The number of NIH-funded trials decreased by 328, while industry-funded trials increased by 1,965, during the period. The total number of newly registered trials increased by 5,410, with industry-funded trials accounting for the majority of growth.
Researchers found ancient lake deposits in Antarctica have remained frozen since at least 14 million years ago, supporting the idea that the East Antarctic Ice Sheet has also remained intact during past climates. This study provides new hope that the EAIS could be stable in today's and future climate conditions.
Research found a heightened risk of subsequent mania and bipolar disorder in adults treated with certain antidepressants, including SSRIs and venlafaxine. The peak age for diagnosis was among patients aged 26 to 35, with an annual risk of 1.2%.
Researchers can follow the emergence of hydrogen-bonded capsules in modern physical organic chemistry, enabling new arrangements of molecules and reaction vessels. The book covers various types of capsules and their functions, providing insights into encapsulation phenomena at the molecular level.
A recent study at Rush University Medical Center found acupuncture to be a safe and effective adjunctive integrative medicine treatment for chronic pain in pediatric patients. The study included 55 children aged 7-20 who experienced chronic pain conditions, with significant reductions in pain levels and related health issues.
Biomedical engineer Prof Helen Lu has received a $1.125M grant to develop a nanofiber-based device for tendon-to-bone integration in rotator cuff repair, aiming to improve healing outcomes and reduce re-tear rates.
Astronomers measured the density of photon fog between Earth and quasar PKS 1441+25 using high-energy gamma rays. The data validated theoretical models for the number and brightness of stars and galaxies in the universe going back 7.6 billion years.
Researchers at Karolinska Institutet identified a gene variant linked to psychotic symptoms and cognitive impairment in people with bipolar disorder. The study found that the gene variant affects levels of specific proteins in the brain, which may lead to new targeted drug development.
Researchers at McMaster University found that using saline water instead of soap and water can lead to lower rates of infection and complications. The study involved 2,400 patients with open fractures and showed that low-pressure saline irrigation was an acceptable alternative to traditional cleaning methods.
A study found that people with higher levels of ADHD symptoms also showed greater distractibility, which can impact daily activities and tasks. Increasing task difficulty can help improve focus and performance for both individuals with high and low distractibility traits.
Diana Shu-Lian Chow, a University of Houston professor, has been named a Fellow of the National Academy of Inventors in recognition of her work on developing new drug formulations. Her work has led to significant improvements in the safety and efficacy of stem cell transplants for leukemia patients.
A new research project proposes employing millions of existing distributed energy resources to balance the power grid, increase reliability and decrease carbon emissions. The approach uses incentive-based coordination and control to make the grid more efficient and resilient.
The study found that stromal cells, specialized fibers, and T helper 17 cells collaborate to form tertiary lymphoid tissues (TLTs) in the brain of MS patients. This discovery may lead to potential treatment options, such as targeted Th17 blockers, by understanding how TLTs are formed.
Researchers have found a compound that can prevent and reverse fatty liver disease and obesity in mice by targeting the farnesoid X receptor. The compound, Gly-MCA, was tested in obese and diabetic mice fed with a high-fat diet and showed significantly less fat and insulin resistance compared to untreated control groups.
The 2015 El Nino event is expected to bring more precipitation to California, with atmospheric rivers intensifying and potentially causing flooding. Meanwhile, the risk of wildfires in tropical regions increases due to reduced rainfall, which can exacerbate carbon dioxide buildup and air quality issues.
A novel spectral confocal microscopy technique enables the visualization of silver- and gold-labeled neurons in three dimensions, providing high-resolution images that can be archived for decades. This method retains image quality even with repeated light exposure, making it ideal for studying neurological disorders and cancer.
Researchers at the University of Cambridge have developed a non-invasive blood test that can diagnose some types of malignant childhood tumour with high accuracy. The test looks for specific genetic code patterns in blood and cerebrospinal fluid samples, allowing for early diagnosis and monitoring without exposure to radiation.
Researchers found that combining TTFields with chemotherapy significantly improved progression-free and overall survival for patients with glioblastoma. The study, published in JAMA, suggests a potential new treatment approach for this devastating brain tumor.
Researchers at Colorado State University are developing smaller satellites called CubeSats to monitor storms and clouds. The project aims to demonstrate real-time storm observation and take thousands of images inside clouds to improve understanding of precipitation processes.
The TUM team developed the RateX method, which overcomes two serious challenges in information theory by bringing together three essential functions. Their approach could enhance flexibility and reduce costs in various communication systems, including wireless, wireline, optical fiber, and satellite systems.
Weaker interactions between brain networks help regulate attention were found in children with ADHD, correlated to the severity of inattention symptoms. Functional MRI scans identified biomarkers that reliably differentiate children with ADHD from others.
The Brown University and Rhode Island Hospital have been awarded grants to integrate substance abuse screening and intervention into their curriculum. The training program aims to expand screening and intervention for opioid overdose deaths in Rhode Island, which has seen a rise in opioid-related deaths. The program will provide traini...
The number of industry-sponsored clinical trials has dramatically increased since 2006, while NIH-funded trials have declined substantially. This trend raises concerns about the influence of commercial interests on medical research, potentially compromising public health outcomes.
A new study from University Hospitals Case Medical Center found that making colonoscopy available at no cost to eligible Medicare beneficiaries did not increase the number of people who regularly undergo the procedure. In contrast, routine mammography screenings significantly increased following the Affordable Care Act's mandate for lo...
MSU has defined food fraud and established strategies to fight it, providing a system-wide focus for prevention. The university's Food Fraud Initiative aims to adjust entire food supply chains to detect and prevent food fraud.
A Stanford University School of Medicine team identified a distinctive pattern of gene expression that distinguishes people with a viral infection from those with a bacterial infection. The meta-virus signature is present even before symptoms appear and can predict up to 24 hours before illness onset.
A systems biology study of over 400 volunteers found that certain molecular signatures predict strong immune responses to seasonal flu vaccines in both young and elderly individuals. The researchers identified a distinct signature associated with long-lasting antibody responses, which may guide the development of more effective vaccines.
Researchers found that freshwater rivers and streams pump about 10 times more methane into the atmosphere than previously estimated, driven by human activity in agricultural and urban watersheds. This discovery highlights the importance of improving stream health in reducing greenhouse gas emissions.
Recurrent Strep A infections may lead to autoimmune neuropsychiatric disorders in children through a previously unknown route. Immune cells triggered by the infection travel along odor-sensing neurons to reach the brain, causing inflammation and promoting neuroinflammation.
A new analysis found that despite federal efforts to diversify clinical research, the number of studies including minorities remains low, and scientists from minority communities are less likely to receive funding. This lack of diversity poses a significant risk to understanding and addressing health disparities in the US population.
The VERITAS telescope detected powerful gamma rays from a distant galaxy, PKS 1441+25, revealing details about the black hole engine at its center. The gamma-ray emission was found to be located within the relativistic jet, but surprisingly far from the black hole, and is estimated to be around 5 light-years away.
Researchers discovered that sepsis causes severe muscle damage, impairing muscle function and leading to debilitating long-term effects. Mesenchymal stem cell transplantation has shown promising results in restoring muscle capacity and repairing mitochondrial dysfunction.
Research suggests children as young as 5 use high-fidelity imitation to re-affiliate with excluded groups, mimicking behaviors such as dress and activities to appear part of the group. Ostracized children exhibit increased anxiety and frustration compared to those included by out-groups.
Researchers identified molecular signatures that predict immune protection in response to flu vaccination, with elderly individuals showing high levels of monocytes and low antibody-producing B cells. This study provides insight into potential mechanisms underlying reduced vaccine efficacy in older adults.
Scientists discover enhanced weathering of rock can draw CO2 out of atmosphere, stabilizing climate and preventing ocean acidification. This process converts CO2 to bicarbonate, which drains away via rivers to the oceans, benefiting coral reefs.
A study by University of Chicago cancer specialists found that expensive research biopsies in early cancer drug studies had no impact on subsequent drug development or treatment decisions. Only a small percentage of the biopsies yielded statistically significant results.
The authors propose that lethal drugs' physical consequences should be listed as immediate cause of death and underlying condition as preceding antecedent cause. Harmonization with vital statistics registrars is crucial for consistency across provinces and territories.
Tetyana P. Shippee, PhD, is awarded the 2015 Senior Service America Senior Scholar Award for her research on long-term care and aging, particularly focusing on cumulative inequality theory and patient-centered measures.
UT Dallas researchers found that boards face two competing normative pressures: corporate elite norms and monitoring norms. Social capital affects how boards conform to those pressures. The study proposes introducing mechanisms for institutional investors to positively influence directors and creating full-time director positions.
At different hydration levels, researchers found that water contributes to subpicosecond structure fluctuations and broadens vibrational transitions in DNA. The study also reveals a pronounced coupling of backbone modes and an energy transfer between them.
A meta-analysis of 19 studies involving over 118,000 patients found that surgery resulted in lower mortality rates compared to radiation treatment. Patients treated with surgery were twice as likely to survive prostate cancer than those treated with radiation.
A new Canadian guideline provides recommendations for diagnosing fetal alcohol spectrum disorder (FASD), a neurodevelopmental disorder resulting from prenatal alcohol exposure. The guideline recommends counseling women and their partners about abstinence during pregnancy, screening pregnant women for alcohol use, and conducting complet...
Researchers found that humans are exceptionally short sleepers, getting an average of seven hours of sleep per night, whereas other primates need up to 17 hours. Human sleep is also more efficient, spending less time in light stages and more in deeper stages.
A team of researchers from Princeton University has discovered new genes that regulate memory and neuron repair in adult worms, which could have implications for human cognitive decline and traumatic brain injury. The study provides a more complete picture of how insulin/IGF-1 signaling pathway controls gene expression in neurons.
Researchers at KU Leuven have developed an alternative production method to create nanoporous thin films, expanding their industrial possibilities. These materials can be used as catalysts, absorb large amounts of material, and store gases, opening up new applications in fields like nanoelectronics.
Scientists at Johns Hopkins University have uncovered the molecular cause of peripheral nervous system dysfunction in Down syndrome. A gene called RCAN1 appears to be overactive, hindering nerve growth and development, which may contribute to heart disease, diabetes, and immune disorders associated with the condition.
A recent IU study analyzing over 100 million Web clicks and 1.3 billion public posts reveals that social media news consumers access a narrower range of sources, contributing to the rise of collective social bubbles. This trend is attributed to people filtering their access to information through social media platforms.
Researchers have developed a new process to grow designer crystals using vapour rather than liquid, enabling the creation of faster and more powerful electronic devices. The method uses metal organic frameworks (MOFs) with extremely large surface areas, allowing for the trapping of other molecules and boosting processing power.
Professor Ian Craddock discusses how IoT technologies can transform health care and reduce costs by managing chronic conditions outside the hospital environment. He will explore challenges, security concerns, and application scenarios for healthcare using his SPHERE project as an example.
A team of researchers at UCSF developed ORACLs, a lineage of genetically modified cancer cells that change their appearance when treated with drugs, inspired by face-recognition software. These cells can quickly organize molecules in institutional compound libraries according to their biological function.
Multiple sclerosis may be triggered by the death of brain cells that make the insulation around nerve fibers. Nanoparticles have been shown to prevent progressive MS in an animal model, offering new hope for human treatments without side effects.
Researchers found biochar produced from tomato crop green waste can be used as a substrate for soilless hydroponic tomato production. The study showed that tomatoes grown in biochar-based substrates had similar growth, yield, and fruit quality to those in pine sawdust.
Researchers found that ringtailed lemurs reserve vocal exchanges for individuals with whom they have close relationships, using them to maintain social bonds even when separated. This study highlights the importance of vocal interactions in establishing familiarity and closeness, a concept applicable to human communication as well.
New research on Serianthes nelsonii, a critically endangered tree species in Guam, highlights two critical factors limiting its survival: root diseases and insufficient light. The study's empirical approach sheds light on previously overlooked threats to the tree's health.
A new study found that experimental drugs changing energy supply in cells can halt tumor growth and extend survival in mice with cancers linked to IDH1 gene mutations. The research team discovered that cancer cells with low levels of a critical metabolic chemical, NAD, are more susceptible to these drugs.
Researchers at FAU and University of Barcelona discovered that platinum nanoparticles lose approximately every tenth electron when in contact with oxide support. This effect can be controlled using theoretical methods, allowing for more efficient catalytic processes and new electronic components.
A recent study published in JAMA Pediatrics has found that taking antidepressants during pregnancy significantly increases the risk of autism in children. The study analyzed data from over 145,000 pregnancies and found an 87% increased risk of autism when antidepressants were used during the second or third trimester.
Scientists evaluated nine spring and six fall crop cultivars for suitability as baby-leaf salad greens in the Pacific Northwest. Pak choi 'Joi Choi' and Mustard 'Komatsuna' showed high marketable weight, quick harvest time, and good weed competitiveness.
A team of astronomers has solved the long-standing mystery of missing water in hot Jupiter-sized exoplanets by analyzing atmospheric data from NASA's Hubble and Spitzer space telescopes. The study found that cloudy atmospheres are responsible for hiding water, ruling out dry hot Jupiters.
High-resolution satellite maps track air pollution trends over the last decade, revealing a human fingerprint on global air quality. Nitrogen dioxide levels have decreased significantly in the US and Western Europe due to environmental regulations, while China saw an increase in emissions.