Articles tagged with In Vivo Imaging
Researchers from Rice University and Princeton University have developed a new technology that allows for the live monitoring of signaling protein networks in living cells. The 'live reporter' system uses unobtrusive proteins to tag specific proteins, which can activate fluorescent markers when they become phosphorylated.
Engineers at Rice University and the University of Maryland developed NeuWS, a technology that can undo light scattering effects, enabling full-motion video through various media. The technology measures wavefronts to rapidly decipher phase information, overcoming the 'holy grail problem' in optical imaging.
Researchers developed chemiluminescent carbon nanodots (CDs) that exhibit excellent in-vivo imaging quality and bacteriostatic rate against various bacteria. The CDs can be used as activatable imaging agents for inflammation-related ROS detection and have potential applications as nanomedicine for antibacterial treatments.
A team from Chalmers University of Technology has developed a method to observe the formation of lithium microstructures in real-time using X-ray tomographic microscopy. This breakthrough aims to improve the safety and capacity of lithium metal batteries, which could replace traditional lithium-ion batteries in the future.
Researchers developed a neural network model that uses terahertz time-domain spectroscopy data to predict burn healing outcomes with high accuracy. The new approach improves upon existing methods by reducing training data requirements, making it more practical for processing large clinical trials.
A novel in vivo expression vector system, TardiVec, has been developed to study anhydrobiosis in live tardigrades, enabling the expression of fluorescent proteins. This technology facilitates further research into anhydrobiosis and stress tolerance, potentially leading to new ways to enhance stress resistance in other organisms.
Researchers at Rice University have developed a new fluorescent dye that can cross the blood-brain barrier, allowing for noninvasive brain imaging and differentiation between healthy tissue and tumor cells. The dye's long-lasting fluorescence enables stable imaging over extended periods.
Researchers created a miniature microscope that can image neural activity on a single-cell level from all cortical layers without interfering with animal behavior. The tool, developed by the Max Planck Institute for Neurobiology of Behavior, allows scientists to study how brain cells respond to environmental light and visual cues durin...
The Beckman Institute has established a new national collaborative Biomedical Technology Research Resource to develop label-free optical imaging technologies. The center aims to create optical and computational imaging technologies that can serve as a resource for clinicians and researchers.
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.
A University of Ottawa research team has made new discoveries on how motor skills are learned and stored in the brain. By studying mice, they found that a specific transcription factor called NPAS4 regulates gene changes in inhibitory neurons, leading to the formation of learning-associated neuron ensembles.
Researchers develop speckle-based compressive imaging technique to improve deep-tissue imaging in Alzheimer's disease studies. The method reduces pixel measurements needed, producing high-resolution images up to 11 times faster and three times bigger than traditional raster-scan approach.
A HKUST research team developed a microscope combining 3PM with adaptive optics, achieving high-resolution imaging of neuronal structures in mouse cortices up to 750µm below the skull. This technology holds great potential to advance in-vivo imaging techniques and facilitate study of living brain.
Researchers have developed a non-invasive method to visualize and quantify brain inflammation using diffusion-weighted magnetic resonance imaging (MRI). This breakthrough has significant implications for the diagnosis and treatment of neurodegenerative diseases such as Alzheimer's, Parkinson's, and multiple sclerosis.
A research team at HKUST has developed a long-term in vivo imaging technique to study spinal cord injury, allowing for repeated and stable imaging without triggering inflammation. The breakthrough enables researchers to track microglia and understand their interaction with degenerating and regenerating axons.
The Mini2P allows for live imaging of thousands of neurons, recording complex behavior and cognitive functions in a naturally behaving animal. By mapping neural landscapes across the cortex, researchers can gain insights into high-resolution brain activity and function.
Researchers at KTH Royal Institute of Technology developed a technique to study lung disease in living mice without using mechanical ventilation. The method uses phase-contrast X-ray tomography to produce high-resolution images of the lungs, including even the smallest airways, with low radiation doses.
The new device, Bio-FlatScope, uses a custom algorithm to reconstruct images of micron-scale targets like cells and blood vessels inside the body. The light captured by Bio-FlatScope can be refocused after the fact to reveal 3D details, making it potentially valuable for detecting cancer or sepsis.
A research team has proposed a new approach to achieve background-suppressed tumor-targeted photoacoustic imaging, enabling deep-tissue tumor-specific imaging in vivo. The approach uses genetically engineered bacteria to deliver a photoswitchable chromoprotein to the tumor site, eliminating interference from blood background signals.
Researchers at OIST used advanced imaging to record signaling within single astrocytes, revealing ultra-fast signals on par with neurons and patterns of activity corresponding to different behaviors. The findings suggest that astrocytes may store memories as 'fingerprints' in specific areas, called hotspot maps.
Researchers have developed microbubbles that can acoustically detect blood oxygen levels, showing a strong correlation between oxygen concentration and acoustic bubble response. This innovation has the potential to benefit medicine and imaging by evaluating oxygen-deprived regions of tumors and in the brain.
Researchers developed a non-toxic, small-molecule probe that provides real-time visualization of disease progression, overcoming limitations of MRI and PET imaging. The probe binds copper ions and detects dysregulated levels, accurately identifying Wilson's disease and other maladies.
A new imaging technique developed by the Skala Lab can predict the efficiency of cardiomyocyte differentiation from human pluripotent stem cells, providing a non-invasive quality control method. The technique uses autofluorescence to measure metabolic activity and has been shown to be accurate in predicting outcome with high consistency.
Artificial neural networks enhance signal-to-background ratio in near-infrared imaging, sharpening blurred images. The technology has potential to improve diagnostics and image-guided surgery in the clinic.
A prototype 16-channel head AIR coil from GE Healthcare has been shown to perform better than a conventional 8-channel head coil for in vivo whole-brain imaging, but not as well as a 32-channel coil. The coil's lightweight and flexible design exhibits improved electrical characteristics that could lead to future design improvements.
Researchers developed a novel photoacoustic imaging method using clinically-approved carbon nanoparticles to trace lymph nodes and guide fine needle aspiration biopsies. The technique improved image quality and accuracy for breast cancer staging, offering a promising alternative to existing methods.
Researchers at Hong Kong University of Science and Technology developed an adaptive optics two-photon excitation fluorescence microscopy system for high-resolution in vivo fluorescence imaging of mouse retina. This breakthrough enables detailed study of retinal structures and dynamics, shedding new light on neurodegenerative diseases.
Researchers develop an approach to super-resolution photoacoustic imaging using advanced statistical analysis, breaking the barriers of conventional imaging hardware. This technique offers a practical and low-cost option for improving biomedical imaging for research and diagnostics.
Researchers developed an in vivo imaging method to observe Meissner's corpuscle mechanoreceptors in living tissue using two-photon microscopy. This method could unlock the mechanism of touch sensitivity and provide a novel diagnostic tool for neural diseases. The study's findings have applications to human health, particularly in under...
A new composite nanoparticle material, silica nanorattles @ gold nanoparticles (SN @ GNs), has been developed for biological imaging. The silica shell reduces the toxicity of gold nanoparticles, increasing their maximum tolerated dose to 200 mg/kg. This innovation provides a promising approach for cancer diagnosis and treatment.
The February issue of Cold Spring Harbor Protocols features a method for quantitative proteomic profiling using laser capture microdissection and nanoscale liquid chromatography/tandem mass spectrometry. Immunoimaging is also explored, with methods for studying immune system dynamics using two-photon microscopy.
Scientists have developed a novel technique for in vivo imaging of neuronal function using bioluminescence, enabling the monitoring of calcium activity in neurons or the brain as a whole. This approach has been validated by recording neurons in the ellipsoid body and demonstrates its sensitivity and ability to study all brain structures.