Researchers at the University of Illinois have identified a single major gene controlling waterhemp's resistance to S-metolachlor, a widely used soil-applied herbicide. This finding poses a significant challenge for farmers, as it increases the risk of spread and limits effective weed management options.
SourceUniversity of Illinois College of Agricultural, Consumer and Environmental Sciences·JournalWeed Science·DateNov 8, 2023
The global antibiotic resistance of Pseudomonas aeruginosa has decreased, with a significant drop in resistance to all tested antibiotics. However, a hypervirulent strain, ST235, has increased in prevalence, causing more aggressive infections and associated with high mortality rates.
SourceUniversity of Córdoba·JournalThe Lancet·TypeMeta-analysis·DateNov 2, 2023
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A new Australian study suggests harnessing genomic surveillance technology can detect the rise of deadly 'superbugs', slowing their evolution and spread to improve global health outcomes. The study highlights the need for a multifaceted 'One Health' approach to surveillance, with practical recommendations for implementation.
SourceUniversity of Technology Sydney·JournalNature Reviews Genetics·TypeSystematic review·DateOct 23, 2023
Researchers found that tumour cells escape immunotherapy by losing or changing BCMA and GPRC5D targets on their surface. This understanding has led to the suggestion of periodically profiling myeloma cells throughout a patient's treatment course to adapt treatment strategies.
SourceUniversity of Calgary·JournalNature Medicine·TypeExperimental study·DateOct 20, 2023
Researchers discovered that lactate-producing intratumoral bacteria drives resistance to radiation therapy. Cancer cells respond to radiation by rewiring metabolic signaling pathways using lactic acid instead of glucose.
SourceUniversity of Texas M. D. Anderson Cancer Center·JournalCancer Cell·DateOct 19, 2023
Researchers at MedUni Vienna discovered that dormant tumor cells surviving chemotherapy can be targeted through the inhibition of P-glycoprotein, opening new possibilities for delaying relapse. This breakthrough could represent a step forward in treating aggressive triple-negative breast cancer, which has limited treatment options and ...
SourceMedical University of Vienna·JournalDrug Resistance Updates·DateOct 2, 2023
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
Researchers developed a novel material that self-assembles into micelle structures targeting cancer cell lysosomes, specifically interacting with Cathepsin B. This leads to dysfunctional lysosomes and apoptotic death of cancer cells. The technology promises a new approach to combat drug resistance in cancer treatment.
SourceUlsan National Institute of Science and Technology(UNIST)·JournalJACS·DateSep 21, 2023
Researchers from MedUni Vienna developed a new approach to fighting resistant cell lines in small cell lung cancer by combining two already available therapeutic agents. The study reveals the molecular mechanism underlying therapy resistance and provides a promising basis for research into successful new therapies.
SourceMedical University of Vienna·JournalClinical Cancer Research·DateSep 21, 2023
Researchers found that DPP4 inhibition increased sunitinib efficacy in RCC spheroids and upregulated DPP4 in sunitinib-resistant cells. This suggests potential repurposing of DPP4 inhibitors to target therapy resistance in renal cell carcinoma.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateSep 20, 2023
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers developed a reliable and reproducible real-time live tissue sensitivity assay (RT-LTSA) using fresh tumor samples to predict patients' clinical response to chemotherapy. The study showed improved disease-free survival and reduced recurrence rates in patients who received RT-LTSA sensitive adjuvant regimens.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateSep 19, 2023
Researchers developed a personalized combination treatment that turned on an immunometabolic switch to effectively control aggressive prostate cancer. The treatment showed complete tumor control and long-lasting survival without side effects in a mouse model of advanced prostate cancer.
SourceUniversity of Chicago Medical Center·JournalClinical Cancer Research·DateSep 18, 2023
Researchers found a strong positive correlation between BRD4 overexpression and chemoresistance in ovarian cancer. The study demonstrated that BRD4-L and BRD4-S isoforms play a role in promoting chemotherapy resistance in high-grade serous ovarian carcinoma.
SourceImpact Journals LLC·JournalGenes & Cancer·TypeExperimental study·DateSep 13, 2023
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
SourceXi'an Jiaotong-Liverpool University·JournalCancer Gene Therapy·TypeExperimental study·DateSep 6, 2023
Researchers create a nanocapsulation strategy to solubilize insoluble aromatic polymers in water, enhancing their processing and development. The approach uses bent aromatic amphiphiles to form micelle-like nanocapsules that encapsulate hydrophobic molecules.
SourceTokyo Institute of Technology·JournalAngewandte Chemie International Edition·TypeExperimental study·DateAug 8, 2023
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
Researchers discovered a way to strengthen polymers by introducing weaker bonds, increasing resistance to tearing up to tenfold. The approach doesn't alter other physical properties and can be used to improve the toughness of other materials like rubber.
SourceMassachusetts Institute of Technology·JournalScience·DateJun 22, 2023
The study found that drug-resistant Leishmania parasites have distinct protein production profiles compared to sensitive parasites, suggesting a global reprogramming of protein synthesis. This pre-emptive adaptation enables the parasite to quickly respond to the presence of the drug and survive when it is absent.
SourceTexas Tech University Health Sciences Center·JournalNature Communications·TypeExperimental study·DateJun 22, 2023
A study by Martin-Luther-University Halle-Wittenberg found a link between high levels of IGF2BP2 and faster-growing bowel cancer tumours with chemotherapy resistance. The protein's role in cell growth and metabolism may lead to the development of new diagnostic procedures and therapeutic strategies.
SourceMartin-Luther-Universität Halle-Wittenberg·JournalMolecular Cancer·TypeExperimental study·DateJun 15, 2023
A study has identified a potential treatment target for prostate cancer that is resistant to hormone therapy, a protein modification involving TRAF4. The researchers found that TRAF4 promotes the spread of cancer and may be associated with a new treatment option for patients.
SourceUniversity of Houston·JournalProceedings of the National Academy of Sciences·DateJun 12, 2023
Researchers discuss chemotherapeutic resistance in recurring ovarian cancer, focusing on the unfolded protein response and its effect on polyploid giant cancer cells. Understanding this mechanism could lead to investigating cancer cell molecular mechanisms and potential therapeutic strategies.
SourceImpact Journals LLC·JournalOncoscience·TypeCommentary/editorial·DateMay 26, 2023
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Cancer-associated fibroblasts (CAFs) are a type of cell that plays a crucial role in the tumor microenvironment. The authors suggest that understanding CAFs is essential for developing effective cancer therapies. Research targeting CAFs has shown promise, but challenges remain due to their complex nature.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateApr 5, 2023
Researchers propose conjugating a cell-penetrating peptide to oxaliplatin to overcome chemotherapy resistance in colorectal cancer. The new approach reduces platinum accumulation in tumour microenvironment and healthy tissues.
SourceIMIM (Hospital del Mar Medical Research Institute)·JournalJournal of Medicinal Chemistry·DateMar 30, 2023
Researchers created a three-dimensional structure that mimics bone and houses osteosarcoma cells beside immune cells, finding increased inflammation reduces chemotherapy effectiveness. The study highlights the importance of the tumor microenvironment in disease progression and treatment.
SourceRice University·JournalBiomaterials·TypeExperimental study·DateMar 20, 2023
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
A new review paper suggests that selective protection of normal cells from chemotherapy could increase the therapeutic window and improve outcomes for cancer patients. The authors propose using antagonistic drug combinations to kill drug-resistant cancer cells, reducing side effects and improving quality of life.
SourceImpact Journals LLC·JournalOncotarget·TypeLiterature review·DateMar 13, 2023
Tumour cells exhibit an innate randomness in their ability to respond to chemotherapy, which can lead to resistance. Researchers identified a marker for resistance and propose combining chemotherapy with drugs targeting this 'noise' to improve treatment outcomes.
SourceGarvan Institute of Medical Research·JournalScience Advances·TypeExperimental study·DateMar 3, 2023
A study published in Nature Communications reveals that platinum accumulates in healthy cells surrounding cancer cells, particularly fibroblasts, and induces gene activation associated with poor response to chemotherapy. Periostin levels serve as a marker of TGF-β activity in fibroblasts and predict treatment benefit.
SourceInstitute for Research in Biomedicine (IRB Barcelona)·JournalNature Communications·DateFeb 23, 2023
A potent plant toxin called albicidin has emerged as a strong new antibiotic candidate, effective in small concentrations and highly potent against pathogenic bacteria. Its unique mechanism targets the bacterial enzyme DNA gyrase, which is essential for cell function.
SourceJohn Innes Centre·JournalNature Catalysis·TypeExperimental study·DateJan 23, 2023
Researchers at Aston University have created the world's first computer reconstruction of a virus, including its complete native genome. This breakthrough could lead to the development of targeted treatments to kill bacteria that are dangerous to humans, reducing the threat of antibiotic resistance.
SourceAston University·JournalFaraday Discussions·TypeComputational simulation/modeling·DateJan 20, 2023
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
A new prostate cancer therapy is being tested in clinical trials, targeting the treatment-resistant form of the disease. The therapy uses a drug called Abivertinib to block a specific protein that allows tumors to produce androgens, a goal of using more targeted treatments like TKIs.
SourceCleveland Clinic·JournalJournal of Clinical Investigation·DateJan 17, 2023
A new project aims to develop a method for producing antimicrobial peptides, which have shown promise in overcoming antibiotic resistance. The peptides' ability to delay microbial resistance development makes them an attractive alternative to conventional antibiotics.
Researchers at Goethe University Frankfurt found that dying colon cancer cells release ATP to neighboring tumor cells, activating a survival signaling pathway. Interrupting this communication can significantly increase the effectiveness of chemotherapy against resistant tumors.
SourceGoethe University Frankfurt·JournalNature·TypeExperimental study·DateNov 17, 2022
Researchers discover chemical inhibitor TIS108 significantly lowers Striga infestation without affecting plant growth or grain yield. The study shows canonical strigolactones contribute to seed germination in root parasitic weeds and play a major role in stimulating invasion by Striga.
SourceKing Abdullah University of Science & Technology (KAUST)·JournalScience Advances·DateNov 2, 2022
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
A study reveals that interleukin 34 (IL-34) modulates the balance between two myeloid-derived suppressor cell populations, leading to immunosuppression and chemoresistance in triple-negative breast cancer. Neutralizing IL-34 with a drug reduces tumor growth and susceptibility to chemotherapy.
SourceHokkaido University·JournalCancer Immunology Immunotherapy·TypeExperimental study·DateNov 1, 2022
Researchers at UNIGE have discovered a way to overcome resistance to chemotherapy in colorectal cancer, using an optimized combination of tyrosine kinase inhibitors. This breakthrough opens up new avenues for developing targeted therapies that can effectively treat patients with low five-year survival rates.
SourceUniversité de Genève·JournalCancers·TypeNews article·DateOct 27, 2022
Cancer cells become resistant to chemotherapies by slowing down DNA replication forks, allowing them to avoid collisions with chemotherapy drugs. A kinase called DNA-PKcs acts as a sensor when a fork is stressed and promotes slowing of the fork and chemo-resistance.
SourceCornell University·JournalMolecular Cell·DateSep 20, 2022
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
Scientists found that weedy rice has developed herbicide resistance through gene flow from crop rice, with most fields showing resistant plants within 20 years of herbicide-resistant rice cultivation. This rapid evolution is due to the close proximity of weedy and crop rice in the same fields, allowing for pollen transfer and outcrossing.
SourceWashington University in St. Louis·JournalCommunications Biology·TypeExperimental study·DateSep 8, 2022
Herbicide companies are shifting their research focus to address growing resistance, using AI, X-ray crystallography, and computer simulations to predict target enzymes and inhibit herbicides. This could lead to new commercial products, but experts caution farmers to moderate use and consider additional crop protection tools.
SourceAmerican Chemical Society·JournalChemical & Engineering News·DateJun 22, 2022
A Phase 3 clinical trial is investigating the effectiveness of a combination of two immunotherapy drugs, nemvaluekin alfa and pembrolizumab, compared to standard chemotherapy for patients with platinum-resistant ovarian cancer. The trial aims to provide a novel treatment option with better efficacy and safety profiles.
Researchers at UC Riverside have found that common microbial communities can degrade a stubborn class of PFAS called fluorinated carboxylic acids (FCAs) by breaking the carbon-fluorine bond under anaerobic conditions. This breakthrough could lead to new methods for environmental remediation and reduce the harm caused by PFAS.
SourceUniversity of California - Riverside·JournalEnvironmental Science & Technology·TypeExperimental study·DateMay 23, 2022
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Researchers found that Australian native rushes, including Phragmites australis, can significantly remove PFAS chemicals from contaminated surface water. The study used floating wetlands as a mechanism for plants to grow hydroponically and showed a 42-53% removal of legacy PFAS contaminants.
SourceUniversity of South Australia·JournalJournal of Hazardous Materials·TypeExperimental study·DateMay 1, 2022
Research finds that intestinal inflammation liberates chemicals that nourish E. coli's growth and promote inflammation, highlighting new treatment targets for Crohn's disease. The study identifies key compounds that feed E. coli, such as phospholipids and amino acids, and shows that these compounds can enhance the bacteria's virulence.
SourceCornell University·JournalJCI Insight·DateApr 27, 2022
Researchers at Ohio State University discover that carbon black nanoparticles are fatal to yellow fever mosquito larvae in standing water. The material accumulates on the larvae's head, abdomen, and gut, blocking basic biological functions.
SourceOhio State University·JournalInsects·TypeExperimental study·DateApr 18, 2022
Research reveals that climate change and drought can cause significant yield losses in soybeans, even with high levels of weed control. To mitigate this, farmers need to adopt integrated weed management strategies, including the use of soil-residual herbicides and late-maturing soybean varieties.
SourceUniversity of Illinois College of Agricultural, Consumer and Environmental Sciences·JournalScience of The Total Environment·DateApr 11, 2022
A new study found that traditional Chinese medicine Shengmai Yin increases the sensitivity of cancer cells to radiation, reducing radioresistance. By altering DNA methylation status, SMY enhances the efficacy of radiation therapy and reduces side effects.
SourceCactus Communications·JournalJournal of Pharmaceutical Analysis·TypeExperimental study·DateFeb 25, 2022
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
A study by University of Illinois researchers found that applying dicamba at the latest growth stage and using a safener can help minimize injury to sweet corn. The results suggest that dicamba could be used safely in sweet corn with proper application timing and formulation, offering practical guidance for farmers.
SourceUniversity of Illinois College of Agricultural, Consumer and Environmental Sciences·JournalWeed Science·DateFeb 8, 2022
Researchers found that seed microorganisms have more staying power than soil microorganisms when colonizing plants. The study suggests that modifying the seed microbiome could lead to more sustainable agriculture and increased crop yields and quality.
SourceAmerican Phytopathological Society·JournalPhytobiomes Journal·TypeExperimental study·DateDec 16, 2021
Researchers have confirmed a Champaign County waterhemp population is resistant to dicamba, with a 65% control rate. The population shows signs of metabolic resistance, activating detoxification genes before the chemical can harm. This finding raises concerns about the potential for broader herbicide resistance.
SourceUniversity of Illinois College of Agricultural, Consumer and Environmental Sciences·JournalWeed Science·DateNov 29, 2021
Research identifies way of using nanoparticles to target and disrupt bacterial cells, making them more susceptible to standard antibiotic treatments. Laboratory studies show a strong effect in killing a range of bacteria, including some linked to hospital-acquired infections.
SourceUniversity of Leeds·JournalChemical Science·TypeExperimental study·DateNov 9, 2021
Researchers found that late-season weeds had a significant impact on corn yields, with minimal control resulting in an average loss of 50% and exacerbating crop losses under hot or dry conditions. The study suggests that climate change is not the only factor affecting corn yield, but rather its interaction with weeds.
SourceUniversity of Illinois College of Agricultural, Consumer and Environmental Sciences·JournalGlobal Change Biology·DateSep 7, 2021
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Researchers identify gene regions responsible for non-target-site herbicide resistance in waterhemp, a key step towards early detection and management tools. By analyzing the genome of waterhemp, scientists have narrowed down the genetic regions controlling resistance to two areas, paving the way for further studies.
SourceUniversity of Illinois College of Agricultural, Consumer and Environmental Sciences·JournalPest Management Science·TypeRandomized controlled/clinical trial·DateAug 16, 2021
Researchers have identified the gene responsible for a male European corn borer moth's preference for its female counterpart's pheromone. The discovery provides insights into the evolution of mating signals and could help predict the spread of resistance to genetically modified insecticides, offering potential benefits for pest control.
SourceTufts University·JournalNature Communications·DateMay 14, 2021
Researchers from the University of Houston and Oregon State University have discovered that water-in-oil microemulsions formed by firefighting foam can retain high levels of PFAS in soil, making remediation difficult. This new understanding may help identify contamination sources and develop new clean-up methods.
SourceUniversity of Houston·JournalEnvironmental Science & Technology Letters·DateJan 19, 2021
Scientists have identified a group of chemicals present in ash leaves that could be used to look for susceptibility or resistance to ash dieback. The same compounds are also used by trees to deter herbivorous insects, raising concerns about unintended consequences.
SourceUniversity of Warwick·JournalScientific Reports·DateNov 11, 2020
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
A new study has identified 37 genes, including 10 new ones, that show resistance to stripe rust in spring wheat varieties. This discovery could lead to the development of more resistant varieties, reducing chemical application and damage to crops.
SourceAmerican Phytopathological Society·JournalPlant Disease·DateSep 17, 2020
Scientists from the University of Edinburgh have made a groundbreaking discovery that fungal cells can develop drug resistance through epigenetic changes, without altering their DNA sequence. This finding has the potential to revolutionize the management of fungal infections in plants and humans.
SourceUniversity of Edinburgh·JournalNature·DateSep 9, 2020
Researchers have found that curium's outer electrons can be altered by shortening the distance between it and surrounding lighter atoms under high pressure. This discovery has potential applications in controlling chemical separation used in nuclear recycling and designing resilient materials for long-term storage of radioactive elements.
SourceFlorida State University·JournalNature·DateJul 15, 2020
Researchers have identified five regions of the genome that show signs of selection for glyphosate resistance in morning glory, suggesting multiple ways the plant may evolve resistance. The study found evidence for both parallel and nonparallel genetic changes associated with glyphosate resistance.
SourceUniversity of Michigan·JournalPLOS Genetics·DateFeb 3, 2020
Researchers create a new approach for efficiently fusing different polymers together, enabling the precise tuning of material properties by selecting appropriate base polymers and mixing ratios. The method involves using dynamic covalent bonds and TEMPS radicals to fuse cross-linked polymers (CPLs) together.
SourceTokyo Institute of Technology·JournalAngewandte Chemie·DateJan 21, 2020
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
A new study has identified corn varieties with moderate resistance to bacterial leaf streak, a foliar disease that can cause up to 20% yield losses. The research also found genetic regions associated with increased levels of resistance and highlighted the importance of host resistance in controlling this disease.
SourceUniversity of Illinois College of Agricultural, Consumer and Environmental Sciences·JournalCrop Science·DateSep 11, 2019
Researchers have discovered that graphene-lined clothing could be an effective mosquito barrier. The ultra-thin yet strong material acts as a physical barrier that mosquitoes are unable to bite through, while also blocking chemical signals that trigger their urge to bite.
SourceBrown University·JournalProceedings of the National Academy of Sciences·DateAug 26, 2019
A team of Australia-UK researchers identified the molecular machinery used by bacteria to resist chemicals, which could be repurposed to produce precursors for new polymers like nylon. This discovery sheds light on how bacteria develop resistance and may lead to the development of new antimicrobial agents.
SourceMacquarie University·JournalProceedings of the National Academy of Sciences·DateAug 12, 2019
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.