Articles tagged with Estrogen Signaling
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Researchers discovered an estrogen-dendrimer conjugate that selectively targets heart-protective pathways in mice, promoting cardiovascular protection without stimulating uterine enlargement or breast cancer growth. The findings pave the way for potential therapeutic interventions targeting non-nuclear estrogen receptors.
A recent study has identified a 'feed-forward' pathway that links estrogen receptors in the uterus to increased local estrogen levels and promotes cell growth. This pathway may be targeted in drug therapies for endometriosis and uterine cancer.
A new study found that increased growth factor activation is associated with poor prognosis and tamoxifen-insensitivity in luminal-B breast cancers. Targeting this pathway may lead to a new therapeutic strategy for these patients.
A study examining caffeine's association with breast cancer risk found that high caffeine intake may increase the risk of hormone-receptor negative and large breast tumors. The study also found a positive association between caffeine consumption and benign breast disease, but not overall breast cancer risk.
Researchers at the University of Florida have discovered a way to improve thought processes in female mice by recharging a naturally occurring estrogen receptor in the brain. This breakthrough suggests that drugs can be developed to offset cognitive decline related to low estrogen levels, protecting against neurological diseases.
Researchers at the University of Iowa have discovered a gene called AP2C that plays a linchpin role in estrogen signaling pathways. Silencing this gene significantly decreased tumor growth and delayed establishment of tumors in mice.
New discoveries in ACS Chemical Biology highlight the potential for snail toxins to lead to new drugs, as well as strategies to minimize the side effects of COX inhibitors. The journal also explores how sex hormones activate cell signaling pathways, and helper peptides influence calcium channel opening.
Research found that estrogen improves host response after traumatic injury and decreases liver enzymes associated with damage. The study identified the critical cell surface receptor, GPR30, involved in estrogen's protective effects on the liver.
A new study has discovered a novel estrogen receptor that differs significantly from existing receptors, with potential implications for anti-estrogen breast cancer therapy. The receptor, hER-?36, is predominantly localized on the cell plasma membrane and stimulates cell growth through the MAPK/ERK signaling pathway.
A new UCI study has identified a gene linked to breast cancer that can also suppress tumor growth by blocking estrogen and growth factor signals. The research provides further insight into how estrogen interacts with mutated BRCA1 genes to promote breast cancer development.
A new study found that infection with a high-risk type of human papillomavirus (HPV) in oral epithelial cells may be an independent risk factor for head and neck cancer. High-risk HPV types detected in oral exfoliated cells were predictive of high-risk HPV types in tumor tissue.
Scientists generate mutant mice with disrupted estrogen receptors, resulting in adult female ovaries transforming into male-like cells. This discovery advances our understanding of the action of estrogen and its role in human fertility and cancer.
Biologists at Washington University in St. Louis have discovered that lower estrogen levels allow cytokines to bind to bone cell surfaces, leading to bone destruction. Estrogen replacement therapy may be able to prevent this by increasing decoy receptor proteins, which inhibit cytokine binding.
UCSF researchers identified a signaling cascade that regulates steroidogenic factor 1, a nuclear receptor involved in sexual differentiation and stress response. The finding suggests a ligand-independent mechanism of action for SF-1, potentially explaining resistance to hormone therapies in certain cancers.
Researchers have discovered the precise three-dimensional shape of the complex between tamoxifen and the estrogen receptor. This clarifies how estrogens turn on genes and shows precisely how tamoxifen blocks this process, setting the stage for intentional drug design with precise action.
Researchers found that anti-androgen drugs can trigger the protein that makes prostate and cancerous cells grow, leading to a possible explanation for why hormone therapy loses effectiveness after one or two years. The study suggests that more research is needed to confirm the results.
Breast-cancer researchers at the University of Illinois have identified four critical amino acids in the binding of estrogen and anti-estrogen hormones to receptor proteins. This discovery may lead to the development of more tissue-selective therapies for breast cancer treatment, addressing resistance to current treatments like tamoxifen.
A new study found that steroid receptors are not mere on-off switches but rather complex molecular control panels. This discovery could lead to the development of targeted therapies for various diseases such as breast and prostate cancer, inflammation, osteoporosis, and endometriosis.