Articles tagged with Tissue Repair
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Researchers discovered that damaged cells and aging induce high levels of oxidative stress and DNA damage in a subset of cells, leading to senescence. Senescent cells repress muscle regeneration by releasing inflammatory factors, while also promoting fibrosis, highlighting the need to remove these cells for improved repair.
Scientists at Duke University have made a breakthrough in controlling gene expression in response to injury, using a segment of fish DNA called TREE. The method successfully targeted gene activity to specific regions and time windows, showing promise for regenerating damaged tissues in mammals.
Researchers from Kumamoto University reveal how hematopoietic stem and progenitor cells orchestrate intestinal tissue repair through microbial signals. The study found that acute gut inflammation triggers the activation and expansion of immune progenitor cells, which migrate to lymph nodes to promote tissue repair.
Scientists at Texas A&M University found that transplanting intestinal epithelial stem cells can repair the gut and reduce inflammation, potentially preserving cognitive function after a stroke. The study suggests that targeting gut health may be key to developing more effective stroke therapies.
Albert Almada's laboratory will explore the role of Nicotinamide Adenine Dinucleotide (NAD+) in muscle repair and regeneration. Lower levels of NAD+ may be inactivating stem cell repair, and re-activating it could promote better muscle healing in older animals.
Researchers developed a new device, MAGENTA, that prevents and supports muscle atrophy recovery. The device stimulates muscles to stretch and contract, triggering key molecular pathways for growth. It has potential applications in treating various diseases such as ALS and MS.
Researchers at Indiana University School of Medicine developed a minimally invasive nanochip device that can reprogram tissue function by delivering specific genes. The technology has shown promise as a treatment for traumatic muscle loss, with improved muscle function observed in rats following volumetric muscle loss.
Researchers have discovered a way to reactivate a fetal repair pathway in adults to improve healing of diabetic wounds. The study used tissue nanotransfection technology to deliver a gene that activates the protein NPGPx, which is active in fetuses but largely inactive in adults and absent in diabetic adults.
Researchers at the University of Alabama at Birmingham have identified TBX20 as a vital regulator of direct human cardiac reprogramming. Adding TBX20 to existing cocktails improves contractility and mitochondrial function in reprogrammed heart muscle cells, suggesting a therapeutic potential for TBX20.
New research from UC San Francisco found that senescent cells promote normal repair and healing in damaged tissues, contradicting the long-held view that they are purely detrimental. The study used senolytics to kill senescent cells and found that injuries healed more slowly. However, the researchers also discovered that senescent cell...
Scientists have identified a protein that regulates cancer cell spread and normal tissue cell shedding, potentially leading to new treatments. The research suggests that metastasis is not an abnormal process limited to cancer but a normal process used by healthy cells.
Stowers scientists investigate macrophage activation states in zebrafish sensory organ, discovering three distinct anti-inflammatory pathways that may inform human regenerative immunotherapies. The study provides valuable insights into the timing and genetic programs of macrophages, a type of white blood cell, in repair and regeneration.
Researchers have created a biomimetic mineralized layer that replicates the structure of natural tooth enamel, exhibiting increased nanohardness and surpassing the natural tissue in terms of strength. The new material can be used to restore or repair damaged enamel due to abrasion, erosion, or improper diet.
Researchers at the University of Pittsburgh have identified a universal mechanism for lysosomal repair, known as the PITT pathway, which helps maintain cellular longevity. The study reveals that damaged lysosomes are quickly repaired through the PITT pathway, but defects in this process can contribute to age-related diseases such as Al...
A study published in Cell Stem Cell found that mitochondrial dynamics regulate the dormant state of adult muscle stem cells, which are essential for tissue stability. The researchers discovered that the protein OPA1 regulates this process and its depletion leads to severe muscle stem cell defects.
Researchers have identified a group of latent stem cells in the central nervous system of mice that respond to injury by dividing, migrating towards damaged areas, and differentiating into astrocytes. If similar cells exist in humans, they could provide a new therapeutic approach for treating spinal cord injuries.
Researchers led by Jianyi Zhang aim to find key pathways for reprogramming adult heart muscle cells to proliferate in response to a heart attack, potentially leading to improved heart attack recovery through growth of new heart muscle cells. The grant will fund three projects at UAB and two other universities.
A team of researchers from McGill University has discovered a way to control the stickiness of adhesive bandages using ultrasound waves and bubbles. This breakthrough could lead to new advances in medical adhesives, especially in cases where adhesives are difficult to apply.
Scientists have identified a critical source of essential molecules that enables the intestine's self-renewal and regeneration after injury. The study reveals that lymphatic endothelial cells play a key role in maintaining stem cell activity and tissues in the intestine.
The National MS Society has launched 40 new research awards to explore myelin repair, clues to MS progression, and wellness strategies to move closer to a world free of MS. The $19 million investment is part of a projected total of nearly $30 million in 2022 to support over 250 new research studies.
A recent study published in Science reveals that hyaluronic acid plays a key role in controlling muscle repair. The natural compound awakens stem cells to start the repair process after a 40-hour cleanup job by immune cells is complete.
Researchers at University of Cincinnati and Case Western Reserve University found a novel drug enables nervous system repair and functional recovery in animal models of severe ischemic stroke. The study demonstrated significant improvement in motor function, sensory function, spatial learning, and memory. NVG-291-R repairs damage throu...
A new study from Tel Aviv University found a promising treatment for long-term COVID-19 symptoms using Hyperbaric Oxygen Therapy (HBOT). Patients treated with HBOT showed significant improvement in cognitive function, attention, and executive functions.
Researchers identified glucocorticoids as a key factor inhibiting cardiac regenerative capacity after heart attacks. The study showed that deleting or blocking the glucocorticoid receptor increased heart muscle cell replication and regeneration.
Researchers used CT and MRI perfusion techniques to analyze 19 patients with successful free flap reconstruction and five with wound failure. The study found that both methods showed significant differences between the two patient groups. Early postoperative scans could help surgeons intervene earlier, potentially reducing hospital stays.
A recent review article highlights the crucial role of macrophages in the progression from acute kidney injury (AKI) to chronic kidney disease (CKD). The study suggests that targeting specific signaling pathways and altering macrophage activation can prevent renal fibrosis and CKD. Therapeutic strategies such as clodronate liposomes an...
Researchers developed a biopolymer film that combines anti-bacterial properties, inflammation dampening, and release of active pharmaceutical ingredients in a targeted manner. The film adheres to sensitive surfaces without damaging tissue, speeding up healing process and completely dissolving by itself.
Researchers at Ann & Robert H. Lurie Children's Hospital of Chicago discovered that macrophages play a crucial role in cardiac repair after a heart attack by inducing vascular endothelial growth factor C (VEGFC) and promoting healing. This finding offers new hope for developing novel therapeutic approaches to preserve heart function.
Researchers at the University of Birmingham have discovered two new DNA repair genes, SETD1A and BOD1L, which can make cancer cells more sensitive to radiotherapy. These findings may lead to improved treatment efficiency and patient outcomes by allowing clinicians to identify targeted treatments for specific patients.
A team of researchers has successfully treated damaged pig hearts with cardiac progenitor cells, demonstrating the formation of new cardiac tissue and improved cardiac function. The treatment could potentially be used to treat patients with serious heart failure, particularly older patients with coexisting conditions.
Scientists at Johns Hopkins Medicine have successfully cultivated human muscle stem cells capable of renewing themselves and repairing muscle tissue damage in mice. The self-renewing stem cells were created by reprogramming laboratory-grown human skin cells, which then differentiated into specific cell types using a nutrient-rich broth.
Researchers at Terasaki Institute for Biomedical Innovation have developed a flexible, antibacterial conductive hydrogel-ePatch that accelerates wound healing with minimal side effects. The e-Patch uses silver nanowires and alginate to promote cell proliferation and migration, resulting in faster wound closure and reduced scarring.
Researchers have discovered that vesicles from human heart cells can repair damaged tissue and prevent lethal heart rhythm disorders. The treatment, using cardiosphere-derived cells (CDCs) and their secreted exosomes, showed improved heart rhythms and reduced scarring in animal models.
Researchers at Massachusetts General Hospital identified genes that play a crucial role in maintaining healthy kidney repair, including FANCD2 and Rad51. Activating a DNA repair mechanism may help preserve kidney function in people with chronic kidney disease.
Researchers found that a blueberry phenolic extract improved vascularization and cell migration in live wounds, leading to a 12% increase in wound closure. The study suggests wild blueberries have the potential to enhance wound healing, particularly for patients with chronic wounds.
A UK team is developing personalized ‘theranostic’ dressings that speed up wound healing while providing diagnostic information. The dressings feature biomimetic macromolecules that replicate natural tissue structures, kickstarting the body’s healing processes.
A team of researchers found that re-activating the Piezo1 protein allows muscle stem cells to repair broken down muscles in mice with Duchenne muscular dystrophy. The study opens doors for potential molecular-level treatments to slow or halt disease progression.
Researchers at RCSI University of Medicine and Health Sciences have discovered that platelets can form a provisional fibronectin matrix, similar to fibroblasts, which has potential implications for maintaining blood clot integrity during vascular repair. This finding challenges existing paradigms in wound healing.
Researchers from Tel Aviv University found that hyperbaric oxygen therapy (HBOT) relieves PTSD symptoms in treatment-resistant veterans, improving brain function and microstructure. The breakthrough study provides new hope for PTSD sufferers, offering an objective diagnostic tool and potential long-term improvements.
Researchers have discovered that p53 protein activates a molecular program turning damaged cells into migratory leader cells for quick epithelial repair. Once repaired, these highly migratory cells are eliminated to restore normal epithelial tissue structure.
A team led by Case Western Reserve University discovered the novel repair properties of Gasdermin B protein, promoting restoration of epithelial layers and effective wound-healing. The findings have significant implications for designing therapeutics to enhance wound repair in various organs.
Researchers create a sticky patch that can seal large tears and punctures in the colon, stomach, and intestines of animal models without causing inflammation or sticking to surrounding tissues. The patch is designed to be biocompatible, flexible, and holds for over a month.
A recent study led by University at Buffalo researchers found that photobiomodulation reduces inflammation, improves blood flow and heals wounds up to 19 days faster. Light therapy accelerated skin healing from cancer radiation therapy by an average of 49-42 days.
A pre-clinical study showed that the use of extracellular matrix supports improved nerve fibre regeneration across large nerve defects. The team's novel ECM-loaded medical device increased pro-repair inflammation, blood vessel density, and regenerating nerves, offering a promising alternative to current therapies.
Research in mice suggests that first-responder cells launching repair after a heart attack promote more inflammation than necessary, threatening optimum healing of the heart.
A group of high school students, with the help of a STRI scientist, discovered that Azteca ants rapidly repair damage to their Cecropia host plants. Within 2.5 hours, the hole's size had been significantly reduced and was often completely repaired within 24 hours.
Researchers developed an injectable, adhesive surgical gel that prevents postoperative adhesions and improves wound healing. The gel, dubbed HAD, was tested in rats and rabbits with promising results, showing a significant reduction in inflammation and mortality rates.
The reNEW Center aims to harness therapeutic potential in stem cell medicine for incurable diseases, with a focus on translation and collaboration. Scientists will work together to develop new treatments and therapies.
A new imaging technique can detect early signs of blood trauma in red blood cells, which could aid in the development of markers to prevent damage. The technique, developed by researchers at Shibaura Institute of Technology and Griffith University, uses high-speed cameras to visualize changes in RBC shape under stress.
Researchers at Keck School of Medicine of USC have developed a stem cell-based bio-implant to repair cartilage and delay joint degeneration. The Plurocart implant successfully integrates into damaged articular cartilage tissue and survives for up to six months.
Researchers discovered that wound macrophages undergo different metabolic programs to coordinate tissue repair, including the use of reactive oxygen radicals for blood vessel growth. Macrophages also utilize a different type of mitochondrial exchange for anti-inflammatory and reparative functions in late-stage wound healing.
A team of researchers at Fudan University has found that the protein NeuroD1 does not induce microglia-to-neuron conversion as previously thought. Instead, it causes microglial cell death. The study suggests that this finding may be due to experimental artifacts and highlights the need for stringent evidence in scientific research.
Researchers at A*STAR's Institute of Molecular and Cell Biology have discovered a novel protein therapy using Agrin to promote wound healing and repair. The study found that timely induction or exogenous supplementation of Agrin accelerates the healing process, preserving the mechanical architecture of injured skin layers.
Researchers developed a method to print skin equivalents with three layers, allowing for complex structures and faster healing. The technique uses suspended layer additive manufacturing and has shown promising results in repairing pig tissue.
Researchers at McGill University create injectable hydrogel that forms stable structure allowing cells to grow and repair injured organs. The material's toughness and porosity make it suitable for heart, muscle, and vocal cord repair.
Researchers at RCSI University of Medicine and Health Sciences have developed a new method to enhance wound healing using 3D printing of platelet-rich plasma. The technique showed promising results in improving vascularisation and reducing fibrosis, leading to faster and more successful wound healing.
Researchers at Durham University have developed a sugar-containing polymer coating that can repair damaged artificial joint implants by mimicking the way cartilage works to lubricate human joints. The coating uses water to create a slippery surface, protecting the surfaces from wear and tear.
Research from Harvard University reveals that physical activity later in life shifts energy towards mechanisms that extend health, reducing chronic illnesses. The study highlights the importance of staying physically active as we age to allocate energy to physiological processes that slow down deterioration.
Johns Hopkins Medicine researchers have developed a 3D map of blood vessels and stem cells in a mouse skull, revealing previously unknown niches for stem cell residence. The map provides precise locations of blood vessels and stem cells, which could be used to repair wounds and generate new bone tissue.
A recent study by James Godwin, Ph.D. has identified the liver as a primary reservoir for pro-regenerative macrophages essential to limb regeneration in axolotls. The research paves the way for regenerative medicine therapies in humans, potentially treating diseases like heart and lung disease with scar-free healing.