Researchers identified genes that govern the development of brown fat cells, which burn energy and generate heat. The discovery may lead to new tools to fight obesity by targeting specific genes with drugs or agents.
Researchers at Joslin Diabetes Center have identified genetic regions involved in autoimmune diseases, including type 1 diabetes. The study found a chromosomal region where T-cells were given the green light to attack beta cells, leading to insulitis and later type 1 diabetes.
Research at Joslin Diabetes Center reveals that prenatal undernutrition can lead to impaired insulin production and higher blood glucose levels, setting the stage for type 2 diabetes. The study found that low-birth-weight mice had abnormal insulin secretion patterns, leading to permanent impairment.
Researchers at Joslin Diabetes Center have identified the critical role of two insulin signaling proteins in controlling glucose and lipid metabolism. By knocking out these proteins in liver cells, they found that diabetes results when both signals are simultaneously low, but not when either is individually depleted.
Joslin and Stanford researchers have made a breakthrough discovery about muscle regeneration, identifying the specific cells that can give rise to new muscle fibers. Contrary to previous studies, these cells are located near muscle fibers and not in blood-forming tissues like bone marrow.
Dr. von Andrian will focus on setting up a new microscopy model at Joslin to study the interaction between islet cells and immune cells, aiming to develop a simple model for studying islet cells in living animals. He will also collaborate with Joslin researchers on stem cell projects and vascular complications in people with diabetes.
A study by Joslin Diabetes Center found that youth ages 8-18 with type 1 diabetes were more likely to monitor their blood glucose levels when playing a guessing game on a wireless-equipped personal digital assistant. The study showed an increase in diabetes knowledge and fewer episodes of hyperglycemia among participants.
A new gene marker has been found to increase the risk of heart disease in people with type 2 diabetes. The CD36 gene variant is associated with higher levels of free fatty acids and triglycerides, leading to a 60% increased risk of heart disease.
Scientists have discovered a new mechanism underlying muscle wasting in various diseases, including cancer and diabetes. Blocking the NF-kB pathway can prevent muscle atrophy and prolong survival in mouse models of disease.
Researchers identified a mechanism for beta-cell growth during insulin resistance, which occurs as a normal protective response to delay type 2 diabetes onset. PDX-1 plays a crucial role in regulating this growth, and modulating key proteins involved may enhance beta cell replication or transplantation
Dr. C. Ronald Kahn receives the award for his groundbreaking work on insulin signal transduction and its link to diseases like diabetes, Alzheimer's, and obesity.
Researchers at Joslin Diabetes Center have developed a new imaging technology using magnetic resonance imaging to detect early signs of type 1 diabetes. The technology tracks miniscule magnetic nanoparticles leaking from the blood vessels of the pancreas, allowing for non-invasive monitoring of the disease's progression.
Researchers studied insulitis lesions in genetically engineered mice and discovered that inducible co-stimulator (ICOS) plays a crucial role in keeping insulitis respectful. Blocking ICOS disrupts the balance between T effector and regulatory cells, leading to diabetes progression.
Researchers found that natural killer cells are associated with destructive insulitis and beta cell destruction, suggesting a potential new target for halting or slowing disease progression. The study's findings have implications for understanding the complex interactions between immune cells and the development of type 1 diabetes.
Research at Joslin Diabetes Center reveals that insulin resistance in the brain may contribute to the development of Alzheimer's disease. Studies using genetically altered mice found a marked reduction in insulin signaling proteins, leading to excessive phosphorylation of tau protein, a hallmark of brain lesions in Alzheimer's.
Obese adults who lost 7% of their weight and did moderate-intensity physical exercise for six months improved their major blood vessel function by approximately 80 percent, regardless of type 2 diabetes status. This improvement in blood vessel function reduced the risk of developing arteriosclerosis and coronary heart disease.
A study by Joslin Diabetes Center shows that care ambassadors can significantly improve blood sugar levels and reduce complications in children with type 1 diabetes. The program helps families establish patterns of lifelong diabetes management, leading to fewer hospitalizations and emergency room visits.
A study by Joslin Diabetes Center has identified a family of metabolic genes associated with type 2 diabetes risk. The research found that 55 genes showed altered activity in both people with diabetes and those at high risk for prediabetes, suggesting a continuum from normal to diabetic states.