Articles tagged with Time Lapse Microscopy
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Scientists from The University of Osaka have created two new fluorescent markers, Gachapin and Gachapin-C, that can visualize dynamic cell-to-cell contacts and connections within a single neuron's extensions. These indicators allow for the monitoring of complex patterns of connectivity in various cell types, including neurons.
For the first time, researchers have directly visualized how newly formed cellular organelles leave the endoplasmic reticulum and transition onto microtubule tracks inside living cells. The study reveals that the ER plays an active role in steering intracellular traffic.
A new technology allows for clear observation of living retina and microglia's behavior, revealing their increased activity before tissue damage in diabetic mice. The study found that the diabetes drug liraglutide reduced microglia's activity in healthy mice too, suggesting a direct modulation mechanism.
Researchers at Duke University have discovered how stem cells decide their fate by analyzing the activity of two key regulators, short-root and scarecrow, in real-time using light sheet microscopy. This finding has implications for understanding cell development and preventing diseases such as cancer.
Researchers developed a novel time-resolved atomic force microscopy (AFM) technique to study ultrafast light-induced phenomena on the nanoscale. The new method allows for measurement of high-speed dynamics in insulators and conductive materials with nanometer resolution.
A recent study elucidated the role of EGF and its downstream signaling cascade in controlling oral keratinocyte behavior, offering new insights for pharmacological manipulation. The findings suggest that activating the EGF/EGFR pathway can enhance oral keratinocyte motility and proliferation.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
A new IVF method using time-lapse monitoring has been found not to improve pregnancy rates or shorten the time it takes to get pregnant. The study, which evaluated 1731 patients over a year, also found that this approach does not lead to extra costs or benefits.
A Pitt lab discovery sheds light on how a specific mutation in the lsr2 gene helps bacteria resist phage infection. The team developed new tools to visualize phages attacking bacteria, revealing critical insights into the mechanisms of phage resistance.
Scientists from the University of Tsukuba created a scanning tunneling microscopy system that captures images as fast as 30 femtoseconds, allowing for faster study of rapid processes in materials. This advancement enables researchers to understand ultrafast dynamics and behavior of materials more accurately.
Researchers have identified two glucose transporters that disrupt the energy supply to invading worm cells and stop them in their tracks. By deactivating these genes, glucose and ATP levels dropped, and worm cells stalled their spread. This discovery could lead to new ways to cut off cancer cells' fuel lines and prevent metastasis.
Scientists discovered a new mitochondrial recycling pathway that may help prevent Parkinson's disease. The study, published in Science Advances, reveals that genes associated with Parkinson's disease play key roles in this process and that disruptions can contribute to neurodegeneration.
Researchers developed a new light-sheet fluorescence microscope with extended field of view and reduced photodamage, enabling high-resolution cellular imaging over three days. The technology contributes to understanding embryonic development and pathogenesis, and is expected to advance drug development.
Researchers developed an algorithm to correct images and make hitherto hidden development steps visible, allowing for more accurate detection of regulatory proteins active during stem cell development. The 'BaSiC' software can correct changes in the background of time-lapse videos, making it a valuable tool for stem cell researchers.
A new software has been developed to analyze time-lapse microscopy movies, enabling the measurement of cellular properties such as cell cycle length and protein expression dynamics. The tool is freely available online and has already led to high-impact publications in top scientific journals.
UT Southwestern Medical Center researchers have designed a powerful 3-D microscope capable of creating high-resolution images of living cancer cells in controlled microenvironments. The new approach enables detailed study of cell interactions with their environment, accelerating discovery in biology.
A PhD student at Brunel University London created a low-cost inverted microscope by adapting a cheap instrument to measure cell motility and study the immune system of snails. The instrument, costing around £160, is significantly cheaper than high-quality equipment that can stretch to hundreds of thousands of pounds.
Researchers at Drexel University developed a program called LEVER that enables biologists to track and study the movement and multiplication of cells using 3D microscopic images. With enhanced version LEVER 3-D, scientists can visualize and analyze cell behavior in real-time.
A new method developed in collaboration with Unisensor A/S can determine the optimal antibiotic treatment for a given bacterial infection within 2-4 hours, reducing the response time by half. This faster diagnosis can help prevent the development of resistant bacteria and shorten disease courses.
The American Society for Cell Biology's Celldance awards recognized top videos showcasing cellular mechanisms in development, health, and disease. Winners included a time-lapse of fruitfly embryonic development and a cancer cell movement video.
The Micropilot software brings machine learning to microscopy, analyzing low-resolution images and automatically performing complex experiments when cells with interesting features are detected. It has been used to uncover the roles of proteins in cell division and will be a key tool for European systems biology projects.
Researchers at Duke University have developed a new method for creating ultra-high resolution 3D images of tiny mouse brains using magnetic resonance imaging. The technology allows for the detailed visualization of brain structures and their relationship to genetics, enabling scientists to study gene-brain connections.