Articles tagged with Clinical Research
A study found that longer duration of type 2 diabetes is associated with decreased brain structure and increased white matter hyperintensities. Despite this, cognition was not affected, highlighting the need for early screening for cognitive disorders in diabetic patients.
A Kaiser Permanente study found that drinking alcohol after a breast cancer diagnosis does not impact a patient's prognosis. The research used data from over 4,500 women diagnosed with invasive breast cancer and tracked their lifestyle changes and outcomes over 11 years.
Researchers at Beth Israel Deaconess Medical Center discovered a non-ectodermal and mesodermal origin for large numbers of enteric neurons born after birth. This finding overturns decades of scientific dogma and offers hope for disease-modifying cures to aging patients.
Researchers used phage PASA16 to treat tough Pseudomonas aeruginosa infections, achieving an impressive 86.6% success rate. The study demonstrated the potential effectiveness of phage therapy as a valuable alternative to conventional antibiotics in combating antibiotic-resistant pathogens.
LSU Health researchers found combining an investigational oral drug with standard-of-care medications reverts hormone resistance and increases effectiveness in experimental models of ER+ and TNBC. The study's findings suggest a new approach for treating treatment-resistant breast cancers.
Researchers have made a significant discovery in gene therapy, showing that genetically engineered blood stem cells can be created while still in the bone marrow. This approach eliminates the need for chemotherapy and transplantation of corrected cells, cutting costs and improving access to critical treatments.
Researchers explore CDK9 inhibitors as a promising combination partner in treating hematological malignancies. They discuss the role of cyclin-dependent kinases (CDKs) in these diseases and highlight the potential synergism with other drugs.
A new approach to immunotherapy has shown long-term survival rates exceeding 50% in children with high-risk neuroblastoma. Stem cell transplantation from a parent provides a renewed immune system that responds better to immunotherapies, improving outcomes.
Researchers developed innovative techniques to treat challenging cancers and manage therapy side effects. Inhibitors targeting PRMT5, a histone-modifying enzyme, alleviated cisplatin-induced hearing loss, while nano-pills delivered combination drugs to liver cancer cells.
Researchers have developed a new explainable AI model to reduce bias and enhance trust in machine learning-generated decisions. The Pattern Discovery and Disentanglement (PDD) model can predict medical results with rigorous statistics and explainable patterns, leading to more reliable diagnoses and better treatment recommendations.
A study of 1,300 patients has identified a specific antibody, MOG-IgA, which may differentiate another MS-like illness from others. This discovery could lead to better understanding of the causes and treatment of these autoimmune diseases.
The American Heart Association is funding three new scientific research projects to examine the use of race in formulas that calculate risk and determine treatment for cardiovascular disease. The teams will assess potential bias in risk models, develop statistical methods to correct algorithm bias, and support equitable care.
The USC NRV Center performs complex revascularization procedures and conducts innovative research to treat debilitating conditions. The center will use the funding to enhance clinical care and education with a focus on technological innovation.
Researchers from Shinshu University have developed a novel neuromodulation approach that incorporates gait-combined closed-loop transcranial electrical stimulation, demonstrating significant gait improvements in patients with Parkinson's disease. The treatment showed encouraging results after just ten repetitions, improving speed, gait...
The Estee Lauder Companies' New Incubation Ventures has launched a breakthrough prize for innovative active ingredient companies, R&D labs and scientists pushing the boundaries of Indian consumers. The prize program aims to discover and support the next generation of Indian beauty brands.
A new NIH grant will help researchers better understand brain respiratory control and develop neuromodulation strategies to prevent Sudden Unexpected Death in Epilepsy (SUDEP). The goal is to identify optimal stimulation paradigms for breathing enhancement during a critical time window after seizures.
Researchers found that inhibiting NLRP3 signaling reduces podocyte senescence, improves lifespan, and slows down healthy podocyte aging in mice. This discovery holds promise for treating age-related kidney diseases.
A new study highlights the difficulty in diagnosing blood disorders like myelodysplastic syndromes/neoplasms (MDS), which can lead to treatment mistakes. The researchers found that expert pathologists disagreed with local pathologists' diagnoses in about 20% of cases, leading to wrong initial treatments for patients.
Researchers found that Epstein-Barr virus induces B cell growth transformation through the activation of the cancer-related gene IMPDH2, leading to uncontrolled proliferation. The study used primary B cells and found that inhibiting IMPDH2 can suppress post-transplant lymphoproliferative disorder (PTLD) development.
Researchers developed an innovative optical tool, the Schistoscope, to capture microscopy images of urine samples for efficient detection of Schistosoma haematobium eggs. A two-stage diagnostic framework using deep learning accurately identified and counted eggs in field settings with high sensitivity, specificity, and precision.
Researchers highlight the need for effective treatment strategies for adenoid cystic carcinoma (ACC) of the head and neck, which is a highly malignant tumor with variable localizations. Proton therapy shows decisive advantages in long-term survival rates for ACC.
A new diagnostic method assesses electrical and mechanical activity in the heart during atrial fibrillation, providing personalized assessment of atrial remodeling. This can help predict disease progression and guide treatment.
The study established a broad range of reptile cell lines, including those from crocodilians, snakes, turtles, tortoises, and lizards. This breakthrough will help advance reptile conservation and replace the need for live animals in scientific research, leading to improved animal welfare.
Researchers found that African ancestry patients with dilated cardiomyopathy have fewer clinically actionable variants in DCM genes compared to European ancestry patients. The study enrolled 1,198 patients with dilated cardiomyopathy, revealing a racial imbalance in genetic trials for heart failure.
Researchers at Duke University Medical Center have identified a fatty molecule in breast milk that triggers a process in which stem cells produce new white matter, reversing neurological damage. This finding holds promise for developing therapies to treat preterm babies with cerebral palsy.
Researchers at NUS and Imperial College London have discovered a new way bacteria share genes, enabling rapid evolution. Lateral cotransduction enables SaPIs to transfer themselves intact with bacterial DNA, making them potent transducing agents.
Researchers discovered that STING, a critical immune regulator, can act as an ion channel to control immune responses. This new function allows STING to translate danger signals into ion flow, activating various defense mechanisms.
Insilico Medicine's inClinico platform uses generative AI to predict Phase II to Phase III clinical trial success with an accuracy of 79%. The tool has been validated in various studies and can provide valuable insights for investors and biotech/pharma companies.
A recent study by Indiana University researchers found that an e-health and telehealth-based collaborative care intervention had a significant impact on patients with depression. The intervention resulted in a 43% reduction in depressive symptoms among participants, compared to only 17% in the usual primary care group.
Researchers discovered that stimulating dopamine neurons in mice's midbrain triggers orofacial movements, which are linked to brain-wide neuronal activities. The study identified two distinct orofacial movements: transient actions upon reward expectation and active, sustained movements upon receiving a reward.
A study found that breast cancer patients with higher body mass index (BMI) are more likely to experience heart damage, or cardiotoxicity, during chemotherapy. The study suggests that addressing obesity and considering the potential risk of cardiotoxicity requires a comprehensive approach.
Researchers have discovered two major mechanisms that contribute to the high risk of complications from lung infections in individuals with Down syndrome: poor ciliary function, which impairs the respiratory tract's ability to clear mucus and viral particles, and immune hyper-reactivity, which leads to an overactive immune response. Th...
Researchers found that translating consent documents can discourage investigators from recruiting patients with limited English proficiency, contributing to low rates of participation from underrepresented groups. By relieving investigators of these costs, studies can become more inclusive and results more accurate and generalizable.
A new study improves the chances of finding the right drug to kill individual cancers in children by incorporating high-throughput drug screening into precision medicine. The approach reveals additional drug sensitivities and predicts clinical response, leading to better treatment options.
A new open-source Python toolbox called simpleNomo has been made available, enabling the creation of nomograms directly from logistic regression coefficients. This facilitates the translation of research findings into practical use, particularly in resource-poor settings or areas without internet access.
Researchers at Weill Cornell Medicine developed a non-opioid designer molecule to calm hyperactive pain-sensing neurons, showing promising results in preclinical studies. The novel drug effectively reversed neuropathic pain signs without cardiac side effects or sedation.
Researchers aim to treat pancreatic ductal adenocarcinoma by targeting amino acid transporter SLC6A14 and compensatory nutrient scavenging mechanisms autophagy and macropinocytosis. Using alpha-methyl-L-tryptophan and hydroxychlorquine, the study seeks to improve therapeutic outcomes in patients with pancreatic cancer.
A new drug formulation designed for treating children with HIV has shown safety, tolerability, and effectiveness in a study published in The Lancet HIV. The formulation contains three medications and was found to suppress HIV levels below 200 copies/mL in 98% of participants.
Researchers found that adults who experienced violence, financial stress, or separation from parents as children were more likely to experience physical and cognitive impairments. Adverse childhood experiences can have lifelong consequences, including difficulty walking, carrying out daily activities, and problems with memory.
A new study by MU researcher Roy Thompson found that immigrant nurses in long-term care facilities often have more 'human capital' than their American-born counterparts, including language skills and additional certifications. This diversity can improve patient health outcomes and create a more equitable workforce.
A new NIHR Dementia and Neurodegeneration Policy Research Unit (DeNPRU) will work with policymakers to produce research on four key questions. The team aims to deliver fairer services, support people living with dementia, and improve patient outcomes.
Researchers at McMaster University developed a new rapid test that can quickly identify eosinophils, key drivers of severe asthma, in complex biological samples. The test uses DNAzymes to track protein signatures and is designed to be simple and adaptable for mass manufacturing.
A new study by UCSF found that half of participants with extensive tobacco exposure had persistently high respiratory symptoms, yet performed well in COPD tests. The study highlights a gap in effective care for tobacco-exposed individuals and emphasizes the need for broader definition of smoking-related lung disease.
A recent study published in Nature Mental Health emphasizes the need for further research on sex differences in depression. The study, led by Georgia Hodes and Dawson Kropp, aims to uncover effective and sex-specific biomarkers for depression onset and target better treatment options.
A new study shows that estrogen receptor (ER) expression in ductal carcinoma in situ (DCIS) is multi-clonal, meaning it varies across different cells. This finding has significant clinical implications, as it may help avoid overtreatment and undertreatment in DCIS patients.
Researchers found that human senescent fibroblasts trigger progressive lung fibrosis in immunodeficient mice by inducing paracrine senescence and pro-fibrotic activities. The study also suggests that senolytic compounds like navitoclax can ameliorate lung fibrosis induced by senescent human fibroblasts.
Dr. Prachi Singh of Pennington Biomedical Research Center has received a $3.7 million grant from the National Heart, Lung, and Blood Institute to investigate the cardiovascular risks associated with limited sleep and extended eating duration.
A new study identifies two distinct subtypes of human papillomavirus-positive head and neck cancers with different treatment outcomes. Tumors with high NF-kB activity are more responsive to radiation therapy, leading to improved patient survival.
A new multi-center study found that having a genetic variant in the prealbumin gene alone is not sufficient for diagnosing transthyretin amyloid cardiomyopathy in older Black patients. Researchers suggest that a blood test measuring prealbumin levels may be useful in identifying patients at risk of developing cardiac amyloidosis.
A novel Raman technique called thermostable-Raman-interaction-profiling (TRIP) allows for label-free and highly reproducible Raman spectroscopy measurements, breaking a 50-year-old challenge. The TRIP method enables the detection of protein-ligand interactions in real-time, potentially shortening drug and vaccine testing timelines.
Researchers at Rutgers University analyzed urine samples from pregnant women to understand how the placenta regulates cadmium exposure. They found that as cadmium levels increased, free testosterone levels decreased, suggesting a link between cadmium and fetal brain development.
A new phase II clinical trial will investigate the effectiveness of an accelerated course of transcranial magnetic stimulation in improving symptoms for patients with mild cognitive impairment and depression. The study aims to identify the optimal dose of stimulation needed to improve both depression and thinking difficulties in MCI, w...
Researchers developed a blood test to detect nerve injury in MS and found it works for children, even when symptom-free. The test measures neurofilament light chain levels, which reflect nerve cell injury.
The Oregon Health & Science University team's free genetic screening program for adults has screened over 13,000 residents since 2018. The study found that 710 participants carried disease-causing variants, highlighting the importance of genetic counseling and expanded gene testing.
A new study published in The New England Journal of Medicine found that the MIND diet had a significant improvement in cognition during the first two years, but no significant difference in three-year changes. The study enrolled 604 people with suboptimal diets and family history of Alzheimer's disease.
Researchers from Sahmyook University found that phyllodulcin, a natural sweetener found in hydrangeas, can efficiently inhibit amyloid beta (Aβ) aggregation and dissociate its aggregates in an animal model study. The study suggests that phyllodulcin may be useful in delaying the onset and progression of Alzheimer's disease.
CHOP and Penn Medicine researchers have developed a proof-of-concept model for delivering gene editing tools directly into diseased blood cells within the body. This approach aims to reduce costs and increase access to gene therapies for blood disorders, which currently require chemotherapy and stem cell transplants.
Researchers from IU School of Medicine have diagnosed a Sumatran Orangutan named Mila at the Indianapolis Zoo with Alkaptonuria, a rare autosomal recessive disorder. The diagnosis was confirmed through molecular analysis of DNA, providing veterinarians with crucial information on Mila's health and treatment options.
Researchers at Queensland University of Technology have developed a new approach to designing molecular ON-OFF switches based on proteins, which can be used in various biotechnological and biomedical applications. The novel technique allows for faster and more accurate diagnostic tests for detecting diseases and monitoring water quality.
A new study by Brighton and Sussex Medical School finds that 24% of autistic doctors have attempted suicide, while 77% have considered it. The study highlights the need for workplaces to provide better support and awareness of autistic healthcare professionals.