Articles tagged with Prostaglandin Signaling
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Prostacyclin has been found to promote fetal membrane repair through the proliferation and migration of amnion mesenchymal cells. This discovery provides new insight into the mechanisms of fetal membrane healing, which could lead to new therapeutic strategies for managing preterm birth and infant mortality.
Researchers found that exposure to persistent organic pollutants (POPs) stored in body fat leads to disruptions in lipid metabolism and altered prostaglandin pathways, contributing to long-term higher blood pressure in adolescents. POPs diminish the beneficial effect of bariatric surgery on improved blood pressure.
Researchers discovered that Prostaglandin E2 drives skin cells to age and enables some of these cells to become pre-cancerous, leading to increased cancer risk. The study found that blocking PGE2 reduced the chances of aged cells becoming precancerous.
Researchers from Kumamoto University discovered that prostaglandin receptors in the uterus enhance decidualization, a crucial process for successful pregnancy. This finding opens the door to developing new fertility treatments targeting these receptors.
Researchers at TUM have uncovered a mechanism by which tumor cells prevent the formation of immune responses, including cytotoxic T cells. This discovery provides rationales for new cancer immunotherapies and could enhance existing treatments.
A study led by Tokyo University of Science researchers identified Dectin-1's role in promoting colorectal cancer by enhancing PGE2 production and suppressing IL-22BP expression. The study used mouse models and clinical samples to validate the findings, which have immediate clinical implications for CRC patients.
A study published in Nature found that a small group of neurons in the airway play a pivotal role in alerting the brain about flu infections. The researchers also identified a second pathway from the lungs to the brain that becomes active later in the infection, which may hold promise for developing new treatments.
Researchers at Linköping University identified the brain cells necessary for a fever reaction in mice, finding that prostaglandin production in these cells is both necessary and sufficient for triggering a fever response. This breakthrough sheds light on the body's defense mechanism against infection and inflammation.
Researchers at Kyoto University identified the mechanism behind active inflammation and immunosuppression in tumor microenvironments. EP2/EP4 inhibitors suppress tumor growth by allowing regulatory T cells to infiltrate and activate within tumors, benefiting patients with certain cancers.
Experimental inhibition of prostaglandin E2 enhanced the ability of mice to combat infectious colitis, resulting in increased migration of defense cells and production of antimicrobial peptides. Inhibiting PGE2 also favored the expression of defensins, considered natural antibiotics, in the colon.
Researchers have identified a key mechanism driving the emotional response to painful inflammation, highlighting potential therapeutic targets for managing chronic pain. Prostaglandins in brainstem serotonin-producing neurons play a crucial role in this process.
Researchers discovered that a molecule involved in fish reproduction, PGF2α, activates the brain via the nose, synchronizing reproductive behaviors between male and female zebrafish. The molecule binds to specific olfactory receptors, activating a dedicated neural pathway to areas of the brain responsible for courtship behavior.
Fever is triggered by prostaglandin signaling substance produced in the brain's blood vessels. A new study confirms this origin, shedding light on inflammation symptoms and potential drug targets.
Researchers at Emory University School of Medicine have discovered a potential lead compound that can reduce mortality when given to mice after drug-induced seizures. The compound, TG6-10-1, blocks signals from prostaglandin E2, which is involved in the toxic inflammation in the brain arising after status epilepticus.
Scientists at Emory University School of Medicine identified a new group of compounds that block signals from EP2, a receptor involved in inflammation. The compounds could potentially treat neurological diseases such as epilepsy and stroke.
Researchers at Stanford University School of Medicine have identified EP4 as a potential new treatment target for stroke. A selective EP4 agonist administered after stroke reduced brain damage and long-term behavioral deficits in mice, suggesting its therapeutic potential.
Researchers at Max Planck Institute discover that flushing phenomenon triggered by nicotinic acid is caused by activation of Langerhans cells and keratinocytes, leading to inflammation and skin redness. Development of novel 'flush inhibitors' could improve treatment outcomes for cardiovascular diseases.
Researchers at the University of Pennsylvania School of Medicine have discovered a new target for maintaining healthy blood pressure. Mice that lack the receptor for PG F2-alpha, a type of prostaglandin, have lower blood pressure and less atherosclerosis than their non-mutant counterparts.
Researchers identified EP1 as a key factor in blood pressure regulation and found that inhibiting it can reduce hypertension. Targeting this receptor subtype may be a viable approach to treating high blood pressure.
Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight due to the absence of the EP3 receptor. The study found that mice without the receptors are more active during their normal sleep cycle and eat more, leading to weight increases of up to 30 percent.
Researchers uncover how alpha-defensin-1 inhibits HIV infection in CD4+ T cells and how lubricin protects cartilage surfaces. These findings provide insights into innate immunity against HIV and may lead to the development of defensin-like drugs for prevention and treatment.
Research reveals that sleep deprivation impairs certain brain areas, including the cerebral cortex, but also activates others, such as the cerebellum. This study sheds light on the complex role of sleep in cellular function and suggests new possibilities for treating sleep disorders.
Research suggests that PGE2 can alleviate intestinal inflammation by inhibiting NF-\u00b8B and JAK/STAT pathways. Additionally, the study highlights the importance of targeting PGE2 receptors in the treatment of inflammatory bowel disease.
A study by Stock et al. reveals that genetic disruption of the PGE2 receptor EP1 significantly reduces pain behavior and blood pressure responses to inflammation. The findings suggest that NSAID treatment's analgesic effect can be explained by inhibition of signaling through this single receptor type.
Researchers used X-ray crystallography to determine the structure of COX-2 with arachidonic acid bound, gaining insights into its interaction with inhibitors. The study's findings may help guide future drug development for pain, inflammation, and cancer treatment.
Researchers at Vanderbilt University Medical Center discovered that mice lacking the EP2 receptor exhibit salt-sensitive hypertension and reduced fertility. The study found that PGE2 excretion increased in response to high salt diets, leading to unmasked constrictor receptors and development of hypertension.
Fibrates, used for decades to treat hyperlipidemia and atherosclerosis, have been shown to reduce inflammation in vascular muscle cells, inhibiting the production of pro-inflammatory cytokines. This mechanism suggests that fibrates may have a beneficial vascular action during atherosclerosis treatment.