Articles tagged with Oligomers
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Scientists at Cambridge's Department of Chemistry have mapped the pathway that generates 'aberrant' forms of proteins, which are at the root of neurodegenerative conditions like Alzheimer's. The breakthrough opens up possibilities for a new generation of targeted drugs and earlier diagnosis of neurological disorders.
A study has found a key difference between brains of people with Alzheimer's disease and those who are cognitively normal but have brain plaques. Researchers detected smaller molecules of amyloid beta called oligomers, which were more closely correlated with dementia symptoms.
Researchers found that curcumin prolongs the lives of fruit flies with Alzheimer's symptoms by up to 75% and maintains their mobility. However, it did not dissolve or decrease the amyloid plaque, but instead accelerated its formation by reducing precursor forms.
New research reveals that tau oligomers, smaller structures formed before neurofibrillary tangles, are the most toxic entities in Alzheimer's. High levels of tau oligomers have been found in some Alzheimer's brains, and their presence has been linked to various biochemical behaviors and structures.
Scientists at the Stowers Institute for Medical Research found that oligomers of a synapse protein are essential for forming long-term memory. The discovery supports a new theory about memory and may have implications for understanding diseases such as Alzheimer's and prion diseases.
Researchers at Mount Sinai School of Medicine found that Alzheimer's pathology begins with Amyloid-Beta oligomers in the brain, rather than previously thought amyloid plaques. The study suggests that these clumps, not plaques, are toxic to brain cells and may be a major target for new treatments.
A new enzyme-linked immunosorbent assay can detect Alzheimer's disease by measuring high molecular weight A-Beta oligomers in spinal fluid. The test showed direct correlation between A-Beta oligomer levels and memory impairment, enabling early diagnosis of the disease.
Researchers identified naturally occurring antibodies in human blood that selectively target toxic beta amyloid oligomers, potentially offering a natural defense mechanism against Alzheimer's. The antibodies recognize misfolded shapes of proteins, which could have implications for immune therapy of other neurodegenerative diseases.
Researchers found that amyloid growth can occur independently of oligomers in yeast prion protein Sup35. The study suggests that creating conditions favoring fiber growth while inhibiting oligomer formation might limit the toxic effects of amyloid plaques.
Researchers found that small toxic molecules triggering cell damage in degenerative diseases have a similar structure. This discovery implies that these molecules are suitable targets for new drugs or vaccines that could halt progression of many degenerative diseases.