A new study confirms that galaxies are being pushed away from a previously unknown region of low density, called the Dipole Repeller. This region exerts a repelling force on our Local Group of galaxies, suggesting that push and pull forces are equally important.
Ex-Tropical Cyclone 03S has transformed into a frontal system in the Southern Indian Ocean, showing an elongated shape and strong wind shear. The Australian Bureau of Meteorology has issued warnings for heavy rain and cold temperatures.
Scientists have identified 107 new gene regions linked to high blood pressure, enabling doctors to target treatments and advise on lifestyle changes. The findings suggest a personalized medicine approach could reduce the risk of heart disease and stroke.
Researchers at MUSC have identified novel potassium channel genes that correlate with drinking levels and may advance personalized medicine approaches for treating heavy drinking. A KV7 channel-positive modulator reduced heavy alcohol consumption in mouse models, suggesting these genes as promising therapeutic targets.
Neuroscientists at the University of Geneva have identified three main sub-groups of inhibitory interneurons in the cortex by analyzing cell-type specific genes and their expression patterns. These findings will aid in understanding neuro-developmental disorders such as autism and schizophrenia.
A new drug developed at the University of Rochester Medical Center extends HIV therapy effectiveness by unleashing a cell's protective machinery on the virus. When combined with nanoformulated antiretroviral drugs, URMC-099 lifts the brakes on autophagy, allowing cells to digest any remaining virus.
A new translation of Mendel's 1866 paper reveals a more engaged and influenced scientist, with connections to contemporary theories of evolution. The work offers insights into the creation of genetics and challenges long-held debates among philosophers and historians.
Genomic analyses reveal that Mongolian yaks are derived from cattle, with a genetic heritage of about 1.5% of their genome coming from domesticated cattle. The study also found that yak breeders selected for polledness in the early stages of domestication, leading to the loss of horns and exploiting this trait worldwide.
A study published in Frontiers in Physiology found that people living at higher altitudes (457-2297 meters) had a lower risk of developing Metabolic Syndrome, which contributes to heart disease and diabetes. The research suggests that high-altitude living may help improve heart and lung function, insulin sensitivity, and weight loss.
Researchers face challenges in scientific writing due to lack of support for highly specialized areas. A recent study surveyed common tools and identified key features that could be used to construct a system for production engineering.
Researchers discovered a viral protein that transforms its structure when interacting with DNA, acting like a sensor to measure out appropriate lengths. This finding reveals a potential drug target for human herpesviruses and offers a new therapeutic strategy.
The IOF-ECTS Position Paper proposes measuring specific bone turnover markers to detect low adherence to oral bisphosphonates, a common issue in chronic diseases. This early identification enables discussion and intervention with patients, potentially improving treatment efficacy.
Researchers found that Earth's rotation affects meltwater behavior, keeping it at depths of several hundred meters. The team measured turbulence in meltwater as it flowed out of a cave beneath the Pine Island Glacier and used a VMP23 to detect subtle fluctuations in water.
Researchers at the University of Missouri found that limiting maternal myostatin levels improved bone strength and density in mice with osteogenesis imperfecta. The study suggests a potential therapeutic approach to treating brittle bone disease.
Misdiagnosing six common foot and ankle injuries can result in poor long-term patient outcomes, including arthritis and disability. Clinicians are advised to be suspicious and obtain additional imaging or a second opinion from an orthopedic surgeon to confirm the initial diagnosis.
A new study by Michigan State University researchers found that children with a growth mindset tend to focus more on their mistakes and improve their performance after errors. In contrast, children with a fixed mindset can also recover from mistakes if they pay close attention to the errors.
A new technology for energy-efficient cultivation and harvesting of microalgae has been developed by Bendy Estime, improving growth rates up to 10 times larger than traditional methods. The Tris-Acetate-Phosphate-Pluronic medium allows algae to grow in clusters without sticking to container walls, eliminating the need for constant stir...
Research shows people prefer those who openly admit bad behavior over hypocrites who condemn it, as the former provides genuine moral insight. Participants viewed hypocritical characters more positively when they condemned bad behavior without direct information about their moral behavior.
A long-term study tracked hundreds of children from kindergarten through high school, finding that chronic bullying was related to lower academic achievement and less engagement in school. Some children were able to recover from bullying if it decreased, revealing a hopeful message.
A UBC study found that students with higher levels of self-compassion felt more energetic and optimistic during their first semester. Self-compassion interventions can help mitigate psychological stress by enhancing autonomy, competence, and relatedness, leading to improved well-being.
A new study found that hospital admissions for cardiovascular diseases decline on snowy days but surge 23% two days later, according to a Harvard T.H. Chan School of Public Health study. The researchers analyzed data from four major Boston hospitals and found cold-weather-related disease admissions increased by 3.7% on high snowfall days.
Scientists have introduced a new family of UVA and UVB filters inspired by natural sunscreen substances found in algae and cyanobacteria. These molecules are highly stable, enhance commercial sunscreen effectiveness, and offer improved sun protection factor.
Researchers found that cognitively normal people 70 and older who engaged in computer use, craft activities, social activities, or playing games had a decreased risk of developing mild cognitive impairment. The study's findings suggest that mentally stimulating activities can be beneficial even for those at genetic risk.
The total economic cost of smoking was US$ 1436 billion in 2012, equivalent to 1.8% of the world's GDP, according to a new study published in Tobacco Control. Developing countries accounted for nearly 40% of this sum.
Scientists have mapped the entire methylome in pancreatic islets, revealing correlations between DNA methylation and impaired insulin function. The study found altered methylation in 25,820 genome regions, including changes in the PDX1 gene linked to type 2 diabetes.
The University of Liverpool is coordinating a £14m European research project, TransQST, to improve drug safety by leveraging public and private data. The project aims to develop novel computational models to address off-target reactions and minimize harm from adverse drug reactions.
Engineers at Caltech and ETH Zurich developed artificial skin that senses temperature changes, similar to pit vipers' prey-sensing organs. The material can detect tiny temperature changes and has a responsivity two orders of magnitude larger than existing electronic skins.
Research found that patients diagnosed with type 2 diabetes are at increased risk of developing pancreatic cancer, particularly within the first year. The study's findings suggest a link between rapid deterioration in diabetes and early detection of pancreatic cancer.
A large study found that breast conserving therapy (BCT) is superior to mastectomy in early-stage breast cancer patients with no metastases. BCT, combined with radiation therapy, offers a survival advantage for patients aged over 50 years and those with comorbidity.
A new genomics study of shark DNA reveals unique modifications in immunity genes that may underlie rapid wound healing and possibly higher resistance to cancers. The research found modified legumain and Bag1 genes, which have counterparts in humans where overexpression is associated with cancers.
A breath test measuring five chemicals has shown promising results for detecting oesophagus and stomach cancers in a large patient trial. The test achieved an overall accuracy of 85%, outperforming the current method of endoscopy.
New cancer drugs have shown clinical benefit, but disparities in national health technology assessment outcomes hinder patient access. In the UK, prices for some common drugs increased by over 1000% between 2011 and 2016.
A new immunotherapy, pembrolizumab, has shown significant activity against mucosal melanoma tumors and prolonged survival in patients with bladder cancer. The treatment demonstrated a response rate of 16% and improved overall survival rates compared to chemotherapy.
A team of researchers has identified the earliest-acting protein needed for cell division, which is critical for organizing cell division in animals. The discovery, made using roundworms, revealed a key advance in understanding centriole duplication, a process vital to cell division and cilia function.
Researchers predict that melanoma death rates will decrease by 2050 due to the aging of populations, but the number of deaths may increase. Effective treatments could lead to a further decline in mortality rates.
Research from the University of British Columbia found that a vitamin A deficiency in the womb or early infancy can increase production of amyloid beta and lead to cognitive impairments. Providing supplements after birth may help slow the degenerative brain disease.
Researchers analyze how ancient South Asian population coped with changing environmental conditions using lake records and speleothem data. They found that the civilization developed in a diverse environment where water was critical for survival, and its populations were well-adapted to varying climate conditions before urbanization.
Researchers have identified a key gene called NucS that reduces mutation rates in mycobacteria, the infectious microbe causing tuberculosis. This discovery has important implications for understanding antibiotic resistance and could help predict and prevent the development of drug-resistant TB strains.
The article discusses the importance of considering genome context (karyotype) in systems biology and molecular cytogenetics. It highlights the need for a new genome-based conceptual framework to integrate these fields, which will mutually benefit both disciplines.
Researchers used AI to predict a trio of reagents that generated a never-before-seen cancer-like phenotype in tadpoles, demonstrating its potential in controlling complex biological systems. The study showcases how AI can help human researchers achieve new outcomes in fields like oncology and regenerative medicine.
A new regulatory mechanism has been identified that allows animals to increase reductive power in response to high sugar intake. This mechanism involves protein kinase SIK3 and glucose metabolism enzyme G6PD, providing protection against oxidative stress and allowing for conversion of excess sugar into fat.
Research at Lund University found that both neural pathways in the striatum, called direct and indirect pathway, work together to control movements, not independently. This discovery may lead to new treatments for movement disorders like Parkinson's disease by targeting both pathways.
A recent study found the mcr-1 gene has spread to a wide variety of Escherichia coli strains in China, raising concerns about the emergence of multi-drug resistance. The introduction of colistin in clinical settings is crucial, but caution must be exercised due to risk factors for its spread.
Researchers discovered that the twin with shorter sleep duration had a depressed immune system compared to their sibling. The findings suggest that chronic short sleep shuts down programs involved in immune response, leading to lower antibody responses and increased susceptibility to illnesses.
Researchers from the University of Granada have reconstructed the Gibraltar Arc's movement 9 million years ago, revealing clockwise and counterclockwise rotations of large land blocks. The study reconciles contradictory data on the region's tectonic history.
A Dartmouth study found that health insurance reduces cancer disparities, but does not eliminate them. Patients from disadvantaged communities showed a larger benefit from health insurance, highlighting the need for improved access to care.
Researchers from Chinese Academy of Sciences found that BCAS2 plays a crucial role in alternative mRNA splicing during mouse spermatogenesis, leading to impaired meiosis initiation. The study provides evidence for the importance of alternative splicing machinery in regulating germ cell development.
Researchers at KAIST create a 3D holographic display that significantly enhances the performance of existing displays, allowing for larger images and wider viewing angles. By controlling volume speckle fields, they achieve an image size increase of up to 2 cm in length, width, and height.
Scientists from Ludwig-Maximilians-Universitaet Munich have successfully measured the lifetime of an excited state in an unstable element, paving the way for the development of nuclear clocks. The research team has characterized the energy transition in the 229Th nucleus and achieved a breakthrough in this field.
A study at Technical University of Munich found that antibodies can activate human nerve cells within milliseconds, modifying their function. This knowledge improves understanding of illnesses associated with certain types of cancer and paraneoplastic syndromes, which occur when the body's autoimmune reaction attacks its own cells.
Researchers propose using portable instruments, spectroscopic techniques, and weathering cells to develop strategies for better artwork preservation. Non-invasive techniques like X-ray radiography, infrared photography, and X-ray fluorescence enable the detailed investigation of historical paints' chemical composition.
Researchers found that climate models underestimates high-elevation temperature changes, with errors of up to 40%, likely due to flawed water vapor content representation. This could lead to more extreme warming in fragile ecosystems like tropical glaciers.
Researchers found that generations born on the leading edge of an invasion can push forward more than those born further back due to evolutionary advantages. This discovery has implications for agriculture and natural resource management as invasive species spread faster and farther.
A new study confirms dogs exhibit prosocial behavior, preferring to deliver treats to familiar partners. The complexity of the task influenced the frequency of food delivery, but social proximity played a significant role.
A new study reveals that changes in translation play a crucial role in the development of skin cancer. The researchers found that eIF2A, a protein involved in translating genetic instructions, is overexpressed in certain types of cancer and can serve as a potential therapeutic target for treating the disease.
Research at Umeå University found a sevenfold increase in methylmercury in zooplankton due to altered food web structures. Climate change scenarios predict similar increases, highlighting the need for considering effects on ecosystems and human exposure.
Researchers demonstrate that massaging hair can increase the delivery of nanoparticles to hair follicles by creating channels for particle transport. The ratchet mechanism enhances particle speed and diffusion when massaged parallel to the resting surface.
A team of researchers at UD has discovered a new function for an enzyme involved in bacterial metabolism. They found that the enzyme plays a major role when generating sugars from non-sugar substrates and facilitates 'back-flow' even when sugar is being consumed.
Researchers have discovered that stem cell secretions, called exosomes, can promote survival of retinal ganglion cells in rats, which could lead to potential therapies for glaucoma. The study found that exosome-treated retinal ganglion cells maintained function and lost fewer cells after optic nerve injury.
Researchers discovered that fruit fly steering muscles are divided into two types, with tonic muscles always in use for fine-tuned adjustments and phasic muscles used for rapid movements. This unique organization enables efficient flight control.