Researchers at Joslin Diabetes Center found that exercise causes dramatic changes to fat, releasing factors into the bloodstream that improve glucose tolerance. The study identified transforming growth factor beta 2 as an adipokine released from fat that has positive effects on health.
Researchers at Joslin Diabetes Center found that paternal exercise improves glucose metabolism, reduces body weight, and decreases fat mass in offspring. Exercise also alters genetic expression in sperm, potentially transmitting beneficial effects to next-generation offspring.
A study highlights strategies to help teens with type 1 diabetes manage high cholesterol and blood pressure, including offering realistic guidance, encouraging regular exercise, and promoting healthy eating habits. The research emphasizes the importance of personalized approach and team effort in addressing these conditions.
A study by Joslin Diabetes Center shows that alanine can activate AMPK, increasing energy production and lowering glucose levels. This finding suggests a new potential way to modify glucose metabolism in the body.
A recent study has shown that adding genetic factors to existing risk assessments can help predict future major coronary events in people with type 2 diabetes. The genetic score provides a significant improvement in correctly predicting cardiovascular risk, particularly when used early in life.
Researchers discovered a protein called JNK that drives response to exercise, stimulating skeletal muscle growth and endurance adaptation. Inhibition of this pathway may improve response to aerobic capacity training.
Researchers at Joslin Diabetes Center found that gut microbes contribute to signs of negative feelings and brain chemistry in obese mice. Antibiotics reversed these behaviors, demonstrating a significant link between the microbiome and mental health outcomes.
A study by Joslin Diabetes Center researchers has found a correlation between long-term type 1 diabetes and mild cognitive decline, particularly in memory. The decline is also associated with an increased risk of cardiovascular disease.
A 20-year longitudinal study found clear predictors of rising A1C levels in young persons with type 1 diabetes, including sex and weight status. Insulin dose data and glycemic control were assessed over time to identify clinical factors associated with glycemic changes.
Researchers at Joslin Diabetes Center have discovered a hormone in fat that boosts metabolism during exercise and cold exposure. The hormone, 12,13-diHOME, is released from brown fat and offers beneficial metabolic effects. Further studies are underway to understand its role in obesity and metabolic disease.
A study in mice suggests that protective immune cells forming outside the thymus may defend against autoimmune diabetes. Gut microbes affecting this cell population may also protect against disease.
A study found that bariatric surgery significantly improves cardiovascular disease risk factors and blood glucose control, while medication has limited effectiveness. The analysis of existing data from two studies showed a 70% improvement rate in A1c levels among surgically treated teens.
Researchers at Joslin Diabetes Center discovered that four viruses can produce insulin-like hormones that bind to human insulin receptors and stimulate cellular signaling. This finding opens up a new field of study in microbial endocrinology, potentially revealing biological mechanisms behind diabetes, autoimmune disease, and cancer.
A new 'smart' glucagon delivery system has been developed to treat post-bariatric hypoglycemia. The system combines a continuous glucose monitor, rapid glucagon delivery, and a mobile platform with a hypoglycemia prediction algorithm, successfully alerting investigators to impending hypoglycemia and reducing episodes.
Scientists at Joslin Diabetes Center found a connection between eye damage and cardiovascular disease in people with type 1 diabetes, suggesting shared biological mechanisms. The study also showed that kidney disease was not necessarily linked to cardiovascular disease, challenging previous assumptions.
A recent study found a link between genetic variants and lower GLP-1 levels, which may predict increased cardiovascular mortality risks in type 2 diabetes patients. The research could lead to personalized patient care by testing genetic risk markers and tailoring treatments accordingly.
Researchers at Joslin Diabetes Center found that mice on a fatty diet who consumed high levels of fructose suffered worse metabolic effects compared to those given similar calories of glucose. The study highlighted the increased production of an enzyme called Khk, which is specifically important in fructose metabolism.
The Joslin Diabetes Center has been awarded $8.2 million from the National Institutes of Health (NIH) in continued support for its Diabetes Research Center program. The funding will enable researchers to advance treatments and potentially find a cure for diabetes.
Researchers at Joslin Diabetes Center identified PKC-delta as a natural protective factor that works against chronic inflammation in diabetes, which can lead to cardiovascular disease. The study found that PKC-delta suppresses the population of macrophages and inhibits a biological pathway that protects cells from dying.
A new study of adults with Type 1 diabetes for at least 50 years found that better glucose control is associated with a lower risk of cardiovascular disease. The research also discovered that exercise plays a significant role in lowering mortality rates from all causes in this population.
Joslin Diabetes Center researchers found impaired insulin effects boost cancer risks in mice with genetically modified intestinal tumors and blood vessels. Insulin resistance may impair blood vessel health and share biological mechanisms with cardiovascular disease.
Scientists at Joslin Diabetes Center have found that healthy individuals with diabetes develop protective enzymes against damage from high blood sugar levels. The researchers identified an enzyme called PKM2 and showed that activating it can stop abnormalities in mouse podocytes and delay diabetic kidney disease progression.
Researchers developed a prognostic tool predicting end-stage renal disease risk in type 1 and 2 diabetes patients. The test uses biomarker values to identify those at high risk, improving the efficiency and cost-effectiveness of clinical trials.
Researchers identified markers of aging in insulin-producing beta cells, revealing diverse populations with different lifespans. Insulin resistance accelerates beta cell aging, contributing to type 2 diabetes development.
Researchers at Joslin Diabetes Center identified a lipid molecule that signals brown fat cells to activate in mice, improving metabolism. The molecule, 12,13-diHOME, may also be used as a biomarker for brown fat activation in humans.
A new study aims to identify factors that result in long-term diabetes remission and better blood sugar control after bariatric surgery. Researchers will follow up with approximately 242 patients over five years to analyze hormone secretion, metabolism, and complications.
Researchers at Joslin Diabetes Center have discovered a biological mechanism that prevents insulin-producing cells from dividing successfully. The study found that the proteins centromere protein A and polo-like kinase-1 are essential for beta-cell growth, and their loss leads to cell death.
Researchers at Joslin Diabetes Center identified a new therapeutic approach by studying the role of microRNAs released from fat cells into the bloodstream. They found that these microRNAs can regulate gene expression in other organs and tissues, potentially leading to new treatments for metabolic diseases and cancer.
The Joslin Diabetes Center is participating in two NIH-funded clinical trials to test artificial pancreas systems that automatically monitor and regulate blood glucose levels. If successful, the trials could lead to regulatory approval for use of these devices, improving glucose control and reducing diabetes self-management burden.
The American Diabetes Association has awarded a $1.625-million grant to develop an animal model studying the connection between gut bacteria and autoimmune attack in type 1 diabetes. The research aims to identify mechanisms that may contribute to the disease and potentially lead to treatments that prevent it.
Researchers at Joslin Diabetes Center have discovered a potential way to reduce complications from blood clot removal during stroke treatment. By targeting the plasma kallikrein protein, they aim to increase the efficacy of tissue plasminogen activator (tPA) therapy while minimizing bleeding and swelling.
Researchers at Joslin Diabetes Center found that mice with reduced brain cholesterol suffer neurological damage and behavioral abnormalities. The study suggests that cholesterol may play a role in the development of Alzheimer's disease in people with diabetes.
A new study by Joslin Diabetes Center shows that participants in the Why WAIT weight loss program experienced reduced cardiovascular disease risks and improved insulin sensitivity even five years after completing the intervention. The study found that maintaining a 7% weight loss was a good predictor of long-term weight loss success.
Researchers at Joslin Diabetes Center have identified a key role for the SHP-1 enzyme in stent failure in people with diabetes. By suppressing smooth muscle cell growth, SHP-1 may lead to more effective surgical stents.
A Joslin researcher will study how exercise affects the body at a molecular level to develop individually targeted exercise recommendations and help people with mobility issues. The project aims to provide valuable insights into harnessing these molecular changes to benefit patients with type 1 and 2 diabetes.
Researchers found that genetic background affects response to antibiotics on gut microbiome, insulin sensitivity, tissue inflammation, and metabolic functions in mice. This study suggests that genetic susceptibility plays a role in predicting the usefulness of microbiome therapies for obesity and metabolic disease.
Scientists at Joslin Diabetes Center have identified a new molecular pathway that may offer targets for drugs to strengthen angiogenesis and improve blood vessel growth in type 2 diabetes. The study found that CITED2 expression is increased in endothelial cells from patients with diabetes, suggesting its potential as a therapeutic target.
Infants of obese mothers exhibit impaired expression of genes regulating cell energy and metabolism, correlating with higher levels of metabolically deleterious lipids in their blood. This study may pave the way for improved healthcare and early interventions for children at risk of obesity.
Researchers at Joslin Diabetes Center found that the protein IRE-1 can react to ROS molecules, triggering an antioxidant response that increases cell resistance to stress. This discovery highlights the need to consider ROS molecules as links in cell pathways, not just as damaging agents.
Researchers found that glucosamine plays a critical role in early embryonic development, helping embryos proliferate normally. This could aid in avoiding birth defects in diabetic pregnancies and improving future stem-cell treatments. Glucosamine is also essential for embryonic cells to grow and develop.
A randomized study found that highly structured nutrition plans lead to the most significant impact on A1C, body weight, and lipid profiles. Participants reduced A1C by an average of 0.67% and lost 3.5Kg over 16 weeks without changing medications or exercise.
Scientists have found that the RGS1 gene affects the frequency of T follicular helper cells, which are important for B cell production and seem to be crucial for the disease. The study suggests that while inhibiting RGS1 did not prevent autoimmune diabetes, it changes the way cells move within lymph nodes and spleen.
Researchers at Joslin Diabetes Center have identified the role of natural killer cells in abdominal fat inflammation and insulin resistance. By modulating NK cell activity, they found that inflammation in abdominal fat is suppressed and insulin resistance improves.
Ultrawide field (UWF) scanning technology improved the ability to identify diabetic retinopathy in patients and judge the need for follow-up examinations or treatment. The study found that UWF imaging reduced ungradable images by 81% compared to traditional digital retinal photographs.
The American Diabetes Association has issued a statement offering practical guidelines for managing type 2 diabetes in older adults in long-term care facilities. The recommendations focus on individualized goals, liberal diet plans, and avoiding sliding scale insulin to balance glycemic control while minimizing hypoglycemia risk.
Researchers at Joslin Diabetes Center have identified a key liver protein that accelerates the growth of insulin-producing beta cells, a critical step in treating all forms of diabetes. The protein, serpinB1, was found to be highly expressed in liver cells and boosted beta cell proliferation in human and mouse islets.
A clinical trial has found that ranibizumab (Lucentis) is highly effective in treating proliferative diabetic retinopathy, with patients showing improved central vision and reduced risk of surgery compared to laser therapy. The study also suggests that Lucentis may help prevent diabetic macular edema.
Researchers at Joslin Diabetes Center found that peripheral lesions in the retina correlate strongly with retinal non-perfusion, a condition caused by lost small blood vessels. This discovery may enable clinicians to estimate disease progression without invasive angiography.
Researchers at Joslin Diabetes Center found that certain gut bacteria strains are associated with insulin resistance and metabolic syndrome in mice models. The team identified three common mouse strains with different microbiota populations, which were affected by diet and genetic background.
Eyes with peripheral diabetic retinal lesions have a three-fold increased risk of progression to advanced stages of vision-threatening diabetic retinopathy. The findings suggest that wider field imaging may change how diabetic eye disease is evaluated and treated.