Articles tagged with T Cell Receptor Signaling
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Scientists have discovered that Vitamin D is essential for activating killer cells in the immune system. Without sufficient vitamin D, T cells cannot detect and fight off serious infections. The researchers found that T cells rely on vitamin D to activate and that a lack of vitamin D can lead to immune suppression.
Researchers tracked three children with DiGeorge Syndrome after thymus tissue transplantation to measure the growth of T-cells and assess receptor diversity. The study found that factors regulating T-cell receptor diversity are a thousand times more common than those treating all T-cells alike.
Researchers have discovered a unique antibody that blocks the S1P receptor on T cells, reducing their numbers in the bloodstream and potentially treating autoimmune disorders such as colitis, lupus, and rheumatoid arthritis. The study's findings suggest a new horizon for reversing disabling and often fatal conditions.
NIH scientists have identified a protein that enables T and B cells to interact, crucial for establishing long-lasting immunity. The finding may explain why individuals with a genetic defect suffer from lethal infections.
Researchers at St. Jude Children's Research Hospital discovered T cells use molecular controls to modulate development and avoid autoimmunity. Subtle defects in these controls may explain the delayed onset of autoimmune diseases.
Researchers at Scripps Institute have discovered a new regulatory mechanism for the binding of proteins to membranes through PH domains. IP4, a small soluble molecule, enhances this process, and its inhibition can block T cell maturation and lead to immunodeficiency in animal models.
A new paradigm in immune regulation has been discovered, where LAG-3 protein acts as an immunological molecular brake controlled by the strength of the T cell receptor signal. The study shows that cleavage of LAG-3 proteins on activated T lymphocytes allows them to greatly increase their proliferation rate during an immune response.
A nationwide team of researchers has discovered several new biochemical pathways that play a central role in post-trauma immune system and organ failure. The study identified the genetic and protein changes in specific immune cells that determine whether trauma is fatal, providing potential insights into many diseases involving human i...
Researchers at NYU Langone Health and University of California, Berkeley, have observed the exchange of information between immune cells that sparks a body-wide response to infection. The study reveals how T cells analyze and react to signals of infection at the immunological synapse.
Researchers developed a technique to manipulate immunological synapses with molecular precision, revealing that spatial arrangement determines signal strength. This breakthrough may help develop treatments for autoimmune diseases and better understand cellular communication.
Research discovers T-cell 'traffic control' system that prevents autoimmune disease and rejection of transplanted organs, promising new treatment for multiple sclerosis and transplant rejection. The system is controlled by a fat-like compound called S1P, which can be blocked with experimental drugs to prevent excessive T cell activity.
Researchers found that HIV uses Nef to activate Rac activity in DOCK2ELMO1 complex, disrupting T cell migration and interaction with other lymphocytes. This study provides biochemical evidence for Nef's role in subverting immune response pathways controlled by receptors on T cells.
Researchers identified a bull's eye-shaped structure between white blood cells that enhances sensitivity to antigens but cuts off signaling beyond a threshold, preventing T-cell death. This adaptive control device enables the immune system to respond to signs of infection over a wide range of magnitudes.
The MAP kinase pathway is activated in response to coxsackievirus infection, leading to increased viral replication. This signaling cascade also triggers host cell responses, including inflammation and immune activation.
SLAP-130 protein plays a crucial role in bridging chemical pathways to activate T cells, generating an immune response. This discovery may lead to new treatments for cancers and autoimmune disorders by learning how to control T cell activation.
Researchers have identified two proteins p73 and E2F1 that play important roles in programmed cell death, regulating the death of immune cells T cells. This discovery provides new insights into cancer research and the potential treatment of autoimmune diseases.
Scientists at UCSF deciphered a pattern of signals that determine the survival of T cells, the body's natural defense arsenal. The research identifies a new role for chemical messages between the immune system and a steroid hormone signal, which may control stress-induced hormone imbalance and autoimmune diseases.