Articles tagged with In Vivo Imaging
Researchers at Janelia Research Campus have developed a method to study cellular communication across the entire animal, capturing signals from nearly every cell in a living vertebrate. This technique, called WHOLISTIC, provides a complete, concurrent picture of how biological systems interact, offering new insights into the machinery ...
Researchers distinguish multiple fluorescent proteins with overlapping emission colors by their lifetime using fluorescence lifetime imaging microscopy (FLIM). FLIM successfully distinguishes several fluorescent proteins with overlapping color emissions within plant cells, enabling simultaneous analysis of multiple proteins.
Researchers used PET imaging to find significantly lower muscarinic acetylcholine M1 receptor availability in schizophrenia patients compared to healthy individuals. This study provides the first in vivo evidence of widespread M1 receptor deficits in schizophrenia, supporting the development of muscarinic-based therapies.
Researchers are developing an AI assistant to analyze petabytes of imaging data from high-resolution microscopes, which can track cells and molecular interactions in real-time. The goal is to help biologists understand complex biological systems and make new discoveries.
A new approach enables computers and machines to capture images at higher resolution and faster speed, making it impervious to reflective surfaces. The technology uses a virtual screen created by repurposing the surroundings of specular objects.
Researchers developed multiplexed MRI technology, enabling simultaneous imaging of signals from multiple molecules in the brain. The technology provides a comprehensive view of the brain's structure, physiology, and molecular processes, allowing for more precise diagnosis and individualized treatment planning.
Using AI-driven analytical methods, researchers have created a custom OCT system that enables the objective measurement of wound progress over time. The platform shows that stiffer mechanical properties improve wound healing outcomes, with faster transition to intact regenerated tissue.
Researchers at Kyushu University develop a new tissue-clearing reagent, SeeDB-Live, enabling repeated, reversible, and real-time imaging of living brains at greater depth and clarity. This breakthrough allows scientists to visualize neural activity in living mice and brain slices, offering new insights into brain dynamics and function.
Researchers developed a novel tool, CytoTape, to record temporal cell activities in situ along a flexible intracellular protein fiber. This technology enables scientists to view interactions on a large scale and over long periods of time, breaking through the tradeoff between resolution and scale.
Researchers at IIT develop optical microscopy technique that combines polarization and dark-field microscopy to observe cells with high contrast, preserving their natural conditions. The next step involves using AI to enrich images with molecular information related to diseases.
Researchers at Colorado State University used AI to modify antibodies into stable intrabodies that can visualize histone modifications in real-time. This allows for better understanding of gene expression and its relationship with cancer and other disorders. The team created 19 new antibody-based probes with a 70% success rate, signifi...
A recent study published in Nature Communications reveals that the mechanical properties of the developing brain play a significant role in synapse formation and electrical signal emergence. The researchers found that softer regions exhibit higher synapse densities, while stiffer regions show lower densities.
Researchers used zebrafish larvae to investigate visual function restoration following optic nerve injury. The study demonstrates that the contralateral eye supplies critical guidance cues for axonal regrowth and behavioral recovery, offering new perspectives on how neural circuits reorganize after injury.
Researchers at the University of Arizona are developing a new optical technology that can image deep into biological tissues without invasive procedures. This approach aims to overcome current challenges in skin cancer imaging, allowing for earlier detection, precise evaluation, and real-time monitoring of treatment response.
A new imaging approach has simplified retina exams by eliminating the need for mechanical focusing, making fundus cameras more accessible. The system uses a diffuser to capture 3D light information and digitally refocus images after they are taken, producing consistent resolution of about 7-10 line pairs per millimeter.
A new study using two-photon microscopy shows that brief interruptions in brain capillary flow can cause rapid drops in oxygen levels, potentially leading to tissue damage. The research found that even minor stalls can lead to significant hypoxia, highlighting the importance of uninterrupted blood flow to the brain.
Scientists have discovered that tiny brain vessels pulse to regulate blood flow through bursts of contraction and relaxation. The research reveals that these bursts originate from the walls of small arteries and spread through the vascular network in short intervals, providing insights into how the brain regulates its blood supply.
Researchers create breakthrough imaging system that shows sensory activity in real time, enabling them to distinguish between different sensations. The technique uses a genetically encoded voltage sensor to observe electrical signals from neurons and has major implications for treating chronic pain and sensory disorders.
A new mouse study uses advanced OCT imaging to reveal the fallopian tube's pumping mechanism in transporting preimplantation embryos towards the uterus. The study sheds light on the biological mechanisms underlying reproductive challenges like infertility and ectopic pregnancy.
Researchers have identified the medial prefrontal cortex (mPFC) as the basis of emotional inference in animals and humans. In a study published in Nature, Xiaowei Gu and Joshua Johansen found that rats can learn inferred emotions by associating a neutral stimulus with an unpleasant experience.
Researchers developed a live brainstem imaging method to study the nucleus tractus solitarii's role in emotion regulation and body-brain interactions. The D-PSCAN technique enabled high-resolution visualization of NTS neural activity in response to vagus nerve stimulation and gut hormone cholecystokinin, shedding light on potential the...
A new brain atlas developed by researchers at Duke University will increase precision in measuring changes in brain structure, making it easier to share results. The tool, the Duke Mouse Brain Atlas, provides a detailed map of the entire mouse brain, from large structures down to individual cells and circuits.
Researchers from OIST and Hebrew University developed a novel method to measure energy usage during movement using video and 3D-tracking via deep learning. This innovative approach expands the study of movement energy in ecology, physiology, and beyond, enabling the accurate measurement of energy consumption in smaller animal species.
Researchers at Waseda University developed a new technique using terahertz imaging to visualize the internal structure of the mouse cochlea with high resolution. The study successfully demonstrated the potential of THz imaging as a non-invasive diagnostic tool for auditory disorders and other medical applications.
Researchers have developed a non-invasive method to visualize the internal details of the mouse cochlea with micron-level spatial resolution using terahertz imaging. This technique has the potential to lead to a new diagnostic method for ear diseases and enable on-site diagnosis of hearing impairments.
Researchers have discovered a novel imaging tool that captures functional activity in mouse models of TMJ injury and inflammation, revealing the simultaneous activity of over 3,000 trigeminal ganglion neurons. This finding suggests that CGRP antagonists could offer a promising solution for TMJ pain relief.
Researchers at Waseda University develop a new imaging technique that uses neutron activation to transform gold nanoparticles into radioisotopes, enabling long-term tracking of their movement in the body. This breakthrough could lead to more effective cancer treatments and precision monitoring of drug distribution.
Elizabeth Hillman, a pioneer in imaging method development, is leading the new Department of Imaging Sciences at St. Jude Children's Research Hospital. The department aims to develop innovative new imaging and measurement approaches that will enable groundbreaking scientific studies and improve patient care.
Researchers developed a supramolecular probe with enhanced phosphorescence properties for biological imaging and sensing. The probe demonstrated outstanding stability, biocompatibility, and specificity in viscosity response, enabling real-time visualization of critical physiological processes in cells and in vivo biosensing.
A new experimental technique has developed a molecular flashlight to monitor molecular changes in the brain caused by cancer and other neurological pathologies. The technique uses vibrational spectroscopy to illuminate nerve tissue, allowing for the analysis of molecular changes caused by tumours or injuries.
Scientists have designed bioluminescent proteins that can produce multiple colors of light for real-time imaging in cellular and animal models. These proteins are small, efficient, highly stable and can be used for non-invasive bioimaging, diagnostics, drug discovery and more.
A $3.7 million NIH grant supports a study to improve PE diagnosis and treatment by using advanced imaging techniques, which may measure the effectiveness of clot-dissolving therapies. The goal is to help clinicians better diagnose and treat patients with PE, a devastating cardiovascular ailment.
A Korean research team has successfully observed living organoids in real time at a high resolution using holotomography. The technology allows for long-term observation of dynamic changes and precise analysis of organoid responses to drug treatments.
Researchers developed a new imaging technique using shortwave-infrared (SWIR) imaging to visualize the lymphatic system, improving resolution and sensitivity compared to traditional near-infrared (NIR) imaging. SWIR imaging with silver sulfide quantum dots offers superior image resolution and outperforms NIR-I imaging techniques.
Biomedical engineers at the University of Rochester have developed a novel technique using ultrasound waves to organize endothelial cells into patterns that promote the growth of new vessel networks. The team aims to treat ischemic injuries caused by damaged tissue in reconstructive and plastic surgeries.
Researchers developed a new two-photon fluorescence microscope that captures high-speed images of neural activity at cellular resolution, providing insights into brain function and neurological diseases. The microscope uses an adaptive sampling scheme to image neurons in real time, reducing damage to brain tissue.
A Rice University-led team is developing an affordable system to improve tumor removal accuracy for breast and head and neck cancer. The AccessPath system enables rapid, automatic tumor margin classification, revolutionizing real-time surgical guidance.
A new hybrid contrast agent has been developed to combine the benefits of MRI and PET imaging techniques, offering improved accuracy and opening new diagnostic applications. The agent has shown potential in detecting kidney problems and other conditions, paving the way for personalized diagnostics and precise imaging.
Researchers at Rice University have developed ultrasmall gas-filled protein nanostructures that can penetrate tissue and reach immune cells, opening up new possibilities for ultrasound imaging and drug delivery. The breakthrough could revolutionize treatment for cancers and infectious diseases.
A new microscopy system called mosTF enables fast and clear imaging of the living brain, improving tracking of rapid changes in neural circuit structure. The system outperforms traditional two-photon microscopy methods by eight times speed and four-fold signal clarity.
Researchers have identified collagen features as valuable biomarkers for evaluating melanoma immunotherapy response. Single-fiber characteristics were found to be more sensitive to treatment-induced changes than bulk collagen features, offering insights into collagen remodeling over time.
A new study shows that psilocybin initiates a pattern of hyperconnectivity in the brain linked to the ego-modifying effects and feelings of oceanic boundlessness. The findings provide insights into how the brain works on psychedelic drugs and their potential use to treat psychiatric disorders.
Researchers developed a novel technique to visualize meningeal lymphatic vessels in vivo using photoacoustic microscopy. The study revealed that these vessels play a crucial role in regulating cerebrospinal fluid circulation and clearing metabolic waste from the brain, which is impaired in early stages of Alzheimer's disease.
Researchers developed a new method to accelerate high-resolution ultrasound localization microscopy using deep learning, enabling faster and more accurate imaging of microvascular structures. The technique, called LOCA-ULM, improves spatial resolution and processing speed while maintaining sensitivity for functional imaging.
Researchers from Osaka University have developed a new approach for super-resolution microscopy that can observe dense microstructures inside cells with excellent sharpness. By selecting only a desired plane to image using thin 'light sheet' illumination, they were able to achieve background-free super-resolution imaging.
A new publication reviews optical scanning endoscopes based on a single multimode fiber, offering insights into their fundamental mechanisms, key performance metrics, and applications. The article discusses techniques to overcome modal scrambling properties and improves imaging resolution and contrast.
Researchers developed a new catheter-based device combining FLIM with polarization-sensitive OCT to image atherosclerotic plaques. The hybrid approach provides unprecedented information on plaque morphology, microstructure, and biochemical composition.
A team of scientists from the Beckman Institute has received a $3 million grant to develop diagnostic tools and imaging agents for the early detection of Alzheimer's disease. They will use a combination of PET and MRI scans to target smaller beta-amyloid peptides and other signs of neuroinflammation and oxidative stress.
Researchers successfully reduced bladder tumor size by 90% in mice using nanorobots propelled by urea. The nanomachines deliver a radioisotope to the tumour, attacking it with precision and efficiency. This breakthrough could lead to more effective bladder cancer treatments and reduced hospitalization costs.
Ashok Veeraraghavan, a Rice University professor, has won the Edith and Peter O'Donnell Award in Engineering from the Texas Academy of Medicine, Engineering, Science and Technology. His research focuses on making invisible objects visible through imaging technology that tackles challenges beyond current technologies.
Researchers developed a method to measure microvascular changes in the skin using AI and optoacoustic imaging technology, enabling non-invasive assessment of diabetes severity. The study identified 32 significant changes in blood vessels, which can be used to monitor disease progression.
Researchers at UC Santa Barbara have created a novel method to measure osmotic pressure in living cells and tissues, allowing for the study of cellular behavior and its impact on organ function. This technique has promising industrial and medical applications, including monitoring skin hydration and diagnosis of diseases.
Researchers developed a new OCT approach to directly image coordination of tiny hair-like structures in live organisms, giving a powerful tool to investigate cilia's role in the female reproductive system. The technique revealed unexpected behaviors that contradict current views and suggested new roles for cilia.
Researchers developed an innovative imaging technique to study cells in bones of mice, revealing distinct pockets of bone resorption activity. This knowledge could lead to new treatments for osteoporosis and dormant cancer cells.
Researchers developed three new two-photon probes that can visualize organelles in cells, enabling better understanding of cellular functions and tissue imaging. The probes are designed to detect pH levels, viscosity, and ionic species, providing more specific insights into cell viability and treatment responses.
A new study explores how alpha-synuclein disrupts metabolic processes in neurons. Researchers used NanoSIMS imaging techniques to visualize isotopic variations and found changes in carbon turnover, suggesting increased metabolic demands on affected cells.
Micro4PAP, a fast-scan Brillouin Microscope, allows for non-destructive, label- and contact-free imaging of biological samples. The device enables sub-millisecond acquisition time, suitable for in-vivo measurements in living cells, promoting early disease detection and diagnosis.
Researchers developed a noninvasive technique to visualize and differentiate nerve tissue using multispectral photoacoustic imaging. The study revealed the optimal wavelengths for identifying nerve tissue, which could improve nerve detection and segmentation techniques.
The research team created a multi-spectral, super-low-dose photoacoustic microscopy system with improved sensitivity, enabling new applications and clinical translation. The system achieved up to capillary-level or sub-cellular resolution at greater depths than traditional optical microscopy methods.
A research team at USTC realized single-pixel imaging of single living cells using 3D light-field illumination, achieving a resolution of up to 2.7 μm laterally and 37 μm axially. This breakthrough enables volumetric imaging of microscopic objects with high-performance 3D SPI.