Articles tagged with Organic Chemistry
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A recent study developed a new folded supramolecular polymer that spontaneously undergoes interchain aggregation, exhibiting potential applications in stimuli-responsive materials. The research team used atomic force microscopy to demonstrate the relationship between unfolding and aggregation.
A team of researchers developed a new chemical reaction to synthesize ADP- and ATP-containing molecules with high yields, overcoming limitations of traditional methods. The reaction uses a hydrolysis-stable reagent and achieves reproducible access to these molecules.
Researchers at Kaunas University of Technology (KTU) develop materials to improve indoor photovoltaic cells, generating electricity even in low-intensity light. The innovation utilizes Internet of Things technologies to efficiently regulate device operation and optimize energy consumption.
Scientists embedded gold nanorods in hydrogels that can contract when exposed to light and expand again upon removal. This expansion and contraction mechanism allows for remotely controlled actuators with endless design possibilities.
Researchers develop new method to create azetidines, a stable form of heterocycle that don't oxidize under physiological conditions, expanding toolkit for drug developers to improve medication safety and reduce side effects. This breakthrough enables the creation of more useful chemical transformations with better medical functions.
Researchers from Chiba University develop sustainable method for producing biodegradable polymers using cuttlefish ink melanin. Decomposition products are converted into polymeric materials with potential applications in circular economies.
Researchers from ICIQ have developed a novel, metal-free intramolecular C(sp3)–N bond forming protocol using hexafluoro-2-propanol (HFIP) to efficiently synthesize biorelevant cyclic molecules and nitrogen-containing heterocycles. This breakthrough enhances pharmaceuticals' biological activities.
Researchers at Okayama University developed a novel method for the total synthesis of scabrolide F, a natural marine compound. The study revealed that synthetic scabrolide F and its related compounds exhibited strong antifouling activity without toxicity, making it a potential solution to prevent biofouling damage.
Researchers have developed a novel technique using a new holmium catalyst for synthesizing hydrocarbazoles with tetrasubstituted carbon. The method uses a lanthanide-based catalyst and can be recycled, paving the way for sustainable chemical processes.
Researchers at Okayama University developed a switchable process to synthesize 3-aminoindolines and 2'-aminoaryl acetic acids from a common substrate using Grignard reagents and azide compounds. The new protocol utilizes tautomerism to control chemoselectivity and achieves efficient synthesis with good yields.
A team of researchers from Chiba University has developed a novel one-step process for indole C5-selective bromination of MTIAs, achieving selective modification at the notoriously challenging indole C5 position. The method operates under mild reaction conditions and accommodates various functional groups.
A team of researchers from Okayama University developed a novel phenothiazine-based organic photoredox catalyst with enhanced stability and recyclability. The new catalyst, PTHS, features a spiral structure that provides improved stability and can be recycled multiple times without losing catalytic activity.
Researchers at Colorado State University have developed a new approach to speed up the development of pharmaceuticals and pesticides. By deconstructing and reassembling common compounds known as heterocycles, scientists can rapidly change their characteristics without extensive synthesis.
This study investigates the cononsolvency mechanism of poly(N-isopropylacrylamide) (PNIPAM) in aqueous methanol solutions. PNIPAM forms rounded structures in pure water but chain structures in pure methanol, leading to hydrophobic hydration and aggregation in aqueous methanol solutions.
A team of researchers from the University of Maryland has developed a novel way to produce and observe carbenes, a class of highly reactive molecules necessary for life. They successfully formed a carbene called hydroxymethylene (HCOH) by breaking down methanol with pulses of ultraviolet radiation.
Researchers at Rice University have successfully synthesized a group of natural compounds known as fusicoccanes, exhibiting diverse biological activities. The study leverages modern organic chemistry and engineered enzymes to achieve the synthesis of complex molecules.
Chemists at the University of Minnesota have created a highly reactive chemical compound that has eluded scientists for over 120 years. The discovery could lead to new drug treatments and safer agricultural products.
This year's winners include Professor Neil Kelleher, Dr. Tamir Gonen, Professor Margaret Sunde, and more, recognized for their pioneering research in top-down proteomics, membrane proteins, amyloid studies, and human health applications.
Researchers have created a more efficient light-driven molecular motor, which can be used for various applications such as controlling molecular self-assembly and creating chiral dopants in liquid crystals. The new design also enables the motor to work more efficiently in medical applications due to its longer wavelength absorption.
Researchers at IOCB Prague have developed a novel method for preparing ribonucleic acid (RNA) containing modified bases using engineered DNA polymerases. This opens the door to applications in chemical biology and therapeutic applications, including mRNA drugs.
A new statistical-modeling workflow can quickly identify molecular structures of products formed by chemical reactions, accelerating drug discovery and synthetic chemistry. The workflow also enables the analysis of unpurified reaction mixtures, reducing time spent on purification and characterization.
Researchers find that heat flows can selectively concentrate prebiotic building blocks, fostering the emergence of life. This process occurs through water convection and thermophoresis, leading to a directed movement of molecules in different places.
Researchers from IOCB Prague have developed a molecule that can switch between three distinct states, enabling the storage of complex information. This achievement opens the door to the development of molecular chips with unprecedented capabilities.
Researchers at Xi'an Jiaotong-Liverpool University developed a new method that enables the efficient production of cysteine-rich peptides and microproteins in their naturally folded 3D structure. The approach uses organic solvents to mimic nature's oxidative folding process, resulting in speeds of over 100,000 times faster than aqueous...
A recent study found that microbial communities thrive on inactive hydrothermal vent smokers, producing organic carbon and fixing CO2. These ecosystems are crucial for understanding the deep-sea carbon cycle and its interactions with the environment.
Researchers developed cresomycin, a conformally restricted antibiotic molecule that optimizes for ribosomal binding, inhibiting Gram-negative and positive bacteria, including multi-drug resistant strains. The findings portend favorably for the future discovery of antibacterial agents broadly effective against antimicrobial resistance.
A rapid diagnosis protocol using a luminescent paper-based platform has been developed to detect the presence of antibiotic-resistant bacteria. The approach uses a supramolecular hydrogel matrix containing terbium cholate that emits green fluorescence when UV light is shined on it.
Scientists investigated the photoluminescence properties of toroidal and randomly coiled supramolecular polymers. The study found that a closed circular structure led to higher energy and more efficient luminescence compared to random coils, which lost excitation energy due to defects.
Scientists develop a new design strategy for molecular-sized gears in crystals, allowing for controllable shifting of motion. The creation of molecular gears could lead to the development of versatile, new materials with unique properties.
Scientists at the University of California, Davis, have successfully synthesized specific chiral molecules using rearrangements of simple hydrocarbons and complex organic catalysts. This breakthrough enables better harnessing of hydrocarbons for various purposes, including precursors to medicines and materials.
Researchers have successfully transmitted a domino effect in redox reactions for the first time. The new mechanism involves a two-part molecule that undergoes structural changes upon oxidation, triggering further oxidation in neighboring groups. This discovery has potential applications in nanoscale computing and energy systems.
A team at Hokkaido University has developed a method to reuse plastic waste while improving process safety and efficiency. The approach uses common plastic materials to initiate radical chain reactions, detoxifying hazardous chemicals and reducing toxicity.
A new AI system, Coscientist, has demonstrated its ability to autonomously learn about Nobel Prize-winning chemical reactions and design successful laboratory procedures. The system achieved this in just a few minutes, outperforming human chemists in some cases.
A novel synthesis method enables easy linkage of therapeutic oligonucleotides to peptide markers, streamlining the process and making it more accessible and cost-effective. This breakthrough has the potential to produce more effective and targeted RNA-based drugs.
The Janelia Fluor dyes have become a staple in biology labs worldwide, and the team has now expanded their spectrum with a new set of far-red shifted dyes that can penetrate deeper into tissue. The researchers developed a novel chemistry to synthesize these dyes, enabling them to create dozens of functional versions relatively quickly.
Researchers at iGCORE in Japan developed two synthetic versions of an ADP-ribose fragment to study cellular functions. The approach enables the production of structurally well-defined oligo- and poly(ADP-ribose) samples, accelerating ADP-ribose biology research.
The research team successfully developed nanomaterials through a bottom-up approach, exploiting the directionality of crystal growth during crystallisation. The resulting nanostructures have potential applications in various fields, including information processing and catalysis.
Researchers at IOCB Prague have described the causes of azulene's blue color and its unusual properties, which can help capture and utilize light energy. The team used a simple concept to explain the molecule's behavior, opening up new possibilities for organic chemistry.
A new study breaks down the complex structure of snail mucus, revealing three unique types of secretions with different functions. The researchers identified novel proteins, some of which have never been seen before, and found that subtle differences in composition can significantly impact properties.
Researchers at UC Santa Barbara have developed a synergistic method that allows for the synthesis of non-canonical amino acids, which are important for therapeutic purposes. The process shortens existing multi-step methods by 3-5 steps and provides stereoselective chemistry.
A team of researchers developed a novel computational approach to identify allosteric sites in integrins, revealing previously inaccessible druggable pockets. This breakthrough has the potential to overcome limitations in integrin-targeting medication and open new avenues for drug discovery.
Researchers have developed a new technique to generically treat several kinds of cancer, showing tumors grew almost three times less and survival rates reached 100% after just one injection. The method targets cancer cells with alpha radiation, sparing healthy tissue.
Researchers have developed a new method to manipulate the shape of double-stranded DNA, known as triplex origami, which can create compacted structures with unique properties. This breakthrough has implications for gene therapy, nanoscale materials engineering, and our understanding of biological processes.
A German federal funding program will support a five-year research collaboration to develop specialty lipids and auxiliaries for mRNA vaccines. The project aims to enhance production capacities and improve the resilience of supply chains for future mRNA therapeutics.
Researchers at Kyoto University created flat fullerene fragments that can accept up to an equal number of electrons as the five-membered rings in their structure without decomposition. These molecules display enhanced absorbance of UV, visible, and near-infrared light, making them suitable for photochemistry applications.
Scientists conducted computational simulations to clarify the origin of life on Earth. The study suggests that chiral asymmetry may have originated in space through CP Lyman-α emission line, influencing the production of biological amino acids.
Researchers developed a machine-learning algorithm to predict the density of states within an organic molecule using core-loss spectroscopy data. The model achieved improved accuracy by excluding tiny molecules and adding specific noise to the data.
Researchers at McGill University have made a major breakthrough in understanding the fundamental structure of melanin, a pigment that gives humans their skin, eye, and hair color. The study revealed that a specific component of melanin can convert light into heat across all wavelengths, providing broad-spectrum protection.
Researchers at Colorado State University have created a new chemical strategy to deliver universal dynamic crosslinkers into mixed plastic streams, transforming them into viable new polymers that can be turned into higher-value materials. The method makes post-consumer plastics usable as a new kind of material with useful properties.
Researchers developed molecular nanocages for selective siRNA delivery, showing promise in targeting cancer cells. The nanocage composition determines siRNA delivery efficiency, making it possible to tailor the system for specific cell types.
Researchers at Colorado State University propose using ultrathin films of molybdenum disulfide to improve solar cell efficiency. The material displays unprecedented charge carrier properties that could lead to drastic improvements in solar technologies.
Researchers at Hokkaido University have developed a simplified Birch reduction method that avoids liquid ammonia and can be carried out in ambient air, making it faster and more eco-friendly. The mechanochemical approach uses a ball mill to break through the surface layer on lithium metal, enabling the Birch reduction to proceed.
Researchers at Hokkaido University and Kyushu University have developed a technique to synthesize potential molecular switches from anthraquinodimethanes (AQDs), a group of overcrowded organic molecules. The synthesized derivatives can stably form twisted and folded isomers, as well as other isomeric forms, in different solvents.
Researchers found that a small molecule called ortho-benzyne can drive the chemical evolution of molecules in cosmic stellar nurseries. This discovery provides new insights into the complex chemistry happening in these environments.
Researchers at Osaka University have developed a method to produce specific hexose and heptose sugars using microwave irradiation, improving the sustainability of industrial chemical production. The new process increases reaction efficiency and purity, paving the way for more environmentally friendly chemicals manufacturing.
Researchers developed a machine learning model using advanced 2D chemical descriptors to predict highly selective asymmetric catalysts without quantum chemical computations. The model demonstrated high accuracy in predicting catalyst structures and selectivity, outperforming existing methods.
Researchers from Osaka University have stabilized atomic carbon for common reaction conditions in organic chemistry, enabling the synthesis of complex drugs in one step. This breakthrough simplifies and lowers the cost of pharmaceutical synthesis.
Researchers have developed a new method to synthesize functionalized dibenzoazacyclooctynes, expanding the possibilities for strain-promoted azide–alkyne cycloaddition reactions in biomolecular analysis. This work enables precise modification of cellular components without affecting overall cell physiology.
Chemists at the University of Groningen have developed a simple one-pot reaction to produce chiral Z-alkenes, previously inaccessible molecules. This method uses a phosphine molecule as a starting point, reducing the need for purification and allowing for the creation of complex functionalised alkenes.
The Martian meteorite Tissint has revealed a rich inventory of organic compounds, offering insights into Mars' habitability. The study, published in Science Advances, discovered an unprecedented diversity of organic molecules, including magnesium compounds not previously seen on the planet.