New study finds blood-forming stem cells can survive without Notch signals, allaying fears of damage during chemotherapy. The findings have implications for a high-profile breast-cancer drug trial combining chemotherapy with a Notch inhibitor.
Francis S. Collins, a renowned geneticist and former Human Genome Project leader, has been awarded the inaugural Inamori Ethics Prize at Case Western Reserve University. The prize recognizes his outstanding contributions to promoting ethical leadership in genetics and improving human health.
Researchers discovered a novel gut-brain-liver circuit that lowers blood sugar when activated, providing a potential new approach to treat diabetes. The discovery suggests stimulating the gut's sensing mechanism may slow down sugar production and lower blood sugar levels.
Researchers found a shared genetic expression pattern between embryonic stem cells and human cancer cells, which may have significant implications for cancer therapeutics. A gene module map was created to relate transcriptional programs in different cell types.
A commentary in Biological Psychiatry highlights attacks on medical researchers conducting non-human primate research, emphasizing their vital role in psychiatric disorder treatment. The authors condemn these acts and advocate for public action to protect scientists.
Regular aerobic exercise can slow or reverse the decline of maximal aerobic power, delaying biological aging and maintaining functional independence. By conserving maximal oxygen intake, individuals may retain their physical abilities longer, reducing the risk of serious disease and improving overall health.
The symposium examined the incidence of inflicted traumatic brain injury in young children and explored issues of definitions, surveillance methods, and prevention strategies. Key findings indicate that SBS is a form of intentional injury with a high mortality rate and long-term disability for survivors.
A new genetic test has identified mutations in 10 genes as a possible cause of cardiac hypertrophy in children. The test found that nearly 50% of children without family histories had mutations in these genes, shedding light on the underlying causes of the condition.
A Management Insights study finds that physicians consider patients' inputs when making prescriptions, improving forecasting performance. However, patient influence diminishes for specialist doctors and those treating severe symptoms. The study has significant implications for pharmaceutical executives and marketing strategies.
Researchers develop biodegradable microspheres to deliver molecules directly into embryonic stem cells, enhancing efficient and pure differentiation. The method, funded by the National Science Foundation, showed improved results in controlling signaling events and promoting specific cell types.
A team of scientists at the Joslin Diabetes Center has identified a key regulator of hematopoietic stem cell migration and proliferation, which could lead to improved bone marrow and blood cell transplants. The discovery also holds promise for treating type 1 diabetes and enhancing recovery from infections after transplantation.
A new study by Scientific Food Solutions demonstrates that Comfort C provides 275 percent faster absorption in the first 60 minutes compared to other brands. This results in higher body weight-adjusted vitamin C concentration changes from baseline at 60 minutes.
The National Institutes of Health has awarded contracts to develop new mechanical circulatory support devices for children with congenital heart defects. These devices are designed to decrease wait list mortality and improve efficiency of organ utilization in pediatric patients.
Researchers from Pitt and the University of Chicago discovered a previously unknown role of two enzymes in regulating heart muscle contractions. By controlling these enzymes, they found that heart muscle fibers become more sensitive to calcium, strengthening contraction without increasing energy consumption.
Researchers link atherosclerosis to widespread organ damage and discover potential targets for treatment. The study found that biochemical signals in arteries can contribute to harm in the lungs, liver, and other organs.
A long-term study published in Neurology found that men who develop diabetes in mid-life are nearly one-and-a-half times more likely to develop Alzheimer's disease than those without insulin problems. The association was strongest in people without the APOE4 gene, which is known to increase Alzheimer's risk.
A new study by researchers at Hasbro Children's Hospital found that children with sleep-disordered breathing (SDB) who are overweight, have short sleep periods, or another sleep disorder like insomnia are more likely to have behavioral problems. The study revealed that SDB severity had a relatively weaker influence on behavioral outcomes.
A study of 418 English test cricketers found that players who appeared in more test matches lived longer than those with fewer appearances. Captaining the team had no impact on lifespan, contrary to expectations.
A new study led by Emory University researcher Charles L. Raison found that Tibetan refugees, especially those born in Tibet, experience high levels of depression and anxiety. The study also showed that time spent in India can improve symptoms, but the emotional trauma remains a concern.
A new study suggests that minimally invasive carotid stenting is as effective as open surgery in preventing strokes among high-risk patients. After three years, patients who underwent stenting had similar rates of stroke, heart attack, or death compared to those who received traditional open surgery.
Researchers at the University of Pennsylvania School of Medicine have found that juvenile cells on their way to becoming mature immune cells can develop into either T cells or other blood-cell types. This challenges the currently accepted model of T-cell development, which suggests that these cells are committed to the T-cell path from...
Dame Anne McLaren was a pioneer in embryonic germ cells and contributed to IVF treatments. Prof Christine Mummery will honor her memory with a keynote lecture on advances in stem cell research, highlighting its potential for treating diseases like heart damage.
A recent study published in The American Journal of Clinical Nutrition found an association between high egg consumption and all-cause mortality. However, the researchers did not control for various factors, such as saturated fat intake, which may confound the interpretation of the findings.
A recent study published in BJU International found that kidney cancer deaths in Europe have declined by 13% for men and 17% for women between 1992 and 2002, with the largest reductions seen in Austria and Germany. However, the study also reveals significant variations in mortality rates across different countries.
Researchers at the University of Michigan have created materials that can detect TNT and alert to its presence remotely, reducing danger for military personnel. The system uses low-cost, battery-free sensors that emit light when excited by infrared light, which is then detected by a specially-designed light-collection system.
Studies found that people living in deprived areas had significantly worse cognitive function and higher mobility problems compared to those in less deprived areas. The research highlights the importance of adequate healthcare and social care in poorer communities.
Researchers found that chronic use of beta blockers alleviates asthma by helping airways relax and dilate, providing longer-term respiratory function. The study builds on earlier breakthroughs in treating congestive heart failure, where beta blockers improved outcomes despite initial worsening symptoms.
A new imaging technique helps demystify the cause of explosive sound waves in rockets, revealing spinning acoustic waves that gain destructive power as they rotate around the combustion chamber. The study provides a clearer understanding of this phenomenon and brings scientists closer to preventing its occurrence.
University of Delaware researchers have discovered a new type of molecule called natural antisense microRNAs (nat-miRNAs) that can turn off genes in rice, which is the primary source of food for half the world's population. These novel molecules may help scientists locate similar gene regulators in other organisms, including humans.
A K-State biology professor is studying the evolution of the state flower, sunflower, using a $610,000 grant from the National Science Foundation. The research focuses on how environmental stress may have caused the activation of retrotransposons in hybrid species, leading to massive genomic expansion and restructuring.
A recent study reveals a drastic decline in shorebird populations over the past 25 years, with migratory species suffering a 73% drop and resident shorebirds declining by 81%. The loss of wetlands and habitats is a significant contributor to this decline, highlighting the need for improved conservation efforts.
A new study from Ohio State University found that conjugated linoleic acid (CLA) may need to be paired with the hormone leptin to prevent side effects of rapid weight loss. The study used mice genetically engineered to have no leptin, finding that CLA diets can result in weight loss but also insulin resistance.
A study published in Nature suggests that closing schools could slow the spread of a flu pandemic and prevent up to one in seven cases. The researchers used computer modeling to explore how school closure would affect the transmission of a theoretical H5N1 avian flu virus in France.
Researchers have created a highly efficient method for producing hydrogen from plant biomass, addressing three major technical barriers to the 'hydrogen economy'. The new system could enable pollution-free and fuel-efficient transportation in the future.
Researchers created a novel cell line that replicates the full spectrum of systemic metastatic cancer, enabling new discoveries about the role of macrophages in cancer's spread. The model has been shown to produce tumors in 100% of mice with healthy immune systems, paving the way for new therapies targeting these cells.
A new pan-European collaboration aims to design an advanced diagnostic tool for coeliac disease, the most under-diagnosed common chronic condition in the UK. The project will unite technologies for point of care diagnostics and embedded communication, enabling easy follow-up and management of patients.
A landmark observational study is tracking the management of osteoporosis in 60,000 postmenopausal women from around the world. The Global Longitudinal Registry of Osteoporosis in Women (GLOW) aims to improve diagnosis and treatment standards, with data collected over five years.
Infants exposed to methamphetamines in utero suffer from irreversible brain damage and impaired recognition of novel objects, according to a new study. The research provides evidence for the cognitive damaging effects of these drugs on fetal development.
Recent research presents mixed findings on infant feeding and obesity, with some studies suggesting potential associations between infant nutrition and health outcomes. These studies provide new insights into the complex relationships between infant feeding practices, maternal factors, and childhood obesity.
Research conducted by Miami Research Associates found that Wellmune WGP supplementation reduced the incidence of medically verified fever in healthy subjects. Additionally, the study showed significant improvements in physical energy and emotional well-being, with no need for work or school absences due to cold-like symptoms.
A study published in the Journal of the American Society Nephrology found that raloxifene increases bone mineral density and reduces vertebral fractures in postmenopausal women with mild to moderate chronic kidney disease. The medication is safe and effective for this patient population, reversing bone loss and fracture risk.
New guidance suggests glitazones have a place in combined treatments but lack evidence for solo use; side effects include heart failure and increased risk of heart attack.
A large Scottish Health Survey study found that just 20 minutes of weekly physical activity, including housework, reduces the risk of stress and anxiety. The more activity a person engages in, the lower their chances of psychological distress.
A recent study by Ohio State University researchers found that seniors who develop serious illnesses later in life lose more of their savings. The study compared the long-term financial repercussions of pre-existing chronic health problems with those caused by the sudden onset of a new health problem late in life. Participants over 70 ...
A new study published in The New England Journal of Medicine has found that carotid stenting with embolic protection is as safe and effective as surgery for patients at high risk for endarterectomy. The SAPPHIRE study showed equivalent stroke and repeat procedure outcomes between the two groups.
Researchers found that repeated methamphetamine use depresses brain areas and leads to permanent changes in neural terminals. Re-administering the drug reverses these changes, suggesting potential new treatment approaches for methamphetamine addiction.
Two studies suggest that Diabetinol, a natural citrus supplement, improves blood glucose numbers and LDL-cholesterol levels in people with type 2 diabetes. The supplement shows promise in lowering blood glucose levels after meals and improving heart health, potentially reducing diabetic complications.
Researchers identified how toxic protein plaque accumulates in the brain of people with Alzheimer's disease. The study found that endocytosis plays a crucial role in transporting amyloid precursor protein into neurons, leading to A
A study of 5,840 people found a connection between low birth weight, excessive weight gain during adolescence and young adulthood, and an increased risk of developing heart disease. Chronic inflammation, measured by C-reactive protein levels, may play a key role in this association.
Researchers found septic acute kidney injury (AKI) patients have higher acuity of illness, lower blood pressure, and worse pulmonary function compared to non-septic AKI. The study suggests septic AKI requires specific clinical interventions to reduce injury and promote kidney recovery.
A recent Université Laval study reveals that omega-3 intake during the last months of pregnancy has a positive impact on an infant's sensory, cognitive, and motor development. The study found a strong correlation between DHA concentration in umbilical cord blood and infant visual acuity and cognitive development.
A study has revealed that endocytosis is necessary for the production of amyloid beta, a key component of Alzheimer's brain plaques. The research found that endocytosis plays a critical role in increasing amyloid beta levels, which are coupled to normal nerve cell communication called synaptic activity.
A study published in BMC Psychiatry found that healthcare staff's emotional reactions to substance abuse patients with personality disorders depend on the type of disorder. Patients with antisocial personality disorder elicit feelings of distance, while those with avoidant personality disorder induce feelings of helpfulness.
The NJIT team won the regional steel-bridge competition with a strategy of optimizing construction time and minimizing builders while reducing overall weight. This is their third consecutive win, and they will now compete at the national level on Memorial Day.
Researchers at Stanford University School of Medicine have successfully created cancer stem cells in a laboratory setting, shedding new light on the origins of these rare and difficult-to-study cells. The breakthrough could lead to new ways of understanding how cancer cells form and developing more effective treatments.
A tiny variation in the CHI3L1 gene increases blood levels of YKL-40, a biomarker for asthma. The genetic variation also lowers YKL-40 levels and protects against asthma. Researchers found similar connections between the CHI3L1 variations, YKL-40 levels and asthma susceptibility in three genetically diverse populations.
Researchers used PET and SPECT imaging to monitor the effectiveness of a new therapy, which successfully preserved healthy heart tissue and corrected blood flow imbalance. Nearly 50% of repaired artery segments showed normalization of glucose metabolism and coronary blood flow.