Articles tagged with Malaria
Malaria eradication remains an elusive goal despite progress in controlling the disease, requiring multiple activities, interventions, and approaches. Scientists must adapt their strategies to address changing parasite behavior and distribution, developing new tools and interventions to keep ahead of emerging challenges.
Research published in the UK-based urology journal BJUI found that women exposed to DDT spraying were more likely to have sons with urogenital birth defects, which can cause missing testicles or problems with their urethra or penis. The study suggests that prolonged exposure to DDT may increase the risk of these defects.
Researchers at Vanderbilt University have received funding from the Gates Foundation to develop a simple and low-cost diagnostic test for malaria using the coffee ring stain phenomenon. The test has the potential to be more reliable and shelf-stable than existing methods, which require refrigeration and highly trained technicians.
Researchers have charted extreme genetic differences in the malaria parasite, which could make it difficult to develop a broadly protective vaccine. The study found that certain regions of the protein are recognized by the immune response, allowing researchers to narrow their focus and reduce the number of immunologically important types.
Scientists have discovered a gene behind malaria-resistant mosquitoes, which could lead to new tools for controlling malaria transmission in endemic areas. The study found that a single section of one chromosome contains a gene called TEP1 that promotes the killing of malaria parasites in mosquitoes.
A new method of biocontrol using fungal biopesticides may be an effective means of reducing malaria transmission, particularly when used in combination with insecticide-treated bednets. The study suggests that this approach can substantially reduce malaria transmission rates and help manage insecticide resistance.
Research published in BMC Public Health found that older children are least protected by mosquito nets, putting them at high risk of developing life-threatening malaria. The study suggests that ensuring universal coverage for this age demographic is crucial to reduce transmission and impact on the community.
Canada faces a pressing challenge to address the deteriorating progress towards Millennium Development Goals (MDGs). The Lancet urges Canada to make significant contributions in five key areas: health system strengthening, climate change, peace through health, Indigenous Health, and establishing a Canadian Health Action Network for Glo...
Introduced Japanese white-eyes are depleting food sources, causing stunted growth and higher death rates among native Hawaiian birds. This is leading to increased susceptibility to diseases like malaria and chewing lice, further threatening the already endangered species.
A recent study found that intermittent preventive malaria treatment in African infants is both safe and effective, with sulfadoxine-pyrimethamine providing protection for up to 6 weeks. However, the use of this drug is limited by potential resistance and its risks. New long-acting antimalarial drugs are urgently needed for this strategy.
A recent study published in Clinical Infectious Diseases reveals key laboratory and clinical features of human P. knowlesi infections, confirming the potentially deadly nature of the disease. The research found that P. knowlesi malaria can cause a wide spectrum of disease, including breathing difficulties and kidney problems.
Researchers found that house screening reduced mosquito numbers by 49-59% and malaria-related anaemia in children by half. The authors suggest integrating house screening into vector management programs to combat malaria.
A new analysis reveals that neglected tropical diseases (NTDs) in sub-Saharan Africa cause immense suffering, with helminth infections accounting for approximately 85% of the NTD burden. The study suggests that investing $200-$400 million annually could significantly reduce the burden of these diseases.
Researchers at McGill University Health Centre have discovered the mechanism by which hemozoin activates the immune system, leading to inflammation and fever in malaria patients. The study provides a new direction for developing vaccine-like treatments to limit the severity of the disease.
Dr. Nicholas J. White receives the sanofi-aventis ICAAC Award for his work on artemisinin-based combination treatments and reduction of malaria transmissibility, leading to a significant decrease in global malaria morbidity.
Researchers at Instituto Gulbenkian de Ciencia discover that an enzyme called heme oxygenase-1 (HO-1) protects mice from developing severe forms of malaria. An anti-oxidant drug, N-acetylcysteine (NAC), has the same effect on Plasmodium-infected mice.
Researchers found that daily temperature fluctuations significantly impact malaria parasite growth and transmission rates. In areas with cooler temperatures, a fluctuation of 45 degrees Fahrenheit reduces the parasites' incubation period, making them infectious nearly two weeks earlier.
Researchers believe a parasite found in chimpanzees in equatorial Africa is the original source of malignant malaria, transmitted to humans through a single mosquito around 5,000 years ago. This discovery could aid the development of a vaccine for malaria, which affects 500 million people annually.
Scientists developed a novel immunization method that induces complete protection against the life-threatening malaria parasite in humans. The method allowed the human immune system to target the parasite at an earlier stage of its life cycle, resulting in significant improvement over other experimental malaria vaccines.
Researchers found malaria parasites in western Cambodia resistant to artemisinin-based therapies, making them less effective and a potential game-changer for malaria control. The study's findings highlight the need for swift action to contain the spread of resistant parasites.
Scientists have created a weakened strain of the malaria parasite that will be used as a live vaccine against the disease. The vaccine, developed in collaboration with researchers from the US, Japan and Canada, will be trialled in humans from early next year to provide protection against deadly malaria.
Case Western Reserve researchers found that prenatal exposure to Plasmodium falciparum results in parasite tolerance, increasing susceptibility to malaria and anemia in young children. The study identified three groups: sensitized, exposed-not-sensitized, and not-exposed, with the latter group having a higher risk of malaria infection.
A study found that babies exposed to malaria before birth are more susceptible to the disease and anemia, while others develop a tolerant phenotype. This finding has implications for malaria vaccine design and prevention strategies during pregnancy.
Researchers have developed a malaria vaccine that effectively blocks the parasite's sexual development, critical for transmission. The vaccine induced a significant immune response in mice and non-human primates, with a 93% transmission-blocking rate after a single dose.
Researchers at University of Nottingham found that quinine blocks cell's ability to take up tryptophan, a key amino acid. Dietary tryptophan supplements may improve quinine performance and combat side effects.
Researchers found that quinine blocks cells' ability to take up essential amino acid tryptophan, leading to adverse side effects. Dietary tryptophan supplements may help alleviate these issues by improving quinine's effectiveness against malaria parasites.
Researchers at Duke University have found that variation in a single gene influences baboons' susceptibility to a closely related parasite, similar to its impact on humans. The study's findings provide a unique example of how the same genetic mechanism can confer resistance to different parasites.
Nearly half of the world's population is at risk of malarial infection, causing over 250 million clinical episodes and one million deaths each year. Researchers identified key challenges in developing a protective malaria vaccine, including identifying which proteins provoke a strong immune response.
A new species of malaria parasite, Plasmodium gaboni, has been discovered in chimpanzees in Central Africa. The parasite is closely related to the human malaria agent Plasmodium falciparum and sequencing its nuclear genome may help discover new potential drug targets.
Honeycreepers' high-altitude refuges are vulnerable to disease invasion and habitat loss as temperatures rise, putting species at risk of extinction. The USGS predicts that climate change will displace these refuge areas, forcing birds to migrate into higher disease transmission zones.
Researchers from Heidelberg University Hospital have discovered that combining methylene blue with newer malaria medications is twice as effective in curbing the spread of malaria parasites than standard therapy. This new approach has significant implications for eradicating the disease, particularly among children under five who are m...
A GIS-driven digital map pinpointed malaria outbreak hotspots in Madhya Pradesh, leading to a 5% reduction in cases. The system enabled timely preventive action and dynamic data updating, highlighting the effectiveness of electronic monitoring and mapping in malaria management.
Researchers at Johns Hopkins University School of Medicine have discovered a natural compound that can stop malaria parasite growth, interacting with the parasite's MetAP2 protein. The compound, fumarranol, was found to be less toxic than existing medications and showed promise in treating malaria in mice.
A £1.1m grant will lead the development of a Field Applicable Screening Tool (FAST) kit to detect insecticide resistance in mosquitoes, crucial for effective malaria control in sub-Saharan Africa. The project aims to identify genes that render mosquitoes resistant to key insecticides.
Researchers found that bacteria in mosquito's gut inhibit infection with Plasmodium falciparum, the malaria parasite. The study suggests that the microbial flora of mosquitoes stimulates immune activity protecting them from malaria infection.
The European and Developing Countries Clinical Trials Partnership (EDCTP) has awarded €11 million to the MiP Consortium to investigate new approaches to prevent and treat malaria in pregnancy. Researchers aim to develop more effective interventions that can prevent up to 50 million women at risk every year, saving lives and reducing ma...
A team of Penn State entomologists is searching for an insect disease that will infect mosquitoes and impair their sense of smell. By doing so, they hope to reduce the ability of infected mosquitoes to find human hosts and transmit malaria.
Vanderbilt University has received a $100,000 Grand Challenges Explorations grant to target the thermal receptors in Anopheles gambiae mosquitoes, disrupting their ability to find prey and potentially eradicating malaria. The project aims to identify small molecules that can block or over-stimulate these thermal detectors.
A panel of experts reviewed studies on the link between DDT and human health, expressing concern over high levels of exposure in regions where malaria is endemic. They called for increased efforts to reduce exposure and develop alternatives to using DDT.
Scientists at Karolinska Institutet have developed a simple blood test that provides accurate results, helping to ensure patients receive the right treatment. The rapid diagnostic tests (RDT) are being used in low-income countries to improve healthcare outcomes and combat malaria.
A study in Zanzibar found that rapid malaria tests reduced prescriptions of antimalarial drugs and increased treatment for non-malarial causes, while also lowering reattendance rates due to perceived lack of cure. The results suggest improved health outcomes with routine use of these tests.
A literature review suggests that global health initiatives and agencies claim to support health system strengthening but often fail to deliver. The study examines the claims made by major global health actors, such as WHO and UNAIDS, and finds a gap between their language and actual activities.
The Malaria Elimination Group provides a roadmap for countries pursuing malaria elimination, reviewing operational, technical and financial decisions. The guidance aims to support countries in achieving universal coverage of preventive and treatment measures by 2010.
A subset of immune cells has been found to contribute to the development of severe malaria by suppressing the immune system and allowing parasites to grow uncontrollably. This discovery could lead to new drug targets and immunotherapies against malaria, as well as insights into other inflammatory diseases.
In the past two years, significant strides have been made in malaria control and elimination, with many countries setting ambitious strategies to achieve low transmission and mortality rates. Research into vaccines, drugs, and other interventions continues to flourish, offering hope for a future malaria-free world.
Researchers have discovered different resistance mutations in east and west Africa, suggesting varying effectiveness of sulfadoxine as an antimalarial drug. Coordinating malaria control efforts across socioeconomically linked areas may be more effective in reducing the malaria burden across the continent.
Resistance to the antimalarial drug sulfadoxine has emerged independently in multiple sites across Africa over the past decade. The study suggests that coordinated control campaigns may be more effective in reducing the African malaria burden by addressing regional differences in parasite strains and levels of resistance.
Researchers at Virginia Tech have received a $3.557 million grant from NIAID to develop vector-specific, resistance-breaking insecticides that could render traditional ITNs ineffective. The new compounds are designed to be safer for humans while maintaining significant insecticidal activity against malaria mosquitoes.
A randomized controlled trial in Kampala showed that home delivery of prepackaged artemether-lumefantrine had little effect on clinical outcomes and led to overuse of the drug. The study suggests that standard care in health facilities is a more effective approach, especially in urban areas with low malaria transmission.
Late-acting insecticides targeting older mosquitoes show potential to reduce malaria transmission by 95% and slow down resistance. The approach could lead to evolution-proof insecticides that never become obsolete.
Researchers have discovered a new approach to controlling malaria by killing only older mosquitoes, reducing the selection for resistant insects. This method could lead to evolution-proof insecticides that never become obsolete, saving millions of dollars in development costs.
A new review sparks debate over climate change's effect on pathogens, with some arguing it may reduce their ranges in affluent regions. However, others believe disease expansion could occur in areas where humans settle high latitudes and altitudes.
A Tanzanian study found that using larvicides to complement existing malaria interventions can dramatically reduce malaria risk, especially in urban areas. The approach is cost-effective and could help control the disease in cities where it poses a significant problem.
A detailed malaria risk map published by the Wellcome Trust shows that three-quarters of the world's high-risk areas have low transmission rates, making malaria control more feasible. The map, developed using state-of-the-art technology, pinpoints malaria risk to an unprecedented resolution of 25km2.
The study provides a comprehensive map of global malaria endemicity, revealing areas where malaria control can be improved and areas where elimination may be possible. The map uses model-based geostatistics to incorporate data from local surveys, providing an important resource for policymakers and researchers.
A team of scientists has developed an automated carbohydrate synthesizer, allowing them to build complex carbohydrates in a few hours. This innovation could lead to the creation of new vaccines and treatments for diseases such as malaria and HIV.
Researchers identified a novel pathway contributing to severe malaria's high mortality in sub-Saharan African children. Disrupted endothelium causes ultra-large von Willebrand factor release, leading to ADAMTS13 inhibition. This study sheds new light on the interaction between malaria parasites and their human host.
Researchers identified a molecular pathway that triggers an immune response in multiple mosquito species, blocking the development of malaria-causing parasites. By activating transcription factor Rel 2, mosquitoes were able to mount an efficient defense against Plasmodium falciparum.
Researchers have discovered a new way the malaria parasite interacts with human red blood cells, identifying the EBL-1 molecule as the attachment site. This finding could lead to the development of a vaccine cocktail to combat malaria.
Researchers at the University of Gothenburg have developed a new method to describe and quantify relationships between dose, concentration, and effectiveness of drugs against HIV/AIDS and malaria. The study found that genetic differences can influence efavirenz metabolism and that reducing daily doses can minimize undesired effects.