Articles tagged with Spleen
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A phase III clinical trial shows that ruxolitinib relieves severe symptoms and extends survival in patients with myelofibrosis. The drug also shrinks swollen spleens, a hallmark of the disease, and improves quality of life for many patients.
A new phase-3 trial confirms that ruxolitinib reduces spleen volume and alleviates symptoms in patients with intermediate or advanced myelofibrosis. The study, led by Stanford Medicine, found significant improvements in patients taking the drug compared to those on placebo.
Researchers discovered neutrophils exist in the spleen without an infection, contributing new knowledge to biology. These cells have an immunoregulating role, interacting with B lymphocytes to produce antibodies.
A study analyzing lung and spleen tissue from patients who died of sepsis revealed biochemical, cellular, and histological findings consistent with immunosuppression. The research found evidence of impaired immunity in patients with sepsis, which could have important therapeutic implications.
A multicenter study found ruxolinitib significantly reduces symptoms of myelofibrosis, including pain and enlarged spleen, compared to placebo. The study also showed ruxolinitib is more effective than best available chemotherapies in reducing symptoms.
Researchers at UTHealth and Athersys found that MultiStem therapy reduced inflammatory damage in the brain and improved motor skills in rats with ischemic stroke. The study suggests potential benefits of stem cell therapy for treating stroke, with implications for improving recovery outcomes.
Researchers found a significant decrease in macrophage activity at spinal cord injury sites in mice without spleens, indicating the spleen's role in promoting inflammation. Understanding how these cells function and manipulating their release could improve treatment options for spinal cord injuries.
A novel JAK inhibitor has shown significant and lasting benefits for patients with myelofibrosis, a debilitating bone marrow disorder. The treatment produces substantial reductions in enlarged spleens, pain, fatigue, and improved quality of life.
A Phase II clinical trial of eliglustat tartrate, an oral therapy, demonstrates significant improvements in spleen volume, hemoglobin level, and platelet count. The treatment also normalizes glucosylceramide plasma levels and improves bone mineral density.
A JAK2 inhibitor has been shown to provide significant and durable relief for patients with myelofibrosis, a rare and debilitating bone marrow disorder. The drug has demonstrated a 33% reduction in spleen volume and improvements in quality of life, exercise capacity, and fatigue.
Researchers at Massachusetts General Hospital discovered an unexpected reservoir of immune cells called monocytes in the spleen, which are essential for recovery of cardiac tissue after a heart attack. The study found that these monocytes released from the spleen directly travel to the injured heart and participate in wound healing.
Researchers identified a new anatomical path through which the brain and spleen communicate, enabling the immune system to respond to disease. The study suggests that stimulating the vagus nerve can suppress inflammation-producing molecules in the spleen, potentially leading to new treatments for sepsis.
Weill Cornell researchers discovered a gene responsible for mutated red blood cells in Cooley's anemia, allowing mice to produce normal red blood cells without splenectomy. The study found that blocking the JAK2 gene reduces spleen size and improves hemoglobin production.
The spleen's unique anatomical and immunological characteristics may explain why isolated splenic metastasis from colorectal carcinoma is rare. Experimental studies have shown that cancer cells injected into the spleen grow more slowly than those in other organs.
Rutgers researchers found that osteopontin-dependent changes in thymus and spleen lead to organ atrophy in mice stressed under simulated weightlessness. This study demonstrates the critical role of OPN in human diseases such as cancer, multiple sclerosis, and autoimmune responses.
Researchers found that tissues taken from pig embryos between 42 days of gestation exhibit optimal growth potential and secrete factor VIII, a blood-clotting protein missing in hemophilic patients. This technique may one day help the body overcome genetic diseases.
Researchers confirm protocol to reverse type 1 diabetes in diabetic mice, with adult precursor cells from the spleen contributing to regeneration of beta cells. The study provides new evidence for a potential source of regenerating islet cells and suggests that older mice may be more responsive to this approach.
A study conducted at the University of California, Davis found that contrast-enhanced sonography accurately depicted 91% of liver, spleen, or renal injuries, outperforming non-contrast enhanced sonography.
Researchers found that new islet cells are host-derived, not from donor spleen cells, and that beta-cell growth was permitted when autoimmunity was suppressed. The study suggests that CFA alone may be effective in treating type 1 diabetes without the need for donor spleen cells.
Researchers found that injections of spleen cells and transplants of islets from healthy mice temporarily cured diabetes in 4 out of 22 mice, but failed to restore insulin-producing beta cells. The procedure's success was confirmed by three independent labs, challenging the previous hypothesis on how it works.
Three research teams successfully replicated a controversial diabetes therapy, curing 32% of treated mice by manipulating the immune system. However, they were unable to regenerate beta cells from spleen-derived stem cells, leaving the source of these cells unknown.
Researchers found that removing the spleen and suppressing related factors can prolong survival in mice with leukemia. The study suggests a potential treatment model for human hematological malignancies, but further research is needed.
The study suggests that the spleen contains a population of primitive stem cells important for healing several types of damage or injury. These cells may produce an even greater variety of tissues than adult stem cells from bone marrow.
Research suggests that more intense therapies lead to better remission rates and longer survival for adults with acute myeloid leukemia (AML) who have normal genetic makeup. Patients with an enlarged spleen are less likely to enter remission, highlighting the need for targeted treatment.
Researchers have discovered that spleen cells can regenerate insulin-secreting islets in mice with Type 1 diabetes, potentially leading to a cure. The study shows that these cells can grow from both the recipient's own cells and donor cells, opening up new approaches to diabetes treatment.
A study by Joanna Fowler and colleagues found significant reductions in MAO B activity in the heart, lungs, kidneys, and spleen of smokers compared to non-smokers, with reductions ranging from 33 to 46%. The findings suggest that smoking impacts peripheral organs and highlight the need for further examination of these consequences.
Researchers performed partial splenectomy on 25 children with congenital forms of anemia caused by abnormal red blood cells. The procedure showed promise in relieving symptoms and improving quality of life, but does not address the cause of these disorders.
B-lymphoproliferative disorders, such as lymphomas, cause almost a quarter of cases of massively enlarged spleens in tropical countries. Malaria is the most common cause, but unexpectedly, B-lymphoproliferative disorders are also prevalent, particularly in women younger than 40 years without raised absolute counts of lymphocytes.
A Johns Hopkins physician cured a 74-year-old woman's long-standing malaria case using a novel test developed by his collaborators. The patient had symptoms for up to 70 years, including severe headaches and cyclical fevers.
A research physician at NIAID successfully treated a 74-year-old woman with the longest known malaria infection on record, using an extremely sensitive genetic test. The patient had been infected for decades and was mistakenly diagnosed with lymphoma earlier in her life.