Articles tagged with Endocrinology
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A self-regulating, implantable living technology has been developed to offer hope for millions with diabetes. The implant continuously senses blood-glucose levels, produces insulin within itself, and releases the exact amount needed, eliminating the need for daily injections.
Vertebral fractures are a devastating complication of advanced kidney disease, associated with increased risk of further fractures and cardiovascular events. The first global consensus statement offers practical recommendations for clinicians to identify and manage vertebral fractures in patients with chronic kidney disease stages G4–G5D.
A new study published in The Lancet Obstetrics, Gynaecology, & Women's Health found that postmenopausal women receiving hormone therapy lost 35% more weight while taking tirzepatide, a GLP-1-based obesity medication. This research could help develop personalized strategies for managing cardiometabolic risk in postmenopausal women.
A new study published in The Journal of Clinical Endocrinology & Metabolism found a causal link between high body mass index (BMI) and dementia. High blood pressure was identified as a driving factor behind the increased risk. Researchers suggest that preventing or treating obesity and high blood pressure could help reduce dementia risk.
Researchers found a neuroendocrine mechanism linking ovarian status to brain signals controlling sexual receptivity in female teleosts. Progesterone analogs restored sexual behavior but not ovulation, suggesting a direct neural pathway for hormone reception.
A new study found that more than one-in-four adults worldwide may be eligible for GLP-1 use, with women and older individuals among the most eligible. The research emphasizes the need to prioritize global access to these medications, particularly in low- and middle-income countries where obesity rates are highest.
New research reveals that DNA's physical property of supercoiling is crucial for cells to respond to oestrogens. The study found that enzymes called topoisomerases regulate DNA coiling and activate target genes.
The Asia Pacific Regional Audit highlights key trends, gaps, and opportunities in 22 countries and regions. The audit reveals a steep rise in fracture rates due to poor bone health and an ageing population, with China, Malaysia, and Australia experiencing significant increases.
NEJM Clinician curates highly relevant clinical insights from over 150 peer-reviewed journals to give physicians clear guidance without the noise. The weekly publication delivers summaries and commentary in a concise, 30-minute read, helping healthcare providers stay informed and confident in their decisions.
Exposure to single and mixtures of perfluoroalkyl substances (PFAS) was associated with higher odds of endocrine disruption (ED) among women. Certain PFAS compounds, particularly n-PFOS, were found to disrupt endocrine function and harm health.
A global initiative has been launched to tackle glycolipid metabolic disorders, which are prevalent and linked to various chronic diseases. The initiative aims to improve public health education and develop an integrated screening-diagnosis-treatment-management system to prevent disease progression.
Dr. Anna Gloyn has been awarded the fifth Transatlantic Alliance Award for her pioneering research on genetic mechanisms of diabetes and precision medicine. Her collaborative work with colleagues across Europe and the United States has significantly advanced our understanding of the genetic basis of diabetes.
A Johns Hopkins Medicine study found hormone-disrupting chemicals shed by plastics are present in the skin of people with hidradenitis suppurativa, potentially worsening symptoms. The researchers believe reducing exposure could ease HS symptom severity and provide a new avenue of relief.
The 9th IOF Asia-Pacific Bone Health Conference will bring together healthcare professionals, researchers, and policymakers to exchange knowledge and shape the future of bone health across the region. The conference will feature keynote lectures, sponsored sessions, and a launch of the IOF Asia-Pacific Regional Audit 2025.
A new study found that maternal thyroid hormones are crucial for fetal neurodevelopment, and gestational thyroid imbalance increases the risk of autism spectrum disorder. Women with persistent thyroid dysfunction across pregnancy were at a higher risk of having children with autism.
The European Society of Endocrinology is launching a new campaign to raise awareness about the importance of hormone health. The #BecauseHormonesMatter initiative aims to improve public understanding of hormones and promote practical steps for better hormone health, following the success of last year's campaign.
A study published in Journal of Translational Medicine found that successful root canal treatment can reduce inflammation linked to heart disease and improve levels of blood sugar and cholesterol. The researchers discovered a link between monitoring blood metabolic markers after dental treatment, which could help assess recovery and risk.
The European Society of Endocrinology has published a revised clinical practice guideline for the treatment of chronic hypoparathyroidism in adults, featuring a new definition and treatment algorithm. The guidelines aim to provide practical guidance for healthcare providers involved in diagnosing and managing the condition.
Researchers from Rutgers University found that metformin blunts improvements in blood vessel function, fitness, and blood sugar control after exercise. This means that people taking metformin may not get the protection they expect to help lower disease risk. The study's lead author, Steven Malin, hopes future research will uncover stra...
Researchers from Arc Institute, UCSF, and Fred Hutchinson Cancer Center identified PTGES3 as a key regulator of the androgen receptor in prostate cancer. The study found that PTGES3 contributes to tumor growth and suggests it could be a promising new target for treating aggressive prostate cancers.
The European Society of Endocrinology (ESE) has announced the winners of the 2026 ESE Awards, which recognize outstanding contributions to improving knowledge and expertise in endocrinology. This year's winners include Martin Reincke for his work on neuroendocrinology and Maria-Christina Zennaro for her research on hypertension.
A team of researchers led by Stephen McCormick has uncovered how fish know when to migrate, revealing that their pituitary gland is studded with photoreceptors that can perceive daylight changes. This discovery sheds light on the enduring migration mystery and will help in planning for climate change's impact on migrating fish populati...
The European Society of Endocrinology has released the EndoCompass Research Roadmap, a major new initiative to align research efforts and improve funding strategies for hormone-related health challenges. The roadmap identifies specific research needs across eight endocrine specialties and five cross-cutting areas.
People with higher muscle mass, as indicated by stronger grip strength, are less likely to develop organ damage or die from obesity. Building and maintaining muscle through weight training may be a practical way to identify individuals at risk and act early.
Researchers have found that GLP-1 therapies may help reduce alcohol and other substance use by modulating neurobiological pathways underlying addictive behaviors. The therapies, which are commonly used to treat diabetes and obesity, have shown encouraging results in early clinical trials.
Researchers discovered a new pathway that could help people with diabetes avoid dangerous hypoglycemia by restoring the function of delta cells. These cells, previously unknown to play a role in blood sugar regulation, release somatostatin to pause insulin production when necessary.
A new study found that over 40% of specialty clinics in the US turn away patients weighing 465 pounds or more due to lack of accessibility features. The study highlights a need for staff training on inclusive care and accommodations for patients with severe obesity.
A new clinical trial found that feeding blueberries to infants as their first solid food can reduce allergy symptoms and support long-term health. The study suggests early introduction of blueberries may improve infants' immune systems and gut health.
A new study published in Clinical Chemistry and Laboratory Medicine has developed a practical tool to support harmonization and quality improvement in vitamin D testing. The multicentre study evaluates the measurement uncertainty of various 25-(OH)D assays and their ability to detect physiologically relevant changes over time.
Researchers have identified a risk category called 'pre-prediabetes' that occurs years before standard criteria for prediabetes are met. This stage is characterized by severe insulin resistance and measurable cardiovascular disease, highlighting the need for early detection and treatment.
The Endocrine Society has recognized 12 exceptional endocrinologists with its 2026 Laureate Awards, honoring their groundbreaking research and clinical breakthroughs in treating hormone disorders. The winners include Robert M. Carey, Christopher Kevin Glass, Rebecca Reynolds, Samuel Klein, and Lisa B. Nachtigall, among others.
The International Osteoporosis Foundation identifies critical global barriers to osteoporosis care, including limited DXA scanning and outdated treatment criteria. The IOF advocates for a paradigm shift in bone health management worldwide, recognizing high fracture risk as a valid criterion for treatment and reimbursement.
A new review emphasizes the importance of both physical activity and reduced sedentary time for optimal skeletal health. Emerging evidence reveals that prolonged sitting and inactivity can harm bone health, even among regular exercisers.
Researchers discovered a brain-liver circuit that connects stress with increased glucose production, potentially linking to type 2 diabetes. Long-term elevations in glucose can cause hyperglycemia and increase the risk of developing type 2 diabetes.
A study by Professor Chunxiu Gong's team identified the clinical presentation of Cornelia de Lange syndrome (CdLS) and genetic alterations in Chinese pediatric patients. The researchers found that 12 patients presented with classic CdLS, while others showed global developmental delays and growth retardation.
A study by Mount Sinai-Duke University identifies specific DNA variants in the DENND1A gene that increase testosterone production in PCOS patients. This finding could lead to new therapies targeting the genetic source of elevated testosterone levels in PCOS, which is a common condition affecting reproductive-age women.
A recent study published in the Journal of the Endocrine Society found that skipping breakfast and having late dinners are associated with an increased risk of osteoporosis. Additionally, unhealthy eating habits were linked to other lifestyle risk factors such as physical inactivity, smoking, and insufficient sleep.
The International Osteoporosis Foundation has issued an updated joint position statement on managing aromatase inhibitor-associated bone loss in women with hormone-sensitive breast cancer. The guidelines incorporate recent clinical trials and systematic reviews to provide evidence-based treatment algorithms for assessing fracture risk ...
Extracellular vesicles play a crucial role in regulating oocyte maturation, follicular growth, and quality. In pathological conditions, EVs can disrupt communication, leading to impaired oocyte development and ovarian failure. Therapeutic EVs show promise in reversing ovarian pathologies by delivering functional molecules.
Researchers identify key apoptotic signaling pathways involved in glucocorticoid-induced osteonecrosis, including CD95/CD95L and PI3K/Akt survival pathways. They also highlight genetic biomarkers and novel therapeutic strategies, such as targeting specific molecular pathways with natural compounds.
The Mount Sinai Hospital has been listed among the nation's top 20 hospitals for care excellence by U.S. News & World Report for 2025-26, with top-10 rankings in five specialties and top-20 rankings in nine. The hospital was also rated High Performing in all 22 procedures and conditions assessed by U.S. News.
A new mouse study suggests that watching others eat, especially palatable food, can cause overeating in the absence of hunger. The study found that satiated mice increased their intake of sucrose diet when observing fasted peers, but dopamine receptor inhibitors suppressed this behavior.
A new study found that anti-obesity medications can normalize testosterone levels in men with obesity or type 2 diabetes. This positive effect on reproductive health was observed after a 10% weight loss, with total and free testosterone levels increasing by 24%.
A study found that night shift work disrupts the body's internal timing, causing irregular reproductive cycles and hormonal imbalances. Women exposed to shiftwork-like light exposure had a higher risk of ovarian disruption, pregnancy complications, and difficult labor, even if they were not experiencing disrupted cycles.
Despite supply shortages and insurance coverage obstacles, patients taking GLP-1 medications achieve clinically significant weight loss when paired with intensive lifestyle interventions. The study found that consistent medication courses combined with lifestyle changes and support remain the most effective weight-loss program option.
A study published by The Endocrine Society found that obesity and early type 2 diabetes in adolescence can interfere with bone development, potentially increasing the risk of fractures and osteoporosis later in life. Researchers followed 48 teenagers for a year, finding that teens with obesity and type 2 diabetes showed less improvemen...
A new study by The Endocrine Society finds a strong link between acromegaly and an increased risk of various cancers, often at younger ages than expected. Patients with the rare growth hormone disorder had higher rates of certain types of cancer, including colon, gastric, breast, lung, ovarian, prostate, and blood cancers.
The Endocrine Society guideline suggests universal screening for primary aldosteronism in people with hypertension. This condition is associated with a higher risk of cardiovascular disease if left undiagnosed and untreated.
Adrenal hormone function was restored in animal studies using implantable cell therapy, demonstrating potential for a functional cure for primary adrenal insufficiency. The treatment also followed the animals' natural circadian rhythm and showed improved survival rates.
A novel AI-powered retina tracker, SMART, analyzes retinal images with near-perfect accuracy in under one second, offering hope for sight-saving screenings for diabetic retinopathy. The tracker expands access to high-quality retinal assessments globally, reducing vision loss from diabetic retinopathy.
A new study found that intermittent energy restriction significantly improved fasting blood glucose and triglycerides, while also increasing insulin sensitivity. The IER group showed the greatest advantages in reducing these markers compared to time-restricted eating and continuous energy restriction groups.
Cancer deaths linked to obesity have increased sharply in the US, especially among women and older adults, with sharp regional disparities. The study highlights the need for targeted public health strategies to address this growing public health crisis.
A study of over 7,600 Brazilian women found that early menarche increases risk for metabolic and heart problems, while late menarche may protect against obesity but increase certain heart issues. Understanding age at first period can help doctors identify high-risk patients and guide personalized screening and prevention efforts.
A study presented at the Endocrine Society's annual meeting found that socially isolated older adults are 34% more likely to have diabetes and 75% more likely to have poor blood sugar control. Social isolation is being recognized as a critical social determinant of health, highlighting its importance in caring for older patients.
A new study presents preliminary data suggesting that grandparents' exposure to endocrine-disrupting chemicals may impact the age when girls get their first period. The research found that certain chemicals in both mothers and fathers were linked to earlier puberty, with stronger effects seen in granddaughters.
The guideline suggests screening women of reproductive age with diabetes for intent to conceive at every reproductive, diabetes, and primary care visit to ensure they receive appropriate preconception care. Women with diabetes who become pregnant are at risk for adverse pregnancy outcomes, such as miscarriages or birth defects, which c...
A study found that consuming aspartame, sucralose, glycyrrhizin and added sugars may increase the risk of early puberty in children, especially those with genetic traits. This association was strongest for central precocious puberty, a condition linked to emotional distress and metabolic disorders.
A novel AI-powered application has been developed to diagnose endocrine cancers with speed and accuracy, leveraging advanced deep learning architectures. The tool analyzes diverse medical data, including imaging scans and histopathology images, and demonstrated exceptional diagnostic accuracy in certain validation datasets.
A real-world study of 120 postmenopausal women found that using tirzepatide and menopause hormone therapy simultaneously led to superior total body weight loss percentage compared to using tirzepatide alone. This combined treatment also resulted in a higher percentage of participants achieving at least 20% weight loss.
Researchers found that tirzepatide reduced body weight and body fat by approximately 20% in mice, resulting in a significant reduction of tumor volume. The study suggests that this new anti-obesity drug may have a beneficial impact on breast cancer outcomes.