A nationwide consortium of scientists has reported a comprehensive genetic analysis of squamous cell carcinoma of the lung, revealing almost 75% of patients' cancers have targetable mutations. The research provides insight into the molecular biology of lung squamous cell carcinoma and identifies potential targets for therapies.
Researchers have characterized the lung squamous cell carcinoma genome, identifying commonly known cancer genes and mutations that could be targeted therapeutically. The study, led by UNC Lineberger scientists, paves the way for developing better, more targeted treatments for this devastating disease.
A team of researchers developed an automated system to map protein-DNA interactions, uncovering a hierarchical structure for the regulatory code. They found that regulatory factors can be classified into three levels, with each tier governing cell type, sub-identity and specialized gene expression.
The AAO-HNSF 2012 meeting showcased groundbreaking research on smoking cessation, cochlear implants, and the relationship between childhood obesity and otitis media. New findings also explored music-induced hearing loss and the assessment of quality of life in bilateral cochlear implant patients.
Researchers used satellite radar images and GPS receivers to detect the 8-14 centimeter rise in the island's surface. The team calculated that the amount of molten rock beneath Santorini has grown by 10-20 years' worth, but this does not necessarily indicate an imminent eruption.
The AAO-HNSF 2012 new poster presentations cover various topics in otolaryngology, including rhinoplasty, facial trauma, and head and neck cancer. The studies aim to improve treatment outcomes and address common challenges in the field.
Researchers have discovered three new genetic regions linked to primary biliary cirrhosis, bringing the total number of known regions to 25. The study used Immunochip technology to survey the genome for signs of autoimmune disease susceptibility.
Researchers have identified several potential therapeutic targets for squamous cell lung cancer, including alterations in the TP53 and CDKN2A genes. These genetic changes may be susceptible to drug inhibition, providing new opportunities for clinical trials and potentially transforming treatment outcomes.
A new study shows that integrating on-site rapid HIV testing into drug treatment programs is cost-effective, with a beneficial cost-effectiveness ratio of $60,300 per QALY. This approach provides better value than off-site referral and can help identify more people infected with HIV.
The 2012 AAO-HNSF Annual Meeting featured cutting-edge research on aging, sleep apnea, chronic rhinosinusitis, and hearing loss. Attendees could access approximately 100 miniseminars, 250 scientific sessions, and 445 posters.
New research suggests that more than 400 terrawatts of power can be extracted from surface winds and over 1,800 terrawatts from high-altitude winds, meeting or exceeding global energy demand.
An international team of scientists has shown at an unprecedented level of detail how cells prioritize the repair of genes containing potentially dangerous damage. Cells use proteins to detect and replace damaged DNA, with critical steps at individual protein reads likely critical for successful repair.
Researchers at OHSU's Vaccine and Gene Therapy Institute studied the mechanism behind protection offered by slightly weakened monkey AIDS virus versions that were too risky for human use. The study reveals that anti-viral T cells in lymphoid tissue are responsible for this protection, which is lost when the virus is further weakened.
A new analysis examines the effects of widespread forest die-offs on ecosystem processes, species diversity, and human services such as water purification and real-estate property values. The study highlights the need for a multidisciplinary approach to understand the complex consequences of climate-driven forest mortality.
Researchers tracked parasite-induced disease and death in reintroduced wolf packs in Yellowstone National Park, finding that mange did not infect wolves until 2007. The diseases that infected the wolves quickly were all viral, including canine distemper and parvovirus, while mange is a skin infection caused by scabies mites.
Researchers have developed a novel oral antiseptic spray, Halo, effective in killing 99.9% of infectious airborne germs, including influenza and rhinovirus. The spray prevents germs from entering the system and kills them, providing sustained protection for up to six hours.
A multi-national team of researchers has identified genetic variations on chromosomes 6p21 and 16q24 associated with Barrett's oesophagus. The discovery provides a basis for genetically screening individuals at high risk, as well as developing new therapy targets.
A Swiss-American team has developed a simple, inexpensive system to detect heavy metal pollutants like mercury in water and fish. The new method uses nanoparticles with tiny hairs that can trap toxic substances, enabling accurate measurements at unprecedentedly small concentrations.
Researchers identified 33 genes associated with GAA/TTC repeat instability and expansions in yeast. These findings may have implications for human disease due to the conservation of genetic machinery across species.