Articles tagged with Canonical Signaling
Researchers from Indiana University have uncovered how the EphA2 protein receptor contributes to cataract formation. The study found that canonical ligand-dependent EphA2 signaling remains stable in aging lens tissue, while non-canonical signaling increases with age, affecting lens fiber cell maturation.
Researchers develop epigenetic clocks based on regional disorder of DNA methylation patterns, identifying common responses and critical differences from canonical clocks. These findings suggest a fundamental decoupling of epigenetic aging processes.
A novel droplet digital PCR assay detects KMT2A fusion markers in AML patients, enabling sensitive MRD detection and guiding treatment decisions. This breakthrough may improve patient outcomes by assessing response to therapy and long-term surveillance.
Researchers propose targeting non-canonical HH/GLI signaling to improve response rate and durability of therapeutic effects exerted by SMO inhibition in melanoma. The findings suggest that combined targeting of hedgehog signaling and BRD4 could provide a novel therapeutic option against melanoma.
Researchers identified toll-like receptor (TLR) signaling as a novel pathway regulating GLI3 expression, which plays a role in inflammatory cytokine production and cancer. They found that IRF3 directly binds to the GLI3 promoter region, increasing its expression upon TLR4 stimulation.
Researchers found a unique bivalent histone-mark switch specific to critical transcription factors that induce genes essential for angiogenesis. The histone modifiers responsible for this modification are vital for postnatal angiogenesis.