Articles tagged with Total Synthesis
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have successfully developed an asymmetric synthesis method for quebracho indole alkaloids using a nickel-catalyzed [2+2] cyclobutanization reaction with flexible antenna ligands. The method achieved high yields and precise control in 7-10 steps, including the first-ever asymmetric syntheses of three naturally occurring comp...
A team from Peking University successfully synthesized hemiketalTTX in 23 steps with a total yield of 0.7%, addressing the scarcity of this natural toxin. The synthesis utilizes a unique Prins cyclization reaction to construct the [3.2.1] bridged ring skeleton.
Researchers at UC Davis have successfully synthesized ibogaine and its related compounds using a new, efficient method. The study's findings suggest that these analogues may be useful in treating substance use disorders and other conditions, and highlight the potential for safer and more effective medicines.
A Japanese research team has successfully synthesized inaoside A, an α-D-ribofuranoside-type compound isolated from the edible mushroom Laetiporus cremeiporus. This achievement paves the way for further investigation into its bioactivities and potential applications in pharmaceuticals and functional foods.
A team of scientists has synthesized a highly complex natural molecule using a novel strategy that functionalizes normally nonreactive C–H bonds. The new method opens up possibilities for synthesizing previously unavailable chemicals, representing a whole new way for chemists to create materials.
Chemists at Emory University and Caltech have developed a revolutionary strategy for functionalizing carbon-hydrogen bonds, transforming low-cost materials into complex building blocks of organic chemistry. The breakthrough enables the synthesis of complex natural molecules with antimicrobial properties.
Researchers at the University of Illinois have developed a method to understand and improve light-harvesting molecules for solar energy applications. By combining AI with automated chemical synthesis and experimental validation, they were able to produce molecules four times more stable than traditional ones.
MIT chemists have developed a new way to synthesize complex oligocyclotryptamines found in plants, which could hold potential as antibiotics, analgesics, or cancer drugs. The approach allows for precise assembly of the rings and control of the 3D orientation of each component.
Researchers from Tokyo University of Science have developed an efficient method to synthesize eutyscoparol A and violaceoid C, two compounds with potential therapeutic properties. The new approach improves yields and simplifies synthesis steps, enabling further research into their pharmacological effects.
David Sarlah joins Rice University as a CPRIT-funded professor to contribute to the university's cancer research, focusing on natural product synthesis and total synthesis for cancer biology. His lab aims to streamline production of compounds used in cancer therapy.
Researchers at Okayama University developed a novel method for the total synthesis of scabrolide F, a natural marine compound. The study revealed that synthetic scabrolide F and its related compounds exhibited strong antifouling activity without toxicity, making it a potential solution to prevent biofouling damage.
A team of researchers from Chiba University has developed a novel one-step process for indole C5-selective bromination of MTIAs, achieving selective modification at the notoriously challenging indole C5 position. The method operates under mild reaction conditions and accommodates various functional groups.
Researchers at University of Basel have developed a new method to synthesize complex natural substances like terpenes, which can be used as the basis for new medications. The approach allows for controlled molecular structure and targeted changes to improve properties, paving the way for the development of new therapeutic agents.
Researchers at Tokyo University of Science achieve first total synthesis of merrillianin, a complex sesquiterpene with potential anti-rheumatic activity. The breakthrough method involves 30 reaction steps and could lead to the development of new treatments for nervous system diseases.
Researchers at Kyoto University successfully synthesized the structure of Lancilactone C, a rare anti-HIV compound. The team's method revealed an incorrect initial structure and showed that electrocyclization occurs in both synthesis and biosynthesis, leading to potential development of novel antivirals.
Researchers at Tokyo University of Science successfully synthesized tanzawaic acid B in large amounts, paving the way for new antibiotic development. The breakthrough method could lead to creation of various compounds for pharmaceuticals, including new antibiotic candidates.
Researchers at Kyoto University have successfully synthesized shagene A, a tricyclic terpenoid effective against the parasitic disease leishmaniasis. The compound kills the parasite without causing detrimental side effects and has attracted attention for its potential in drug discovery.
A German team led by Thorsten Bach successfully synthesized agarozizanol B, a complex sesquiterpene with potential pharmaceutical applications. The researchers developed a photochemical reaction cascade to form the molecule from an indanone derivative, achieving both enantiomers of the natural product.
Researchers at Waseda University have successfully developed a method for the total synthesis of cotylenin A, a plant growth regulator with promising bioactivity as an anti-cancer agent. The new method allows for the production of a stable and effective anticancer drug without the side effects associated with traditional treatments.
Researchers have introduced a novel total synthesis method for tetrodotoxin, a strong nerve toxin with potential as a pain reliever for cancer treatment. The new route enables easy and reliable production of the compound.
Researchers at the University of Basel have developed a new strategy for synthesizing complex natural products, including Epicoccin G and Rostratin A, using C-H bond activation. The approach results in high yields and reduces the number of steps compared to previous methods, opening up new avenues for medicinal applications.
Researchers at Harvard University have synthesized sufficient quantities of the potent anti-cancer agent E7130 to enable rigorous studies of its biological activity, pharmacological properties, and efficacy. The team's achievement is a landmark in drug discovery, providing new insights into the molecule's complex mode of action and pot...
Researchers at KAIST successfully synthesized the natural product (-)-flueggenine C via an accelerated intermolecular Rauhut-Currier reaction. The conventional RC reaction is non-selective and high-temperature, but the team modified it to use a base at ambient temperature.
Researchers have developed a facile synthesis method for complex biologically active oligopeptides, including feglymycin. The new approach uses micro-flow amide bond formation to overcome challenges in synthesizing arylglycine-containing peptides, which are present in various natural products with potent biological activity.
The Rice University lab has developed a streamlined total synthesis of delta12-prostaglandin J3, a molecule with potential as an anti-cancer agent. The new method requires only six steps from commercially available starting materials, making it more efficient and desirable for large-scale synthesis.
A team of researchers from the University of Hong Kong has successfully developed a novel strategy for synthesizing cortistatin A, a molecule with potent anti-angiogenic activity. This breakthrough could lead to the creation of more effective anti-cancer therapies.
Researchers at Ludwig-Maximilians-Universität München develop efficient synthesis of epicolactone, a complex natural product produced by the endophytic fungus Epicoccum nigrum. The 8-step pathway reveals how the molecule is assembled and provides insight into its biochemical significance.
Researchers Aaron C. Smith and Robert M. Williams successfully reproduced the Rabe-Kindler protocol for synthesizing quinine, a key step in its 'formal' total synthesis. They found that using aluminum powder as a reducing agent was crucial to achieving high yields of quinine.
Researchers have developed a way to synthesize ciguatoxin, the toxin responsible for seafood poisoning, which will enable scientists to better understand its effects on humans and prepare toxin-fighting antibodies. The breakthrough could lead to more efficient methods for detecting infected fish before they reach the market.