocompromised and need proactive infection management.
Scientists have discovered families of proteins that can predict liver transplant rejection, allowing for early detection and modification of immunosuppression. The Blood Proteoform Atlas outlines over 56,000 protein molecules associated with immune cell proteins that change with rejection.
A study of 1,000 patients found that some recoverees from hepatitis C still face liver cancer risks after treatment. Researchers propose a 2-step strategy combining FIB-4 and transient elastography/ultrasound to predict high-risk cases.
A new study published in Mayo Clinic Proceedings found that patients with alcohol-associated cirrhosis had significantly higher post-ICU death rates and mortality at 30 days after ICU discharge compared to those with cirrhosis attributed to other causes. The study, which analyzed case files of 1,174 patients, suggests that early diagno...
Researchers developed a novel multi-organoid system to simulate the human liver-islet axis, enabling 3D co-culture of hiPSC-derived organoids for up to 30 days. The system exhibited cooperative interaction between liver and islet organoids, reflecting the dynamic interplay among organs in type 2 diabetes.
Researchers have identified a molecular mechanism underlying liver cirrhosis, a deadly disease poorly understood. The discovery, made using genetically modified mice, reveals that the lack of MCRS1 protein leads to bile acid accumulation and fibrosis, opening new avenues for treatment.
A new review suggests that moderate coffee consumption can stimulate digestive processes and help movement through the colon. The study also found a possible association between coffee consumption and reduced risk of gallstones and certain liver diseases. However, further research is needed to confirm these findings.
Researchers found that alterations in the RNF43 and ZNRF3 genes lead to an accumulation of lipids and inflammation in the liver, increasing the risk of developing non-alcoholic steatohepatitis (NASH) and fatty liver disease. These genetic changes also affect liver cell proliferation, contributing to the progression of liver diseases.
The American Society for Radiation Oncology (ASTRO) has released a new clinical guideline outlining the use of external beam radiation therapy (EBRT) to treat adult patients with primary liver cancers. The guidelines emphasize multidisciplinary care and provide evidence-based recommendations on indications, dosing, techniques, and trea...
Researchers found that a diet rich in butyrate sharply reduced the risk of biliary atresia in mouse pups, and identified glutamine as a key compound with similar protective effects. The findings suggest a potential role for maternal microbiome manipulation in preventing liver disease.
Researchers at MUSC identified a potent antifibrotic peptide that reverses scarring in human and mouse tissues by activating an antifibrotic pathway. The E4 peptide has the potential to treat various diseases, including heart disease, lung fibrosis, liver cirrhosis, and chronic kidney disease.
The new technology can reliably distinguish between cancerous and healthy liver tissue, aiding diagnosis and potentially reducing errors in biopsies. The researchers plan to continue measuring fluorescence lifetime parameters in patients with different types of tumors to generate real-time diagnostic classifiers.
A study by Kanazawa University researchers found that the chemokine CCL3 plays a significant role in inducing inflammation as nonalcoholic fatty liver disease develops. The presence of CCL3 increased liver macrophage accumulation, leading to liver inflammation and scarring.
A new study projects that increased alcohol consumption during the COVID-19 pandemic will result in 8,000 additional deaths from liver disease and 18,700 cases of liver failure by 2040. The researchers estimated a one-year increase in consumption to cause 100 additional deaths and 2,800 cases of liver failure by 2023.
Research from MUSC suggests that physicians should be cautious when using laboratory tests to diagnose alcoholic cirrhosis due to false negative results. Patients with advanced liver disease often show subtle signs and symptoms in the early stages of cirrhosis.
New research suggests that cannabis use can lead to harmful drug-drug interactions by interfering with two families of enzymes that metabolize a wide range of drugs. This could result in unintended side effects such as toxicity or accidental overdose, particularly for older individuals using medications.
Researchers at University of California San Diego found a way to boost innate immunity in liver cancer, making tumors highly responsive to immunotherapy. The combination of anti-PD-L1 antibody and polyIC molecule showed remarkable synergistic effects in liver tumor inhibition.
A study found that spaceflight alters liver gene expression and reduces antioxidant capacity in mice, leading to increased oxidative stress. However, exposure to artificial gravity can mitigate some of these effects, suggesting potential for dietary supplementation to offset changes during spaceflight.
A new microfluidic photoreactor treatment approach has shown promising results in reducing bilirubin levels in newborns with severe jaundice. The treatment uses high-intensity light to target and remove excess bilirubin from the blood without causing damage to red blood cells.
A large-scale epidemiologic study in China identified links between long-term exposure to ambient air pollution and metabolic-associated fatty liver disease (MAFLD). Long-term exposure to air pollution may increase the risk of MAFLD, especially in individuals with unhealthy lifestyles and central obesity.
A team of researchers at UC Davis Health has developed a novel PET imaging-based tool to detect liver inflammation in non-alcoholic fatty liver disease. The tool uses dynamic PET imaging and mathematical modeling to measure glucose transport from blood to liver tissue, allowing clinicians to quantify liver inflammation.
Researchers found that video-based, telehealth-delivered exercise and weight loss programs improved pain and function in people with knee osteoarthritis and overweight or obesity. The intervention with dietary component led to substantial weight loss and additional benefits.
A cohort study of 165 patients with hepatitis C-related hepatocellular carcinoma found that treating the virus with direct-acting antivirals reduces tumor progression and metastasis. The study showed a 72% reduction in tumor progression and an 88% reduction in risk of death from HCC.
A Cleveland Clinic study shows that bariatric surgery significantly lowers the risk of progression to cirrhosis, liver cancer, or liver-related death. Bariatric surgery also reduces the risk of developing serious cardiovascular diseases such as heart attack and stroke.
Researchers found that albino mice with a mutated tyrosinase gene are more susceptible to non-alcoholic steatohepatitis (NASH) than black mice. This study provides new insights into the genetic factors contributing to NASH and its progression.
An international research team discovered that intestinal bacteria can distribute their metabolic products throughout the body via the bloodstream using membrane vesicles. The study found that these vesicles can overcome the blood-brain barrier and enter brain cells, suggesting a new method for delivering drugs or vaccines.
The American Gastroenterological Association (AGA) has released new clinical guidelines that recommend against extensive preprocedural testing to estimate clotting in patients with cirrhosis. This change aims to reduce the risk of morbidity and mortality associated with unnecessary blood clotting tests.
A study published in Nature Communications identified C-terminal binding protein 2 (CtBP2) as a global regulator of metabolism that balances sugar and fat levels in the liver. CtBP2 is crucial for controlling glucose and lipid balance, making it a promising drug target for treating symptoms associated with obesity.
Researchers have identified a novel estrogen compound that provides benefits similar to hormone replacement therapy but without the risk factors associated with it. The compound has been shown to reduce excess lipid deposition in the liver and prevent the progression of fibrosis, which can lead to liver failure and metabolic problems.
During the pandemic, registrations for alcoholic hepatitis and deceased donor liver transplants increased by over 50%, associated with rising alcohol sales. Alcoholic hepatitis can lead to permanent scarring and long-term damage if left untreated, highlighting the need for public health interventions around excessive alcohol consumption.
Researchers found that hepatitis C treatment reduces the activity of proteins involved in cirrhosis, potentially indicating an early sign of liver recovery. The study suggests a possible pathway toward healing scarred liver tissue after virus elimination.
A new analysis of US national data finds that external-beam radiation therapy is a proven treatment option for patients with unresectable liver cancer but is rarely prescribed, with only 3.6% of patients receiving it. The study suggests that institutional and regional practice patterns play a key role in driving treatment decisions.
A VCU study found that people with advanced liver scarring caused by obesity and diabetes are dying from liver disease, underscoring the need for new treatments. The research provides a roadmap for future therapies to prevent liver transplants and save lives.
A new protocol combining patient monitoring and monoclonal antibody therapy reduced hospitalizations by half and deaths to zero for eligible patients. The study, conducted at Keck Medicine of USC, shows improved outcomes among liver and kidney transplant recipients with COVID-19.
Researchers identified five genes mutated in people with liver disease, affecting insulin sensitivity and fat metabolism. These mutations reduce the liver's ability to respond to dietary sugars and fats.
Researchers from Sanford Burnham Prebys have discovered a new source of stem cells that could help treat people living with Alagille syndrome. These 'outside the box' liver stem cells may offer hope for those with the rare genetic disorder, which causes severe liver damage and death.
New research reveals that boosting numbers of immune cells called dendritic cells may be key to overcoming colorectal cancers' immunotherapy resistance. By augmenting dendritic cells in liver metastases, treatment led to increased cytotoxic T lymphocytes and made tumors sensitive to immune checkpoint inhibitors.
Researchers found a chemical inhibitor of PDE9 stimulates cells to burn more fat in mice, reducing obesity and fatty liver. The study's findings suggest the experimental drug may be effective in treating severe obesity and improving heart function.
Researchers found that liver transplant recipients who contracted COVID-19 recovered faster and with less severe inflammation compared to heart or kidney recipients. The study suggests testing certain immunosuppressants to treat COVID-19 patients, regardless of their transplant status.
A research team at TUM has discovered that the protein TIMP1 is associated with a significantly higher risk of liver metastasis and death in male patients, particularly those with pancreatic, colon, and melanoma cancers. This finding may lead to improved diagnosis and targeted therapy options for men.
A prospective study found that liver stiffness measurements obtained by shear-wave elastography decreased significantly after image-guided intervention for chronic Budd-Chiari syndrome in children. Disease recurrence was typically associated with an increase in liver stiffness measurements compared to prior assessments.
A multidisciplinary taskforce developed a Clinical Care Pathway for NAFLD/NASH, outlining practical guidance from screening to patient care management. The pathway aims to provide efficient, safe, and value-based care for patients with NAFLD and NASH, highlighting the importance of early interventions and shared decision-making.
The European Association for the Study of the Liver (EASL) is hosting its 57th International Liver Congress (ILC) 2022 in London, where experts will present and share the latest science on liver diseases. The event aims to enhance awareness, prevention, treatment, and management of liver diseases globally.
Researchers developed a non-toxic, small-molecule probe that provides real-time visualization of disease progression, overcoming limitations of MRI and PET imaging. The probe binds copper ions and detects dysregulated levels, accurately identifying Wilson's disease and other maladies.
Researchers have found that synthetic bile acid Nor-UDCA directly affects the immune system and reduces inflammation in chronic-inflammatory liver disease. The therapy also guides misdirected CD8-T cells back onto their correct path, allowing them to resume their normal function.
Researchers found that liver fat is higher in people with type 2 diabetes, even at seemingly healthy levels, and that weight loss induced remission reduces intra-organ fat. A significant proportion of participants achieved remission of their T2D after a weight management programme.
A recent study published in AJR found that gallbladder polyps can fluctuate significantly in size and number over time. The authors suggest revising guidelines to reflect this variability, with no cases of gallbladder carcinoma identified in patients who underwent cholecystectomy.
Skeletal muscle secretes a molecule that regulates around 35% of liver functions, with the remaining basal functions independent of muscle activity. Ageing alters this communication, leading to non-optimal functions and accelerated ageing.
A collaborative research between Owkin and Cleveland Clinic has developed an AI model that predicts liver cancer recurrence following liver transplantation. The model outperformed traditional scoring systems and showed promise for improving patient outcomes.
Children who receive living donor liver tissue for transplants have nearly twice the survival rate and reduced risk of organ rejection compared to those receiving deceased donor livers. Living donation also shortens wait times for pediatric patients.
Researchers found that DNA methylation patterns at specific genomic sites correlated with levels of fibrosis in non-alcoholic fatty liver disease (NAFLD). The study suggests that these patterns could be used to diagnose the severity of this condition, potentially leading to earlier treatment and improved outcomes.