Articles tagged with Spleen
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Researchers identified the spleen as a key control center for transplant tolerance, triggering donor-specific regulatory T cells to calm the immune response. This targeted approach induces controlled, donor-specific state in T cells, preserving body's ability to fight infections while supporting long-term graft acceptance.
The USPSTF recommends early, universal screening for syphilis infection during pregnancy to prevent congenital syphilis. Untreated syphilis can cause premature birth, low birth weight, and stillbirth in the fetus.
Researchers at TUM developed an AI-powered algorithm to predict kidney damage in prostate cancer patients undergoing lutetium-177 PSMA therapy. Early detection could enable personalized treatment adjustments to prevent organ damage.
Researchers have identified the spleen as a critical organ in cryptic malaria infections, where over 95% of Plasmodium vivax biomass is stored. Extracellular vesicles facilitate the parasite's adherence to spleen cells, enabling its survival and evasion of immune responses.
Researchers at MMRI have developed a novel approach to minimize cardiac damage after a heart attack by targeting the spleen with histone deacetylase inhibitors. This targeting strategy results in a significant decrease in cardiac scar size and preservation of heart function, even after just one dose.
Researchers discovered Leishmania parasites in blood-related stem cells of chronically infected mice, challenging the textbook understanding of the disease. The finding may lead to new treatment options and improve our understanding of why some people develop visceral leishmaniasis despite having immune disorders.
A new AI tool utilizing deep-learning algorithms and volumetric thresholds accurately detected splenomegaly in patients undergoing CT scans. The study analyzed a large sample of 8,901 patients, revealing that splenic volume is strongly associated with weight.
Researchers found that lymphoid depletion lesions in the spleen of SARS-CoV2-infected mice may trigger novel therapies to restore defective antigen-presenting cell functions in humans. The severity of COVID-19 varies significantly, with dysregulated immune responses linked to poor outcomes.
Scientists discovered that inhibiting microRNA-141-3p can reduce chronic inflammation, muscle loss, and bone degradation in aged mice. By blocking this tiny RNA, researchers found improvements in the spleen's immune response, lower levels of pro-inflammatory proteins, and a more youthful profile in bones and muscles.
A recent study led by Children's Hospital of Philadelphia identifies two different regulatory T cell populations, one related to autoimmunity and the other to protective immunity. The findings could pave the way for new treatments that target the immune system selectively.
Researchers report an updated analysis from a phase I study of mivavotinib, a spleen tyrosine kinase inhibitor, in patients with relapsed/refractory B-cell lymphoma. The study showed a 45% overall response rate and median duration of response of 28.1 months in the overall cohort.
Researchers developed a microfluidic device to model the spleen's filtration function in patients with sickle cell disease. The study found that low oxygen levels can cause the spleen's filters to become clogged, while boosting oxygen levels can unclog them, potentially explaining how blood transfusions help patients.
A new risk assessment method combines functional magnetic resonance imaging (fMRI) with splenic diameter to predict complications in patients with chronic liver disease. The study found that patients with low FLIS scores and large spleens had a higher risk of liver-associated complications.
Naked mole-rats of higher social rank have a larger spleen, which may enable them to fight infections better and deal with inflammation more easily. The researchers also suspect that the spleen influences an animal's longevity, as successful naked mole-rats live longer.
A study of 74 healthy individuals found correlations between spleen volume and gender, age, and certain blood parameters such as HGB, HCT, RBC, ALT, but not others like LYM%, PLT. Spleen volume was estimated using the Cavalieri principle and stereological method.
A UCLA-led team has improved a method to kill HIV-infected cells, using natural killer cells to target and eliminate them. The approach could lead to reducing or eliminating the virus from infected individuals who rely on medication.
Researchers found a novel therapy called AVID200 safe and well-tolerated, with modest improvements in symptom burden, anemia, and spleen enlargement. The therapy needs to be combined with other drugs to optimize impact in patients.
Researchers developed a graphene-based electrode, the sutrode, to modulate spleen function and immune response in diseases like rheumatoid arthritis and sepsis. The device can control different terminal nerves, increasing precision in organ function regulation.
CD8+ T cell priming in the spleen generates long-lived, stem-like memory T cells with enhanced ability to differentiate into T effector cells. Spleen-primed T cells have superior capacity to respond to rechallenge infection and expand into infection-fighting T effector cells.
A new preclinical study validates the spleen's role in cardiac healing and suggests targeting S1P as a potential treatment for heart failure. The study discovered interactions between S1P and the heart during transition from acute to chronic heart failure.
A study published in PLOS Medicine reveals that malaria parasites survive and replicate within the spleen of asymptomatic individuals infected with Plasmodium vivax. The research found a substantial biomass of intact asexual-stage malaria parasites accumulated in the spleen, targeting immature red blood cells for invasion.
A study found that malaria parasite Plasmodium vivax accumulates in the spleen to a greater extent than its relative P. falciparum after infection. Imaging techniques revealed increased glucose metabolism in the spleen of participants infected with P. vivax.
A pilot clinical trial is underway to evaluate the efficacy of ultrasound stimulation in reducing COVID-19-related inflammation. The study, called UNITE Study, will recruit 40 patients with severe symptoms and compare the treatment group's recovery time to a control group receiving standard medical care.
Researchers used bioelectronic stimulation to modulate lymphocyte activation in the spleen, potentially influencing hypertension. The study suggests a non-pharmacological approach to treating high blood pressure.
The study found a connection between dystrophic muscles and the lymphatic system in mice with Duchenne disease. The researchers identified changes in protein expression in the spleen, which suggests that the disease causes secondary effects on the immune response and inflammatory processes.
Researchers found that electroacupuncture can significantly reduce pro-inflammatory molecule levels and increase survival rates in mice with a life-threatening inflammatory condition. The treatment worked by exciting norepinephrine-producing nerves, which activated receptors that suppressed inflammation.
A new vaccine platform technology called Erythrocyte-Driven Immune Targeting (EDIT) successfully slowed the growth of cancerous tumors in mice by delivering antigens to antigen-presenting cells in the spleen. The approach uses red blood cells as delivery vehicles, generating an immune response without the need for adjuvants.
Researchers from Nanjing University and University of Macau successfully transformed a mouse's spleen into a fully functional liver, overcoming key challenges in tissue engineering. The innovative approach could potentially provide a new solution for patients with end-stage organ failures due to limited donor availability.
Extracellular vesicles play a key role in the pathology of malaria vivax by promoting parasite adhesion to human spleen fibroblasts. The study found that EVs induce the expression of ICAM-1 on fibroblast surfaces, serving as an anchor for parasite-infected red blood cell adherence.
Researchers find that repositioning the spleen during surgery can lead to physical changes and altered immune responses, suggesting a key role of mesothelial cells in modulating inflammation. The study suggests that breaking connections between these cells and the spleen may have consequences for immune function.
Research reveals that malaria parasite P. vivax adheres to human spleen cells via variant proteins, allowing it to hide from the immune system and evade elimination. This finding suggests a double role for the spleen in malaria pathology and opens new avenues for vaccine targets and exposure markers.
Researchers found that mice lacking an inflammation resolution sensor developed spontaneous obesity, heart disease, and shortened lifespan, indicating impaired inflammation resolution. This study sheds light on the sensor's integrative role in managing cardiometabolic health and inflammation-resolution processes.
Scientists have discovered that white blood cells enter the spleen primarily via vessels in the red pulp and migrate to other structures. The Clever-1 molecule controls this process, also regulating antibody-producing white blood cell expression.
Researchers have discovered that noninvasive daily ultrasound stimulation of the spleen in mice with inflammatory arthritis results in significantly less joint swelling compared to untreated mice. The study is a first step towards developing new treatment options for rheumatoid arthritis, an autoimmune disease affecting millions of peo...
A novel mechanism discovered by researchers at the University of York and Queen Mary University London reveals that miR-132 controls how immune cells respond to infection. This tiny molecule acts as a 'handbrake' on the immune system, preventing over-reaction and promoting protective immunity.
Researchers found that carprofen pretreatment before experimental heart attack in mice impairs the resolution of acute inflammation after cardiac injury. This leads to a non-resolving inflammation characterized by an amplified CD47 marker on neutrophils, which resists clearance and triggers more inflammatory responses.
Researchers found that doxorubicin targets enzymes controlling immune responses in the spleen and heart, disrupting metabolism and leading to impaired inflammation resolution. The drug also poisons specific immune cells, causing a loss of host defense and promoting chronic non-resolving inflammation.
Researchers discovered that Anaplasma bacteria alter the microbiota of mouse and shrew spleens, changing bacterial compositions. The study highlights wild animals as potential reservoirs for tick-borne diseases with public health importance.
Medical College of Georgia scientists found that drinking baking soda encourages the spleen to promote an anti-inflammatory environment, reducing destructive inflammation in autoimmune diseases. This shift was observed in rats and healthy people, with a reduction in pro-inflammatory cells and an increase in anti-inflammatory macrophages.
A study published in Cell found that the Bajau people of Southeast Asia, who spend their lives at sea, have larger spleens than non-divers due to genetic adaptation. The research suggests that this adaptation is a rare example of natural selection in modern humans and could provide insights into managing acute hypoxia.
The Bajau people's larger spleens enable them to dive longer and deeper by injecting more oxygenated red blood cells into the circulation. Genetic analysis reveals a link between increased thyroid hormone levels and enhanced diving ability in this Southeast Asian group.
A study found that the Bajau people have genetically enlarged spleens, allowing them to free dive for extended periods. The discovery could lead to new insights into Acute Hypoxia and its treatment.
Researchers found that splenic leukocytes play a key role in resolving inflammation after a heart attack, coinciding with cardiac repair. The study highlights the need to investigate macrophage-derived specialized proresolving mediators in heart failure.
Researchers have discovered that neural crest cells colonize the spleen during embryogenesis and persist into adulthood, displaying markers indicating a glial lineage. These cells are arranged anatomically adjacent to blood vessels, pericytes, and nerves, suggesting an astrocyte-like phenotype.
Pacritinib significantly reduces spleen size among people with very low levels of platelets, while a twice-daily dose improves symptoms. The study also showed that pacritinib is effective in treating patients who have previously been treated with ruxolitinib.
A new computer model demonstrates how the tiny slits in the spleen prevent old, diseased or misshapen red blood cells from re-entering the bloodstream. The study provides a better understanding of how the spleen's function affects diseases that impact red blood cell shape and structure.
A new study finds that the spleen filters blood cells by imposing a 'physical fitness test' through its narrow passages, which defines the shape and size of red blood cells. This discovery has implications for understanding diseases affecting blood cell shape, such as malaria, and developing novel drug targets.
Researchers have developed a simple and rapid way to treat an immune-related disorder in mice, which could eventually help multiple sclerosis patients. The approach attaches disease-related protein fragments to spleen cells, preventing brain and spinal cord inflammation.
Scientists at Children's Research Institute discovered a secondary, emergency blood-formation system activated in the spleen during times of hematopoietic stress. Blood-forming stem cells migrate from bone marrow to spleen, where they form new blood cells under normal circumstances.
A new study by USF researchers suggests that transplanted human bone marrow stem cells preferentially migrate to the spleen, reducing systemic inflammation and secondary brain cell death in post-stroke rats. The anti-inflammatory effects of the stem cells promoted reduced lesions caused by acute stroke.
A new study published in Nature Communications reveals that certain antibodies targeting specific proteins on platelets lead to destruction in the liver or spleen. Researchers discovered that drugs like Tamiflu may inhibit liver's immune response, offering a potential new approach for treating the autoimmune disease.
Pacritinib significantly reduced severe spleen enlargement and debilitating side effects in over 20% and 46% of patients, respectively. The therapy also showed promise in treating thrombocytopenia, a life-threatening condition often associated with myelofibrosis.
A phase 3 trial found eliglustat significantly improved spleen volume reduction by 30%, hemoglobin levels, and platelet count in adults with untreated Gaucher disease type 1. The treatment showed no serious adverse events or patient discontinuations.
Researchers found that aged mice developed more severe intestinal permeability and bacterial infections after stroke, leading to higher mortality rates. In contrast, social isolation improved recovery in aged mice by reducing inflammation and enhancing brain function.
A new study published in Immunity reveals that placental growth factor (PlGF) in the spleen activates harmful immune responses leading to high blood pressure. Mice genetically engineered to lack PlGF were protected from hypertension-related damage, suggesting PlGF as a potential therapeutic target.
A new study published in the British journal Proceedings of the Royal Society B suggests that increased genetic diversity can limit the spread and severity of viral infections in livestock and endangered species. Researchers found that viruses replicated more slowly and caused less severe disease when transmitted through genetically di...
Researchers found a link between natural killer cells and hematopoiesis in CMV-infected mice, revealing an antiviral reaction that could lead to new treatments for viral infections. This process involves the elimination of infected cells and mobilization of immune cells to combat the pathogen.
Researchers identified a defective gene responsible for isolated congenital asplenia (ICA), a rare disorder characterized by the absence of the spleen. The RPSA gene mutation affects approximately 50% of patients with ICA, leading to a lack of splenic tissue.
When the malaria parasite infects human red blood cells, it launches a 48-hour remodeling process that enhances cell membrane stiffness through the RESA protein. This increased rigidity impairs microcirculation, especially at fever temperatures.
A new study has identified the Nkx2.5 gene as the first gene linked to congenital asplenia, a rare condition where babies are born without a spleen and are at risk of fatal infections. The discovery raises hopes for genetic prenatal screening to alert parents to potential issues.