Articles tagged with Muscle Tissue
A new study found that bioelectrical impedance analysis can accurately assess knee muscle function, offering a non-invasive alternative to traditional methods. The findings suggest that thigh PhA is a better predictor of knee extensor strength than whole-body PhA.
Researchers found that calf muscle stiffness contributes to passive ankle joint stiffness, especially when dorsiflexed. The study suggests that exercises to relieve triceps surae stiffness can improve joint flexibility and reduce injury risk.
Researchers have genetically engineered human muscle cells to take up more sugar from the blood, reducing blood glucose levels by 20% in diabetic mice. The new tissue also shows promise for a single injection of tissue providing long-lasting glucose control.
Researchers at Tokyo Metropolitan University discovered that a protein excreted by type I muscle fibers can differentiate surrounding myoblasts into type I fibers, upending the notion that fiber ratios are fixed at birth. This finding has significant implications for treating conditions such as type 2 diabetes and aging populations.
A study published in Cell Stem Cell found that mitochondrial dynamics regulate the dormant state of adult muscle stem cells, which are essential for tissue stability. The researchers discovered that the protein OPA1 regulates this process and its depletion leads to severe muscle stem cell defects.
Researchers from Tokyo Medical and Dental University found a novel GLP-1R agonist, PF1801, that can suppress muscle inflammation and restore muscle strength in patients with polymyositis. The study suggests PF1801 could be used to treat patients with muscle wasting disease and improve symptoms associated with inflammatory myopathies.
Researchers tested a new needle ablation technique called SERF to treat ventricular tachycardia in patients who had not responded to other treatments. The study found that 31 of 32 patients experienced eliminated clinical ventricular tachycardia, with device therapies reduced by 89% during follow-up.
A recent study published in Science reveals that hyaluronic acid plays a key role in controlling muscle repair. The natural compound awakens stem cells to start the repair process after a 40-hour cleanup job by immune cells is complete.
A recent study investigated the relationship between passive muscle mechanical properties and dynamic performance in athletes. The research found a positive correlation between the shear modulus of the vastus lateralis muscle and performance outcomes during high-speed activities, suggesting that passive muscle properties are essential ...
The SARS-CoV-2 spike protein activates the natural immune response in heart muscle cells, causing damage and inflammation. The study found that the spike protein also caused hypertrophic remodeling and cardiac dysfunction in lab mice, highlighting a novel, ACE2-independent pathological role of the virus.
Researchers discovered increased cell cycle activity and proliferation in cardiomyocytes after heart surgery, allowing for remuscularization of the left ventricle. The study identified key genes involved in pathways regulating heart development and cell proliferation.
A collaborative initiative aims to establish common protocols for assessing and comparing diffuse optics systems used in medical diagnosis. The study presents the results of a multi-laboratory comparison of 12 institutions and 28 systems, proposing simple numeric values for easy comparison across instruments.
Researchers have found that light-based therapies such as photobiomodulation and photodynamics can effectively treat a range of post-COVID complications, including muscle and joint damage. The studies, conducted in Brazil, utilized laser irradiation, negative pressure, and other technologies to improve symptoms and promote healing.
A team of researchers has successfully treated damaged pig hearts with cardiac progenitor cells, demonstrating the formation of new cardiac tissue and improved cardiac function. The treatment could potentially be used to treat patients with serious heart failure, particularly older patients with coexisting conditions.
A team from the Terasaki Institute for Biomedical Innovation has created a method to repair tendons using silk fibroin scaffolds, which showed improved healing and regeneration of injured tendons. The scaffold combines silk fibroin with GelMA to promote cell attachment, growth, and differentiation.
A study published in the American Journal of Cardiology found that measuring intramuscular fat in thigh muscles can predict cardiovascular health outcomes in heart failure patients. Patients with lower intramuscular fat had higher grip strength and were less likely to be hospitalized.
Scientists at Johns Hopkins Medicine have successfully cultivated human muscle stem cells capable of renewing themselves and repairing muscle tissue damage in mice. The self-renewing stem cells were created by reprogramming laboratory-grown human skin cells, which then differentiated into specific cell types using a nutrient-rich broth.
A recent clinical trial has shown that sodium thiosulfate does not reduce injury to damaged areas of heart muscle following a heart attack. Despite promising results in animal studies, the trial did not meet its primary endpoint or show significant differences in secondary endpoints.
Researchers at the University of Maine used zebrafish to test the effectiveness of neuromuscular electrical stimulation (NMES) on muscle strength and structure. The study found that only one NMES regimen, endurance neuromuscular stimulation (eNMES), improved muscle health when combined with an antioxidant and a specific receptor.
Researchers at Osaka City University found that globin family members can suppress liver inflammation and fibrosis in mice. The proteins' antioxidant capacity was greater than glutathione and vitamin C, suggesting a potential therapy for liver fibrosis.
A team of researchers found that re-activating the Piezo1 protein allows muscle stem cells to repair broken down muscles in mice with Duchenne muscular dystrophy. The study opens doors for potential molecular-level treatments to slow or halt disease progression.
Dr. Zhiqiang Lin has been awarded a $3.2 million NIH grant to investigate the roles of YAP and IRF2BP2 in the cardiac innate immune response, with the goal of reducing cardiac inflammation and promoting heart recovery after a heart attack.
Researchers found that bilobalide, an active ingredient in Ginkgo biloba extract, protects the heart from ischemic injuries by preserving ATP generation and enhancing metabolic flux. The study suggests that bilobalide may provide a new herbal therapy for treating myocardial ischemia.
A team from UNIGE demonstrates that cells can self-organize to generate forces that model the shapes of our tissues. Topological defects create cellular tornadoes that concentrate forces and shape tissues similar to those observed in embryo development.
A comprehensive study of exercise performed at different times of the day has identified distinct health-promoting signaling molecules produced by the body in an organ-specific manner. The findings suggest that exercising at the right time can optimize health benefits, particularly for individuals at risk of obesity and type 2 diabetes.
Fibrodysplasia ossificans progressiva (FOP) may be rooted in impaired and inefficient muscle tissue regeneration, which enables unwanted bone growth. This discovery could lead to new therapies targeting both extra-skeletal bone formation and muscle function.
Researchers have developed a technique called cryobioprinting that combines bioprinting with cryopreservation to create frozen, complex structures. The technology allows for the fabrication of anisotropic tissues with microscale pores aligned in specific directions, opening up new possibilities for muscular tissue engineering and beyond.
Researchers found that up to one in five patients experience increased troponin levels after major surgery, indicating potential heart damage. These patients were also more likely to be anaemic before the operation.
Researchers at McGill University create injectable hydrogel that forms stable structure allowing cells to grow and repair injured organs. The material's toughness and porosity make it suitable for heart, muscle, and vocal cord repair.
Researchers at MDI Biological Laboratory discovered that muscle tissue is protected from reduced protein synthesis during nutrient scarcity, accelerating growth and reproduction. The study suggests potential for developing anti-aging drugs preserving muscle tissue while prolonging lifespan.
Researchers discovered that chemotherapy drugs can affect protein synthesis in muscle cells, even at low doses. This finding has significant implications for cancer treatment and exercise rehabilitation programs, suggesting that even non-oxidative stress effects of chemotherapy should be considered.
A recent study has called for reduced forceps use in Canada and better education for both clinicians and mothers on how to avoid injury during childbirth. The researchers analyzed nearly two million birth records from Canada, Norway, Sweden, and Austria, finding that five percent of women had third or fourth degree tears to the perineum.
A recent study reveals that muscle regeneration after physiological damage relies on the rearrangement of nuclei, accelerating repair of contractile units. Nuclei are attracted to injury sites and deliver mRNA molecules to initiate protein synthesis for muscle repair, offering a new insight into muscle biology.
The study found that the Wntless (Wls) gene plays a critical role in heart regeneration in mice by facilitating signal molecule secretion from cardiomyocytes to cardiac fibroblasts. This promotes heart functional recovery by suppressing CF activation and reducing scar formation.
Researchers at Washington University in St. Louis have developed a method to produce synthetic muscle protein using microbes, which can be spun into fibers with exceptional toughness and strength. The resulting material has potential biomedical applications, such as sutures and tissue engineering.
BioAesthetics Corp., a Tulane University spin-out company, has received a $256,000 grant to develop a novel graft for treating pelvic organ prolapse (POP). The graft, strengthened with biodegradable polymers, will be tested in Kristin Miller's lab to compare its elasticity and strength to normal tissue.
Researchers have created a dynamic model that accurately recreates hemodynamic loads on engineered heart muscle tissues, providing unprecedented insights into how genetics and mechanical forces contribute to heart muscle function. This breakthrough model allows for the study of various heart diseases with genetic mutations, development...
Researchers at the University of Bath have developed a bioengineering process that uses grass blades to create scaffolds for animal cells to grow on, resulting in cultured meat. The study successfully demonstrates significant cell adhesion and tissue formation, paving the way for a more sustainable meat production method.
Researchers identify succinate as a key molecule released by muscle cells during exercise, triggering tissue remodeling and increased strength. The study found that succinate levels rise in muscle fibers and interstitial spaces after exercise, leading to improved metabolic efficiency and enhanced athletic performance.
Researchers analyzed gene expression in liver, heart, and muscle tissues of aging mice to define an 'aging footprint.' This data helped identify genes and proteins controlling the aging process, which may also be relevant in human aging. The study's findings have implications for understanding age-related diseases.
A team of researchers at the University of Münster has discovered a new mechanism that regulates myocardial distensibility, which is the elasticity of the heart muscle. This mechanism, called UnDOx, is triggered by oxidative stress and changes the stiffness of the cardiac walls.
A new study demonstrates the effectiveness of a Human-on-a-Chip technology in modeling amyotrophic lateral sclerosis (ALS) pathology. The system reproduces assays used in clinics to assess ALS deficits, showing promise for accelerated drug development and treatment screening.
A study of 22 COVID-19 patient autopsies found a unique pattern of cell death in scattered heart muscle cells, challenging traditional myocarditis theories. The researchers propose several theories to explain the cardiac injury and suggest further investigation for potential treatment interventions.
Researchers found that only an extremely small percentage of ingested microplastic particles made it into the fish fillets. The majority were excreted, suggesting that fish can isolate and remove these particles before they penetrate their tissues.
Duke University researchers have made time-lapse movies of the sheet-like latticework surrounding animal tissues, revealing dynamic movement within the matrix scaffolding. The study provides a new toolkit for studying basement membrane defects underlying tissue degeneration and diseases such as kidney disease and aging.
Researchers found that cells protect themselves from mechanical stress by not only deforming cell nuclei but also softening the genetic material itself. This mechanism helps prevent DNA damage and disease, including cancer. The study also reveals that healthy stem cells are more resistant to mechanical stretch than cancer cells.
Researchers at Johns Hopkins University launch a project to study the effects of microgravity on human heart tissues. The team sends heart muscle tissues on tissue chips to the ISS for observation, with the goal of understanding aging and developing treatments for heart disease.
A team of bioengineers from Trinity College Dublin has developed a prototype patch that mimics the electrical signalling properties and mechanical demands of heart tissue. The patch, manufactured via melt electrowriting, withstood repeated stretching and showed good elasticity, addressing key requirements for cardiac biomaterials.
Rutgers engineers create tiny needles inspired by parasites using 4D printing, achieving stronger tissue adhesion and more stable drug delivery. The microneedle outperforms previously reported examples, offering a potential solution to painful injections.
A team of engineers at MIT has developed a bionic 'heart' to test prosthetic valves and other cardiac devices, reducing the need for animal testing and increasing design efficiency. The device combines real heart tissue with soft artificial muscles to mimic the natural beating motion of a human heart.
A research team at Toyohashi University of Technology has developed a donut-shaped kirigami device for EMG recordings, reducing device displacement on large deformable muscle surfaces. The device enables accurate and robust signal acquisition, offering potential for prosthesis control in amputees.
University of Delaware researchers identify gene expression irregularities and lipoprotein lipase enzyme as causes of wooden breast syndrome in broiler chickens. This metabolic disorder can make the meat hard and chewy, causing significant economic losses for growers.
Scientists have devised a method to sort out which heart cells can replicate and which cannot, a critical step toward treatments that may one day help the heart heal itself after injury. This technique combines molecular beacon technology and fluorescence activated cell-sorting to specifically isolate cells that successfully divide.
A new clinical trial found that a cost-effective generic medication, spironolactone, is just as effective as the more expensive drug eplerenone in preserving cardiovascular function in boys with Duchenne muscular dystrophy. The study also showed stabilization of kidney and lung function, with no serious side effects.
During their 6,000-km journey to spawn, European eels undergo dramatic silvering and skeleton breakdown, redistributing minerals for energy reserves. The study found significant bone loss in females, with toxic metals transferred to ovaries, raising concerns about conservation impacts.
A team of biomedical engineers has developed a stem cell cardiac patch made with tissue engineered with tiny blood vessels to mimic real heart muscle. The patch can connect to native vasculature, bringing nutrients and oxygen, making it potentially effective for treating myocardial infarction.
Researchers have developed micromachines that can mechanically stimulate cells and microtissues, potentially preventing diseases. These gummy-like robots use cell-sized artificial muscles powered by laser beams to carry out complex tasks.
Researchers have identified midkine as a key driver of inflammation in the heart muscle that can lead to heart failure in patients with myocarditis. The study found that inhibiting midkine reduced neutrophil infiltration and improved heart function.
Researchers at Queen Mary University of London and University of Cambridge developed auxetic materials with smooth curves, enabling repeated deformations without damage. These materials can be used in energy-efficient gripping tools, re-configurable shape-on-demand materials, and lattices with unique thermal expansion behaviour.
EMBL researchers used optogenetics to reconstruct epithelial folding in cells that normally don't undergo the process. This allowed them to build tissues in customized shapes without affecting cell function. The technique has implications for regenerative medicine and ex vivo stem cell culture systems.