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Making injectable medicine safer

University at Buffalo researchers have created a method to strip away excess surfactants from common injectable drugs, potentially making them safer and more effective for millions. The breakthrough removes potentially harmful additives, improving the formulation of anti-cancer medicine, testosterone, and other drugs.

SourceUniversity at Buffalo·JournalNature Communications·DateMay 19, 2016

Researchers find molecular mechanisms within fetal lungs that initiate labor

Researchers at UT Southwestern Medical Center have identified two proteins responsible for initiating the labor process, which control genes for pulmonary surfactant components that promote labor. Surfactant is essential for normal breathing outside the womb. Understanding these molecular mechanisms may help prevent preterm birth.

SourceUT Southwestern Medical Center·JournalJournal of Clinical Investigation·DateJun 22, 2015

Fat damages the lungs of heavy drinkers

Researchers at Thomas Jefferson University found that alcohol consumption leads to a buildup of fat in the lungs, weakening the immune system and increasing the risk of pneumonia and acute respiratory distress syndrome. This discovery offers a potential new explanation for why heavy drinkers are more susceptible to lung disease.

SourceThomas Jefferson University·JournalAmerican Journal of Respiratory Cell and Molecular Biology·DateJun 30, 2014

Gadget genius

Researchers at the University of Akron have developed new nanoscale materials that can be used to create ultra-lightweight electronics. These materials, known as 'giant surfactants,' have the potential to revolutionize the tech industry by enabling the creation of smaller and more efficient devices.

SourceUniversity of Akron·JournalProceedings of the National Academy of Sciences·DateJul 26, 2013

Findings suggest optimal dose

A national study found that continuous positive airway pressure (CPAP) treatment may be a viable alternative to routine intubation and surfactant administration in preterm infants. Infants treated with CPAP required less frequent intubation, fewer days on ventilators, and fewer steroid drugs after birth.

SourceUT Southwestern Medical Center·JournalNew England Journal of Medicine·DateJun 2, 2010

Higher oxygen levels improve preterm survival, increase risk for eye condition

Researchers found that higher oxygen levels in preterm infants improve survival rates, but also increase the risk of retinopathy of prematurity. A new treatment using continuous positive airway pressure (CPAP) is as effective as traditional ventilator therapy and may result in fewer complications.

Breathe easy with the protein LPCAT1

Researchers identified LPCAT1 as a key protein in lung surfactant production, essential for air breathing transition in mice. Decreased LPCAT1 expression may underlie fatal respiratory distress syndrome in premature infants.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateApr 19, 2010

Anesthetic approach stops pain without affecting motor function

Researchers at Boston Children's Hospital have discovered a novel anesthetic approach that selectively blocks pain sensation in nerve cells while preserving motor function. This breakthrough could lead to the development of longer-lasting local anesthetics for childbirth and musculoskeletal disorders, with minimal impact on mobility.

SourceBoston Children's Hospital·JournalProceedings of the National Academy of Sciences·DateFeb 1, 2010

Cellular construction methods emulated

The Dutch team used two types of self-aggregating compounds: surfactants and gelators. They formed aggregates that coexisted without interfering with each other, resulting in complex structures with separate compartments. This orthogonal self-aggregation enables the creation of versatile compartmentalized systems.

SourceWiley·DateMar 5, 2008

Congenital diaphragmatic hernia

Research suggests that congenital diaphragmatic hernia does not disrupt pulmonary surfactant maturation in human fetuses, contrary to previous findings. The study provides new insights into the development of this complex condition.

SourcePLOS·JournalPLOS Medicine·DateJul 30, 2007

New nanomethod may help compress computer memory

Researchers at Brown University have developed a technique to synthesize iron-platinum nanorods and nanowires with controlled size, composition, and magnetic alignment. The method produces batches of similarly-sized nanowires or rods in solution, showing promise for high-density information storage and other applications.

Emulsion with a round-trip ticket

Researchers successfully create a double inversion of an emulsion by adding surfactant to a nanoparticle-containing mixture. The process, which uses silica nanoparticles and a specific type of surfactant, allows for the conversion between oil-in-water and water-in-oil emulsions.

SourceWiley·DateJun 14, 2007

Nanoscale cubes and spheres

Researchers at the University of Minnesota have created uniform porous silicon oxide nano-objects with defined sizes and structures by disassembling larger lattice-like structures. The resulting particles exhibit worm-like pores and can be easily customized by varying the colloidal crystals used as moulds.

SourceWiley·DateJan 3, 2007

Alveolar type I cells

Researchers have identified alveolar type I cells as potential diagnostic markers for acute lung injury. The study's findings suggest that these cells may play a crucial role in the development of pulmonary diseases.

SourceBlackwell Publishing Ltd.·JournalThe Journal of Physiology·DateMay 5, 2006

Genetic mutation linked to infant lung disease

A genetic mutation in the ABCA3 gene is linked to severe surfactant deficiency in infants, leading to fatal lung disease. Researchers found mutations in 16 infants, with 15 dying from their illness, and discovered a potential mechanism for the defective transport of phospholipids critical for surfactant function.

SourceJohns Hopkins Medicine·JournalNew England Journal of Medicine·DateMar 24, 2004

American Thoracic Society Journal news tips for November 2003 (first issue)

An asthma intervention study showed a 60% reduction in total hospitalizations among patients with frequent asthma exacerbations. Researchers also found that initial use of three antibiotics followed by diagnostic testing led to better patient survival and reduced antibiotic use for ventilator-associated pneumonia. Additionally, prematu...

SourceAmerican Thoracic Society·JournalAmerican Journal of Respiratory and Critical Care Medicine·DateOct 30, 2003