Scientists at Joslin Diabetes Center have found that a protein called alpha-myosin heavy chain triggers inflammatory heart disease in people with type 1 diabetes. The discovery could lead to diagnostic and therapeutic tools for this condition, which is often fatal.
Researchers at Joslin Diabetes Center have found a molecular pathway that is activated in people with insulin resistance and type 2 diabetes. This pathway holds promise as a target for novel diabetes therapies, offering new hope for patients with the disease.
Joslin Diabetes Center researchers discovered that plasma kallikrein interferes with brain clotting, leading to increased bleeding during strokes. Normalizing blood glucose levels may block this effect and reduce brain hemorrhage.
Scientists at Joslin Diabetes Center have identified progenitor cells in mouse white fat tissue and skeletal muscle that can be transformed into brown fat cells. The study found that exposure to the protein BMP-7 and the diabetes drug rosiglitazone increased conversion rates, suggesting a potential for cell-based brown fat therapies.
Joslin researchers found that brain cholesterol synthesis decreases in mouse models of diabetes, affecting nerve function and potentially leading to increased appetite and weight gain. The study suggests a link between diabetes and altered brain function, including changes in Alzheimer's disease risk and diabetic neuropathy.
Researchers at Joslin Diabetes Center discovered that diabetes can reduce brain cholesterol synthesis, which could impact brain function and increase the risk of Alzheimer's disease. This finding has broad implications for people with diabetes and may also play a role in diabetic neuropathy.
Researchers at the Joslin Diabetes Center have demonstrated that adult humans still have a type of 'good' fat called brown fat, which is active in burning calories and using energy. Brown fat was found to be more common in thin adults with normal blood glucose levels, but less likely to be present in those who were overweight or obese.
Researchers at Joslin Diabetes Center have identified a crucial link between insulin and glucagon levels. The study suggests that targeting insulin receptors or proteins in alpha cells could lead to the development of a new treatment for diabetes, particularly for type 1 patients who are at risk of hypoglycemia.
A multi-center clinical trial is being conducted to investigate the effect of salsalate on blood glucose levels in adults with poorly controlled type 2 diabetes. The study aims to determine if targeting inflammation can lead to an inexpensive way to treat this common form of diabetes.
A study by researchers at Joslin Diabetes Center found that nearly three-quarters of youths with type 1 diabetes have insufficient levels of vitamin D, which may lead to bone fragility and increased fracture risk. The study recommends vitamin D supplementation to children with diabetes, especially those with inadequate sun exposure and...
A new study by Joslin researchers found that a common genetic variant associated with an increased risk of coronary artery disease is also linked to poor glycemic control in people with diabetes. Those with the variant and poor glucose control experienced a four-fold increased risk for CAD relative to those without the variant and good...
Researchers at Joslin Diabetes Center have identified pancreatic progenitors that can form into insulin-producing cells after birth or injury, contradicting earlier studies. This finding offers new hope for treating and potentially curing diabetes through replacement therapy.
Researchers at Joslin Diabetes Center identified a protein called BMP-7 that induces the formation and function of brown fat cells. This discovery may lead to new treatments or prevention strategies for obesity and its associated diseases.
Researchers at Joslin Diabetes Center have successfully transplanted muscle stem cells into mice with muscular dystrophy, improving muscle function and replenishing the stem cell population. This breakthrough study demonstrates the potential of stem cell therapy for treating degenerative muscle diseases like Duchenne muscular dystrophy.
A study at the Joslin Diabetes Center found that children with type 1 diabetes who closely adhered to prescribed dietary recommendations had lower A1C levels and reduced risk of diabetes-related complications. The study highlights the importance of dietary adherence in achieving optimal glucose control.
Researchers at Joslin Diabetes Center have discovered that subcutaneous fat, typically found in the hips and thighs, can lower insulin levels and enhance insulin sensitivity. This discovery offers a new avenue for finding substances produced by subcutaneous fat that may improve glucose metabolism.
A team of scientists at the Joslin Diabetes Center has identified a key regulator of hematopoietic stem cell migration and proliferation, which could lead to improved bone marrow and blood cell transplants. The discovery also holds promise for treating type 1 diabetes and enhancing recovery from infections after transplantation.
Researchers at Joslin Diabetes Center have found that insulin inhibits a master gene regulator protein, SKN-1, which controls the Phase 2 detoxification pathway. Increased SKN-1 activity increases lifespan, providing potential insights into increasing resistance to chronic diseases and influencing longevity.
A new study by Joslin Diabetes Center found that restricting insulin doses in women with type 1 diabetes is associated with a three-fold increased risk of death and higher rates of disease complications. The study also highlighted the connection between insulin restriction and eating disorder symptoms, often referred to as diabulimia.
A new study found elevated markers of blood vessel inflammation in overweight Hispanic children with normal blood glucose levels, increasing their risk for type 2 diabetes and cardiovascular disease. The research highlights the need for obesity prevention strategies tailored to this high-risk population.
A new study led by Joslin Diabetes Center researchers shows that leptin plays a major role in islet cell growth and insulin secretion, potentially leading to new treatments for type 2 diabetes. The study found that mice lacking leptin receptors in the pancreas showed improved glucose tolerance and greater insulin secretion.
A new study at Joslin Diabetes Center identified a protein called Sirt2 as playing a major role in how fat is produced and stored in the body. Increasing Sirt2 levels may block fat cell differentiation and reduce fat storage.
A national Joslin-led study found that maintaining tight blood glucose control in people with type 1 diabetes does not lead to long-term loss of cognitive ability. The study, part of the EDIC study, followed participants for 12 years and showed no adverse effects on cognition.
A Joslin-led study identified insulin receptors as crucial for promoting beta cell growth, a potential target for treating type 2 diabetes. The research found that mice lacking insulin receptors failed to grow more islet cells, highlighting the importance of insulin receptors in overcoming insulin resistance.
A recent study by Joslin researchers has identified the glucose transporter 2 (Glut2) protein as a key contributor to the development of birth defects in children born to mothers with diabetes. Glut2 enables high blood glucose levels to enter embryonic cells, increasing the risk of malformations.
Researchers identified genetic and cellular mechanisms that enable mice with high-fat diets to resist obesity and diabetes, suggesting a role for brown fat cells. The study may lead to new therapies for obesity and prevention of type 2 diabetes.
A Joslin Diabetes Center-led team identified a group of proteins that may play critical roles in causing blood vessel leakage in the eyes of people with diabetic retinopathy. One of these molecules causes retinal blood vessel leakage, contributing to swelling and vision loss.
A recent Joslin Diabetes Center-led study has discovered that the appetite hormone melanin concentrating hormone (MCH) plays a crucial role in the growth of insulin-producing beta cells and insulin secretion. This finding may lead to the development of new treatments that stimulate beta cell growth to treat type 1 and type 2 diabetes.
A new study by Joslin Diabetes Center has shown that with proper training and follow-up, over 80% of children and teens can successfully use insulin pumps to manage type 1 diabetes. The study identified key risk factors for failure, including infrequent blood glucose monitoring and high rates of severe hypoglycemia.
Researchers at Joslin Diabetes Center found that circulating bone-marrow derived cells do not produce oocytes or facilitate their ovulation. The study used a parabiotic mouse model and hormones to stimulate ovulation, demonstrating that oocytes are not seeded by blood-borne cells.
A long-term study of DCCT participants found no cognitive impairment from severe hypoglycemic reactions, supporting the safety of intensive diabetes therapy. Higher A1C readings were associated with a decline in motor speed and psychomotor efficiency, but not other cognitive domains.
Researchers found that 48% of participants reported no or very little microvascular complications, and that some patients still have residual islet function. The study suggests that many patients with long-term type 1 diabetes may have some residual insulin production, paving the way for new treatments.
A study by Joslin researchers found that the PKC-beta enzyme is responsible for fluid retention and weight gain associated with popular type 2 diabetes drugs. The study suggests a potential treatment using PKC-beta inhibitors to prevent these side effects.
A Joslin-led study has discovered that insulin signals to the liver differently for glucose and lipid metabolism, opening the door to developing targeted therapies. The research reveals new insights into phosphoinositide 3-kinase (PI3K) pathway, which regulates insulin's action in the liver.
Researchers at Joslin Diabetes Center found that beta cells can develop and grow normally even when both insulin and IGF-I receptors are missing. This discovery suggests the presence of independent growth factors and pathways necessary for beta cell development, which may lead to new treatments for people with diabetes.
Researchers found that genetic makeup can predict fat distribution patterns and obesity risk, identifying key genes involved in controlling development. The study suggests that different forms of obesity may be a developmental problem starting early in life.
Researchers found that new islet cells are host-derived, not from donor spleen cells, and that beta-cell growth was permitted when autoimmunity was suppressed. The study suggests that CFA alone may be effective in treating type 1 diabetes without the need for donor spleen cells.
Researchers at Joslin Diabetes Center discovered a link between Necdin and E2F4 proteins, altered after patients took the drug rosiglitazone. The study suggests that thiazolidinediones work by altering cell differentiation states, offering new potential targets for diabetes treatment.
A Joslin Diabetes Center study reveals insulin's critical role in blood vessel formation, which may lead to new treatments for heart attacks in diabetes patients. The researchers found that insulin activates a pathway producing VEGF, essential for new blood vessel growth.
Researchers find that histamine contributes to joint blood vessel leakage in rheumatoid arthritis, potentially leading to more effective treatments. The discovery may also apply to other autoimmune conditions and infectious diseases.
A study by Joslin's Asian-American Diabetes Initiative found that Chinese-speaking immigrants with type 2 diabetes had less knowledge of disease management and poor blood glucose control compared to English-speaking immigrants. Bilingual education improved their understanding and led to better blood glucose control in laboratory tests.
Researchers detected lower gray matter density in brains of patients with Type 1 diabetes, associated with poorer glycemic control and depression. The study opens up new approaches to understanding the central nervous system in diabetes.
The Joslin Diabetes Center study found that online discussion boards provide a less threatening way to discuss sensitive concerns about diabetes. The study, which tracked over 330,000 visits to the discussion boards, found that nearly 75% of respondents rated participation as having a positive effect on coping with diabetes.
Three patients underwent gastric bypass surgery and developed severe hypoglycemia, requiring partial or complete pancreas removal. Abnormal insulin-producing islet cell proliferation was found in all cases.
Research shows that women with diabetes are at risk of having babies with heart and spinal cord birth defects due to high blood glucose levels. Maintaining good glycemic control throughout pregnancy is crucial, especially during the first eight weeks when organs form.
A new imaging technology has shown promise in detecting pancreatic inflammation in type 1 diabetes, allowing for early prediction of disease progression and response to treatment. The technique uses magnetic nanoparticles and MRI to identify inflamed pancreatic islets, potentially reducing the need for invasive biopsies.
Researchers at Joslin Diabetes Center have identified a new gene, ARNT, that plays a crucial role in the development of type 2 diabetes. The study, which used DNA chips to analyze islet cells from patients with the disease, found a marked down-regulation of ARNT, suggesting a possible new target for treatment.
A new clinical trial has shown that the oral treatment RBX may reduce the risk of moderate vision loss caused by macular edema in patients with type 1 or type 2 diabetes. The study, led by Joslin Diabetes Center, evaluated the safety and effect of RBX on retinopathy progression and visual loss.
Researchers used genetic engineering techniques to develop mice with overexpressed PKC-beta 2, demonstrating its role in the progression of diabetic kidney disease. The study found that albumin levels were tenfold higher and oxidative stress three times higher in these mice compared to normal mice.
A Joslin study finds that maintaining a controlled diet and preventing weight gain can prevent the development of glucose intolerance in individuals born with low birth weight. The researchers observed improved insulin sensitivity and reduced risk of diabetes in mice on calorie-restricted diets compared to those allowed to eat freely.