Groundbreaking research reveals changes in pancreatic beta cells at the onset of Type 1 Diabetes, identifying a novel mechanism for protection and a promising therapeutic target in mice and humans. Boosting levels of METTL3 enzyme may slow disease progression.
A phase 3 clinical trial found that oral empagliflozin provided clinically meaningful and statistically significant improvements in glycemic control in young people with type 2 diabetes. The study demonstrated the safety and efficacy of empagliflozin in this population, while linagliptin did not show significant effects.
Researchers found that exercise induces a cycle of fatigue and recovery in muscles, paralleled by mitochondrial network rebuilding. Long-term training programs improved middle-aged fitness, while AMPK interventions enhanced exercise capacity during aging.
A new study reveals that exercise training has opposite effects on muscle and fat tissues compared to high-fat diet-induced obesity. Exercise is found to down-regulate extracellular matrix-related pathways, while obesity up-regulates them. Conversely, exercise up-regulates circadian rhythm pathways, which are reversed by obesity. This ...
Researchers found that endothelial cells in blood vessels drive the body's metabolism and produce nitrous oxide to regulate brown fat production. This discovery reverses long-held ideas about the relationship between diabetes, fat and cardiovascular disease.
Researchers at Joslin Diabetes Center identified a human gut bacterium that makes a protein mimicking the insulin peptide targeted by the immune system in type 1 diabetes. The presence of this bacterium accelerates the onset of diabetes in a mouse model and is linked to its development in children at genetic risk.
Researchers at Joslin Diabetes Center and Brigham and Women's Hospital found that cold exposure can resolve obesity-induced inflammation while improving insulin sensitivity and glucose tolerance in diet-induced obese mice. Brown adipose tissue is activated to produce anti-inflammatory molecules, including Maresin 2.
Researchers found that grandmaternal exercise improved glucose tolerance and decreased fat mass in adult male and female grand offspring. The study suggests that exercise during pregnancy may have long-lasting effects on metabolic health, potentially reducing the worldwide incidence of obesity and type 2 diabetes.
A new study suggests that glucose-lowering medications can restore aerobic exercise capacity in people with high blood sugar. The research, published in the journal Diabetes, found that combining a medication like canagliflozin with exercise training may improve exercise response in individuals with diabetes.
Researchers have identified pyruvate kinase M2 as a potential therapeutic target for preventing diabetic kidney disease in people with type 1 diabetes. The enzyme's activation may help normalize and maintain kidney function, even after seven months of elevated blood sugar levels.
A study from Joslin Diabetes Center reveals insulin resistance in non-diabetic individuals is caused by complex cell-specific signaling defects. The research also found sex-specific differences in these defects, which could serve as novel targets for therapies.
Researchers identified three proteins - FGF20, ANGPT1, and TNFSF12 - that offer protection against progressive kidney decline in diabetes patients. Elevated levels of these proteins were found to reduce the risk of end-stage renal disease.
Scientists have discovered dramatic differences in gut microbiomes between ancient North American peoples and modern industrialized populations. The analysis of human paleofeces from dry caves reveals novel species of microbes and higher numbers of transposases, which may help microbes adapt to changing environments.
A study published in Nature Metabolism reveals that vascular smooth muscle-derived Trpv1+ progenitors are a source of cold-induced energy-burning brown fat cells. This finding could lead to the development of new therapies targeting obesity and metabolic disorders by increasing overall energy expenditure.
Research at Joslin Diabetes Center found that exercise in pregnancy boosts SOD3, a protein linked to glucose metabolism, and improves metabolic health in offspring. Vitamin D also plays a critical role in this process.
A study found associations between retinal changes and memory problems in older people with type 1 diabetes. Researchers used routine eye scans to detect structural changes in the retina that may be linked to cognitive decline. The findings could lead to better understanding, diagnosis, and treatment of Alzheimer's disease and other co...
A lipid metabolite called 12,13-diHOME is found in human breast milk and appears to be associated with beneficial infant weight gain and body composition. Maternal exercise may boost levels of the metabolite, potentially benefiting offspring growth and development.
Researchers found that intensive glycemic control reduced CAN risk in individuals with no history of cardiovascular disease by 17%, while intensive blood pressure control reduced risks by 22%. Intensive glucose treatment was more effective in individuals without a history of CVD, whereas blood pressure lowering was more effective in ol...
A novel 'disease-in-a-dish' model has been developed to study the basic molecular factors leading to type 2 diabetes. The model, using reprogrammed induced pluripotent stem cells from patients with type 2 diabetes and healthy controls, reveals defects in proteins with unknown roles in metabolism or diabetes.
Scientists at Joslin Diabetes Center have developed a novel cell-based therapy using 'HUMBLE' cells, genetically modified human white fat cells that mimic heat-generating brown fat cells. Transplanted into mice with type 2 diabetes, these cells improved insulin sensitivity and glucose clearance, reducing weight gain and related chronic...
Joslin Diabetes Center researchers discover targeting renalase protein strengthens beta cells against stress and autoimmune attack. An FDA-approved drug, pargyline, is shown to protect human cells, potentially slowing disease progression in a clinical trial.
Scientists at Joslin Diabetes Center discovered that increased blood sugar levels can impair aerobic fitness and muscle adaptation in mice and humans. Despite this, regular aerobic exercise is still recommended for maintaining health, especially when combined with dietary changes.
Research found a significant increase in insulin pump use and a decline in diabetic nephropathy, while pre-pregnancy obesity rose. The percentage of mothers with excess weight gain during pregnancy also increased. Despite this, the prevalence of very large babies born remained the same.
A clinical trial found that reducing uric acid levels with the medication allopurinol did not slow the progression of kidney disease in people with type 1 diabetes. Despite a significant drop in uric acid levels, participants showed no improvement in their kidney function.
Researchers at Joslin Diabetes Center have discovered two subtypes of human white subcutaneous fat cells with distinct patterns of gene expression, which may help control whether cells become mature fat cells. This study highlights the potential of bringing together biology, artificial intelligence, and data analysis to better understa...
Researchers found that even small increases in blood glucose levels can cause significant changes in the behavior of insulin-producing beta cells, making them more vulnerable to autoimmunity and inflammation. This discovery may improve understanding of type 1 and type 2 diabetes and shed light on potential treatments.
Research from Joslin Diabetes Center found that autoantibodies against heart muscle proteins are associated with increased volume of the left ventricle, reduced pumping function, and higher risk of failure. The study suggests a novel process involving the heart linked to poor glycemic control in type 1 diabetes patients.
Researchers from Joslin Diabetes Center have identified a potential early biomarker for non-alcoholic fatty liver disease (NAFLD), which is linked to the regulation of liver fat metabolism and fibrosis. The protein NREP was found to decrease in levels as NAFLD progressed, suggesting its role as an early indicator of the disease.
Researchers discovered a novel pathway that boosts brown fat cell's heat-generating capacity without increasing fat accumulation. This finding suggests that activating this pathway may benefit people with obesity, diabetes, and related metabolic diseases.
A new study from the Joslin Diabetes Center reveals that ultra-wide field (UWF) fluorescein angiography detects over three times more microaneurysms than UWF color imaging, highlighting the need for cautious use of these techniques when evaluating and treating diabetic retinopathy. The research also suggests that AI can automate the gr...
Researchers developed an automated glucagon delivery system to treat post-bariatric hypoglycemia, reducing the risk of unpredictable low blood sugar levels. The closed-loop system, comprising a CGM and glucagon pump, provides patients with a safe and reliable treatment option.
A three-year clinical study found that reducing uric acid levels with the generic drug allopurinol did not slow diabetic kidney disease progression in type 1 diabetes patients. The study's conclusions provided a clear answer to an important scientific question, while suggesting further research may be needed.
A multi-center trial found that the artificial pancreas system improved users' blood glucose control throughout the day and overnight, reducing hyperglycemia and hypoglycemia events. The study showed significant benefits of the new system over existing treatments, with no severe hypoglycemia events occurring in either group.
A comprehensive review of connected diabetes care products found the potential for improved outcomes and reduced healthcare burdens. However, awareness and use of these programs remain low among healthcare professionals and patients.
Researchers found that high fructose diets specifically inhibit the liver's ability to metabolize fat, while glucose improves fat-burning function. High fructose diets damage liver mitochondria, leading to an increase in fatty liver disease risk and metabolic syndrome.
Researchers at Joslin Diabetes Center have made a breakthrough in identifying diseased beta cells in type 2 diabetes by uncovering the role of m6A mRNA methylation. The discovery has significant research and therapeutic implications, offering new insights into how the disease progresses.
Researchers at Joslin Diabetes Center have identified a protein found in the eye that protects against and potentially treats diabetic eye disease. Retinol Binding Protein 3 (RBP3) prevents the development of diabetic retinopathy, and introducing it early can reverse the effects of the complication in rodent models.
A study from Joslin Diabetes Center found that a minority of patients treated for decades with type 1 diabetes may have monogenic diabetes, which can be treated with oral drugs. The research suggests screening for genetic mutations in young people diagnosed with type 1 diabetes to identify potential treatment options.
Joslin researchers will contribute to mapping specific tissues in the healthy human body using chemical imaging and single-cell sequencing. The goal is to understand how disease affects cells and develop new treatments for metabolic diseases.
Researchers found Veillonella bacteria in elite athletes' microbiomes, which converts lactic acid into propionate to improve exercise capacity. Supplementing with Veillonella may boost sedentary individuals' exercise abilities and protect against chronic diseases.
Researchers from Joslin Diabetes Center have identified a genetic factor linked to the development of diabetic peripheral neuropathy. The study suggests that people carrying a specific variant in a sodium channel may be protected from the complication, providing a potential target for pharmacological therapy.
A study from Joslin Diabetes Center found that removing senescent beta-cells can recover their function and improve glucose metabolism in mice with insulin resistance. The researchers hope to develop a potential treatment using senolytics, which target aging cells contributing to disease dysfunction.
Researchers have identified protective factors that play a strong role in preventing diabetic kidney disease. The study found that certain enzymes, including PKM2, are present in people with good kidney function and may be used as biomarkers and targets for personalized clinical intervention.
Researchers at Joslin Diabetes Center found that increasing beta cell growth before signs of type 1 diabetes can halt the disease. In animal models, continuous generation of new insulin-producing beta-cells protected against autoimmune reactions.
A new study found that closely monitoring patients with diabetic macular edema who have good vision can be an acceptable initial strategy, with prompt treatment starting if vision worsens. The two-year study showed similar visual acuity outcomes among groups receiving aflibercept injections, laser photocoagulation, or observation.
Scientists at Joslin Diabetes Center discovered a group of 17 inflammatory proteins associated with diabetic kidney disease progression. These Kidney Risk Inflammatory Signature (KRIS) proteins, including TNF receptors, are indicative of systemic inflammation and may serve as drug targets to prevent and treat end-stage renal disease.
New research finds differences in breast milk composition between normal weight and overweight mothers, with specific metabolites identified as risk factors for childhood obesity. The study suggests that a tailored mix of nutrients in breast milk could be therapeutic targets to protect children from obesity.
Researchers at Joslin Diabetes Center have discovered a mechanism linking caloric restriction to immune system regulation, leading to increased longevity. Caloric restriction reduces innate immunity by decreasing p38 activity, triggering a chain reaction effect.
Researchers found that SGLT-2 inhibitors induce a fasting state by causing the body to lose glucose, triggering weight loss and reduced fatty liver disease. The medication also activates beneficial metabolic pathways similar to those seen during fasting or calorie restriction.
Researchers at Joslin Diabetes Center found impaired insulin signaling in the brain negatively affects cognition, mood, and metabolism in Alzheimer's disease. The study used a novel mouse model to demonstrate the impact of disrupting insulin and IGF1 receptors on learning, memory, and mood.