Articles tagged with Muscles
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Researchers have identified the matchmaker protein SYG-1, which guides nerve cells to form synapses during embryonic development. This discovery may lead to new treatments for disorders such as chronic epilepsy and chronic pain, where synapse formation goes awry.
A major study found that patients who survive acute respiratory distress syndrome (ARDS) show significant improvement in exercise capacity and quality of life over time. Despite persistent muscle wasting and weakness, survivors achieve 66% of healthy patient exercise capacity at one year and return to work in most cases.
Eating high-quality protein helps maintain muscle mass during weight loss efforts, burning more calories. A study found that a moderately high-protein diet resulted in greater weight loss and reduced body fat compared to a low-carbohydrate diet.
UT Southwestern researchers have identified a gene called twist that regulates muscle development in fruit flies and found it to be crucial in preventing cachexia in mice. The study suggests that the gene down-regulates proinflammatory cytokines, which are involved in various diseases including cancer, arthritis, and asthma.
Researchers found that cockatiels and turtledoves generate more power in linear flight than magpies, attributed to their tail and wing structure. The study provides insight into how muscles are used to produce power for flight at different speeds.
Researchers studied patients' understanding of living wills, finding significant differences in interpretation, and found that certain ventilator modes can worsen sleep quality. Inspiratory muscle training also improved respiratory function in patients with severe COPD.
Researchers have found that blocking myostatin in mice with muscular dystrophy improves muscle function, providing a potential new treatment for the condition. However, further studies are needed to address concerns about the approach's limitations and potential side effects.
Researchers discovered that mice without the myostatin gene had less physical damage to their muscles and were stronger than those with Duchenne muscular dystrophy. Blocking the myostatin protein may help delay progression or improve quality of life, but more studies are needed in humans.
A recent UK study published in Neurology found no association between Gulf War exposure and specific impairments of peripheral nerves, neuromuscular junction, or skeletal muscles. The study used robust neurophysiologic tests and included representative comparison groups to rule out objective dysfunction.
A new study aims to prevent urinary incontinence in women after childbirth by promoting spontaneous pushing and daily perineum massage. The research, funded by the National Institutes of Health, hopes to empower women with tools to have a natural birth experience.
A study found that aerobic exercise did not prevent aging-related bone loss, while higher body fat, especially in the abdomen, was linked to increased bone mineral densities. Muscle strength also played a role in maintaining bone health, contrasting previous studies suggesting aerobics could have a protective effect.
Scientists at Rutgers and Albert Einstein College of Medicine investigate C. elegans worm model to understand age-related muscle deterioration. They find a key enzyme involved in this process, which could lead to novel therapeutic strategies for sarcopenia in humans.
Researchers developed a mechanical system that stimulates muscle activity in the legs by mimicking natural sensory input, which could aid astronauts and bed-ridden patients. The technology uses plungers to push against the bottom of the foot in specific patterns, generating enhanced neuromuscular activity.
Researchers have found that deacetylase inhibitors enhance muscle gene expression and formation in human and mouse myoblasts. This discovery may lead to methods to induce muscle growth, regeneration, and repair in adults with muscular dystrophy.
Researchers at Duke University Medical Center have discovered a rare genetic mutation in sheep that causes large, muscular bottoms without excess fat. The 'callipyge' gene is imprinted, meaning it's only active in the offspring of the affected parent, and its discovery could illuminate how muscle and fat are deposited in humans.
Researchers have successfully delivered the full-length dystrophin gene to mice with muscular dystrophy using stripped-down vectors, restoring normal muscle function. The breakthrough could pave the way for human clinical trials to assess the safety of this method in patients.
Researchers at Imperial College London identified a neural signal called WNT-3 that helps form connections between sensory and motor neurons in the spinal cord. The discovery has important implications for understanding neural regeneration following spinal injury.
A study by National Space Biomedical Research Institute found that amino acid supplements can maintain protein synthesis rates and body mass during bed rest, a model for muscle loss in space. The supplements also showed potential in reducing muscle atrophy in elderly, burn patients, and those after major operations.
Researchers at Dana-Farber Cancer Institute discovered a chemical switch called PGC-1 that can transform fast-twitch fibers into slow-twitch fibers, increasing muscular endurance. This finding could lead to the development of a new drug to manipulate muscle fiber type and improve muscular function in patients with medical conditions.
Scientists have successfully transformed sedentary mouse muscles into fatigue-resistant type I muscle fibers by introducing the PGC-1Q protein, which activates energy production and oxidative metabolism. This breakthrough discovery holds promise for treating muscle fatigue in patients and individuals confined to bed rest.
A recent study published in the New England Journal of Medicine found that botulinum toxin type A injections significantly improved muscle tone and function in patients with wrist and finger spasticity after a stroke. The treatment showed sustained effects for at least 12 weeks, with some cases lasting up to 24 weeks.
Defects in enzymes responsible for processing dystroglycan protein cause several rare forms of muscular dystrophy. The discovery will help doctors diagnose and provide genetic counseling to patients. It also raises questions about links between muscle physiology and neurobiology, potentially improving understanding of learning and memory.
Muscle stem cells have shown potential in treating muscular dystrophy by differentiating into other cell types and resisting rejection, overcoming major obstacles such as low survival rates and immune system rejection. The study's findings could lead to more effective treatments for MD and other muscle-related diseases.
A new study suggests that Btx-B may be effective in treating face wrinkles, with a faster onset of action but shorter duration compared to type A. The low-dose study found that patients injected with Btx-B experienced rapid wrinkle reduction within 48 hours, but the effect did not last as long as type A.
A study by E. Todd Schroeder and colleagues found that androgen therapy increased muscle mass, strength, and power in older men, improving their ability to perform daily activities. The findings suggest that supplemental androgen therapy might benefit older men prone to losing muscle mass due to sarcopenia.
A study by Troost found Botox to be an effective preventive therapy for headache treatment, with 92% of patients experiencing improvement after four treatments. This alternative approach can reduce medication use and side effects, offering a promising solution for debilitating headaches.
Researchers found that a therapy combining electrical stimulation with bilateral movement significantly improved motor skills in stroke patients compared to unilateral movement or physical therapy alone. The study suggests that involving the unaffected limb can help restore function and create new neural pathways.
Researchers at UF found that combining therapies with mild electrical stimulation and motion training to both arms improved motor recovery in people with chronic weakness and partial paralysis. Participants regained significantly more motion, reaction times, and sustained muscle contractions.
In a study, 50 patients with various voiding dysfunctions reported a 82% decrease or absence of incontinence after Botox injections. The treatment alleviated symptoms for approximately six months without long-term complications. Overactive bladder affects 17 million Americans, causing significant quality-of-life issues.
Researchers at the University of Pittsburgh School of Medicine have developed a promising new therapy for urinary incontinence using muscle-derived cells. The therapy, which uses genetically engineered muscle cells to replace damaged bladder muscles, shows long-term effectiveness in improving bladder function.
Studies by Johns Hopkins researchers found that excessive myostatin levels cause rapid muscle and fat loss in mice without affecting appetite. This discovery offers hope for new treatments for muscle-wasting diseases like muscular dystrophy and extreme weight loss associated with certain cancers, AIDS, and other conditions.
A new mouse model has shown promise in treating muscular dystrophy by increasing muscle mass and regeneration, reducing muscle cell death. The combination of better muscle regeneration and less muscle wasting could lead to improved muscle capacity over time.
Researchers at the University of Pittsburgh have discovered a unique population of muscle stem cells that can be transplanted into mice with Duchenne muscular dystrophy, delivering the key protein dystrophin and improving muscle regeneration. The study suggests these cells may hold promise for treating the genetic disease.
A study by researchers at Ball State found that older adults who performed low-volume, high-intensity resistance training once a week maintained their muscle strength over time. In contrast, those who stopped exercising after three months experienced significant declines in thigh muscle strength and size.
A damaged DNA synthesis enzyme has been shown to cause progressive muscle weakening in a rare eye condition. The researchers found that the faulty enzyme makes errors ten-fold more frequently than healthy individuals, leading to accumulation of mistakes and muscle degeneration.
Researchers propose a new test for diagnosing malignant hyperthermia by measuring carbon dioxide pressure after caffeine injection, showing increased CO2 levels in susceptible individuals. Further testing is needed to define sensitivity and specificity of the test before it can be used for diagnosis.
A new study is investigating the use of anabolic drug therapy to stimulate muscle growth and improve strength in women with emphysema and chronic bronchitis. The research, led by Dr. Richard Casaburi, aims to develop practical methods to reverse muscle dysfunction and improve quality of life.
Researchers found that fibromyalgia patients exhibit a blunted response to exercise-induced sympathetic nervous activity, indicating normal muscle physiology. The study also revealed no increased pain or fatigue in the post-exercise period, challenging previous assumptions about the role of physical effort in exacerbating symptoms.
Research reveals women fatigue less than men under aerobic conditions, but equally when deprived of oxygen. Efficient utilization of aerobic pathways results in reduced by-product production, leading to decreased muscle fatigue. Further study is needed to explain the mechanism behind this difference.
Researchers at the University of California, San Diego, have discovered an enzyme that can halt muscle wasting in mice with Duchenne muscular dystrophy. The study found that adding supplemental amounts of CT GalNAc transferase to skeletal muscles inhibited muscle destruction.
Researchers discovered a protein enzyme called calmodulin-dependent protein kinase (CaMK) that controls mitochondrial production in muscle tissue, leading to improved metabolic properties. This finding has the potential to develop new drugs that mimic the effects of regular exercise for individuals unable to exercise.
Researchers found that a calcium-signaling protein transforms sedentary, easily fatigued muscle fibers into energy-producing, fatigue-resistant type I muscle fibers. This discovery could lead to novel measures to stimulate muscles in patients with chronic diseases or individuals confined to bed rest.
Researchers discovered a gene, atrogin-1, that plays a critical role in muscle atrophy. This protein triggers excessive protein breakdown, leading to muscle loss in various conditions, including space-related muscle wasting.
Researchers found high levels of prions in skeletal muscle of mice, which may lead to transmission in cattle. The team suggests investigating the distribution of prions in the muscles of animals with prion diseases to improve diagnostic tools and disease understanding.
A study published in the Journal of Applied Physiology found that ultra-long-distance runners experience a decline in maximal voluntary force capacity due to central fatigue, but also exhibit strengthened twitch mechanical responses and unaltered M-wave characteristics.
A study of 641 older women with hypertension found that ACE inhibitor users had slower declines in walking speed and muscle strength. The results suggest that these drugs could be used to delay disability in older adults, potentially improving their quality of life.
Researchers found that continuous ACE inhibitor users had a lower average decline in muscle strength and walking speed compared to intermittent users of other antihypertensive drugs. The study suggests that ACE inhibitors could be used to slow physical decline in elderly people without congestive heart failure.
A new study found that sustained caffeine intake counteracts the benefits of creatine supplementation, reducing muscle relaxation time and fatigue. This means that consuming high amounts of caffeine over a short period can negate the effects of creatine on exercise performance.
Scientists discovered that mice without the myostatin protein gain less fat as they age, even though they eat the same amount of food. This could lead to a new approach for treating type 2 diabetes by increasing muscle mass, which may improve insulin sensitivity.
Researchers at Stanford University used biomechanics to estimate T. rex's running speed, concluding it was unlikely to reach high speeds. The team found that large animals face limitations when trying to support their weight with muscle, making fast running impossible.
Researchers found that nicotine withdrawal causes inflammation and similar biochemical responses as acute or chronic illnesses, potentially leading to depression, fatigue, muscle aches, and appetite changes. Anti-inflammatory treatments may alleviate these symptoms, increasing the likelihood of successful quitting.
A new study found that rural older women with urinary incontinence can significantly improve their symptoms through behavioral management interventions, which reduced severity by 61%. The interventions involved goal-setting, bladder training, and pelvic muscle exercises with biofeedback.
A recent study reveals a critical link between obesity and type 2 diabetes through the AMPK pathway and leptin hormone. Researchers found that AMPK activation, triggered by leptin, inhibits an enzyme involved in fat metabolism, increasing fat burning.
Researchers have found that immunoglobulin therapy significantly reduces symptoms of Stiff Person Syndrome (SPS), including stiffness and spasm, and improves mobility. The study showed a statistically significant decrease in symptoms for patients treated with IVIg, with 11 out of 14 patients becoming less stiff and more mobile.
Researchers found that people with back injuries use many unnecessary muscles to compensate for hurt areas, increasing twisting and compressive forces on the spine. A new rehabilitation strategy that emphasizes learning to use back muscles naturally could reduce the likelihood of repeat injuries.
Researchers at Saint Louis University School of Medicine found that small doses of botulinum toxin Type A effectively relaxed muscles involved in triggering tension headaches, resulting in reduced frequency and intensity for most patients. The injections were also easier to control symptoms.
Researchers found that certain fish muscles specialized for fast mating calls are now mutually exclusive with other functions like swimming. The study, on toadfish Opsanus tau, reveals the limitations of biological systems when optimized for one function.
A series of studies suggests honey is a viable carbohydrate option for endurance athletes due to its low glycemic index and positive metabolic response. Honey has been shown to improve power and speed in exercise, making it an attractive natural energy boost.
Francisco Valero-Cuevas is awarded a research grant to study the biomechanics of the human thumb, aiming to improve surgical procedures for hand injuries. He will use cadaver hands and a dynamometer to measure the force of the thumb in various directions.
A Mayo Clinic study found that patients with obstructive sleep apnea syndrome experienced a 24% rate of adverse postoperative outcomes compared to 9% without the condition. The study also revealed longer hospital stays and increased severity of upper airway obstructions in these patients.