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Successful, rapid protein crystallization possible with technique developed by UCSD researcher

A new technique developed by UCSD researcher Virgil Woods employs DXMS to identify unstructured regions in proteins that interfere with crystallization. Removing these regions through 'molecular surgery' enables proteins to crystallize well, overcoming a major obstacle in structural genomics.

SourceUniversity of California - San Diego·JournalProceedings of the National Academy of Sciences·DateJan 15, 2004

Helical piezoelectric 'nanosprings' could be actuators & transducers in nanosystems

Researchers have developed nanoscale helical 'nanosprings' from zinc oxide that exhibit piezoelectric and electrostatic polarization properties. These structures could be used as sensors to detect small fluid flows, strain forces, and air flows, and as actuators in micro-systems. The new materials also display unusual electrostatic pol...

New algorithm offers fast and accurate X-ray crystal structure identification

Researchers at the University of Illinois have developed an algorithm that provides fast and accurate structure determination for organic compounds with a center of symmetry. The new approach reformulates the phase problem into an integer programming problem, allowing for rapid solution finding using off-the-shelf optimization software.

SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalActa Crystallographica Section A·DateSep 2, 2003

Nature designs hard and tough materials at the nanoscale

Researchers found that there exists a critical nanometer size where mineral particles in biocomposites become insensitive to flaws, maintaining strength equivalent to a perfect crystal despite inherent defects. This phenomenon suggests that the engineering concept of stress concentration at flaws is no longer valid for nanoscale design.

SourceMax-Planck-Gesellschaft·JournalProceedings of the National Academy of Sciences·DateMay 14, 2003

Crystals on a ball

Researchers have discovered that spherical crystals develop unique 'scar' defects to compensate for the curved surface, allowing them to pack in place. The findings, supported by experiments with water droplets and tiny beads, provide insights into how such structures form and persist in nature.

UK scientists crack lobster shell colour puzzle

Scientists from Imperial College London and the University of Manchester have solved the structure of Beta-Crustacyanin, a protein that bends Astaxanthin's shape to create different colours. The discovery could lead to new uses of Astaxanthin as a drug-delivery mechanism and improve food colourants.

SourceImperial College London·JournalProceedings of the National Academy of Sciences·DateJul 29, 2002

Natural antifreeze yields secrets

Researchers at the University of California, Davis have discovered how antifreeze glycoproteins interact with ice, preventing ice crystals from growing and preserving liquid water around the protein. This discovery may lead to safer storage for food or blood products and help scientists understand biomineralization.

SourceUniversity of California - Davis·JournalBiophysical Journal·DateMar 15, 2002

The RANKL cytokine at 2.6 Å

The RANKL cytokine at 2.6 Å resolution provides detailed information on its structure and function in the body. Researchers used this high-resolution imaging technique to study RANKL's role in bone formation and immune system regulation.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateSep 26, 2001

Earth's deepest secrets

Scientists have long known that Earth's core is primarily composed of iron, but the cause of seismic waves traveling faster in certain directions was unclear. Recent studies using supercomputer simulations revealed a temperature-dependent alignment of crystal structures in the inner core, shedding new light on this phenomenon.

SourceUniversity of Michigan·JournalNature·DateSep 5, 2001

Structure solved by scientists at The Scripps Research Institute marks important milestone in effort to develop HIV vaccine

Researchers at The Scripps Research Institute have solved the structure of a neutralizing antibody against HIV, marking an important milestone in the development of an effective vaccine. This breakthrough demonstrates that the human immune system can produce antibodies effective against HIV and provides a template for vaccine design.

SourceScripps Research Institute·JournalScience·DateAug 10, 2001

Strontium titanate - a deformable ceramic

Researchers discovered strontium titanate deforms plastically at low stresses and temperatures, contrary to its brittle nature. Detailed analysis reveals the existence of different dislocation core structures, suggesting potential applications in forming or enhancing ceramic properties.

SourceMax-Planck-Gesellschaft·JournalPhysical Review Letters·DateAug 6, 2001

Semiconductors With A Twist

Researchers at Cornell University have developed a technique to grow pure, defect-free single crystals of almost any material on any substrate by bonding thin films at a misaligned angle. The new method has the potential to revolutionize electronics manufacturing by overcoming current limitations.

SourceOffice of Naval Research·JournalApplied Physics Letters·DateApr 1, 1999

3D Sight From Sonic Imaging

Researchers developed a new technique to visualize the three-dimensional internal structure of objects using sonic imaging. This method stacks planar ultrasound images and provides detailed analysis without physically cutting open the part.

SourceInstitute of Materials·JournalMaterials World·DateApr 1, 1999

Modeling Material Defects From Atoms Up

A new research program at Cornell University is using computer simulations to understand how tiny cracks in materials can grow into major ones. The project, called Multiscale Modeling of Defects in Solids, involves creating models that show how defects at the atomic level can lead to changes at increasingly larger scales.

Scientists Show How Defects Can Improve Technology In Science Magazine's Special Issue On Materials Science

Scientists discover that adding defects to materials can enhance their performance in semiconductor devices, leading to breakthroughs in information technology, high-speed communications, and the development of new LED technologies. Researchers are also exploring ways to exploit defects in optical fibers to increase bandwidth capacities.