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Scientists create viable, reproducing yeast-cyanobacterial hybrids

Researchers at the University of Illinois have successfully engineered artificial photosynthetic life-forms through endosymbiosis between cyanobacteria and yeast. The engineered chimera can survive and reproduce under optimal conditions, shedding light on the evolutionary origins of eukaryotic cells.

SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalNature Communications·TypeExperimental study·DateMay 2, 2022

Exploiting parasitic yeast to kill yeast pathogens

Researchers discovered a parasitic yeast species that can kill emerging multi-drug resistant yeast pathogen Candida auris. The study identified genes and proteins involved in the predatory behavior of Saccharomycopsis schoenii, which could lead to new biocontrol agents or novel antifungal agents.

SourcePLOS·JournalPLOS Pathogens·DateMay 9, 2019

Fungi cause brain infection and impair memory in mice

Researchers found that Candida albicans can cross the blood-brain barrier, triggering an inflammatory response and forming granuloma-type structures, leading to temporary memory impairments in mice. The findings also suggest a possible link between fungal infections and chronic neurodegenerative disorders like Alzheimer's disease.

SourceBaylor College of Medicine·JournalNature Communications·DateJan 4, 2019

Expanding the stable of workhorse yeasts

A team of researchers has sequenced the genomes of over 29 yeast species, revealing a wider diversity than expected. The study identifies new genetic pathways and enzymes that can be used to produce biofuels and other valuable products from a range of sugars.

SourceDOE/Joint Genome Institute·JournalProceedings of the National Academy of Sciences·DateAug 15, 2016

Lichen: Apparently happy couple really a threesome

Researchers discovered yeast living in the cortex of lichen species, suggesting a possible role in creating large structures and solving the mystery of why macrolichens are hard to grow in the lab. The study found a variety of yeast species associated with different lichen species from around the world.

SourceCIFAR·JournalScience·DateJul 22, 2016

Fungi must die

Researchers from Lomonosov Moscow State University develop method to suppress fungal resistance to antifungal drugs by targeting ABC-transporters. The discovery has potential to improve effectiveness of antifungal medications and combat growing multidrug-resistant fungal strains.

SourceLomonosov Moscow State University·JournalFEMS Yeast Research·DateApr 21, 2016

How yeast makes heads or tails of itself

Researchers at the University at Buffalo discovered how yeast cells decide their direction of growth, revealing the concept of polarity and its role in propelling single-celled organisms forward. The study found that Bud proteins play a crucial role in determining cell orientation, adapting to changes in nutrient availability.

SourceUniversity at Buffalo·JournalProceedings of the National Academy of Sciences·DateMar 21, 2016

Powerful drug's surprising, simple method could lead to better treatments

Researchers at the University of Illinois have debunked a widely held misconception about an often-prescribed drug, discovering that it works by binding to a lipid molecule essential to yeast's physiology. This finding could lead to better treatments for fungal infections and diseases caused by ion channel deficiencies.

SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalProceedings of the National Academy of Sciences·DateJan 16, 2012

'My dishwasher is trying to kill me'

A study found 62% of dishwashers contain fungi on the rubber band in door, including polyextremotolerant black yeasts that can tolerate high temperatures, salt concentrations, and detergents. These extremophilic fungi pose a significant risk to human health due to their potential for causing fatal infections.

SourceElsevier·JournalFungal Biology·DateJun 20, 2011

Researchers at Case Western Reserve discover a new way the body fights fungal infection

Researchers at Case Western Reserve University have identified a critical role of interleukin-1β in protecting against oral colonization by Candida albicans. The study found that IL-1β is secreted by human immune cells in response to Candida infection and helps modulate the immune system, providing new avenues for therapeutic targets.

SourceCase Western Reserve University·JournalCell Host & Microbe·DateJun 11, 2009

Beating hospital yeast infection

A systematic review of over 5,500 patients found that both single-drug antifungal prophylaxis (SAP) and selective digestive tract decontamination (SDD) reduce yeast-related morbidity and mortality. SDD was more effective in reducing yeast colonization and infection, while SAP responded best to candidemia.

SourceBMC (BioMed Central)·JournalCritical Care·DateDec 5, 2007

Prion propagates in foreign host

Researchers have successfully propagated a prion from one organism into another, expanding our understanding of these infectious proteins and their role in fatal neurodegenerative diseases. The discovery opens up new avenues for studying prion propagation and highlights the need to search for additional prions.

SourceUniversity of Illinois Chicago·JournalMolecular Cell·DateJul 5, 2007

Hives ferment a yeasty brew, attract beetle pest

Researchers found that small hive beetles can detect some alarm pheromones at levels below those detected by honeybees. The beetles associate the alarm chemicals with a good food source and head for the hive. Domesticated European honeybees are not as diligent in cleaning their hives, making them more susceptible to infestation.

SourcePenn State·JournalProceedings of the National Academy of Sciences·DateMay 16, 2007

Biologists ID defense mechanism of leading fungal pathogen

Researchers at Rice University have discovered the genetic basis of Candida's defense mechanism against nitric oxide, a key player in slowing down yeast growth. The study identifies a specific gene that allows Candida to sense NO levels and ramp up its defenses, providing a potential target for new drug therapies.

SourceRice University·JournalEukaryotic Cell·DateJun 25, 2004

Scientists develop 'super peptide' that kills Candida albicans

Researchers at Zengen developed a 'super peptide' that kills Candida albicans with high candidacidal activity, outperforming existing antimicrobial peptides. The discovery may help understand the unique mechanism of action of a-MSH peptides and unlock new treatments for fungal infections.

SourceZengen·JournalJournal of Materials Chemistry·DateFeb 20, 2003