A multicenter clinical trial found that the transcatheter mitral valve repair significantly reduced hospitalizations and mortality for heart failure patients with moderate-to-severe or severe functional mitral regurgitation. The procedure improved symptoms, quality of life, and survival rates.
Researchers are conducting a Phase 1 clinical trial using Lutetium 177Lu-PSMA-617 to target PSMA in men with progressive prostate cancer. The therapy aims to deliver precise radiation therapy and shrink the cancer, even in cases without visible tumors.
Researchers from NewYork-Presbyterian and Weill Cornell Medicine found that the landmark national study's methodology was flawed, leading to misinterpreted results that questioned the effectiveness of PSA testing. They suggest reconsidering prostate cancer screening guidelines.
Researchers develop experimental small molecule agent MI-2 that irreversibly inactivates MALT1 protein responsible for cancer cell growth. The treatment shows promise in animal models without toxicity, paving the way for combination therapy regimens to reduce treatment toxicity and improve patient outcomes.
Scientists have discovered how antibiotics work inside tuberculosis bacteria cells using mass spectrometry. The study's findings suggest that current drugs can be improved by modifying their molecules to withstand bacterial degradation, paving the way for more effective treatments.
Researchers discovered epigenetic marks drive development of three deadly white blood cell cancers, including BCR-ABL1-positive B-ALL. The study identified key biomarkers and potential treatments, such as targeting the CD25 protein and blocking cancer-driving genes like BCL6.
Researchers at Weill Cornell Medical College have discovered a way to utilize diagnostic prenatal amniocentesis cells to regenerate damaged blood vessels and repair injured organs. The study, published in Cell, shows that reprogrammed endothelial cells can be frozen and banked for potential use in patients with vascular diseases.
A new study by Weill Cornell researchers found that EHRs enhance the quality of patient care, particularly for physicians using commercially available systems. The study used data from five different health plans and found significant improvements in four measures, including hemoglobin A1c testing in diabetes.
The study found that 91% of children currently diagnosed with a DSM-IV autism spectrum disorder would be diagnosed with ASD using DSM-V, suggesting that the new criteria will not exclude most children. DSM-5 has also been shown to have higher specificity than DSM-IV.
A new study published in the Proceedings of the National Academy of Sciences found that adolescents' brains have impaired fear extinction learning, making it difficult for them to overcome fear. This may explain why anxiety and depression rates surge during adolescence.
Researchers at Weill Cornell Medical College reveal that taxanes work by stopping protein movement in cancer cells, not just cell division. This understanding could lead to novel therapies and improved treatment outcomes for prostate cancer patients.
Researchers have found that an off-patent anti-inflammatory drug, oxyphenbutazone, can kill both replicating and non-replicating drug-resistant tuberculosis in laboratory tests. The effective drug may offer a potential new therapy for the over 500,000 people worldwide whose TB has become resistant to standard drug treatments.
A new study shows that combining a protein inhibitor with VEGF targeting could more effectively treat diseases by shutting down abnormal blood vessel growth. This approach may also lead to improved treatments for eye diseases and autoimmune disorders.
A new study shows that integrating on-site rapid HIV testing into drug treatment programs is cost-effective, with a beneficial cost-effectiveness ratio of $60,300 per QALY. This approach provides better value than off-site referral and can help identify more people infected with HIV.
Weill Cornell Medical College has received $1.8 million in grants to support translational research for blood cancers, focusing on leukemia, AML, multiple myeloma, and long-term therapy effects. Researchers will investigate novel therapies and genomic diversity to develop targeted treatments.
Researchers developed a new prostate cancer screening method that combines drug therapy with changes in PSA levels to identify men with high-risk prostate cancer. The study showed that using PSA with these drugs can help differentiate between prostate cancer and benign disease, even in patients with difficult diagnoses.
Weill Cornell researchers develop a novel vaccine that protects mice against nicotine addiction, using the liver to continuously produce antibodies. The vaccine is designed to prevent nicotine chemicals from reaching the brain and heart, offering hope for smokers who struggle with addiction.
Weill Cornell researchers devise innovative boxer-like strategy to deliver one-two punch to multiple myeloma by weakening defenses and then killing cancer cells. The approach, using two anti-cancer drugs, shows potential for treating other tumor types.
The study reveals STING protein's double wing-like crystal structure that captures secreted molecules from invading pathogens, activating the body's powerful immune response. This discovery provides insights into how STING activates an immune response by engaging with specific molecular patterns linked to microbial pathogens.
Researchers found that high doses of nicotinamide riboside (NR) in mice fed a fatty diet led to significant weight loss, improved energy expenditure, and enhanced muscle performance. NR also prevented diabetes development and improved insulin sensitivity, all without toxicity.
Researchers discovered that cancer cells release exosomes containing pro-metastatic proteins that fuse with distant organs, establishing a nurturing environment for tumor growth. This discovery offers fresh diagnostic and treatment potential, including the use of exosomal protein profiles to predict tumor aggressiveness.
Weill Cornell Medical College researchers discovered that a chromosomal rearrangement in prostate cancer cells creates a new 'fusion' gene, warping DNA structure and triggering abnormal growth. The study suggests a model for how other chromosomal translocations contribute to cancer formation.
Researchers have identified a unique molecular subtype of prostate cancer associated with mutations in the SPOP gene, accounting for up to 15% of all cases. The study reveals that these mutations may lead to an accumulation of proteins driving cancer growth.
Researchers at Weill Cornell Medical College have identified a novel base modification in RNA, which pervades the transcriptome and affects up to 20% of human mRNA. The discovery reveals widespread effects on gene expression, with links to diseases such as cancer, autism, and schizophrenia.
Researchers discovered that alpha 2 delta determines calcium channel presence at synapses, controlling neurotransmitter release. The study found that increasing or decreasing alpha 2 delta levels can triple or reduce the number of channels.
A new study has identified the Nkx2.5 gene as the first gene linked to congenital asplenia, a rare condition where babies are born without a spleen and are at risk of fatal infections. The discovery raises hopes for genetic prenatal screening to alert parents to potential issues.
Researchers have identified two inherited-genetic deletions in the human genome that significantly increase a man's risk of developing aggressive prostate cancer. One deletion affects a known gene, while the other is found in non-coding DNA and regulates a cascade of genes.
Researchers have designed a powerful gene therapy strategy to treat beta-thalassemia and sickle cell anemia by transferring a healthy beta-globin gene into diseased cells. The new technique has shown promising results, with increased production of normal hemoglobin in patients.
A study published in NEJM shows that bariatric surgery dramatically improves type 2 diabetes remission rates, with 95% of patients undergoing BPD achieving remission and 75% of those receiving RYGB. The study's authors suggest that the mechanisms behind the surgery are key to improving diabetes control.
Researchers developed a computer program to track dementia spread in the human brain, predicting future cognitive declines. The model identifies neural sub-networks where misfolded proteins collect, altering normal brain function across affected areas.
A study published in JAMA found that the number of stroke victims transported via ambulance has remained relatively static over the years, emphasizing the importance of recognizing stroke symptoms and calling 911. Early treatment is possible with effective drugs and surgeries that can minimize brain damage from a stroke.
Researchers at Weill Cornell Medical College have developed a new tool to image small-molecule metabolites in living cells, offering clues about how to treat disorders. The technology uses modified RNA called 'Spinach' to sense levels of target metabolites in real-time.
Researchers at Weill Cornell Medical College found that a single protein, versican, is key to reversing the process of cancer metastasis in breast cancer. When versican was stopped from functioning, breast cancer could not seed itself into the lungs and form secondary tumors.
A study by NewYork-Presbyterian/Weill Cornell researchers has identified simple methods to detect consciousness in patients with severe brain injuries. Despite being unable to communicate, some patients can generate reliable patterns of brain activity in response to instructed commands.
Researchers found that daily positive affect and self-affirmation strategies helped patients make better decisions about their health. The interventions increased physical activity for coronary artery disease patients and improved medication adherence for those with high blood pressure.
Researchers found that HIV induces expression of the COX-2/prostaglandin E2 inflammatory pathway in cervical tissue samples from Haitian women. Aspirin's potential role in preventing cervical cancer is being explored as a simple and inexpensive solution for high-risk populations.
The FDA has established an international consortium of orthopedic registries to develop a unified method for analyzing and reporting multinational registry data. The ICOR aims to identify the best implants for patients worldwide, improving patient safety.
Researchers have developed a new tumor-targeting compound called PU-H71 that can reveal the complete set of aberrant signaling pathways driving cancers in individual patients. This breakthrough method uses the compound to identify abnormal proteins bound to heat shock protein 90, which are crucial for cancer cell growth and survival.
Researchers have developed a mouse model that can correct cleft lips, opening up possibilities for prevention and treatment of the condition. The study identified key genes and signaling pathways involved in facial development, including Wnt activity.
A new study reveals that nearly 40% of seniors receiving home health care are taking potentially inappropriate medications, often due to inadequate communication between physicians. The study highlights the need for improved medication coordination and enhanced physician communication in home health care settings.
Researchers have identified a genetic vulnerability in an aggressive type of prostate cancer, found in fewer than 2% of tumors but potentially treatable with targeted therapy. The study discovered that a specific drug, PHA-739358, showed dramatic responses in animal models and is now being tested in human trials.
A new study found that autism diagnoses vary significantly across different clinical centers, with varying use of subcategories like Asperger syndrome. The research suggests that a more standardized approach to diagnosing autism spectrum disorders would provide more accurate and consistent information about individual patients.
Researchers at Weill Cornell Medical College uncover biochemical signals that trigger generation of new lung alveoli in mice. The study identifies molecular triggers behind this process, which may be relevant to humans and potentially lead to treatment for chronic obstructive pulmonary disease (COPD).
Researchers uncovered a wide range of new insights into common diseases and their genetic basis, including cardiovascular and kidney disorders, diabetes, cancer, and more. The study provides details on the genetics behind these conditions and elucidates the role of individual differences in metabolism.
Researchers will study the role of folic acid in preventing neural tube defects, with the goal of developing individualized prevention strategies. The study aims to identify which genes are modified by folic acid levels and how those patterns can be used to assess risk for spina bifida.
A study published in PLoS Medicine found that early treatment of HIV significantly reduces mortality by 75 percent. The researchers also found that the benefits of early ART outweigh its costs, making it a cost-effective intervention in resource-poor settings.
A large clinical trial has found that intensive medical treatment is more effective than stenting in preventing a second stroke in patients at high risk. The study, funded by the National Institute of Neurological Disorders and Stroke, showed that patients who received aggressive medical management had significantly fewer strokes and d...
A 40-year follow-up study revisits preschool children who were tested with marshmallows and cookies, revealing that their ability to delay gratification remained consistent into adulthood. Brain imaging showed key differences between high and low delayers in the prefrontal cortex and ventral striatum.
Physician practices in the US spend significantly more time interacting with health insurers and payers, resulting in higher per capita health spending. The study found that if US physicians had similar administrative costs to those in Canada, it could save $27.6 billion per year.
Researchers at Weill Cornell Medical College developed an RNA mimic of green fluorescent protein called Spinach to track the mysterious workings of various forms of cellular RNA. This technology will help unlock secrets of RNA's diverse roles in human biology and disease.