Muscle Tissue
Articles tagged with Muscle Tissue
Hidden muscle fat poses danger to heart, metabolism
Researchers used MRI to analyze muscle composition in 11,348 participants and found that higher intermuscular fat and lower muscle mass were associated with increased cardiometabolic risk factors. Lean muscle mass was only protective against these risks in men, while women's muscle mass declined after age 40.
People who consume ultra-processed foods have worse muscle health
Researchers found a diet high in ultra-processed foods is associated with higher amounts of fat stored inside thigh muscles. This increased intramuscular fat may increase the risk for knee osteoarthritis. The study suggests that addressing obesity and improving dietary quality are crucial to preserving muscle health.
Testosterone level not a given sign of well-being
A higher testosterone level does not always indicate well-being in men, according to a study at the University of Gothenburg. Muscle health and inflammation are linked to testosterone levels, but symptoms like fatigue and depression have weaker connections.
Bioprinting muscle that knows how to align its cells just as in the human body
A research team from Xi'an Jiaotong University has developed a method to align cells in muscle tissue using electric forces during electrohydrodynamic bioprinting. This breakthrough allows for the creation of living muscle tissues with tightly aligned cells, enabling the production of functional muscle constructs.
Artificial tendons give muscle-powered robots a boost
MIT engineers developed artificial tendons made from hydrogel to connect lab-grown muscles with robotic skeletons. The tendons improved the robot's motion and force output by three times, enabling faster and more efficient biohybrid robots.
UBC researchers uncover how statins harm muscles—and how to stop it
Researchers have identified a key mechanism behind statin-induced muscle damage, paving the way for new statins with reduced side effects. By understanding how statins interact with muscle proteins, scientists can design safer alternatives that preserve cholesterol-lowering benefits.
Shape of your behind may signal diabetes
Researchers used MRI 3D mapping to analyze changes in gluteus maximus shape over time and its association with type 2 diabetes. The study found that men showed muscle shrinkage, while women showed enlarged muscle, highlighting sex-specific differences in response to insulin tolerance.
Dr. Johnson V. John appointed as a Standing Member of the NIH Musculoskeletal Tissue Engineering (MTE) Study Section
Dr. Johnson V. John has been appointed as a standing member of the NIH's Musculoskeletal Tissue Engineering (MTE) Study Section, ensuring innovative research receives support. His expertise in biomaterials and tissue engineering will contribute to national research priorities.
Robots that flex like US: The rise of muscle-powered machines
Researchers are developing 'biohybrid robots' that flex and move using biological tissue, offering potential applications in medicine and industry. The field is advancing through advanced fabrication methods, such as 3D bioprinting and electrospinning, which enable precise control over muscle cells.
PolyU research boosts garment fit and performance for sports and medical apparel with groundbreaking anthropometric method to precisely measure tissue deformation
Researchers developed a novel method to precisely measure tissue deformation, providing highly accurate measurements to enhance compression-based apparel. The approach minimizes motion artifacts, offering actionable insights on material properties and garment design.
Variation inside and out: cell types in fruit fly metamorphosis
A study published in PLOS Computational Biology reveals that different cell types and variation within these cells play a crucial role in muscle remodeling during Drosophila development. The findings show that sarcolytes, hemocytes, and fat body cells work together to break down larval muscles and scatter the fragments.
Muscle “marbling”: Good in steak, bad in our bodies
A new study suggests that marbling of fat inside muscles is a strong indicator of poor health, including obesity, Type 2 diabetes, and neuromuscular disorders. The research found that intramuscular fat acts as a physical barrier obstructing muscle healing and regeneration.
New aging clock predicts early risk of muscle loss in older adults
A new study introduces a novel muscular clock, MAA, which measures how quickly an individual's muscles are aging compared to their actual age. The research found that about 25% of healthy middle-aged and older adults experience accelerated muscle aging, increasing the risk of sarcopenia.
Studying cardiac cells in space to repair heart damage on Earth
Researchers from Emory University are using the International Space Station to study cardiac cells and accelerate the development of cell-based regenerative therapies. The team's findings have led to multiple peer-reviewed publications and could significantly advance methods to produce cardiac cells for heart disease treatment.
One-step creation of Cre-loxP organisms: precise control and modification of gene expression
Scientists developed a new technology to produce Cre-loxP organisms in a single step, reducing the need for crossbreeding and decreasing production time. The method involves introducing a TAx9 sequence to prevent Cre gene expression in E. coli bacteria, allowing for precise control and modification of gene expression.
Drug reverses groin hernias in male mice without surgery, shows promise in humans
Researchers successfully reversed existing inguinal hernias in male mice using an anti-estrogen drug, restoring their anatomy without surgery. Human tissue samples also showed identical molecular markers as in the mouse model, suggesting a promising treatment target for inguinal hernia repair.
Improving blood transfusion monitoring in critical care patients: Insights from diffuse optics
A recent study investigated hybrid diffuse optics to monitor changes in blood flow and oxygen levels noninvasively. The technology provided detailed insights into how oxygen is delivered and utilized in the body, suggesting improved outcomes for critically ill patients undergoing red blood cell transfusions.
Microvascular over-dilation may lead to muscle hypoxia
Persistent microvascular over-dilation may cause muscle hypoxia, worsening chronic limb-threatening ischemia outcomes. Research suggests this phenomenon could be used to screen and treat patients with the disease.
Infertility linked to onset of systemic autoimmune rheumatic disease after childbirth
Women with infertility are at higher risk of developing SARD, including lupus and Sjögren's syndrome, even after accounting for pre-eclampsia and other pregnancy complications. Infertility treatments do not appear to increase this risk, suggesting that women may be undiagnosed or untreated.
When muscles work out, they help neurons to grow, a new study shows
A new study by MIT engineers reveals that exercise can stimulate nerve growth, with neurons growing four times farther in the presence of myokines released during muscle contractions. Physical effects of exercise, such as repeated stretching and pulling, also promote nerve growth, challenging previous biochemical-only theories.
Groundbreaking surgical technique makes combined face and whole-eye transplantation a reality
The world's first combined face and whole-eye transplantation successfully used personalized surgical cutting guides and a novel 'shortcut' to maintain blood flow. Innovative techniques ensured optimal blood flow to the retina, safeguarding the viability of the transplanted eye during the procedure.
Duke-NUS discovery advances quest for treatment for age- and cancer-related muscle degeneration
Researchers found that maintaining optimal levels of DEAF1 is crucial for muscle repair and regeneration, and that restoring balance with DEAF1 may counteract some effects of aging on muscle tissue. This could lead to improved treatments for sarcopenia and cachexia, conditions affecting millions of older adults and cancer patients.
Low gravity in space travel found to weaken and disrupt normal rhythm in heart muscle cells
Researchers found that low gravity conditions in space weaken and disrupt the normal rhythmic beats of human bioengineered heart tissue samples. The tissues on the International Space Station beat about half as strong as those on Earth, and developed irregular beating patterns that can cause a human heart to fail.
New bacteria-derived hydrogel heals tissue
Researchers at Technical University of Denmark developed a new biopolymer, PAMA, derived from bacteria to heal tissue. The PAMA bactogel shows significant muscle regeneration properties and nearly 100% mechanical recovery in rats.
To walk, you only need fins (and maybe a sense of adventure)
Researchers studied the anatomy of mudskippers to understand their adaptations to life on land. They found that the fish's muscles in the pectoral fins are bigger and that some bone-connecting tendons were replaced by fascia tissue, providing stability and strength for walking.
NUS scientists discover a novel way of activating muscle cells’ natural defenses against cancer using magnetic pulses
A team of researchers from NUS has developed a novel method to stimulate muscle cells using magnetic therapy, which produces and releases proteins with anticancer properties. The study demonstrates that this non-invasive approach can prevent cancer cell growth and invasion, similar to exercise.
Healing faster: Unveiling the future of tissue & organ repair
A team of scientists at the University of Ottawa has developed a novel peptide-based hydrogel that can be used for on-the-spot repair to damaged organs and tissues. The material shows great potential for closing skin wounds, delivering therapeutics to damaged heart muscle, and reshaping and healing injured corneas.
Aligned peptide ‘noodles’ could enable lab-grown biological tissues
Researchers at Rice University have developed a novel fabrication process to create aligned peptide nanofiber hydrogels, which can guide cell growth in a desired direction. The study revealed that cells need to be able to 'pull' on the peptide nanofibers to recognize alignment, and excessive rigidity can prevent this.
Presence of specific lipids indicate tissue ageing and can be decreased through exercise
Research reveals specific lipids accumulate in tissues as we age and can be decreased through exercise, according to a recent study published in Nature Aging. The findings suggest that exercise may have a role in reversing age-related changes in human muscle tissue.
Post-COVID not necessarily a barrier to exercise
Researchers from Karolinska Institutet show that post-COVID does not mean strict exercise avoidance. Patients with post-COVID can benefit from supervised exercise, with improved fitness and muscle strength found in those who participated.
School-age girls with obesity are more likely to experience joint and muscle pain
Research by Queen Mary University of London found that girls with obesity are 1.7 times more likely than those with a healthy weight to have at least one GP consultation for musculoskeletal symptoms or diagnosis in childhood. Knee pain was the most common symptom reported, and researchers hope their findings will raise awareness about ...
Pusan National University's breakthrough in muscle regeneration: Nanotech scaffolding supports tissue growth
Researchers develop nanofibrous matrices containing MXene nanoparticles to aid in muscle regeneration. The study reveals molecular mechanisms behind the effects of MXene nanoparticles on muscle growth, suggesting a promising avenue for treating volumetric muscle loss and muscle-related ailments.
Tests can reveal whether an antibody can turn into a killer
Researchers discover antibody-dependent enhancement of toxicity (ADET), a phenomenon where antibodies can amplify venom's potency. The breakthrough contributes to expediting the development of a new generation of antivenom, potentially saving millions from snakebites yearly.
Sarcopenia - an emerging syndrome of advancing age
A new special issue of Calcified Tissue International & Musculoskeletal Research sheds light on sarcopenia's pathogenesis, clinical implications, and therapeutic targets. Researchers have made significant progress in evaluating, managing, and developing interventions for this condition.
Fascicle gearing dynamics: Unveiling 3D rotation effects in muscle elongation
Researchers at Waseda University used diffusion tensor imaging to reconstruct fascicles in three dimensions, finding that a gearing mechanism reduces individual fascicle elongation during stretching. This mechanism allows muscles to extend without significant fiber length changes, preventing overstretching and injury.
New “injectable tissue prosthesis coupled with closed-loop bioelectronic system” to aid in damaged muscle/nerve regeneration and robot-assisted rehabilitation
Researchers from the Institute for Basic Science developed a novel approach to healing muscle injury using conductive hydrogels and robot-assisted rehabilitation. The injectable tissue prosthesis enhances gait in rodent models without nerve stimulation, while improving long-term muscle tissue regeneration.
Moving muscle fibers with magnets “programs” how they align within tissue
Using magnets, scientists have found a way to align muscle fibers in tissue, allowing for the development of model tissues and potential therapies for muscle injuries or diseases. The method, which involves mechanically stimulating muscle cells with magnetic forces, shows promise for understanding muscle growth and function.
Ancient metal cauldrons give us clues about what people ate in the Bronze Age
A new study analyzed protein residues from ancient cooking cauldrons and found evidence of deer, sheep, goats, and cow family members being consumed during the Maykop period. The researchers also discovered milk proteins, indicating that dairy was a part of the diet.
Sports concussions increase injury risk
Research at University of South Australia finds that concussions can lead to a significant increased risk of future injury, even after recovery. The study suggests longer recovery times may be needed for youth athletes suffering from head trauma.
Wearable ultrasound patch provide non-invasive deep tissue monitoring
A team of engineers at UC San Diego has developed a stretchable ultrasonic array capable of serial, non-invasive imaging of tissues up to 4cm below the skin surface. This technology offers several key applications in healthcare monitoring, including cancer detection and sports injury assessment.
Lab-grown fat could give cultured meat real flavor and texture
Researchers at Tufts University have successfully produced bulk fat tissue in a lab that has a similar texture and makeup to natural animal fat. The aggregated fat cells can be fine-tuned to resemble real-life fat within meat, offering a key step towards mass production of cultured meat.
Metformin & leucine prevent cellular senescence & proteostasis disruption
Researchers found that metformin + leucine (MET+LEU) treatment prevents myotube atrophy by reversing cellular senescence and improving proteostasis. The study used C2C12 myoblasts, aged mouse single myofibers, and human primary myotubes to demonstrate MET+LEU's skeletal muscle cell-autonomous properties.
RNA: Don't kill the messenger
A protein complex formed of HuR and YB1 is crucial for messenger RNA stability during muscle-fiber formation. Further research could help scientists influence protein synthesis and develop novel therapeutics for muscle-related pathologies.
Heart tissue heads to space to aid research on aging and impact of long spaceflights
Researchers from Johns Hopkins Medicine are collaborating with NASA to send human heart tissue into space to monitor its changes in low-gravity conditions. The mission will test the impact of long-duration spaceflights on heart muscle cells, potentially informing age-related cardiac problems treatments.
Vitamin B3 nicotinamide riboside improves muscle mitochondria and gut microbiota composition
Nicotinamide riboside has been found to increase muscle mitochondria, improve gut bacterial composition, and boost NAD+ concentrations in humans. The findings suggest that NR supplementation may be a promising therapeutic option for diseases characterized by muscle mitochondrial dysfunction and/or gut microbiota imbalance.
Illinois Tech professors’ paper challenging classical view of muscle contraction could lead to new cardiac treatments
Researchers discovered that myosin motor proteins must be activated before muscles can contract, potentially leading to breakthroughs in treating inherited cardiac conditions. This new understanding could lead to medical remedies for diseases like dilated cardiomyopathy and hypertrophic cardiomyopathy.
Squid tissues and chemistry combine for versatile hydrogels
Researchers at Hokkaido University developed a hybrid hydrogel combining natural squid tissues with synthetic polymers, exhibiting hierarchical anisotropy and toughness.
Tears in Tokyo: Muscle–tendon injuries during Olympic competition can spell heartbreak
Researchers analyzed MRI images of Olympic athletes' injuries during the 2020 Tokyo Games and found that those with tendon tears were more likely to drop out. The study aims to improve injury management and prevention by understanding different types of muscle injuries and their outcomes.
Ceramides accumulate in the aged muscle – Researchers identify a new hallmark of ageing
Ceramides accumulate in aged muscle, impairing its function and affecting functional capacity in older adults. This finding encourages researchers to develop potential pharmaceutical agents to combat sarcopenia and age-related diseases.
How damaged cells inhibit muscle regeneration over lifetime
Researchers discovered that damaged cells and aging induce high levels of oxidative stress and DNA damage in a subset of cells, leading to senescence. Senescent cells repress muscle regeneration by releasing inflammatory factors, while also promoting fibrosis, highlighting the need to remove these cells for improved repair.
Forget barbells: materials derived from cells may be an exercise alternative for astronauts
Astronauts in space can lose up to 20% of muscle mass after two weeks due to microgravity. Researchers are exploring the use of extracellular vesicles, which contain restorative chemicals, to trigger post-exercise recovery without traditional exercise.
Vitamin D deficiency increases risk of losing muscle strength by 78%
Researchers found that vitamin D deficiency increases the risk of dynapenia, an age-associated loss of muscle strength, by 70-78%. Vitamin D supplementation was shown to reduce this risk. The study analyzed data from over 3,000 individuals aged 50 and over, highlighting the importance of vitamin D for maintaining muscle strength.
Doubling in proportion of male professional footballers’ hamstring injuries and lay-off days over past 20 years
The proportion of hamstring injuries and associated lay-off days among male professional European footballers has doubled over the past 20 years. Nearly one in five injuries were recurrences, occurring within two months of return to play, with most injuries being structural and resulting in more lay-off days.
Researchers awarded $2.1M to study muscles
The UMass Lowell-led team aims to understand how proteins affect biting function in animals, with potential applications in treating diseases like muscular dystrophy. The research will involve studying molecular properties of myosin, a fibrous motor protein, and its impact on muscle force and velocity.
Wasting muscles built back better
Researchers developed a new device, MAGENTA, that prevents and supports muscle atrophy recovery. The device stimulates muscles to stretch and contract, triggering key molecular pathways for growth. It has potential applications in treating various diseases such as ALS and MS.
Aerobic activity can reduce the risk of metastatic cancer by 72%
Research at Tel Aviv University found that high-intensity aerobic exercise increases glucose consumption in internal organs, reducing energy availability for tumors. The study reduced the risk of metastatic cancer in humans and animal models by up to 72%.
New study shows better way to easily assess knee muscle function
A new study found that bioelectrical impedance analysis can accurately assess knee muscle function, offering a non-invasive alternative to traditional methods. The findings suggest that thigh PhA is a better predictor of knee extensor strength than whole-body PhA.
Muscling through: Linking muscle and joint stiffness of the lower human limbs
Researchers found that calf muscle stiffness contributes to passive ankle joint stiffness, especially when dorsiflexed. The study suggests that exercises to relieve triceps surae stiffness can improve joint flexibility and reduce injury risk.
Genetically engineered muscle tissue being developed to treat type 2 diabetes
Researchers have genetically engineered human muscle cells to take up more sugar from the blood, reducing blood glucose levels by 20% in diabetic mice. The new tissue also shows promise for a single injection of tissue providing long-lasting glucose control.