Parasitic Diseases
Articles tagged with Parasitic Diseases
Can new research findings help overcome challenges to malaria treatment?
Researchers have identified PEG400 as a potential antimalarial therapy by targeting the malaria parasite's enzyme Falcipain-2. This study offers hope for selective and cumulative benefits in reducing malaria treatment challenges.
Clinical trial using a controlled human infection model paves way for an effective vaccine against hookworm disease
A phase 2 human clinical trial of a hookworm antigen has shown effective in limiting the intensity of infection, paving the way for a vaccine. The study found that vaccination with Na-GST-1 reduced the severity of infection in participants.
Professor helps uncover widespread genetic exchange in disease-causing parasites
A study published in the Proceedings of the National Academy of Sciences found that over 70% of Leishmania parasite isolates showed evidence of genetic mixing, indicating sexual reproduction and hybridization play a major role in their evolution. This challenges longstanding assumptions about the reproduction mechanisms of these parasi...
Shedding light on how parasites exit host cells
A team from The University of Osaka has identified the MIC11 gene as essential for parasite egress, disrupting the parasite life cycle. This finding could guide the development of novel treatments for parasite-borne diseases.
Parasitic tapeworm — a risk to domestic dogs and humans — found in Washington coyotes
A disease-causing tapeworm has been detected in Washington coyotes, which can spread to domestic dogs and humans if ingested through contaminated food or feces. The parasite's life cycle involves multiple hosts, including rodents and other canid species, making it a public health threat.
FAU study finds parasites defy biodiversity rules, thriving far from the equator
Researchers found that trematode parasites are more abundant in cooler temperate waters, defying the typical pattern of higher biodiversity near the equator. Temperature and host mobility play a major role in shaping parasite distributions, with certain species thriving in areas where hosts can tolerate infections better.
Study illuminates benefits of red blood cell exchange in severe babesiosis
A multicenter study found that red blood cell exchange transfusion significantly improves clinical outcomes for patients hospitalized with severe babesiosis, a potentially life-threatening tick-borne infection. The procedure was associated with substantially lower risk of in-hospital death or readmission.
University of York scientists solve 40-year-old biological mystery behind Sleeping Sickness
Researchers at the University of York have discovered a protein that allows the African trypanosome parasite to evade detection by destroying specific parts of its genetic instructions. This breakthrough provides new vulnerabilities for future treatments and could revolutionize our understanding of infection.
Malaria-transmitting mosquitoes in South America evolving to evade insecticides
A new study by Harvard T.H. Chan School of Public Health found that Anopheles darlingi mosquitoes are evolving to evade insecticides, threatening malaria control efforts in South America. The study sequenced complete genomes of over 1,000 mosquitoes across six countries and identified resistance-related genes.
New research explains how the gut detects parasites and triggers sickness response
Researchers at Adelaide University have discovered a new gut–brain signalling pathway that governs how parasitic infections lead to nausea, appetite loss and other sickness symptoms. The study shows two specialised gut cell types work together to sense parasites and activate protective responses through the vagus nerve.
First Chagas disease conference on US soil highlights a turning point in national awareness
The inaugural US-based Chagas disease conference will strengthen research and patient care efforts in the US, building on recognition of the disease as a national concern. Approximately 300,000 Americans are infected with Chagas disease, and improved surveillance, testing, and research can help address severe heart complications.
Ticks carrying more than one pathogen are on the rise in US Northeast
A recent study by the Cary Institute of Ecosystem Studies reveals a concerning trend of ticks carrying multiple pathogens in the US Northeast. More than 1 in 10 nymphal ticks tested positive for at least two disease-causing pathogens, with co-infection rates approaching 11% for Lyme disease and babesiosis. This increase in co-infection...
Scientists identify key protein that stops malaria parasite growth
Researchers have identified a unique protein named Aurora-related kinase 1 (ARK1) essential for the malaria parasite's survival and transmission. Turning off ARK1 in the lab causes replication to fail, preventing disease progression and transmission.
New study on avian malaria finds most of Hawaii’s birds contribute to deadly pathogen’s transmission
A new study reveals that both non-native and native birds play a key role in the transmission of avian malaria, which has contributed to the extinction of over a dozen species of Hawaii's native birds. The disease is transmitted by mosquitoes and infects birds' red blood cells, leading to low blood oxygen levels and damage to organs.
Scientists find hidden diversity inside common brain parasite
A study by UC Riverside scientists reveals that the cysts of Toxoplasma gondii contain multiple distinct subtypes of parasites, each with different biological roles. This discovery offers new insights into how the parasite causes disease and why it has been difficult to treat.
High levels of Chagas disease parasite found in bugs near U.S.-Mexico border
A UTEP study has discovered a significant increase in parasitic infection rates among kissing bugs in the Borderlands, raising concerns about local transmission of Chagas disease. The research suggests that the disease is becoming an increasingly public health issue for the Southwest, affecting approximately 6 million people worldwide.
Roman soldiers defending Hadrian’s Wall infected by parasites, study finds
A new study found that Roman soldiers at Vindolanda fort near Hadrian's Wall were infected with intestinal parasites, including roundworms, whipworms, and Giardia duodenalis. This suggests inadequate sanitation and hygiene practices, potentially leading to malnutrition and chronic infections.
Pandemic ‘beneath the surface’ has been quietly wiping out sea urchins around the world
A study found that a global pandemic is quietly wiping out sea urchins around the world, with populations nearing local extinction in the Canary Islands. The 2022-2023 mass mortality event affected the entire population of the species across the archipelago, causing a 74% decrease in La Palma and a 99.7% decrease in Tenerife.
Researchers warn: Climate change could expand habitats for malaria mosquitoes
A new study from the University of Copenhagen predicts that climate change could create more favorable conditions for malaria mosquitoes, exposing millions to increased risk of infection. The researchers warn that if left unchecked, this could put between 200 million and up to 1 billion people at additional risk.
How does a parasitic nematode infect a wide variety of plants?
A 15-member research team has gained insight into the DNA of the Northern root-knot nematode, a parasitic nematode that causes significant economic damage to many crops. The study reveals an unusual DNA repeat at the ends of its chromosomes, which may provide a clue to its ability to infect a wide range of plants.
Stinky socks help replace human bait in surveys for blinding disease – new research
A new study by Sightsavers and GLIDE has found that using worn socks with yeast-generated CO2 is as effective as traditional methods for catching blackflies that spread river blindness. The research could provide an alternative to 'human bait' and reduce the risk of disease transmission, offering communities long-term protection.
Mathematicians model the menace of mosquitoes
Researchers have created a model that can handle complex mosquito behavior and its impact on human diseases. The study reveals surprising findings, such as it may be better to let a mosquito bite you in terms of overall transmission.
USF study: AI and citizen science reveal potential first detection of invasive malaria mosquito in Madagascar
Researchers from the University of South Florida have used artificial intelligence and citizen science to identify what may be the first specimen of Anopheles stephensi — an invasive and deadly malaria-carrying mosquito — ever detected in Madagascar. The study demonstrates how AI-powered image recognition and public participation can t...
Winners of Applied Microbiology International Horizon Awards 2025 announced
The winners of the Applied Microbiology International Horizon Awards 2025 have been recognized for their groundbreaking contributions to global challenges through applied microbiology. The awards celebrate excellence across various domains, including drug discovery and sustainable agriculture.
University of Houston professor awarded $3.9 million to fight deadly parasites that threaten children and immunocompromised adults
A University of Houston professor has received funding to develop effective treatments for Cryptosporidium infections, which cause severe diarrhea and have no existing cure. The team aims to design drugs that target the parasite's enzyme CDPK1 to minimize systemic exposure and maximize efficacy.
Natural antimicrobial drugs found in pollen could help us protect bee colonies from infection
Researchers have discovered that the same beneficial bacteria occur in pollen stores of honeybee colonies and on nearby plants, producing compounds that kill pathogens of bees and plants. These endophytes can be used to develop new treatments for crops and hives.
A promising treatment for leishmaniasis found in Okinawan marine sponges
Researchers discovered onnamides, a family of compounds from Okinawan marine sponges, showing remarkable potential against Leishmania major. These compounds demonstrate potency and safety exceeding current treatments, offering new approaches to overcome drug resistance.
Gut infections often overlooked in men who have sex with men
A new review article highlights the need for effective control and prevention strategies for sexually transmitted gut infections, which can persist longer and be harder to treat. The authors emphasize the importance of prompt diagnosis, appropriate treatment, and community-level education and testing.
Kiss goodbye to deadly disease – new research finds antibodies for killer parasite
Researchers have successfully produced antibodies that kill the parasite carried by the 'kissing bug' that causes the potentially deadly Chagas disease. These antibodies target the parasite's infective stage and show neutralization rates exceeding 95%, making them a key step towards developing an effective vaccine.
Researchers are inching closer to stopping parasitic worms from getting under your skin
A UCLA research team has discovered a key mechanism that allows parasitic worms to penetrate human skin and is now exploring a topical preparation to disrupt this pathway. The therapy aims to prevent infection by targeting the same molecule associated with pleasure in humans, but which drives parasite entry.
Tackling neglected tropical diseases among migrant populations
A study published in PLOS Neglected Tropical Diseases has shown that combining country-level information with individual-level variables can improve the identification of soil-transmitted helminth infections among migrant populations. Researchers found that country-level indicators are stronger predictors than individual-level variable...
Pitt study uncovers how the immune system fends off gut parasites
Researchers discovered a new pathway to boost immunity against parasitic infections, suggesting that NSAIDs like ibuprofen could be repurposed as anti-parasitic treatments. Gasdermin C plays a crucial role in this process, targeting and penetrating Rab7-positive vesicles to reduce prostaglandin d2 levels.
Beetles under climate stress lay larger male eggs: Wolbachia infection drives adaptive reproduction strategy in response to rising temperature and CO₂
Researchers found that azuki bean beetles infected with Wolbachia bacteria produce larger eggs yielding exclusively male offspring when exposed to elevated temperature and carbon dioxide. This adaptive reproduction strategy enhances the survivability of their offspring.
New study suggests Florida has the potential for local Chagas disease transmission
A new study found that over 30% of kissing bugs in Florida harbor the parasite Trypanosoma cruzi, which causes Chagas disease. The researchers suggest preventative measures such as inspecting homes for entry points and removing wood piles to safeguard against transmission.
UGA researchers develop first test of cure for Chagas disease
Researchers developed a new protocol to detect even low levels of T. cruzi parasites in patients, allowing for accurate monitoring of treatment outcomes and potentially leading to more effective drug treatments. The test was tested on human, macaque, and canine subjects, with promising results.
How a common brain parasite disrupts neural communication
A UC Riverside study found that Toxoplasma gondii can significantly disrupt brain function by interfering with communication between brain cells. Infected neurons release fewer extracellular vesicles, which can lead to seizures, neural damage, or altered brain connectivity.
Heatwaves greatly influence parasite burden; likely spread of disease
A new study found that heatwaves can increase disease burden by up to 13 times, driven by complex interactions between temperature attributes and baseline temperatures. This knowledge is crucial for predicting the impact of heatwaves on disease spread and highlights the need for more detailed models.
Freshwater fish in US carry introduced human-infecting parasites
A study found that over 90% of popular freshwater game fish in Southern California contain invasive parasitic worms, which can cause gastrointestinal problems and other issues. Proper cooking or freezing fish before consumption kills the parasites, but chronic infection poses a greater health risk.
Genetic deep dive dispels fear of hybrid worm threat
A genetic analysis reveals that human parasites do not recently interbreed with those that infect cattle, contrary to previous concerns. This finding has implications for controlling schistosomiasis, a disease affecting over 200 million people globally.
Novel molecular maneuver helps malaria parasite dodge the immune system
A team of researchers at Weill Cornell Medicine has discovered that the malaria parasite Plasmodium falciparum can shut down a key set of genes to avoid detection by the immune system. This finding suggests that asymptomatic adults may harbor undetectable parasites, making it more challenging to eliminate malaria.
Low-cost formulation reduces dose and increases efficacy of drug against worms
Researchers have developed a low-cost, nanotechnology-based praziquantel formulation that increases efficacy and reduces dosage for treating worms. The new formulation, requiring only half the usual dose, demonstrates greater efficacy in eliminating schistosomes than the active ingredient alone.
A faster route to eliminating parasitic infection endemic to Africa
A clinical trial finds that moxidectin is more effective than current treatment ivermectin for lymphatic filariasis, a disease affecting millions in Africa. Moxidectin has a persistent effect and may require fewer rounds of treatment, potentially accelerating its elimination.
Amazon research tackles £50 million parasite devastating fish farmers around the world
A mysterious parasite is devastating fish farms globally, causing £50 million in losses annually. Researchers have discovered a new gene regulation process that could lead to the development of gene-based vaccines.
Disrupting ‘communication’ with plants could limit soybean cyst nematode infections
A study co-authored by an Iowa State University professor identified a single protein that triggers chemical signals called effectors in cyst nematodes, which hijack plant cells. Disrupting this protein could severely reduce nematode infections, making it a powerful method for reducing crop damage.
Parasite avoidance study could shed new light on social distancing's role in disease prevention
New research by a University of Virginia biologist aims to explore how organisms evolve to avoid parasites and the importance of movement in defending against infection. The study focuses on nematode Caenorhabditis elegans and challenges traditional focus on the immune system as the best defense strategy.
A probiotic bacterial strain proven more effective for treating a common intestinal infection
Researchers have discovered a new probiotic bacterial strain that is 15% more effective in treating giardiasis than the existing strain. The strain, Lactobacillus johnsonii CNCM I-4884, has significant anti-Giardia activity and can transform conjugated bile salts into toxic compounds for the parasite.
Museum collections reveal worldwide spread of butterfly disease
A study from the University of Georgia used museum specimens to track the spread of Ophryocystis elektroscirrha, a parasite affecting millions of monarchs during their annual migration. The research found evidence of infection in the Americas, Europe, Asia, Africa, and Oceania, with limited species affected.
Sensing sickness
Researchers found the UBeeO test can identify colonies resistant to several pests and pathogens that can decimate bee populations. The test mimics the pheromones emitted by sick or dying bees, allowing for a more selective and realistic assessment of hygienic behavior in honey bees.
Park entrances may be hotspots for infective dog roundworm eggs
New study finds park entrances in Dublin, Ireland, to be heavily contaminated with infective Toxocara canis eggs, posing a risk of zoonotic infection. The researchers call for increased measures to prevent dog feces disposal at these locations.
UTEP researchers test new, more reliable method to detect chagas disease
UTEP researchers have developed a new diagnostic method that significantly enhances the sensitivity of parasite detection in blood samples, making it a more reliable indicator of parasites in the blood. The method uses magnetic beads to extract parasitic DNA from blood samples, outperforming traditional silica columns.
Children’s Hospital of Philadelphia researchers use a “Trojan Horse” approach to develop new antimalarial drugs
Children's Hospital of Philadelphia researchers have discovered a key process where malarial parasites take up human blood cell enzymes, which could provide a new approach for antimalarial treatment. The findings suggest that a human enzyme, acylpeptide hydrolase (APEH), is the major activating enzyme of multiple antimalarial prodrugs.
Enhancing mosquito repellent effectiveness
Researchers have identified novel mosquito repellents with high success rates from natural sources, including food and flavoring materials. The team's machine learning-based cheminformatics approach also pinpointed pyrethroid analogs up to 100 times more effective than existing industry standards.
Genomic tools provide clearer view of health for endangered bats
Researchers used advanced molecular tools to survey health status of endangered Indiana bats, identifying microbiome changes resulting from parasitic infections. The analysis revealed that bats with high loads of a protozoan parasite had a corresponding proliferation of certain bacteria.
An unexpected mechanism regulates the immune response during parasitic infections
Researchers at the University of Liège uncover a mechanism regulating the immune response against parasites, where virtual memory T cells express CD22 to prevent excessive inflammation. This discovery opens new perspectives on controlling immune responses and mitigating autoimmune diseases.
The deadly pathogen that decimated sea urchins in Eilat has now spread to the Indian Ocean
A deadly ciliate parasite has decimated sea urchin populations in the Caribbean, Red Sea, and Indian Ocean, with mortality rates reaching over 90%. The International team of researchers is working to track the disease and preserve sea urchins, which play a crucial role in maintaining coral reef health.
High uric acid levels linked to deadly outcomes in children with severe malaria
Children with severe malaria are at risk of serious health complications, higher mortality rates, and long-term cognitive impairment due to elevated uric acid levels. The study suggests that lowering uric acid may reduce hospital deaths and improve treatment strategies.
Investigating immune connections between obesity and parasitic worms
Researchers investigate how sex-specific immune responses affect disease outcomes in obesity and helminth infections, aiming to develop new treatments for metabolic disorders and parasitic infections. The study focuses on macrophage-eosinophil interactions and the role of RELMalpha protein.
Skin-penetrating nematodes have a love-hate relationship with carbon dioxide
Researchers discovered that skin-penetrating nematodes, like Strongyloides stercoralis, interact with human hosts through CO2-sensing pathways. The study found that infective larvae are repelled by CO2, while noninfective larvae and adults have a neutral reaction.
Guidance on animal-borne infections in the Canadian Arctic
The review highlights seven zoonotic infections in people, including those transmitted through traditional diets and hunting practices. Climate change is affecting the local ecosystem, altering animal behavior and parasite life cycles, posing a risk to vulnerable populations.