A study of 580 women found that nearly half experienced persistent lymphedema, a condition causing fluid buildup in arms and hands. Lymphedema affects quality of life, requiring lifestyle changes such as compression garments.
Researchers used genetic engineering techniques to develop mice with overexpressed PKC-beta 2, demonstrating its role in the progression of diabetic kidney disease. The study found that albumin levels were tenfold higher and oxidative stress three times higher in these mice compared to normal mice.
A new study demonstrated add-on effects of ACTOS on diabetic dyslipidemia, reducing triglycerides and increasing HDL cholesterol. Patients with type 2 diabetes who switched from Avandia to ACTOS showed significant improvements in lipid levels, regardless of age or gender.
Research linking obesity and asthma suggests that weight loss can reduce eotaxin levels, a key inflammatory mediator. The study found that obese patients experienced significant reductions in eotaxin levels after losing weight, offering new hope for treating debilitating asthma symptoms.
Researchers discovered that macrophages in the innate immune system may play a role in Alzheimer's development. They found that healthy individuals can clear amyloid-beta, but Alzheimer's patients' macrophages struggle with this task.
A Joslin study finds that maintaining a controlled diet and preventing weight gain can prevent the development of glucose intolerance in individuals born with low birth weight. The researchers observed improved insulin sensitivity and reduced risk of diabetes in mice on calorie-restricted diets compared to those allowed to eat freely.
Researchers from Johns Hopkins report that the band leader controlling DNA copying also brings the jam session to a close, intricately connecting the two processes. This discovery sheds light on the development of immune system cancers.
The NIH/National Library of Medicine (NLM) will administer a new public health information expert training program, funded by the $3.68 million grant. The program aims to develop more public health professionals skilled in applying computer technology to enhance their work.
A recent study published in The Lancet suggests that early treatment with antiepileptic drugs may not provide significant long-term benefits for patients with infrequent seizures. In fact, the trial found that delayed medication did not increase the risk of chronic epilepsy or improve quality of life.
Deep-sea organisms rely on 'sinkers', discarded mucus nets of larvaceans, as a vital food source. Researchers found that these cast-off 'houses' carry large amounts of detritus and tiny animals towards the seafloor.
Researchers have identified ERG as the first proto-oncogene commonly overexpressed in early-phase prostate cancer, providing a promising target for diagnosis and treatment. The study also found correlations between ERG expression and PSA recurrence-free survival of prostate cancer patients after radical prostatectomy.
At the DoD 'Era of Hope' breast cancer meeting, Vanderbilt-Ingram researchers presented their groundbreaking research on various aspects of breast cancer, including tumor microenvironment, diagnostic imaging, and biological pathways. The conference brought together a diverse group of researchers to share their work and collaborate with...
Researchers found that women who exercised during and after chemotherapy had improved activated lymphocytes and reduced inflammation. The exercise program improved physical functions and overall quality of life compared to non-exercisers.
Researchers found that microRNAs play a crucial role in regulating gene expression and enabling stem cells to pass from the normal stop phase to the stage of replicating their DNA for later division. The discovery suggests that microRNAs may also control cell division in cancer cells, encouraging proliferation.
Researchers found that volcanic aerosol particles and sulfuric acid reduce methane production in wetlands, leading to a cooling effect. This mechanism may have played a role in past climate changes, with potential impacts on modern Earth's atmosphere.
A recent study by ECRI found that digital mammography does not significantly improve breast cancer detection rates compared to traditional X-ray imaging. While the new technology may offer some incremental benefits, such as reduced radiation exposure, its cost-effectiveness and diagnostic accuracy need further evaluation.
A Harvard Medical School study reveals that phosphatases play a crucial role in regulating cell survival and chemoresistance. The researchers identified tumor suppressor phosphatases whose loss of function leads to chemoresistance, providing potential new targets for cancer treatment.
A recent study published in Ecology Letters explores the complex relationships between biodiversity and ecosystem function. The research reveals that both high and low levels of biodiversity can have negative consequences for ecosystem health, with intermediate levels often being the most beneficial.
Researchers identify genetic changes in hepatitis C virus that evade immune system, leading to chronic infections. The findings suggest a 'consensus sequence' could serve as basis for effective vaccines against both acute and chronic infections.
Scientists at the Salk Institute have discovered that a specific conformation of the prion protein is the infectious entity behind deadly prion diseases. By altering this shape, researchers may find a strategy to control these untreatable brain-wasting diseases.
Researchers found that media violence exposure may be associated with alterations in brain function, particularly in the frontal cortex, which is linked to attention and self-control. High exposure to violent media was linked to reduced activity in this area, while low exposure showed increased activity.
Scientists at the University of California - Irvine have developed a method to send data at speeds of up to 10 gigahertz using nanotubes, breaking conventional copper wire limitations. This technology has the potential to revolutionize high-speed electronic devices and wireless systems.
A study found that chronic CMV infection is associated with frailty in older women, particularly those with high levels of inflammatory markers. The research highlights the importance of understanding the causes of frailty and developing potential treatments to improve outcomes for aging populations.
Researchers induce indefinite organ allograft survival in rhesus monkeys by stimulating recipient T cells with donor cells, generating immunosuppressive anergic T cells. These cells suppress renal allograft rejection without additional immunosuppressive agents.
Women now account for nearly half of the 40 million people worldwide infected with HIV, a significant shift from the early days of the pandemic. The increased number of female cases is attributed to various factors, including heterosexual transmission and cultural influences.
A randomised trial found that a brief pain management programme delivered by physiotherapists was as effective as a package of physiotherapy incorporating spinal manual-therapy techniques in treating low back pain. The programme resulted in fewer treatment sessions and referrals to secondary care.
Researchers at Oregon Health & Science University found elevated levels of leptin may be the cause of cachexia, a common complication of CKD. Blocking the MC4-R pathway in the brain may provide a novel therapeutic strategy to combat this life-threatening complication.
A study by Michigan Medicine found that adults use over-the-counter hydrocortisone creams in limited and appropriate ways, with a 73% compliance rate. In children, hydrocortisone cream was used primarily for insect bites, rashes, eczema, and itchy skin, with 72% of use following recommended guidelines.
The Beilstein Journal of Organic Chemistry publishes full research articles on various aspects of organic chemistry. Authors can submit their work online and retain copyright without publication charges.
A new review of 10 studies on HIV treatment programs in developing countries found that nearly 57% of patients had undetectable HIV levels one year after starting ART. Free or low-cost ART programs have been shown to improve adherence and treatment outcomes, suggesting a significant link between access and success.
A review of published and unpublished data reveals striking gaps in information about childhood disease burden, especially in the poorest countries. The study highlights the need for targeted investment in health research to obtain accurate data from regions with limited access.
Researchers at Mayo Clinic discovered a therapy that removes immune system blockages without harming the immune system, boosting its natural ability to reject breast cancer. T-regulatory cells play a disease-promoting role in breast cancer, and blocking them boosts natural immunity.
The study highlights the catastrophic effects of the December 26, 2004 tsunami on Banda Aceh and Lohknga in Indonesia. Water reached 9 meters at the shoreline and over 15 meters inland, with wave-driven sea water inundating areas up to 25 meters above sea level.
A team of scientists found that the oceans took tens of thousands of years to recover from a massive carbon dioxide release during the Paleocene-Eocene Thermal Maximum. The study suggests that the recovery time for current fossil fuel emissions could be similar, highlighting the need for urgent action.
A seven-year study of over 3,000 black and white men and women aged 70 to 79 found that regular exercise reduced the risk of mobility problems by half. Participants who exercised regularly had lower rates of disability and health decline compared to those who were inactive.
A study by Brandeis University researchers found that baby-faced individuals are often perceived as less competent than those with more mature features. Babyfaced adults, regardless of sex or ethnicity, share characteristics such as a round face, large eyes, and small chin, which can lead to overgeneralization and perceptions of naivet...
Plant cells use programmed cell death to protect against viruses, but this process must be controlled to avoid killing the plant. Researchers found that silencing a specific gene, BECLIN-1, helps regulate PCD and prevent infection from spreading.
Researchers studied the La Jolla submarine canyon's effect on ocean waves, finding that up to 60% of wave energy was reflected back into the open ocean. Another study tracked sulfur hexafluoride through the Denmark Strait to understand its role in driving global climate.
Kansas State University professors Dann Fisher and Swanson advocate for a new national rule requiring three hours of accounting and business ethics coursework for certified public accountants. The proposed rule aims to prevent corporate ethics scandals like Enron and Arthur Andersen by emphasizing moral judgment in accounting graduates.
A new technique called laparoscopic inversion esophagectomy (LIE) has been developed to improve the removal of diseased tissue from the esophagus. LIE eliminates technical obstacles that plagued the original procedure, allowing for faster recovery and fewer complications.
Researchers found a significant increase in tornado warnings after WSR-88D radar installation, with almost doubled warnings and increased lead time. The study also revealed expected fatalities and injuries were 45% lower for tornadoes occurring after radar installation.
A new method using quantum dots detects RSV in a matter of hours, reducing the need for lengthy tests. The system has potential benefits including increased proper use of antiviral medicines, reduced inappropriate antibiotic prescriptions, and improved patient separation.
Researchers at the University of Colorado Boulder have developed a new polymer that maintains its strength even when exposed to light, offering potential solutions for dental fillings and electronic packaging. The polymer's unique properties could also have applications in boats, automobiles, and structural materials.
Researchers at the University of Pittsburgh have developed a new microscopy technique that allows them to observe electrons moving through a nanostructured silver film. This breakthrough could lead to more efficient semiconductors and reduce heat dissipation, making electronic devices faster and more powerful.
A study by Washington University postdoctoral fellow Alan Castel found that expert video game players exhibit a 20% reduction in response times compared to non-players. This suggests that expertise is acquired through practice rather than being an innate ability.
A team of engineers has successfully removed bioaerosols from a hospital therapy pool using a new generation of hybrid filters. The filters reduced concentrations of culturable bacteria by up to 80% and total bacteria by up to 76%, significantly improving pool safety and reducing illness risks.
Researchers at Dartmouth discovered a molecule called Smad7, found in half of all human pancreatic cancers, that interferes with pathways regulating cell growth. Smad7 suppresses the function of the retinoblastoma protein, enabling cancer cells to grow unchecked and increasing metastasis.
A study of 1400 patients with single or infrequent seizures found that delaying antiepileptic drug treatment reduced short-term seizure recurrence. However, there was no significant difference in long-term outcomes, suggesting that immediate treatment may not offer long-term benefits.
A recent study published in Cancer Epidemiology, Biomarkers & Prevention found that women with low physical activity levels and higher body mass indexes were at increased risk of developing breast cancer. Conversely, those who engaged in approximately three METs of exercise per day had a lower risk, suggesting that promoting weight con...
A Cornell University professor and his team analyzed the devastation from the 2004 Indian Ocean tsunami, finding that educating residents and tourists about tsunami signs can significantly reduce casualties. The experts also emphasize the importance of protecting sand dunes and coral reefs as natural buffers from the sea.
Researchers found that tsunami waves were more destructive on the west coast of Sri Lanka due to human intervention, such as coral poaching and beach re-landscaping. The study's findings highlight the importance of preserving natural coastal defenses against tsunamis.
Scientists have developed a method to create an infectious form of the hepatitis C virus in a test tube, allowing researchers to study its life cycle and develop new drugs. This breakthrough could lead to better understanding and treatment of liver diseases associated with HCV.
Researchers found that combining SGS742 with Aricept improves memory in rats by altering gene control machinery involved in long-term memory consolidation. The combination therapy protocol may provide a potential treatment for Alzheimer's disease symptoms and improve patient quality of life.
In a study published in Psychophysiology, researchers found that humans display decreased balance control and increased muscle stiffness when viewing unpleasant images, mirroring the behavior of deer in a threatening situation. This phenomenon is linked to neural circuits promoting defensive survival and is observed in various species.
A study by Emory University researchers has found that variations in microsatellite sequences of the vasopressin receptor gene can influence social behavior and parenting behaviors in voles. These findings suggest that junk DNA may play a role in shaping individual differences and social diversity.
A novel tool has been developed to accurately classify human cancers based on microRNA expression patterns, offering a promising diagnostic approach. The study reveals striking correlations between miRNA profiles and specific tumor types, providing new insights into the genomic approaches to cancer diagnosis.
Researchers found that longer junk DNA variations affected gene expression patterns in the brain of male prairie voles, leading to increased social behavior and parental care. The study's findings have implications for understanding human social diversity and personality traits.
Researchers have discovered that specific proteins in the fruit fly eye play a crucial role in organ development, including kidney formation. These proteins, Roughest and Hibris, are also found in human kidneys and are essential for proper filtration and filtering of unwanted molecules.
A study published in the Journal of Clinical Investigation shows that reinfusing anergic T cells into rhesus monkeys after kidney transplantation leads to prolonged and potentially indefinite graft survival without additional immunosuppressive agents. This approach has shown promise for improving organ transplantation outcomes in humans.
Researchers at Florida Tech are developing a method to produce oxygen on the moon using the FFC Cambridge process, which could significantly reduce costs and masses of rocket fuel. Locally produced oxygen would be crucial for achieving affordable human robotic programs to explore the solar system.