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Glowing tags reveal split-second activity of pathogenic circuitry

Researchers at Rice University have created a new optical tool called homo-FRET that allows them to observe the real-time activity of two-component systems in bacteria. This breakthrough enables scientists to study the behavior of deadly pathogens and antibiotic-resistant bacteria, shedding light on their mechanisms and potential targe...

SourceRice University·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateAug 25, 2022

Study reveals how bacterial pathogen adapts to nutritional stress

Researchers at Illinois provided insight into the signal transduction mechanism utilized by Staphylococcus aureus's TCS ArlRS in response to host-imposed manganese and glucose starvation. The study found that histidine kinase ArlS is necessary for activation of response regulator ArlR under both manganese and glucose-limited conditions.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalJournal of Bacteriology·TypeExperimental study·DateDec 6, 2021
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