Articles tagged with Circadian Pathway
A new gene called Tango10 has been identified as critical for daily behavioral rhythms, modulating the activity of neurons to drive the animal's sleep-wake cycle. The study suggests that targeting this molecular pathway could lead to therapeutics to address sleep problems and related human diseases.
A team of international scientists has shown that skeletal muscle cells from people with type 2 diabetes have a different circadian rhythm, leading to altered mitochondrial metabolism. The study suggests that considering cellular rhythms when prescribing treatments for type 2 diabetes could optimize their effectiveness.
Researchers found that the human immune system is most active just before dawn, making it an important consideration for vaccination and cancer therapy. The study's findings suggest that stimulating the immune system at the right time could lead to better treatment outcomes.
Researchers reconstituted cyanobacterial circadian clock in a test tube, enabling real-time study of clock protein interactions and their role in gene expression. The study reveals mechanisms of circadian timekeeping and provides insights into the genetic origins of clock disruption.
Researcher Jennifer Hurley is using in-vivo experimentation and big data analytics to identify environmental cues that tune the circadian clock's control over metabolism. Her study aims to find genes responsive to environmental signals, such as nutrients, to understand how environment affects sleep-wake cycle.
Research in mice reveals that coordinated clock-gene and neuronal activity rhythms are necessary for daily hormone release, with the suprachiasmatic nucleus (SCN) and paraventricular nucleus (PVN) working together to generate circadian rhythms. Disruption of these clocks can lead to various pathologies.
Researchers visualize key proteins in Drosophila brains, revealing their daily oscillations and spatial organization. The study highlights the importance of clock proteins in regulating circadian rhythms, which control sleep-wake cycles, metabolism, and cancer risk.
Skeletal muscle secretes a molecule that regulates around 35% of liver functions, with the remaining basal functions independent of muscle activity. Ageing alters this communication, leading to non-optimal functions and accelerated ageing.
The Daylight Award 2022 is now open for nominations, honoring groundbreaking research on the effects of daylight on human health and well-being. The award also recognizes innovative architectural projects showcasing unique uses of daylight, aiming to improve living conditions and environmental impact.
New research reveals that certain internal clock neurons in fruit flies, previously thought to send time-keeping cues to the brain, actually receive cues from the external environment. This finding has significant implications for understanding circadian rhythm disruptions and their associated health problems.
A study published in PLOS Biology found that global brain fluctuations decrease as the day progresses, affecting cognitive function and connectivity. The researchers analyzed fMRI data from over 900 subjects and observed a cumulative decrease in global signal fluctuation and functional connectivity with time of day.
Researchers at the University of Minnesota Medical School found that a little stress can actually improve the functioning of our internal biological clock. Stress leads to rhythmic phosphorylation of eIF2α, promoting production of ATF4 protein, which activates Per2 gene, ultimately making the clock tick faster.
A recent review article by Dr. Tobias Eckle and colleagues reveals a link between circadian rhythms and cardioprotection in the face of limited oxygen availability. The study identifies period 2 (PER2) as an adenosine signaling target, which plays a crucial role in cardiac adaptation to hypoxia.
Researchers have identified a novel pathway that allows green algae to reset its circadian clock when exposed to red or violet light. The study reveals the existence of at least two different pathways in algae that sense and respond to different colors of light.
Researchers discovered that IR25a plays a key role in entraining fruit fly brains to small changes in temperature. The study found that when temperature fluctuations were large, flies lacking IR25a could adapt, but when they were small, the flies struggled to synchronize their circadian clocks.
Researchers funded by the National Institutes of Health are unraveling the mystery of how blue light from artificial lighting and electronic devices disrupts the human body's natural circadian rhythms. The study aims to understand the chemical basis for this disruption, which can lead to health problems such as sleep disorders, cancer ...
Researchers have identified the molecular signals that influence circadian rhythms in organisms, including humans, mice, and fruit flies. The study reveals how cryptochrome protein interacts with light to regulate these rhythms.
Research suggests that red light can impact alertness at night via pathways other than the circadian system, contradicting previous assumptions about blue light's dominance. The study found that moderate levels of red light increase alertness in individuals, making it a viable alternative to blue light for improving nighttime alertness.
A study by University of Notre Dame biologist Giles Duffield and his team sheds new light on the circadian clock's response to light signals, focusing on the Inhibitor of DNA-binding 2 (Id2) gene. The research has important implications for understanding the development and functioning of the circadian clock in the brain and peripheral...
Researchers at Cold Spring Harbor Laboratory cloned the band gene, finding it's an allele of ras-1, which plays a crucial role in circadian rhythms. The study uses Neurospora crassa as a model organism, demonstrating how a dominant point mutation in ras-1 affects circadian growth cycles.
Researchers discovered that melanopsin, a protein in the eyes, absorbs light and triggers a biochemical cascade to signal the brain about brightness. This allows ipRGCs to synchronize the body's daily rhythms with the sun's rising and setting, controlling alertness, sleep, hormone production, and organ function.
Researchers found that Arabidopsis plants respond differently to light and temperature signals, with one gene focused on photosynthesis and the other sensitive to temperature. This discovery suggests that plants have multiple internal clocks operating within a single tissue, allowing them to make critical decisions about flowering.
Amita Sehgal and colleagues report a new link between the neurofibromatosis-1 gene and the body's circadian clock, revealing a new facet of the circadian control system. The findings show that the Nf1 protein regulates the cellular switch MAP kinase.