Articles tagged with Clinical Research
A University of Saskatchewan researcher is building tiny pseudo-organs from stem cells to help diagnose and treat Alzheimer's disease. These 'mini-brains' more accurately reflect a fully-fledged adult human brain, allowing for closer examination of neurological conditions.
A new study has revealed that high-income individuals have a 32% lower risk of post-stroke mortality. Those with higher education also face a 26% lower risk of death post-stroke.
Researchers developed a shoulder actuation testbed for rehabilitation, integrating pneumatic and electromagnetic forces for high precision and transparency. The system allows for natural-like interaction forces during disturbances, making rehabilitation experiences more natural and effective.
A study published in the Journal of American Academy of Child and Adolescent Psychiatry found that pharmacological treatment of ADHD reduced violence- and public-order related crimes among patients in the grey zone for treatment. However, it had no effect on other types of crimes. The study used a quasi-experimental design with populat...
A new study published in Journal of Neurotrauma found that more than 30% of patients with traumatic brain injury who underwent withdrawal of life-sustaining treatment recovered at least partial independence. The study suggests that a lifetime in a vegetative state or severe disability is not a common outcome even after a serious injury.
Researchers at UC San Francisco found that dispensing abortion pills through the mail is a safe and effective method, with nearly 98% of patients completing their abortions. The study suggests that this model can help increase access to abortion care for clinicians and patients alike.
A recent study published in Anesthesiology found that liposomal bupivacaine is not sufficient to control pain during surgery, with successful blockade achieved in only a third of test subjects. However, the substance did lead to a reduction in pain sensitivity for 3.5 days post-operatively.
Researchers analyzed data from 1,392 TBI patients and found that some who died after withdrawing life support may have survived and recovered independence. The study suggests delaying decisions on withdrawal might be beneficial for certain patients, as assumptions about poor outcomes can lead to a self-fulfilling prophecy.
Researchers found that specific combinations of interferon proteins, including I, II, and III, are associated with various lupus symptoms like skin rashes, kidney inflammation, and joint pain. Elevated levels of these interferons can lead to severe disease presentations.
A plant-based diet is associated with a 47% lower risk of prostate cancer progression in men. Eating one or two extra servings of healthy foods daily can significantly reduce the disease's worsening chances.
A team of scientists at the University of Ottawa has developed a novel peptide-based hydrogel that can be used for on-the-spot repair to damaged organs and tissues. The material shows great potential for closing skin wounds, delivering therapeutics to damaged heart muscle, and reshaping and healing injured corneas.
Researchers developed an algorithm to stratify people with type 2 diabetes using routine data, revealing metabolic diversity and insulin sensitivity variability. The study's findings have the potential to change the way we understand and treat type 2 diabetes.
Researchers discuss therapeutic opportunities for hypermutated urothelial carcinomas that are resistant to immunotherapy, including the potential of targeted therapies. High TMB is associated with defects in mismatch repair proteins and can lead to increased sensitivity to cancer treatments.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center have found a combination immunotherapy treatment that enhances the immune response for people with malignant gliomas. Adding an immune-boosting agent, poly-ICLC, to a personalized dendritic cell vaccine improves the immune response and activity of T cells in patients.
Australian researchers have identified biomarkers that can predict which children are likely to outgrow their peanut allergy. The study found that two-thirds of children with a peanut allergy remain allergic by age 10, but most who naturally outgrew their allergy did so by age six.
Researchers developed a Pix-2-Pix GAN model to correct PSMA PET/CT images, improving image quality and quantitative markers. The AI-generated images show high correlation with original images and potential for reducing CT scans without compromising image quality.
Researchers have identified a promising new vaccine adjuvant called C100, derived from chitin, which stimulates key sensing and signalling molecules to regulate anti-tumour immune responses. The discovery offers hope for developing effective adjuvants for in situ vaccines in cancer immunotherapy.
Starting people with opioid use disorder on extended-release, injectable naltrexone within five to seven days of seeking treatment is more effective than the standard method. This rapid treatment protocol requires closer medical supervision and could make XR-naltrexone a more viable option for treating opioid use disorder.
Researchers at UCSF used an AI model to analyze clinical notes and determine patient urgency, achieving an accuracy rate of 89% and surpassing human physician performance in 88% of cases. The study suggests AI could help alleviate ED overcrowding by providing backup decision-making tools for clinicians.
Researchers have discovered a protein marker to help identify cells able to repopulate in patients with damaged blood vessels. These cells could form new blood vessels and contribute to the repair of heart tissue after a heart attack.
The Academic Payvider model enhances value-based care by fostering improved coordination, reduced insurance hassles, and increased staff attention. This joint approach between payers and providers aims to drive complex care down through innovative reimbursement structures.
Researchers found that SARS-CoV-2 spike protein interrupts p53-MDM2 interaction but does not bind with p53 protein in cancer cells. The study also shows that SARS-CoV-2 spike suppresses p53-dependent gene activation, leading to increased cell viability after chemotherapy exposure.
A recent study in Saudi Arabia assessed the effectiveness of an educational program improving epilepsy care among caregivers. The intervention showed a significant decrease in knowledge gaps, with 23.2% having sufficient knowledge post-intervention compared to 60% before.
The world's largest study of cerebral palsy genetics found genetic defects are responsible for over a quarter of cases in Chinese children. Researchers identified 81 genes with causation mutations, indicating that improper brain development may be the underlying cause of cerebral palsy rather than lack of oxygen at birth.
A head-mounted device generating an ultra-low frequency magnetic field has improved symptoms of four male patients with major depressive disorder. The study suggests that future trials may offer a safe and non-invasive way to treat depression.
Undergraduate nursing students in Morocco struggle with a disconnect between classroom learning and real-world practice. Insufficient support, lack of supervision, and poorly scheduled internships are among the main issues identified.
A new study published by the University of Bath found that adolescents are more vulnerable to cannabis use disorder than adults, despite using cannabis less frequently. The study showed that adolescents reported greater negative impacts on daily functioning and symptoms of cannabis use disorder.
Researchers will discuss key findings on pediatric mental health, vaccination, autism diagnosis, social determinants of cardiovascular health, and treatment of bronchiolitis. Studies examine the relationship between socioeconomic factors and hypertension in youth, long wait times for autism evaluations, and the impact of HPV vaccine up...
A new study found extensive alternative splicing of messenger RNA in untreated multiple sclerosis patients compared to healthy controls. Interferon-ß therapy corrected dysregulated alternative splicing, linking it to future clinical exacerbations.
Severe hip OA linked to worse functional impairment and increased ASD severity even after surgery, according to a study published in The Journal of Bone & Joint Surgery. Patients with severe bilateral hip OA had poorer physical functioning, disability scores, and correction of spinal alignment.
Researchers found that T cells and memory B cells provide durable protection against symptomatic SARS-CoV-2 infection, with levels attainable after two doses of mRNA vaccination. The study suggests a two-dose vaccination regimen for children against COVID-19.
Glioblastoma cancer cells change their appearance and behavior to evade T-cell attack, rendering immunotherapy ineffective. Researchers found that these 'plastic' cells can also exhaust T-cells, making glioblastoma resistant to treatment.
Researchers found a strong association between favorable survival outcomes and high populations of tissue-resident memory T cells in melanoma patients. The study identified 11 distinct gene signatures that correlate with T cell abundance and patient survival, suggesting a crucial role for T cells in immunomodulation.
The Society for Cardiovascular Angiography and Interventions (SCAI) has awarded 3rd Annual Early Career Research Grants to support junior investigators in interventional cardiology. The grants, funded by Edwards Lifesciences, Medtronic, and Shockwave Medical, aim to advance scientific knowledge and impact clinical practice.
Research suggests that four proposed AI search engines for automating search and retrieval of digital histopathology slides have inadequate performance for routine clinical care. The algorithms showed less than 50% accuracy in some cases, highlighting the need for rigorous external validations and standardization before clinical adoption.
Researchers found PLS occurs significantly more frequently in unequal AB0 settings, leading to haemolysis and anaemia in patients. Blood group A patients with O transplants are particularly at risk.
The American Society for Nutrition's NUTRITION 2024 will bring together thousands of experts to share emerging scientific and policy developments in food, nutrition, and public health. Over 1,600 original research studies will be presented during the meeting.
A Mayo Clinic study found that laparoscopic sleeve gastrectomy can improve the health and eligibility of patients with advanced chronic kidney disease and obesity. The procedure reduced cardiovascular risks, including diabetes and hypertension, and improved access to kidney transplantation.
The American Journal of Respiratory and Critical Care Medicine has released the ATS 2024 International Conference Abstracts, featuring research on heat exposure and RSV among other topics.
A new study suggests that proteins detectable in the blood could improve predictions about risk of liver cancer, potentially leading to earlier therapeutic interventions. The researchers used proteomics to develop a prediction model and identified 56 plasma proteins associated with liver cancer.
Researchers found that metformin decreases the amount of COVID-19 virus in the body and lowers the chances of viral rebound. The study showed a significant reduction in long COVID cases and hospitalizations among adults treated with metformin.
A new study found that brief anger episodes can negatively impact blood vessel function, leading to increased risk of heart disease and stroke. The researchers investigated the effects of anger, sadness, and anxiety on blood vessel function and found that evoking an angered state led to blood vessel dysfunction.
A new study reveals that women make up just 13% of the American Academy of Facial Plastic and Reconstructive Surgery membership. The authors highlight the need for education, mentorship, and sponsorship to address these disparities and promote a more inclusive future for female surgeons.
A team of researchers has developed a hemostasis sponge that swiftly staunchs kidney bleeding and facilitates wound recovery. The material uses kidney-derived decellularized extracellular matrix to recreate the kidney's microenvironment, boasting high biocompatibility.
Researchers will investigate sleep patterns in adolescents with TBI, explore behavioral changes in individuals with spatial neglect, and develop a caregiver training program for TBI care. The studies aim to improve treatment outcomes and rehabilitation experiences for individuals with traumatic brain injury.
Researchers validated pediatric emergency department guidelines promoting safer CT scan use, finding both predictive rules safe and effective in minimizing unnecessary radiation exposure. The study enrolled thousands of children and adolescents nationwide, showing high accuracy in identifying cases requiring immediate intervention.
Researchers at the University of Missouri have developed a soft, self-charging material that can track vital signs like blood pressure and heart activity wirelessly. This innovation has significant implications for early disease detection and timely interventions in chronic conditions.
Researchers have developed a new anticoagulant with an on-off switch, providing rapid control of bleeding risks in surgery and blood clots. The supramolecular approach combines a tsetse fly protein with a synthetic peptide, allowing for the anticoagulant to be rapidly deactivated by introducing correctly matched strands of free PNA.
Researchers at UW–Madison developed a method using short electric pulses to increase gene therapy material uptake in liver cells, reducing dosage needed. The technique could help treat genetic diseases like cystic fibrosis and sickle-cell disease.
A novel combination of two existing drugs has been discovered to eradicate AML cancer cells in lab-based tests, offering hope for patients diagnosed annually with the disease. The treatment, pairing venetoclax with a STING agonist, showed high promise in AML samples driven by a mutated p53 protein, a type of AML generally harder to treat.
A study by Edith Cowan University and Fiona Stanley Hospital found that up to 50% of ICU patients experience sleep disturbance due to noise, which can hinder recovery. The researchers identified potential for medical equipment designers to consider alarm speakers' directivity and reducing volume levels to minimize noise exposure.
A novel oral amphotericin B formulation, MAT2203, has demonstrated encouraging results in treating invasive mucormycosis. The study showed MAT2203 was as effective as the current standard treatment, LAMB, in extending survival time and improving overall health.
Researchers at NeuRA and UniSA found that early detection and comprehensive treatment can lead to significant recovery for most people with Complex Regional Pain Syndrome (CRPS) within 12-18 months. The study reviews the latest advances in CRPS epidemiology, pathophysiology, diagnosis, and treatment.
Researchers discovered that the anatomical location of pancreatic tumors impacts treatment outcomes, suggesting a tumor-location-based model for improving patient care. The findings may lead to more specific treatment plans and better immunotherapy effectiveness.
An experimental monoclonal antibody drug called mAb43 appears to prevent and reverse the onset of clinical type 1 diabetes in mice, lengthening their lifespan. The drug targets insulin-making beta cells directly and shields them from immune system attacks, raising the possibility of a new treatment for the autoimmune condition.
A Weill Cornell Medicine study found that over 15-fold more Haitians have early-onset heart failure than previously thought, with elevated blood pressure being the leading risk factor. The research suggests a shift in focus to early prevention and treatment of cardiovascular diseases in low-income countries.
The American Heart Association has funded four new grants to evaluate the use of race in predicting heart disease risk and develop unbiased clinical algorithms. The research projects will test various risk models to remove racial bias from care decisions, improving patient outcomes.
Scientists at DTU and Lund University have found new enzymes that can remove both the A and B blood antigens and their blocking sugars, enabling the production of universal donor blood. This breakthrough has the potential to reduce logistics and costs associated with storing four different blood types.
Researchers have identified an inflammatory protein profile associated with poor survival in aggressive B-cell lymphoma patients. Protein profiles from blood samples can help classify subtypes of the disease and monitor patient response to treatment.
A national US study found that nearly a quarter of children with symptoms of brain injuries or concussions were not checked for the condition. Younger children were more likely to be overlooked. Routine checks can help ensure these children receive necessary care and support their mental and social well-being.