Articles tagged with Proteins
CARM1 plays a significant role in triple-negative breast cancer (TNBC) progression by interacting with HIF1A. The study demonstrates that CARM1 promotes proliferation, invasion, EMT, and stemness in TNBC cells, highlighting its potential as a biomarker for cancer progression.
Researchers found a correlation between protein folding and evolution in certain globular protein families, with most conserved exons corresponding to better foldons. However, the general trend did not hold for all protein families, suggesting other biological factors may influence protein folding and evolution.
Researchers at Rice University discovered two types of motorized chain models: swimming motors and grappling motors, which manipulate chromosome structures. The study reveals how these proteins impact ideal polymer chains, leading to contraction or expansion depending on forces exerted.
Han Xiao aims to develop cells that can biosynthesize and utilize non-canonical amino acids as in vivo sensors for enzymes involved in posttranslational modifications. This research could lead to new strategies in treating diseases by providing real-time insights into enzyme activities.
Professor Helle Ulrich will investigate how a small regulatory protein called ubiquitin contributes to DNA replication and repair, and decipher how cells direct different pathways. The ERC Advanced Grant aims to gain a deeper mechanistic understanding of ubiquitin's function in preventing mutations that can cause ageing and cancer.
Researchers at the Lewis Katz School of Medicine will investigate how injured heart cells communicate with other cells throughout the body using microvesicles known as exosomes. The study aims to understand how specific molecules, such as microRNAs, facilitate communication pathways between cells in the heart and vasculature.
A study by TUM researchers discovered four subtypes of Amyotrophic Lateral Sclerosis (ALS) with different molecular processes, including sex differences. The findings suggest repurposing an approved cancer drug targeting the MAPK pathway as a promising therapeutic approach for ALS.
Researchers used 2D infrared spectroscopy to investigate milk protein structures and dynamics in coffee beverages. The study found that milk proteins remained intact, retaining their original properties, even when exposed to caffeine and coffee grounds.
Researchers developed and validated a new DNA methylation clock (iCAS-DNAmAge) to estimate chronological age in Chinese cohorts, outperforming existing clocks. The study provides valuable tools for assessing biological age and informs aging intervention strategies.
A breakthrough discovery by Nara Institute of Science and Technology researchers identifies EPHA2 as a critical surface protein for preserving stem cell potency. This finding holds promise for safer regenerative medicine by reducing the risk of tumorigenesis, paving the way for organ repair and treatment of degenerative conditions.
A team of researchers from Xi'an Jiaotong-Liverpool University has engineered a short sequence of artificial DNA to target the mutant protein p53-R175H, linked to lung, colorectal, and breast cancers. The new molecule, dp53m, inhibits cancer cell growth and increases sensitivity to chemotherapy agent cisplatin.
Researchers have developed an AI algorithm that can track protein clumping under the microscope in real-time, revolutionizing the study of neurodegenerative disorders. The tool helps identify key characteristics of clumped proteins, which can lead to new therapies.
Researchers have identified an ancient protein that partners with a modern plant enzyme to synthesize lignin, a key component of plant cell walls. This discovery provides insights into the evolution of plant protective mechanisms and their potential industrial applications.
Researchers at Bielefeld University discovered that certain gluten-derived molecules, including the 33-mer deamidated gliadin peptide (DGP), form nanosized structures that accumulate in gut epithelial cells and lead to leaky gut syndrome. This triggers chronic inflammation and autoimmune responses in celiac disease patients.
A new food systems perspective study from the University of Washington shows that pork meat is a high-quality protein source, affordable, and associated with lower greenhouse gas emissions. The study highlights the importance of separating pork from other red meats in nutrition and epidemiology research.
A team at Osaka University uses novel RNA sequencing techniques to reveal the molecular basis for sexual dimorphism in Daphnia, a species of water flea that can change its form and behavior despite being genetically identical. The study identifies genes that switch which isoforms are expressed in a sex-dependent manner.
Researchers at the University of Seville discovered Galectin-3's crucial role in brain tumour progression, finding its inhibition significantly reduces glioblastoma size and brain metastases. Inhibition promotes pro-inflammatory markers and reverses immunosuppressive biomarkers, leading to improved outcomes.
Researchers at UC Riverside identify NMD pathway as crucial for early brain development and preventing microcephaly. The study links NMD regulation of brain size control to the tumor suppressor gene p53, suggesting potential new connections between NMD and cancer.
This year's winners include Professor Neil Kelleher, Dr. Tamir Gonen, Professor Margaret Sunde, and more, recognized for their pioneering research in top-down proteomics, membrane proteins, amyloid studies, and human health applications.
Researchers have developed a new anticoagulant with an on-off switch, providing rapid control of bleeding risks in surgery and blood clots. The supramolecular approach combines a tsetse fly protein with a synthetic peptide, allowing for the anticoagulant to be rapidly deactivated by introducing correctly matched strands of free PNA.
Scientists from OIST created synthetic droplets to mimic biological processes, finding that pH gradients facilitate Marangoni effect and enabling droplets to detect and migrate towards each other. This study sheds light on the movement of simplest forms of life in primordial soup billions of years ago.
Researchers identified a link between Bacteroides fragilis-secreted BFT-1 and breast cancer resistance, highlighting the importance of targeting microbiota in cancer treatment. Inhibiting the NOD1 pathway may sensitize breast cancer cells to chemotherapy, providing a promising avenue for novel therapeutic strategies.
ILF3 interacts with DNA/RNA helicases to resolve telomeric R-loops, maintaining telomere homeostasis. This study provides new insights into R-loop regulation and its implications for aging biology.
Researchers have developed an AI pipeline to identify molecular interactions crucial for developing new treatments and understanding diseases. The AF-CBA Pipeline offers unparalleled accuracy and speed in pinpointing the strongest peptide binders to specific proteins.
A research team has made a significant breakthrough in understanding the GPR156 receptor protein's role in maintaining auditory function. The study reveals that GPR156 exhibits sustained activity even without external stimuli, highlighting its potential as a target for treating congenital hearing impairments.
Emerging from a need to understand organelle interactions, researchers have developed OrthoID, a novel strategy that refines protein identification at organelle contact sites. This method uses mutually orthogonal binding pairs to label and isolate proteins involved in cellular communication.
A study published in Brain, Behavior, and Immunity found that normal levels of interferon-β are required for normal memory function, and its absence changes nerve cell components in a sex-dependent fashion. The research also showed that higher or lower than normal levels of interferon-β affect the brain in a sex-dependent manner.
Researchers at the University of Southampton have developed a method for fast mixing using droplet microfluidics, allowing for the creation of 'movies' of proteins in action. This enables scientists to observe proteins in motion and gain insights into their function.
Researchers at Xi'an Jiaotong-Liverpool University developed a new method that enables the efficient production of cysteine-rich peptides and microproteins in their naturally folded 3D structure. The approach uses organic solvents to mimic nature's oxidative folding process, resulting in speeds of over 100,000 times faster than aqueous...
Researchers have developed a method to identify extremophiles using protein fragments, leading to the discovery of two new 'extremophile' microbes from high-altitude lakes in Chile. This breakthrough could potentially help scientists search for extraterrestrial life and explore Earth's biodiversity.
A new tool using electrocatalysis enables precise modification of site-specifically incorporated 5-hydroxytryptophan residues on many different proteins, including full-length therapeutic antibodies. The eCLIC method has potential applications in developing novel biotherapeutics and protein-based research tools.
Researchers used advanced techniques to study TMEM16F's structure and function in its native environment, uncovering previously overlooked structural conformations. The study reveals a dynamic and flexible functioning of the protein, essential for regulating cell functions such as blood coagulation and immune defense.
Researchers will develop new tools to understand how proteins interact and regulate the nervous system. The project aims to identify new therapeutic targets for brain disorders and generate diagnostic tools.
Researchers discovered a potential treatment for Alzheimer's disease also prevents Type 2 diabetes by blocking the formation of toxic IAPP clusters. A synthetic peptide was shown to bind and neutralize these clusters, keeping beta cells alive.
A UC Riverside-led study has devised a way to make large quantities of the Membrane protein, which plays a crucial role in how SARS-CoV-2 acquires its spherical structure. The researchers found that when the M protein interacts with the membrane, it coaxes the membrane to curve, leading to the virus's characteristic shape.
PandaOmics uses advanced AI algorithms to process vast quantities of diverse data, performing gene and pathway analysis and target predictions. The platform has been extensively validated in multiple therapeutic areas, including oncology, inflammation, and immunology.
Scientists successfully synthesized pantetheine, a chemical essential for all living things, in lab conditions mimicking early Earth. The compound is crucial for metabolism and may have played a role in the emergence of life on Earth.
Researchers at Karolinska Institutet used DNA origami to activate the Notch receptor in a new way, revealing it can be activated 'on demand' with the help of a protein called Jag1. The study opens new avenues for understanding the Notch signalling pathway and its role in serious diseases like cancer and Alagille Syndrome.
Researchers at IRB Barcelona developed BioExcel-CV19, a repository of Molecular Dynamics simulations to understand SARS-CoV-2 infection. The database provides over 10,000 trajectories for key proteins and facilitates community-wide analysis.
Researchers found that anthrax lethal toxin (LT) and tumor necrosis factor-alpha (TNF-α) synergize to induce mouse death, primarily through damage to intestinal epithelial cells. Both necroptosis and apoptosis pathways are involved in this process, which could lead to a new target for preventing anthrax-caused death.
A chemically defined, xeno-free culture system for culturing and deriving monkey PSCs has been successfully developed. The system allows for the global gene expression analysis and genome-wide hypomethylation patterns distinct from human cells, enabling the tracking of cell migration and proliferation.
Scientists have discovered the protein that enables poison dart frogs to accumulate and store potent toxins in their skin for self-defence against predators. The findings may suggest potential therapeutic strategies for treating humans poisoned with similar molecules.
Researchers found that cytoglobin, a protein similar to hemoglobin, plays a vital role in the correct left-right pattern of the heart and other asymmetric organs. The study's findings could lead to new therapeutic interventions for rare birth defects affecting cilia function.
Researchers have discovered a new approach to targeting transcription factors in prostate cancer by exploiting the formation of protein droplets. This process can be used to inhibit androgen receptor activity, which is essential for the growth and survival of cancer cells.
Researchers at Chalmers University of Technology have discovered a new method for capturing proteins in nano-sized traps to study difficult-to-treat diseases. The technique allows for the trapping of hundreds of proteins in a small volume, enabling the study of early development and potential drug countermeasures.
Researchers have developed an engineered LIMK1 protein that can be activated by administering the drug rapamycin, resulting in improved memory function. This innovative approach has great potential applications in understanding memory processes and facilitating the identification of solutions for neuropsychiatric diseases.
Researchers discovered an enzyme that can improve the quality and alcohol content of sorghum-based beers. By optimizing brewing parameters, brewers can create wort with higher concentrations of fermentable glucose, resulting in better-tasting drinks.
Stanford researchers have discovered a pathway to break down problematic proteins, which can be harnessed to develop new treatments for diseases such as Alzheimer's and cancer. The findings also offer insights into lysosome storage disorders, rare conditions that affect babies and children.
Researchers used molecular dynamics simulations to study how urea and alcohol induce structural changes in proteins, with a focus on stabilizing helices and coils. The team identified preferential binding parameters for both cosolvents, demonstrating opposing effects that can be predicted using computational methods.
A new study doubles the number of protein families known up until now and identifies many novel structure predictions using a massive analysis of 1.3 billion proteins. The researchers leveraged AI methodologies to unravel the roles of previously unknown protein sequences, expanding the horizons of potential functions.
Researchers discovered that inhibiting IGF2BP1 can extinguish its cancer-causing effects, leading to the formation of neuroblastomas. The study provides a promising new potential therapeutic approach for treating this childhood cancer.
Researchers at the University of Sydney have developed a nanoscale optical technique to monitor protein aggregates forming in cells, which can lead to neurodegenerative diseases such as Alzheimer's and ALS. The study provides a new window into the transition of proteins from liquid to solid phase.
Complex proteins adopt multiple structural states in solution, making it challenging to determine their three-dimensional structure. A new approach combining NMR spectroscopy and computer simulations reveals the dynamic properties of these proteins.
Researchers successfully created stem-cell derived organoids from human stem cells that secrete three essential enamel proteins. These proteins form a matrix that undergoes mineralization to create a hardened enamel structure. The breakthrough offers hope for developing novel treatments to repair and regenerate teeth.
Researchers from Osaka University have shed light on how certain proteins contribute to the formation of piRNAs, a type of RNA that protects the genome. Tejas plays a key role in recruiting Vas and Spn-E, facilitating nuage formation and piRNA processing.
Researchers developed a targeted chemotherapy that selectively disrupts DNA replication and repair in cancer cells, leaving healthy cells unaffected. The investigational small molecule AOH1996 has been effective in treating various types of solid tumors in preclinical research.
Researchers at the University of Pittsburgh have developed a new method to create unnatural amino acids, expanding the toolkit of human biochemistry. This breakthrough could lead to novel protein-based therapies and organic chemistry branches.
TRIM11 protein levels decreased in Alzheimer's disease models, suggesting replenishment may improve cognitive and motor function. The study reveals that TRIM11 plays a key role in removing tau protein tangles that cause neurodegenerative diseases like AD.
Researchers investigate how bacteria modify host RNA using effector proteins to ensure their survival, a process previously unknown in eukaryotes. The team aims to decipher the mechanisms behind this process and its benefits for the bacteria.
A new study suggests that replacing traditional protein sources with mealworms in high-fat diets can slow weight gain and improve immune response, inflammation, energy metabolism, and cholesterol profiles. Mealworm protein also beneficially alters the ratio of good to bad cholesterol.