Articles tagged with Muscle Tissue
Researchers found trevogrumab significantly reduced lean mass loss by 50% when used with semaglutide. Participants who received trevogrumab experienced a mean increase in lean mass of +0.4%, while those who received placebo experienced a mean decrease of -2.4%.
A new study published in Nature Communications finds that a protein called saxiphilin can neutralize the potent neurotoxin saxitoxin, preventing and even reversing paralytic shellfish poisoning. The discovery could have important public health implications as saxitoxin accumulates in shellfish and causes poisoning when consumed.
Researchers have discovered a key protein, Mylpf, essential for fast-twitch muscle fibers to form and contract. The study found that even partial reduction in Mylpf function can hinder muscle formation, leading to diseases like muscular dystrophy.
A study reveals that S-1-propenyl-L-cysteine, a bioactive compound found in aged garlic extract, promotes inter-organ communication between fat tissue and the brain, enhancing muscle strength. Long-term administration of S1PC reduced frailty scores and increased skeletal muscle force in aged mice.
Researchers used MRI to analyze muscle composition in 11,348 participants and found that higher intermuscular fat and lower muscle mass were associated with increased cardiometabolic risk factors. Lean muscle mass was only protective against these risks in men, while women's muscle mass declined after age 40.
Researchers found a diet high in ultra-processed foods is associated with higher amounts of fat stored inside thigh muscles. This increased intramuscular fat may increase the risk for knee osteoarthritis. The study suggests that addressing obesity and improving dietary quality are crucial to preserving muscle health.
A higher testosterone level does not always indicate well-being in men, according to a study at the University of Gothenburg. Muscle health and inflammation are linked to testosterone levels, but symptoms like fatigue and depression have weaker connections.
A research team from Xi'an Jiaotong University has developed a method to align cells in muscle tissue using electric forces during electrohydrodynamic bioprinting. This breakthrough allows for the creation of living muscle tissues with tightly aligned cells, enabling the production of functional muscle constructs.
MIT engineers developed artificial tendons made from hydrogel to connect lab-grown muscles with robotic skeletons. The tendons improved the robot's motion and force output by three times, enabling faster and more efficient biohybrid robots.
Researchers have identified a key mechanism behind statin-induced muscle damage, paving the way for new statins with reduced side effects. By understanding how statins interact with muscle proteins, scientists can design safer alternatives that preserve cholesterol-lowering benefits.
Researchers used MRI 3D mapping to analyze changes in gluteus maximus shape over time and its association with type 2 diabetes. The study found that men showed muscle shrinkage, while women showed enlarged muscle, highlighting sex-specific differences in response to insulin tolerance.
Dr. Johnson V. John has been appointed as a standing member of the NIH's Musculoskeletal Tissue Engineering (MTE) Study Section, ensuring innovative research receives support. His expertise in biomaterials and tissue engineering will contribute to national research priorities.
Researchers are developing 'biohybrid robots' that flex and move using biological tissue, offering potential applications in medicine and industry. The field is advancing through advanced fabrication methods, such as 3D bioprinting and electrospinning, which enable precise control over muscle cells.
Researchers developed a novel method to precisely measure tissue deformation, providing highly accurate measurements to enhance compression-based apparel. The approach minimizes motion artifacts, offering actionable insights on material properties and garment design.
A study published in PLOS Computational Biology reveals that different cell types and variation within these cells play a crucial role in muscle remodeling during Drosophila development. The findings show that sarcolytes, hemocytes, and fat body cells work together to break down larval muscles and scatter the fragments.
A new study suggests that marbling of fat inside muscles is a strong indicator of poor health, including obesity, Type 2 diabetes, and neuromuscular disorders. The research found that intramuscular fat acts as a physical barrier obstructing muscle healing and regeneration.
A new study introduces a novel muscular clock, MAA, which measures how quickly an individual's muscles are aging compared to their actual age. The research found that about 25% of healthy middle-aged and older adults experience accelerated muscle aging, increasing the risk of sarcopenia.
Researchers from Emory University are using the International Space Station to study cardiac cells and accelerate the development of cell-based regenerative therapies. The team's findings have led to multiple peer-reviewed publications and could significantly advance methods to produce cardiac cells for heart disease treatment.
Scientists developed a new technology to produce Cre-loxP organisms in a single step, reducing the need for crossbreeding and decreasing production time. The method involves introducing a TAx9 sequence to prevent Cre gene expression in E. coli bacteria, allowing for precise control and modification of gene expression.
Researchers successfully reversed existing inguinal hernias in male mice using an anti-estrogen drug, restoring their anatomy without surgery. Human tissue samples also showed identical molecular markers as in the mouse model, suggesting a promising treatment target for inguinal hernia repair.
A recent study investigated hybrid diffuse optics to monitor changes in blood flow and oxygen levels noninvasively. The technology provided detailed insights into how oxygen is delivered and utilized in the body, suggesting improved outcomes for critically ill patients undergoing red blood cell transfusions.
Persistent microvascular over-dilation may cause muscle hypoxia, worsening chronic limb-threatening ischemia outcomes. Research suggests this phenomenon could be used to screen and treat patients with the disease.
Women with infertility are at higher risk of developing SARD, including lupus and Sjögren's syndrome, even after accounting for pre-eclampsia and other pregnancy complications. Infertility treatments do not appear to increase this risk, suggesting that women may be undiagnosed or untreated.
A new study by MIT engineers reveals that exercise can stimulate nerve growth, with neurons growing four times farther in the presence of myokines released during muscle contractions. Physical effects of exercise, such as repeated stretching and pulling, also promote nerve growth, challenging previous biochemical-only theories.
The world's first combined face and whole-eye transplantation successfully used personalized surgical cutting guides and a novel 'shortcut' to maintain blood flow. Innovative techniques ensured optimal blood flow to the retina, safeguarding the viability of the transplanted eye during the procedure.
Researchers found that maintaining optimal levels of DEAF1 is crucial for muscle repair and regeneration, and that restoring balance with DEAF1 may counteract some effects of aging on muscle tissue. This could lead to improved treatments for sarcopenia and cachexia, conditions affecting millions of older adults and cancer patients.
Researchers found that low gravity conditions in space weaken and disrupt the normal rhythmic beats of human bioengineered heart tissue samples. The tissues on the International Space Station beat about half as strong as those on Earth, and developed irregular beating patterns that can cause a human heart to fail.
Researchers at Technical University of Denmark developed a new biopolymer, PAMA, derived from bacteria to heal tissue. The PAMA bactogel shows significant muscle regeneration properties and nearly 100% mechanical recovery in rats.
Researchers studied the anatomy of mudskippers to understand their adaptations to life on land. They found that the fish's muscles in the pectoral fins are bigger and that some bone-connecting tendons were replaced by fascia tissue, providing stability and strength for walking.
A team of researchers from NUS has developed a novel method to stimulate muscle cells using magnetic therapy, which produces and releases proteins with anticancer properties. The study demonstrates that this non-invasive approach can prevent cancer cell growth and invasion, similar to exercise.
A team of scientists at the University of Ottawa has developed a novel peptide-based hydrogel that can be used for on-the-spot repair to damaged organs and tissues. The material shows great potential for closing skin wounds, delivering therapeutics to damaged heart muscle, and reshaping and healing injured corneas.
Researchers at Rice University have developed a novel fabrication process to create aligned peptide nanofiber hydrogels, which can guide cell growth in a desired direction. The study revealed that cells need to be able to 'pull' on the peptide nanofibers to recognize alignment, and excessive rigidity can prevent this.
Research reveals specific lipids accumulate in tissues as we age and can be decreased through exercise, according to a recent study published in Nature Aging. The findings suggest that exercise may have a role in reversing age-related changes in human muscle tissue.
Researchers from Karolinska Institutet show that post-COVID does not mean strict exercise avoidance. Patients with post-COVID can benefit from supervised exercise, with improved fitness and muscle strength found in those who participated.
Research by Queen Mary University of London found that girls with obesity are 1.7 times more likely than those with a healthy weight to have at least one GP consultation for musculoskeletal symptoms or diagnosis in childhood. Knee pain was the most common symptom reported, and researchers hope their findings will raise awareness about ...
Researchers develop nanofibrous matrices containing MXene nanoparticles to aid in muscle regeneration. The study reveals molecular mechanisms behind the effects of MXene nanoparticles on muscle growth, suggesting a promising avenue for treating volumetric muscle loss and muscle-related ailments.
Researchers discover antibody-dependent enhancement of toxicity (ADET), a phenomenon where antibodies can amplify venom's potency. The breakthrough contributes to expediting the development of a new generation of antivenom, potentially saving millions from snakebites yearly.
A new special issue of Calcified Tissue International & Musculoskeletal Research sheds light on sarcopenia's pathogenesis, clinical implications, and therapeutic targets. Researchers have made significant progress in evaluating, managing, and developing interventions for this condition.
Researchers at Waseda University used diffusion tensor imaging to reconstruct fascicles in three dimensions, finding that a gearing mechanism reduces individual fascicle elongation during stretching. This mechanism allows muscles to extend without significant fiber length changes, preventing overstretching and injury.
Researchers from the Institute for Basic Science developed a novel approach to healing muscle injury using conductive hydrogels and robot-assisted rehabilitation. The injectable tissue prosthesis enhances gait in rodent models without nerve stimulation, while improving long-term muscle tissue regeneration.
Using magnets, scientists have found a way to align muscle fibers in tissue, allowing for the development of model tissues and potential therapies for muscle injuries or diseases. The method, which involves mechanically stimulating muscle cells with magnetic forces, shows promise for understanding muscle growth and function.
A new study analyzed protein residues from ancient cooking cauldrons and found evidence of deer, sheep, goats, and cow family members being consumed during the Maykop period. The researchers also discovered milk proteins, indicating that dairy was a part of the diet.
Research at University of South Australia finds that concussions can lead to a significant increased risk of future injury, even after recovery. The study suggests longer recovery times may be needed for youth athletes suffering from head trauma.
A team of engineers at UC San Diego has developed a stretchable ultrasonic array capable of serial, non-invasive imaging of tissues up to 4cm below the skin surface. This technology offers several key applications in healthcare monitoring, including cancer detection and sports injury assessment.
Researchers at Tufts University have successfully produced bulk fat tissue in a lab that has a similar texture and makeup to natural animal fat. The aggregated fat cells can be fine-tuned to resemble real-life fat within meat, offering a key step towards mass production of cultured meat.
Researchers found that metformin + leucine (MET+LEU) treatment prevents myotube atrophy by reversing cellular senescence and improving proteostasis. The study used C2C12 myoblasts, aged mouse single myofibers, and human primary myotubes to demonstrate MET+LEU's skeletal muscle cell-autonomous properties.
A protein complex formed of HuR and YB1 is crucial for messenger RNA stability during muscle-fiber formation. Further research could help scientists influence protein synthesis and develop novel therapeutics for muscle-related pathologies.
Researchers from Johns Hopkins Medicine are collaborating with NASA to send human heart tissue into space to monitor its changes in low-gravity conditions. The mission will test the impact of long-duration spaceflights on heart muscle cells, potentially informing age-related cardiac problems treatments.
Nicotinamide riboside has been found to increase muscle mitochondria, improve gut bacterial composition, and boost NAD+ concentrations in humans. The findings suggest that NR supplementation may be a promising therapeutic option for diseases characterized by muscle mitochondrial dysfunction and/or gut microbiota imbalance.
Researchers discovered that myosin motor proteins must be activated before muscles can contract, potentially leading to breakthroughs in treating inherited cardiac conditions. This new understanding could lead to medical remedies for diseases like dilated cardiomyopathy and hypertrophic cardiomyopathy.
Researchers at Hokkaido University developed a hybrid hydrogel combining natural squid tissues with synthetic polymers, exhibiting hierarchical anisotropy and toughness.
Researchers analyzed MRI images of Olympic athletes' injuries during the 2020 Tokyo Games and found that those with tendon tears were more likely to drop out. The study aims to improve injury management and prevention by understanding different types of muscle injuries and their outcomes.
Ceramides accumulate in aged muscle, impairing its function and affecting functional capacity in older adults. This finding encourages researchers to develop potential pharmaceutical agents to combat sarcopenia and age-related diseases.
Researchers discovered that damaged cells and aging induce high levels of oxidative stress and DNA damage in a subset of cells, leading to senescence. Senescent cells repress muscle regeneration by releasing inflammatory factors, while also promoting fibrosis, highlighting the need to remove these cells for improved repair.
Researchers found that vitamin D deficiency increases the risk of dynapenia, an age-associated loss of muscle strength, by 70-78%. Vitamin D supplementation was shown to reduce this risk. The study analyzed data from over 3,000 individuals aged 50 and over, highlighting the importance of vitamin D for maintaining muscle strength.
Astronauts in space can lose up to 20% of muscle mass after two weeks due to microgravity. Researchers are exploring the use of extracellular vesicles, which contain restorative chemicals, to trigger post-exercise recovery without traditional exercise.
The proportion of hamstring injuries and associated lay-off days among male professional European footballers has doubled over the past 20 years. Nearly one in five injuries were recurrences, occurring within two months of return to play, with most injuries being structural and resulting in more lay-off days.
The UMass Lowell-led team aims to understand how proteins affect biting function in animals, with potential applications in treating diseases like muscular dystrophy. The research will involve studying molecular properties of myosin, a fibrous motor protein, and its impact on muscle force and velocity.
Researchers developed a new device, MAGENTA, that prevents and supports muscle atrophy recovery. The device stimulates muscles to stretch and contract, triggering key molecular pathways for growth. It has potential applications in treating various diseases such as ALS and MS.
Research at Tel Aviv University found that high-intensity aerobic exercise increases glucose consumption in internal organs, reducing energy availability for tumors. The study reduced the risk of metastatic cancer in humans and animal models by up to 72%.