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Targeting GITR in cancer immunotherapy – there is no perfect knowledge

Researchers discuss the potential of glucocorticoid-induced TNFR-related protein (GITR) as a target for cancer immunotherapy. Preclinical studies have shown potent anti-tumor efficacy, but clinical trials have yielded inconsistent results due to complexities in immune responses and antibody structure.

SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateJun 21, 2023

Beating HIV and COVID-19 may depend on tweaking vaccine molecules

Scientists at La Jolla Institute for Immunology discover that high-valency antigens can lead to a more-is-better immune system reaction, while low-valency antigens result in a smaller, more targeted B cell response. The study suggests that selecting antigens with the right valency will depend on the disease being targeted.

SourceLa Jolla Institute for Immunology·JournalImmunity·DateAug 27, 2020

Scientists unlock physical, chemical secrets of plutonium

Researchers at Rutgers University have developed a new theory that explains the physical and chemical properties of plutonium, which can help create safer and more versatile nuclear materials. The study finds that valence electrons in solid plutonium metal fluctuate among different orbitals on a short time scale.

SourceRutgers University·JournalNature·DateMar 28, 2007
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