Articles tagged with Chlorides
Researchers at Yale University have discovered that curcumin, a compound found in turmeric, can correct the defective chloride channel responsible for cystic fibrosis. In tissue culture and mouse model systems, curcumin restored normal function to the nasal and rectal epithelia of CFTR mice.
A team of UC scientists discovered a gene that controls the production of methyl halides in terrestrial plants, contributing to ozone destruction. The HOL gene, found in Arabidopsis and other plants, is likely a common trait among all terrestrial plants.
Researchers found that glutamate regulates the movement of bicarbonate and chloride into epithelial cells, controlling mucus transport and water flow. This discovery contributes to understanding how cystic fibrosis is controlled by gland cell membranes and may lead to future therapies for severe forms of the disease.
Researchers at Vanderbilt University Medical Center have developed a novel gene therapy approach that repairs messenger RNA, which could lead to effective treatments for inherited diseases. The method uses ribozymes to correct defective genes and has shown promising results in animal models.
Researchers identified a new compound, thiazolidinone, that effectively inhibits CFTR-mediated chloride secretion, reducing excess intestinal fluid secretion in mice with secretory diarrhea. The study's findings suggest that this compound may be useful in treating secretory diarrhea linked to the cystic fibrosis gene.
Researchers discovered that ion channels in bacteria allow them to withstand stomach acid by enabling an electrical shunt. This finding suggests a similar mechanism exists in human cells, potentially related to maintaining acidic conditions within endosomes.
A new family of chloride ion channels has been identified in humans, which causes hereditary eye disorders. The discovery was made by a team of researchers at the Howard Hughes Medical Institute and found at least three other members of this channel family in humans, four in fruit flies, and 24 in the worm Caenorhabditis elegans.
Rockefeller University scientists have solved the three-dimensional structure of a type of chloride channel called ClC, providing new insights into its mechanism and selectivity features. The research findings are crucial for developing drugs to target ion channel impairments linked to heritable diseases such as cystic fibrosis.
Researchers have determined the three-dimensional structure of the chloride ion channel using x-ray crystallography, resolving a long-standing biochemical puzzle. The discovery provides insights into how nature arranges proteins to stabilize anions like chloride inside cell membranes.
Scientists at UNC Chapel Hill have discovered a highly ordered array of signaling molecules controlling the passage of chloride and other ions in healthy people. This breakthrough may lead to new treatments for cystic fibrosis by restoring CFTR function through genetic engineering or drug therapy.
Scientists develop a new process using chromium chloride to produce hundreds of thousands of compounds in just one experiment. The innovation enables faster screening of industrial products, including drugs and dyes.