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Nanorattles shake up new possibilities for disease detection

Researchers at Duke University developed nanorattles that amplify signals from separate biomarkers, allowing for accurate detection of head and neck cancers without biopsies. The technology uses machine learning algorithms to tease apart multiple biomarker signals, making it possible to target multiple diseases simultaneously.

SourceDuke University·JournalJournal of Raman Spectroscopy·TypeExperimental study·DateSep 13, 2022

New photoacoustic endoscope fits inside a needle

Researchers have created a photoacoustic imaging endoscope probe that can fit inside a medical needle, resolving subcellular-scale tissue structural and molecular information in 3D. The device has an ultra-thin design, allowing for real-time 3D characterization of tissue during minimally invasive procedures.

SourceOptica·JournalBiomedical Optics Express·DateJul 27, 2022

Towards stable, sustained Raman imaging of large samples at the nanoscale

A research team from Japan has developed a stable TERS system that enables characterization of defect analysis in large-sized WS2 layers at high pixel resolution. The team successfully imaged nanoscale defects over a period of 6 hours in a micrometer-sized WS2 film without significant signal loss.

SourceInstitute of Post-LED Photonics, Tokushima University·JournalScience Advances·TypeExperimental study·DateJul 15, 2022

Strain-sensing smart skin ready to deploy

The new system, S4, offers a high-resolution view of stressed specimens comparable to or better than established technologies like DIC. It also overcomes optical challenges posed by cement in concrete, providing a reliable strain measurement technology.

SourceRice University·JournalScientific Reports·TypeExperimental study·DateJul 14, 2022

Using raw materials more sustainably

Scientists elucidated the structures at the interface between a working catalyst and reacting molecules in vanadium pentoxide, revealing which oxygen atoms activate hydrocarbons. The study showed that temperature and gas composition influence the reaction, leading to more sustainable oxidation processes.

SourceMax-Planck-Gesellschaft·JournalThe Journal of Physical Chemistry C·TypeExperimental study·DateMar 7, 2022

New analysis approach could increase the number of usable donor kidneys

Researchers developed a new SERS-based multiplexing technique to detect kidney injury biomarkers SLPI and IL-18, achieving high sensitivity and reliability. The approach shows promise for objectively assessing donor kidney quality, potentially reducing discard rates and recipient complications in clinical practice.

SourceOptica·JournalOptics Express·TypeExperimental study·DateJan 5, 2022

Raman holography

Researchers have developed a new method called Raman holography, which uses surface-enhanced Raman scattering to image and analyze single particles in three dimensions. This technology has the potential to revolutionize fields such as live cell imaging and anti-counterfeiting.

SourceICFO-The Institute of Photonic Sciences·JournalNature Nanotechnology·DateNov 30, 2020

Looking inside the glass

A team of researchers from The University of Tokyo used electron spectroscopy and computer simulations to study the internal atomic structure of aluminosilicate glass. They found intricate structures that have not yet been analyzed by scientists, including complex coordination networks among aluminum atoms within phase-separated regions.

SourceInstitute of Industrial Science, The University of Tokyo·JournalThe Journal of Physical Chemistry Letters·DateNov 16, 2020

Researchers can now build an inexpensive and flexible micro-raman system

Researchers have developed an inexpensive and flexible micro-Raman system for non-destructive analysis of biological samples, offering a fraction of the cost and capability of commercial tools. This system allows for label-free detection of variations in biomolecular composition and correlates it with corresponding biological changes.

SourceIOS Press·JournalBiomedical Spectroscopy and Imaging·DateJun 6, 2016

Almost as sensitive as a dog's nose

Scientists developed a new SERS sensor with high sensitivity and reproducibility, detecting a specific organic species in low concentrations. The sensor uses vertically arranged carbon nanotubes to amplify Raman-scattered light signals.

SourceETH Zurich·JournalAdvanced Materials·DateAug 29, 2013

NIST 'stress tests' probe nanoscale strains in materials

Researchers at NIST have demonstrated a way to measure low levels of stress in semiconductor devices as small as 10 nanometers across. By combining two techniques - electron back scattered diffraction and confocal Raman microscopy - they resolved the long-standing disagreement between two widely used methods of stress measurement.

SourceNational Institute of Standards and Technology (NIST)·JournalApplied Physics Letters·DateNov 25, 2008