Spinal Cord
Articles tagged with Spinal Cord
Rare extraluminal esophageal cancer invades spine despite normal endoscopy
A USC team is targeting the spinal cord to solve paralysis’ most overlooked problem
A USC team has created a neuroprosthetic device that can restore coordinated bladder control in small animal models, proof of concept for a future treatment that could transform lives after spinal cord injuries. The device targets the dorsolateral funiculus region of the spinal cord to mimic the natural signals that trigger the need to...
UC San Diego Health performs first west coast AI robotic spine surgery
The new robotic system combines artificial intelligence, data-driven alignment planning, patient-specific implants, navigation, and robotic screw delivery to enhance precision and coordination. This technology streamlines operating room workflows, reducing procedure time and supporting recovery for patients undergoing spine fusions.
Overlooked brainstem pathway controls human hands
A new study identifies a previously unknown brainstem pathway controlling hand and arm movements, revealing a multi-stage pathway integrating signals from the cortex, brainstem, and spinal networks. This finding may lead to new therapies for stroke rehabilitation, providing additional targets for neuromodulation treatments.
Paralysis treatment heals lab-grown human spinal cord organoids
Researchers developed an advanced organoid model for human spinal cord injury and tested a promising regenerative therapy. The treatment triggered neurite growth and reduced scarring in injured organoids, offering validation for its potential to work in humans.
New study: Immune cells linked to Epstein-Barr virus may play a role in MS
Researchers found that certain types of CD8+ killer T cells are more abundant in people with MS and target the EBV virus, indicating the virus may trigger an immune response leading to progressive neurological damage. The study suggests that interfering with EBV could have a significant impact on other autoimmune diseases.
Pusan National University researchers develop light-activated tissue adhesive patch for rapid, watertight neurosurgical sealing
Researchers have developed a breakthrough light-responsive Janus dural patch using photocurable hyaluronic acid, providing strong wet adhesion and preventing unwanted tissue adhesion. The patch seals wounds within five seconds with minimal swelling and high biocompatibility.
SPINECRAFT: a platform aiming to transform the study of spinal cord biology
The SPINECRAFT project aims to create a cutting-edge, 4D human spinal cord construct that mirrors the architecture and functionality of the real spinal cord. This platform will enable detailed studies of spinal cord biology and integrate patient-derived cells to recreate disease-specific environments.
Do hormones explain why women experience more gut pain?
Estrogen activates previously unknown pathways in the colon, triggering pain and increasing sensitivity to certain foods. This explains why women are more likely to suffer from IBS and provides potential new ways to treat the condition.
How do spinal cord injuries heal?
Researchers at Cedars-Sinai Medical Center have identified a mechanism that could help treat patients with spinal cord injuries, stroke, and neurological conditions. Astrocytes, a type of cell in the central nervous system, play a critical role in responding to damage and disease, sending signals to immune cells to clean up debris resu...
How multiple sclerosis harms a brain long before symptoms appear
Scientists analyzed thousands of proteins in blood samples to understand when multiple sclerosis attacks the myelin sheath and nerve fibers. Researchers identified a protein called IL-3, which plays a key role in this early phase of damage.
Researchers find potential link between chronic pain, immune condition
A study led by Julie Pilitsis, MD, PhD, found a possible connection between chronic pain and eosinophilia, a white blood cell condition, in patients undergoing spinal cord stimulation or implanted pain medicine pumps. The study suggests that eosinophilia may be an immune biomarker for chronic pain.
More than a reflex: How the spine shapes sex
The study found that a specific spinal circuit is involved in both ejaculation and arousal, and integrates sensory inputs to adjust its output based on the animal's internal state. The researchers also discovered that Gal⁺ neurons receive sensory input from the penis and can trigger ejaculation, but their effects are suppressed by brai...
‘Rhythm beats volume’: How the brain keeps the world looking familiar
Researchers used ultraflexible probes to track neurons in the visual cortex of mice for 15 consecutive days, revealing that millisecond rhythms explain how the brain maintains a stable picture of the world. The findings provide new insights for brain-computer interfaces, sensory prostheses and therapies for neurological disease.
Researchers develop novel treatment for central nervous system injury
A new exosome-based therapeutic agent has been developed to treat traumatic CNS injuries, alleviating neuronal apoptosis and restoring glial homeostasis. The treatment, SeNExo, promotes neuronal repair and reduces oxidative damage, showing potent therapeutic benefits in mouse models.
New discovery reveals the spinal cord’s role in bladder control
A USC research team has made a groundbreaking discovery about the human spinal cord's role in bladder control. The study used functional ultrasound imaging to observe real-time changes in blood flow dynamics during bladder filling and emptying, revealing areas where activity is correlated with bladder pressure.
RCSI researchers develop 3D printed implant to help repair spinal cord injuries
Researchers at RCSI University of Medicine and Health Sciences have developed a 3-D printed implant that delivers electrical stimulation to injured areas of the spinal cord, enhancing nerve cell growth. The study has shown promising results in lab experiments and may enable new medical devices for traumatic spinal cord injuries.
Scientists hunt for ligament clues behind the development of curved spines
Researchers assess ligament maturation and movement impact on scoliotic conditions, providing new insights into the structural hallmarks of embryonic spinal ligaments. The study aims to identify potential connections between embryonic movement and spinal deformities in adolescent idiopathic scoliosis.
Cultured nerve tissue can be used in ALS studies
Researchers at Uppsala University have created a model of human nerve tissue using 3D printing, enabling the testing of new drug treatments in a lab environment. This innovation allows for more precise medicine and could potentially lead to improved treatment options for ALS patients.
Focused ultrasound halts growth of debilitating brain lesions
A new technique using focused sound waves and microbubbles has shown great promise in treating debilitating brain lesions called cerebral cavernous malformations. The approach has halted the growth of lesions almost entirely, offering a potential paradigm shift in treatment.
Kosair for Kids and UofL announce expansion of facility for children recovering from spinal cord injury
The Kosair for Kids Center for Pediatric NeuroRecovery is expanding its facilities to increase treatment capacity by 50%, allowing up to 24 children per day to receive life-changing therapies. The new 12,500-square-foot space will also enhance research collaboration and improve patient care.
Building ‘cellular bridges’ for spinal cord repair after injury
Researchers introduced a recombinant protein to pericytes, which change shape and create cellular bridges that support axon regeneration. In mouse experiments, the treatment promoted robust axon regenerative growth and restored leg function.
Paralyzed Veterans of America grant funds University of Cincinnati research with end users in mind
University of Cincinnati researchers, in collaboration with end users, develop a user-centered, easy-to-use assistive device to help restore hand grasping motions. The team aims to combine an exoskeleton device with functional electrical stimulation (FES) technology to create a hybrid system.
Suspected fibrocartilaginous embolus in Asian small-clawed otter (Aonyx cinereus)
An 11-year-old Asian small-clawed otter developed left-sided paralysis after a fall, but improved with treatment for a suspected fibrocartilaginous embolus. Follow-up MRI showed a diminished lesion one year later.
Estrogen and progesterone stimulate the body to make opioids
Researchers discovered a mechanism that harnesses immune cells to produce opioids, potentially alleviating chronic pain. Estrogen and progesterone drive this process, which could lead to more effective treatments for women experiencing pain after menopause.
Robotics and spinal stimulation restore movement in paralysis
A team developed a system integrating implanted spinal cord neuroprosthesis with rehabilitation robotics, delivering well-timed electrical pulses to stimulate muscles. The technology enhances immediate mobility and fosters long-term recovery, presenting a more effective rehabilitation approach than robotics alone.
Researchers develop conductive gel to improve study of spinal cord injuries
Binghamton University researchers have created a hydrogel electrode that includes conductive carbon nanotubes to monitor nerve activity in spinal cord neurons and leg muscles in mice. The technology solves the problem of rigid materials causing damage during movement, allowing for long-term functionality and single-cell signal detection.
New PET tracer reveals potential for recovery in spinal cord injuries
A new PET tracer has been developed to visualize intact nerve connections in the spinal cord, which may indicate a better chance of recovery. This breakthrough has the potential to help diagnose injuries more precisely, monitor recovery, and evaluate the effectiveness of new therapies.
University of Cincinnati study to test use of spinal cord stimulation to treat depression
Researchers are testing noninvasive electrical stimulation of the spinal cord to treat major depressive disorder. The trial, funded by the National Institute of Mental Health, aims to confirm whether this method reduces signaling in specific pathways related to depression.
Kessler Foundation in partnership with Overlook Medical Center is first in NJ to implant novel spinal stimulator
The Tim and Caroline Reynolds Center at Kessler Foundation has successfully implanted a spinal cord epidural stimulator in an individual with paralysis. The treatment uses electrical impulses directly into the spinal cord, potentially allowing individuals to regain critical bodily functions such as bladder function and motor control.
Spinal cord stimulation restores neural function, targets key feature of progressive neurodegenerative disease
A new drug-free intervention targets the root cause of progressive loss of neural function in SMA by gradually reawakening functionally silent motor neurons. Early results show improved leg muscle strength and walking in adults with SMA, regardless of symptom severity.
How specific brain regions drive chemotherapy-induced pain response
Scientists at Indian Institute of Science have found how diverse neurons across different brain regions work together to control chronic pain in mice. The lateral parabrachial nucleus (LPBN) plays a key role in driving chemotherapy-induced peripheral neuropathy, allowing mice to cope with or suppress pain.
Study unveils differential lineage plasticity of ependymal cells and astrocytes in spinal cord injury repair
Researchers discovered ependymal cells have limited proliferative capacity after spinal cord injury, whereas astrocytes can transdifferentiate into oligodendrocytes to promote remyelination. Material transplantation enhances astrocyte-mediated repair, offering a promising approach for future SCI therapies.
Biomaterials to regenerate the nervous system: Carl Zeiss Foundation sponsors InteReg project at Mainz University
The InteReg project aims to create interactive biomaterials that instruct cells to regenerate after brain or spinal cord injuries, potentially treating MS and other neurological disorders. The project, funded by the Carl Zeiss Foundation, brings together experts in biology, chemistry, medicine, and polymer research.
Brain scan predicts effectiveness of spinal cord surgery
A 10-minute brain scan can predict the effectiveness of a risky spinal surgery to alleviate intractable pain. The study found that patients who responded better to spinal cord stimulation therapy had weaker connections between certain brain networks.
$1.7 million CDC grant will allow researchers to study spina bifida across the lifespan
The University of Arizona researchers aim to gain a better understanding of factors contributing to the health and quality of life of people living with spina bifida. The project will collect data on patients of all ages, providing insights into gaps in care and unmet needs for individuals with spina bifida across the lifespan.
A matter of time
Researchers at ISTA used miniature 2D organs and rubbery silicone molds to study morphogen signaling dynamics during spinal cord development. The study found that BMP morphogen signaling gradients emerge quickly, then fade away, only to reappear again, shedding light on the complex process of tissue development.
Scientists discover ‘entirely unanticipated’ role of protein netrin1 in spinal cord development
Researchers at UCLA discovered that protein netrin1 limits BMP signaling to specific regions of the spinal cord, crucial for sensory neuron development. This finding reshapes our understanding of complex spinal circuits and could inform future therapeutic strategies for spinal cord repair.
Spinal cord stimulation vs medical management for chronic back and leg pain
A systematic review and network meta-analysis found spinal cord stimulation therapies to be more effective in reducing chronic back and leg pain. These findings suggest spinal cord stimulation as a valuable option for chronic pain management.
Researchers develop minimally invasive neural interface in revolutionary study
Researchers at Rice University developed a minimally invasive neural interface technique called endocisternal interfaces (ECI), allowing for simultaneous access to the brain and spinal cord without skull surgery. The innovative method uses cerebral spinal fluid as a pathway to deliver targeted devices, enabling new possibilities for th...
McMaster University researchers uncover potential treatment for rare genetic disorders
Researchers at McMaster University have identified a potential treatment for Sandhoff and Tay-Sachs diseases, two rare lysosomal storage disorders that cause progressive damage to nerve cells. The FDA-approved drug 4-phenylbutyric acid (4-PBA) showed significant improvements in motor function, lifespan, and healthy motor neurons.
New treatment helps children with rare spinal condition regain ability to walk
A new study demonstrates that Transcutaneous Spinal Cord Stimulation (TSS) and movement training can improve walking ability in children with Acute Flaccid Myelitis (AFM). Three children showed significant improvements in walking distance, posture, speed, and overall function.
Kessler Foundation scientist to explore effects of transcutaneous spinal stimulation's impact on motor recovery in traumatic brain injury
A four-year study funded by a $2.5 million grant will investigate the impact of spinal cord transcutaneous stimulation combined with gait training on motor recovery in individuals with traumatic brain injury. The research aims to improve clinical treatment strategies and decision-making for improved gait and functional recovery.
Article reveals enhanced cardiovascular function with spinal cord transcutaneous stimulation in high-level spinal cord injury
Research reveals that lumbosacral vertebrae region stimulation significantly elevates low blood pressure, unlike cervical or upper thoracic stimulation. This approach offers a non-invasive therapeutic intervention to regulate cardiovascular function in SCI patients.
Evidence review makes the case for further research into Tethered Spinal Cord
A comprehensive evidence review on tethered spinal cord found that while surgery can benefit symptomatic patients, data for asymptomatic patients is lacking. The study also highlights the need for more research into conservative management and potential risks of surgical complications.
Lab-grown spines unlock safer treatment for women with epilepsy
Researchers have developed a lab-grown spine model that can test the effects of valproic acid on fetal development. The study found that co-treatment with Rapamycin can prevent the negative effects of valproic acid, enabling women to take life-saving medication while having healthy children.
How are stretch reflexes modulated during voluntary movement?
A new study proposes a theoretically new mechanism to modulate spinal reflexes at the same spinal cord level as stretch reflexes during voluntary movements. The research, led by Biomedical engineering doctoral student Grace Niyo, suggests that a simple spinal circuit can correct self-perturbations from stretch reflexes to produce smoot...
Research points a way to modulate scarring in spinal cord injury
Researchers at UCSF have identified a molecular pathway that controls the formation of scar tissue in spinal cord injuries. By activating this pathway, they were able to reduce scarring and promote healing in mice with spinal cord injuries.
Mechanisms of how morphine relieves pain mapped out
A study at Karolinska Institutet reveals that morphine activates a 'morphine ensemble' of neurons in the brain, leading to pain relief. This understanding may help develop new strategies to treat pain without triggering addiction and overdose.
Imaging technique uncovers protein abnormality in motor neurone disease
Researchers have identified a metal deficiency in SOD1 protein associated with motor neurone disease using native ambient mass spectrometry imaging. This breakthrough could lead to new insights and treatments for the disease, which affects around 5,000 people in the UK.
WVU scientists taking a close look at what causes immune cells to attack the central nervous system
Researchers study T cells and monocytes interaction in the meninges before they attack the brain and spinal cord, potentially leading to new disease progression targets. The findings could provide a pathway to treating other neurological diseases like Alzheimer's and Parkinson's.
Rice neuroscientists to build state-of-the-art neural recording system
Chong Xie and his team at Rice University have won a $2.9 million grant from the National Institutes of Health to develop an implantable neural electrode system for high-resolution, long-term neural recording and stimulation. The project aims to improve the resolution of existing devices by increasing the density of neurons sampled.
New ways to study spinal cord malformations in embryos
Researchers created tiny force sensors directly in chicken embryos to study spinal cord malformations. The study aims to prevent congenital malformations by identifying new preventative and therapeutic strategies. Quantifying mechanical forces during embryonic development promises a step change in understanding development.
Rice engineers’ probe could help advance treatment for spinal cord disease, injury
Researchers at Rice University have developed a nanosized sensor that records the electrical activity of spinal neurons in action. The sensor, called spinalNET, can track individual neurons over multiple days, providing valuable insights into the mechanisms controlling movement and sensation in the spinal cord.
ASTRO clinical guideline on radiation therapy for bone metastases emphasizes patient-centered care
The updated clinical guideline recommends multiple dose-fractionation schemes to relieve pain and symptoms of bone and spine lesions. Advanced radiation techniques like intensity-modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT) are now routine clinical care for many patients.
Sweet move: a modified sugar enhances antisense oligonucleotide safety and efficacy
Researchers developed a modified sugar that increases the effectiveness and safety of antisense oligonucleotides, a treatment strategy for central nervous system disease. The modification, called BNAP-AEO, decreases toxic side effects while improving gene silencing in brain cancer cells and mice.
Illuminating neuro-vascular dynamics throughout the body: 3D-printed implants and bioluminescence duet shed light on brain–spinal interactions
A team of visionaries at the Carney Institute developed 3D-printed brain and spinal cord implants, revolutionizing surgical implantations and optical access. Bioluminescence imaging overcomes limitations of traditional fluorescent microscopy, providing unprecedented observation of neural and vascular activity.
‘Wraparound’ implants represent new approach to treating spinal cord injuries
Researchers at the University of Cambridge developed flexible electronic devices that wrap around the spinal cord, recording nerve signals and stimulating limb movement. The devices could lead to treatments for spinal injuries without brain surgery, improving safety for patients.
Robotic nerve ‘cuffs’ could help treat a range of neurological conditions
Researchers developed tiny, flexible devices that can wrap around individual nerve fibers without damaging them. The robotic nerve cuffs are sensitive enough to grasp delicate nerves and only require tiny voltages to change shape.