Articles tagged with Yeasts
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Researchers found that Candida albicans can cross the blood-brain barrier, triggering an inflammatory response and forming granuloma-type structures, leading to temporary memory impairments in mice. The findings also suggest a possible link between fungal infections and chronic neurodegenerative disorders like Alzheimer's disease.
Scientists have identified the biochemical pathway that allows bioluminescent fungi to light up and created an artificially luminescent eukaryote by inserting the necessary genes into a non-glowing yeast. The discovery could lead to widespread applications, including glowing plants and animals.
Researchers found that dark-pigmented yeasts capture more heat from the sun and thrive in colder conditions than their light-colored counterparts. This 'thermal melanism' effect could help predict microbial survival at different latitudes as temperatures rise.
The study used baker's yeast expressing fluorescent proteins fused with membrane transporters to investigate fungal drug resistance mechanisms. The results showed that the resistance of yeast to antimycotic agents is more complex than previously thought, involving hyperactivation of ABC-transporters and xenobiotic sensors.
Scientists propose a new strategy using insect-yeast ecology to inform the search for industrially relevant yeasts. Insects are drawn to yeasts due to their sugar presence, and these mutualistic relationships can lead to yeast deposition in new environments.
Researchers developed a yeast-based tool that can detect fungal pathogens responsible for major human disease, agricultural damage, and food spoilage. The one-component biosensor is extremely low-cost, easy to use, and doesn't require cold-storage facilities, making it a game-changer for global pathogen surveillance.
Researchers at Imperial College London have successfully engineered baker's yeast to produce penicillin molecules, demonstrating the effectiveness of synthetic biology in discovering new antibiotics. The study could lead to the development of novel antibiotics and anti-inflammatories using re-engineered yeast cells.
A team of researchers has sequenced the genomes of over 29 yeast species, revealing a wider diversity than expected. The study identifies new genetic pathways and enzymes that can be used to produce biofuels and other valuable products from a range of sugars.
Researchers discovered yeast living in the cortex of lichen species, suggesting a possible role in creating large structures and solving the mystery of why macrolichens are hard to grow in the lab. The study found a variety of yeast species associated with different lichen species from around the world.
Researchers have uncovered yeast as a hidden third partner in lichen symbiosis, producing chemicals that help ward off predators and repel microbes. This discovery explains the genetic similarities between genetically identical lichens with distinct physical features.
Researchers from Lomonosov Moscow State University develop method to suppress fungal resistance to antifungal drugs by targeting ABC-transporters. The discovery has potential to improve effectiveness of antifungal medications and combat growing multidrug-resistant fungal strains.
Researchers at the University at Buffalo discovered how yeast cells decide their direction of growth, revealing the concept of polarity and its role in propelling single-celled organisms forward. The study found that Bud proteins play a crucial role in determining cell orientation, adapting to changes in nutrient availability.
Research reveals that yeast species and fungal communities on grape surfaces can create differences in wine flavor even among grapes from the same vineyard. The study's findings suggest that viticulturalists and winemakers can plan microharvests better and implement more consistent wine blending strategies.
Researchers at the University of Illinois have debunked a widely held misconception about an often-prescribed drug, discovering that it works by binding to a lipid molecule essential to yeast's physiology. This finding could lead to better treatments for fungal infections and diseases caused by ion channel deficiencies.
Researchers found that injecting mice with killed baker's yeast protected them from fatal aspergillosis and reduced infection load. The study suggests a 'panfungal' vaccine could protect against multiple fungal infections in immunocompromised individuals.
A study found 62% of dishwashers contain fungi on the rubber band in door, including polyextremotolerant black yeasts that can tolerate high temperatures, salt concentrations, and detergents. These extremophilic fungi pose a significant risk to human health due to their potential for causing fatal infections.
Scientists have isolated an improved variant of yeast Cryptococcus flavescens that tolerates fungicide and is being evaluated as a biocontrol agent. This yeast has shown promise in reducing scab damage by up to 85% when combined with other fungicides.
A research team at Worcester Polytechnic Institute found that yeast produce a plant hormone called indole-3-acetic acid (IAA) that can trigger fungal cells to become more infectious. The hormone is known to regulate plant growth, but its presence in sufficient quantity within the yeast's environment also triggers morphogenic transition...
Researchers have found a yeast called Pichia anomala that can compete with unwanted mold Aspergillus flavus for nutrients and space, reducing aflatoxin contamination in tree nuts by up to 97%. The versatile yeast may also protect other crops from various microorganisms.
Researchers have identified a three-pronged mechanism of the human immune system attacking fungal yeast cells, including recognition of specific cell wall components and glucan targets. Understanding these interactions could lead to effective immunotherapy and new treatments for patients with weakened immunity.
Researchers discovered that Candida albicans, a human fungal pathogen, engages in same-sex mating alongside traditional opposite-sex mating. This finding expands understanding of sex mechanisms in microbial species and suggests increased opportunities for sex in natural populations.
Researchers at Case Western Reserve University have identified a critical role of interleukin-1β in protecting against oral colonization by Candida albicans. The study found that IL-1β is secreted by human immune cells in response to Candida infection and helps modulate the immune system, providing new avenues for therapeutic targets.
Scientists discovered that Cryptococcus yeast cells hide inside macrophages and use them as vehicles to travel through the body before attacking and spreading. This new escape mechanism allows the yeast cells to evade antifungal drugs and the immune system, making fatal infections harder to treat.
A systematic review of over 5,500 patients found that both single-drug antifungal prophylaxis (SAP) and selective digestive tract decontamination (SDD) reduce yeast-related morbidity and mortality. SDD was more effective in reducing yeast colonization and infection, while SAP responded best to candidemia.
Researchers have successfully propagated a prion from one organism into another, expanding our understanding of these infectious proteins and their role in fatal neurodegenerative diseases. The discovery opens up new avenues for studying prion propagation and highlights the need to search for additional prions.
Researchers found that small hive beetles can detect some alarm pheromones at levels below those detected by honeybees. The beetles associate the alarm chemicals with a good food source and head for the hive. Domesticated European honeybees are not as diligent in cleaning their hives, making them more susceptible to infestation.
Researchers have discovered critical regions within prions that determine much of their behavior, providing a new framework for exploring prion biology. These regions, known as recognition elements, can be activated by environmental conditions and amino acid sequence alterations.
A Lancet study found that Pfizer's Vfend is an effective alternative to a two-drug candidemia regimen, with comparable efficacy but fewer serious side effects. The treatment was found to be more tolerable, particularly in reducing renal toxicity and visual disturbances.
Researchers found that urine's limited niacin triggers Candida glabrata's adhesion-promoting genes, allowing it to stick to host cells. The study provides insights into the mechanism of C. glabrata's adherence to mucosal tissues and blood vessels.
Researchers at Rice University have discovered the genetic basis of Candida's defense mechanism against nitric oxide, a key player in slowing down yeast growth. The study identifies a specific gene that allows Candida to sense NO levels and ramp up its defenses, providing a potential target for new drug therapies.
Researchers at Zengen developed a 'super peptide' that kills Candida albicans with high candidacidal activity, outperforming existing antimicrobial peptides. The discovery may help understand the unique mechanism of action of a-MSH peptides and unlock new treatments for fungal infections.