A new study by Joslin researchers reveals that alterations in the DNA damage checkpoint pathway machinery and higher levels of miR200 are associated with severe complications in type 1 diabetes. This finding holds promise for early detection and treatment of complications through therapeutic interventions targeting miR200.
Researchers created human cell lines to study gene expression in precursor cells, enabling the prediction of UCP1 expression and potential transformation of white fat cells into brown fat cells. This breakthrough offers a promising tool for developing personalized obesity treatments.
A new class of treatments may be effective in preserving vision for people with diabetic macular edema (DME). Researchers found that high levels of plasma kallikrein and associated molecules contribute to DME, and targeting this pathway may lead to new therapies.
Researchers have identified the Clec16a gene as a regulator of T cell education, which is central to the development of autoimmunity. The study shows that turning off the gene protects mice from developing diabetes, suggesting its role in preventing autoimmune diseases.
A clinical trial by Joslin Diabetes Center found that adjustable gastric band surgery and intensive group-based medical diabetes and weight management program achieved similar improvements in controlling blood sugar levels after one year. Participants experienced significant weight loss and better quality of life with both approaches.
Joslin researchers find insulin resistance in brain cells may lead to behavioral disorders like anxiety and depression, with potential therapeutic implications for treating these conditions. The study suggests that correcting the metabolic changes could help alleviate symptoms.
A clinical trial found that all three anti-VEGF drugs were effective in improving vision and preventing vision loss in patients with diabetic macular edema. Aflibercept showed more significant visual gains in patients with worse vision at the start of the trial, providing robust data for clinicians to guide treatment decisions.
Researchers have developed a novel imaging technique using ferumoxytol and MRI to visualize pancreatic inflammation in patients with newly diagnosed type 1 diabetes. The study found clear evidence of ongoing inflammation in the pancreas, which could help predict disease progression and identify potential therapeutic targets.
Researchers at Joslin Diabetes Center used C. elegans to identify a new path that could lead to drugs to slow aging and chronic diseases, and might even impact cosmetics. Production of collagen and other ECM components plays a key role in longevity, suggesting agents promoting tissue remodeling might slow aging in humans.
Researchers found that DNA Methyltransferase 3b enzyme prevents Pax3 gene from turning on, leading to neural tube defects. Dr. Loeken's discovery sheds light on a biochemical pathway and may lead to better stem cell therapy.
A new study by Joslin Diabetes Center shows that Asian Americans who followed a traditional high-fiber, low-fat diet for 16 weeks lowered their insulin resistance and improved their LDL cholesterol levels. In contrast, those on a typical western diet experienced greater increases in insulin resistance.
Joslin researchers found that microRNAs play a major role in fat cell development and whole body metabolism. They also discovered that low levels of Dicer expression in fat tissue may contribute to the development of HIV-related lipodystrophy, a complication limiting therapy in some patients.
A long-term observational study found that people with type 1 diabetes who have developed kidney complications can slow the progression of their complications by improving control of their glycemic levels over the long term. Those who lowered their HbA1C levels demonstrated a significantly lower risk of end-stage renal disease after a ...
Joslin Medalists with type 1 diabetes for 50+ years have higher levels of endothelial progenitor cells (EPCs) and circulating progenitor cells (CPCs), associated with lower cardiovascular and kidney disease. These findings suggest that measuring CPC levels may help identify people at risk for complications.
A new study by Joslin Diabetes Center identified three core factors and thirteen strategies to increase buy-in from practice teams in transitioning to Patient-Centered Medical Homes (PCMHs). The findings emphasize the importance of effective communication, resource utilization, team environment, defined work roles, and targeted resources.
A study by Joslin Diabetes Center found that care managers in Patient-Centered Medical Homes (PCMHs) increased improvements in diabetes patients. Care managers who were embedded in the care team and used electronic medical records showed better patient outcomes.
A recent study by Joslin Diabetes Center researchers has identified key metabolic factors that may contribute to diabetic kidney failure. The study found increased levels of uremic solutes and myo-inositol in patients who developed end-stage renal disease, suggesting a potential link between tubular injury and kidney failure.
Joslin researchers have discovered that the hormone FGF21 stimulates the browning of white fat, leading to improved glucose metabolism and calorie burning. This finding has implications for the development of new medications for type 2 diabetes and obesity.
Joslin researchers found T cells, not B cells, contribute to beta cell proliferation in type 1 diabetes. Immune cells secrete inflammatory cytokines and chemokines that enhance beta cell growth.
The Joslin Diabetes Center will conduct a clinical trial to evaluate the benefits of allopurinol in reducing kidney function loss among people with type 1 diabetes. The five-year trial aims to determine if high serum uric acid levels are the cause of diabetic kidney disease.
A genetic variant in the GLUL gene is linked to an increased risk of CHD in type 2 diabetics, potentially leading to new treatments. The finding may also provide insights into mechanisms underlying CHD risk and enable development of cardioprotective drugs
Researchers found that excessive PKC beta in endothelial cells exacerbates atherosclerosis, a condition where blood vessel walls thicken due to fatty deposits. This inhibition leads to decreased nitric oxide production, increasing cardiovascular disease risk.
Joslin scientists found that salsalate effectively lowers blood glucose and improves glycemic control in type 2 diabetes. The study involved 286 participants with inadequately controlled diabetes, who showed significant reductions in hemoglobin A1c levels and fasting glucose concentration.
Researchers found that human brown adipose tissue is abundant in deep neck regions and can be grown into functional cells. These findings open possibilities for studying BAT's role in metabolism and developing treatments to combat obesity.
A new study by Joslin researchers found that dietary fat can impact glucose levels and insulin dosing for people with type 1 diabetes. The study's findings have significant implications for managing the condition, highlighting the need to consider both carbohydrates and fats in insulin calculations.
Researchers found a cross-talk between two types of brown fat that helps maintain body temperature and protect against diet-induced obesity. The study's findings may lead to new therapies that increase BAT formation to treat obesity.
Researchers at Joslin Diabetes Center have successfully generated human induced pluripotent stem cells (hiPSCs) from patients with maturity onset diabetes of the young (MODY), a rare form of diabetes. The hiPSCs offer a powerful tool for studying the genetic mechanisms underlying MODY and testing potential treatments.
Researchers at Joslin Diabetes Center have identified TRIP-Br2 as a major regulator of energy metabolism and fat storage. In mice fed high-fat diets, TRIP-Br2 levels were elevated in visceral fat, leading to increased fat accumulation and decreased energy expenditure.
Joslin scientists have discovered that brown adipose tissue has beneficial effects on glucose tolerance, body weight, and metabolism. The study showed improved insulin sensitivity, lower body weights, and decreased fat mass in mice with BAT transplantation.
Researchers have identified a genetic variant associated with an increased risk of autoimmune diseases like type 1 diabetes. In a mouse model study, turning off the PTPN22 gene reduced the risk of autoimmune diabetes and increased regulatory T cells.
Researchers at Joslin Diabetes Center have identified a key molecular process in fat cells that affects aging and stress resistance. The study found that reducing microRNA processing in fat tissue promotes longevity and stress resistance, providing potential new avenues for treatment.
Scientists at Joslin Diabetes Center have identified the biological mechanisms by which glucagon-like peptide-1 (GLP-1) protects against kidney disease, including its ability to inhibit the signaling pathway of angiotensin II. The study suggests that effective therapeutic agents could be developed to enhance GLP-1R on the endothelium, ...
Scientists at Joslin Diabetes Center have identified a new cause of cardiac damage after heart attacks in people with type 1 diabetes. A runaway autoimmune response triggered by alpha-myosin leads to chronic inflammation, cardiomyopathy, and heart failure. The study offers promising targets for future interventions to protect the heart.
Researchers at Joslin Diabetes Center found that cold exposure stimulates brown fat energy expenditure with fewer other systemic effects, suggesting a promising approach to treating obesity. The study disproves the use of ephedrine as a weight loss drug, which has side effects.
Researchers have identified significant differences in how diabetes affects Asian populations, including unique markers for type 1 diabetes diagnosis. The study highlights the need for culturally sensitive care, tailored treatment guidelines, and expanded education programs.
Researchers at Joslin Diabetes Center have identified a critical mechanism involving the TOR protein kinase and master gene regulator proteins SKN-1 and DAF-16, which can increase stress resistance and longevity in various species.
A new Joslin study contradicts long-held assumptions about the relationship between hyperinsulinemia and atherosclerosis. Hyperinsulinemia is associated with atherosclerosis in humans due to insulin resistance, but research suggests that excess insulin alone does not cause atherosclerosis.
Scientists at Joslin Diabetes Center identified two novel markers that can predict renal failure in patients with Type 1 and Type 2 diabetes, ten years in advance. High concentrations of TNFR1 and TNFR2 accurately predict the risk of renal function loss.
A study published in Cell Stem Cell found that defects in myelin sheath regeneration surrounding nerves can be at least partially corrected following exposure to young immune cells. This suggests that regenerative therapies may work throughout the duration of MS, regardless of age. The findings provide new hope for treating this disease.
Researchers at Joslin Diabetes Center have identified a critical diagnostic marker that differentiates type 1 from type 2 diabetes in young Asian Americans, highlighting the importance of insulin resistance. The study also found physical differences in Asian patients with diabetes that should inform treatment recommendations.
Researchers at Joslin Diabetes Center have identified two major molecular signaling pathways that regulate cell growth and division, hallmarks of cancer biology. The study provides new candidate targets for treating soft-tissue sarcomas, which can be controlled but not cured by current treatments.
A $3.9 million grant will enable research to identify protective factors that prevent diabetes complications in long-term insulin-dependent diabetes patients. The study aims to find biomarkers and therapeutic agents to halt diabetic retinopathy and nephropathy, which significantly impact lifespan and quality of life.
A Joslin study found that stimulation of the metabolism-sensing enzyme AMP kinase regulates crucial gene expression, causing neural tube defects and other heart defects in babies born to diabetic mothers. Even with controlled blood sugar levels, the risk is still twice that of the general population.
Researchers at Joslin Diabetes Center have identified two molecular pathways that activate brown fat, a type of fat that burns energy rather than storing it. The study provides new opportunities to stimulate brown fat growth, which could lead to the development of treatments for obesity and diabetes.
Researchers at Joslin Diabetes Center have identified the Sirt3 enzyme as a potential target for treating type 2 diabetes and prediabetes. The study found that Sirt3 levels are decreased in skeletal muscle cells of individuals with diabetes, contributing to insulin resistance and energy metabolism issues.
A study at Joslin Diabetes Center and Children's Hospital Boston found that 'good' brown fat is prevalent in leaner children, increasing until puberty and then declining. Boosting brown fat activity may be an effective approach to combating childhood obesity.
Scientists at Joslin Diabetes Center have discovered a new connection between obesity and insulin resistance through altered protein splicing. The study suggests that changes in RNA splicing proteins may contribute to the development of type 2 diabetes, offering potential targets for novel diabetes drugs.
Researchers found that mice on high-fat diets who received extra leucine showed improved glucose tolerance and insulin sensitivity. Adding leucine to the diet improved metabolic health in animals with prediabetes or metabolic syndrome.
Researchers at Joslin Diabetes Center identified PKC-delta as a major factor for insulin resistance in mice, correlating with obesity-related conditions. The enzyme's activity was found to be increased in both human and mouse models of insulin resistance, suggesting it as a promising target for drug development.
A study of Joslin Medalists reveals that some individuals with diabetes for decades exhibit remarkably few complications, pointing to the presence of protective molecular mechanisms. The researchers identified a link between advanced glycation end products (AGEs) and both disease progression and protection.